Yang Xin Fu

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
    Y X Fu
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:5739-43. 1997
  2. pmc B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
    Y X Fu
    Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 187:1009-18. 1998
  3. pmc Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation
    Hyung Sik Kang
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 198:1643-52. 2003
  4. pmc Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor
    Q Wu
    Committee on Immunology and the Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 193:1327-32. 2001
  5. pmc The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues
    Q Wu
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:629-38. 1999
  6. ncbi request reprint Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation
    Y X Fu
    Departments of Laboratory Medicine Pathology and Internal Medicine, and Howard Hughes Medical Institute and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:2508-14. 2000
  7. pmc Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells
    Ping Yu
    Deptartment of Pathology, Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 197:985-95. 2003
  8. ncbi request reprint Development and maturation of secondary lymphoid tissues
    Y X Fu
    Department of Pathology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Annu Rev Immunol 17:399-433. 1999
  9. ncbi request reprint Priming of naive T cells inside tumors leads to eradication of established tumors
    Ping Yu
    The Committee on Immunology and Department of Pathology, University of Chicago, MC3083, Chicago, IL 60637, USA
    Nat Immunol 5:141-9. 2004
  10. ncbi request reprint B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion
    Ping Yu
    Department of Pathology and Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 168:5117-23. 2002

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. pmc Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
    Y X Fu
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:5739-43. 1997
    ..These data demonstrate that the signals that regulate the development of distinct T and B cell zones as well as the signals that regulate B cell activation to produce clusters of PNA+ cells differ between the spleen and LNs...
  2. pmc B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
    Y X Fu
    Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 187:1009-18. 1998
    ..Thus, B cells themselves provide an essential signal that induces and maintains the lymphoid microenvironment essential for GC formation and class-switched Ig responses...
  3. pmc Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation
    Hyung Sik Kang
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 198:1643-52. 2003
    ..Therefore, this work has revealed that lymphotoxin is essential for IgE production, and a physiological role of IgE in the airway may consist of maintaining the balance of Th1 and Th2 responses to prevent aberrant inflammation...
  4. pmc Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor
    Q Wu
    Committee on Immunology and the Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 193:1327-32. 2001
    ..Thus, LTbetaR-Ig can disassemble the well established lymphoid microenvironment in the islets, which is required for the development and progression of IDDM...
  5. pmc The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues
    Q Wu
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:629-38. 1999
    ..Taken together, these results support the notion that the signaling via LTbetaR by membrane LTalpha/beta is required for the presence of DCs in lymphoid tissues...
  6. ncbi request reprint Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation
    Y X Fu
    Departments of Laboratory Medicine Pathology and Internal Medicine, and Howard Hughes Medical Institute and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:2508-14. 2000
    ....
  7. pmc Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells
    Ping Yu
    Deptartment of Pathology, Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 197:985-95. 2003
    ..Therefore, our paper demonstrates that effective immune protection against tumors requires the cross-priming of CD8+ T cells under conditions that require either CD4+ T cell help, or draining lymph nodes...
  8. ncbi request reprint Development and maturation of secondary lymphoid tissues
    Y X Fu
    Department of Pathology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Annu Rev Immunol 17:399-433. 1999
    ..It also discusses new insights into how the structure of these tissues supports effective immune responses...
  9. ncbi request reprint Priming of naive T cells inside tumors leads to eradication of established tumors
    Ping Yu
    The Committee on Immunology and Department of Pathology, University of Chicago, MC3083, Chicago, IL 60637, USA
    Nat Immunol 5:141-9. 2004
    ..Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy...
  10. ncbi request reprint B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion
    Ping Yu
    Department of Pathology and Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 168:5117-23. 2002
    ..In turn, CR-Fc(+) DCs and T cells home to B cell follicles to interact with B cells in the developing germinal center...
  11. ncbi request reprint The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function
    Jing Wang
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Eur J Immunol 32:1969-79. 2002
    ..These findings uncover the potential interaction between LIGHT and one of its receptors, LTbetaR, in supporting even in the absence of LT the development and maintenance of lymphoid microenvironment...
  12. ncbi request reprint Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling
    Yonglian Sun
    Department of Pathology and Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 175:884-90. 2005
    ..These studies have revealed a previously unappreciated role of T cells in the regulation of FDC networks...
  13. ncbi request reprint The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 174:8173-82. 2005
    ..Furthermore, we demonstrated that up-regulation of LIGHT is associated with active CD. These data establish a new mouse model resembling CD and suggest that up-regulation of LIGHT may be an important mediator of CD pathogenesis...
  14. ncbi request reprint Contribution of the lymphotoxin beta receptor to liver regeneration
    Robert A Anders
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:1295-300. 2005
    ..Therefore, our study has revealed an unexpected role of lymphocyte-restricted ligands and defined a new pathway in supporting liver regeneration...
  15. pmc Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection
    Sumit K Subudhi
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 113:694-700. 2004
    ..Ig fusion protein augmented naive T cell priming both in vitro and in vivo. Our results demonstrate that B7-H1 can provide positive costimulation for naive T cells to promote allograft rejection and autoimmune disease pathogenesis...
  16. pmc The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses
    Yang Wang
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 115:711-7. 2005
    ..Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases...
  17. ncbi request reprint Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis
    Yonglian Sun
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:1457-65. 2002
    ..This study indicates that the agonistic Ab against 4-1BB can potentially be used as a novel immunotherapeutic agent for treating autoimmune diseases...
  18. ncbi request reprint Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation
    Yonglian Sun
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 177:814-21. 2006
    ..CD137-mediated suppression of Th2 response is independent of IFN-gamma and T regulatory cells. Our study has identified a novel pathway to inhibit Th2 responses in a CD137-dependent fashion...
  19. pmc Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues
    James C Lo
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 112:1495-505. 2003
    ....
  20. ncbi request reprint Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production
    Hyung Sik Kang
    Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Nat Immunol 3:576-82. 2002
    ....
  21. ncbi request reprint Immunology. Autoreactive B cells migrate into T cell territory
    Yang Xin Fu
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Science 297:2006-8. 2002
  22. ncbi request reprint LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide
    Jing Wang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:3986-93. 2003
    ..Taken together, LIGHT plays a role in negative selection of thymocytes via inducing the apoptosis of thymocytes bearing high affinity TCR during negative selection...
  23. ncbi request reprint Lymphotoxin pathway directs thymic Aire expression
    Robert K Chin
    Department of Pathology and Committee in Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 4:1121-7. 2003
    ..These findings define the essential cross-talk between thymocytes and thymic stroma that is required for central tolerance...
  24. ncbi request reprint Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion
    Yu Gang Wang
    Department of Pathology, University of Chicago, Chicago IL 60637
    J Immunol 175:6997-7002. 2005
    ..Therefore, LTbetaR signaling on DCs is required for their homeostasis during physiology and pathological conditions, and increased LIGHT-LTbetaR interaction could stimulate DC expansion for T cell-mediated immunity...
  25. ncbi request reprint Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure
    Youjin Lee
    Committee on Immunology, Department of Pathology, The University of Chicago, 5841 S Maryland, Room J541, MC3083, Chicago, Illinois 60637, USA
    Immunity 25:499-509. 2006
    ..Thus, the TNFSF14-LTbetaR pathway appears to be critical in the development and maintenance of TLO for the onset of diabetes...
  26. pmc B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism
    Xingluo Liu
    Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 197:1721-30. 2003
    ..Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC...
  27. ncbi request reprint Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen
    Robert K Chin
    Department of Pathology and Committee in Immunology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 177:290-7. 2006
    ..These findings define the existence of additional pathways of ectopic peripheral Ag expression, parallel to and independent of AIRE, which may cover an extended spectrum of peripheral Ags in the thymus...
  28. pmc Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases
    Ping Yu
    Committee on Immunology and Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 179:1960-8. 2007
    ..Therefore, targeting the primary tumor with Ad-LIGHT before surgical excision is a new strategy to elicit better immune response for the eradication of spontaneous metastases...
  29. pmc IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation
    Sarah E Blink
    Committee on Immunology, University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Cell Immunol 264:54-60. 2010
    ..We demonstrate a novel role for IgE in regulating differentiation of adaptive inflammatory responses through direct interaction with FcgammaRIII on dendritic cells...
  30. pmc Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
    Bin Zhang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:49-55. 2007
    ..Under these conditions, tumor rejection was complete. These findings may set the stage for developing rational clinical protocols for combining irradiation or chemotherapy with CTL therapy...
  31. pmc Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 113:826-35. 2004
    ..These observations indicate the critical contributions of dysregulated LIGHT expression and intestinal inflammation to the pathogenesis of IgAN...
  32. pmc Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
    Xiaohuan Guo
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 40:25-39. 2014
    ..Activated STAT3 could directly bind to the Il22 locus. Thus, cancer therapies that utilize STAT3 inhibitors increase the risk for pathogen-mediated diarrhea through direct suppression of IL-22 from gut ILCs...
  33. pmc NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway
    Mingzhao Zhu
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:2964-71. 2006
    ..Thus NF-kappaB2 downstream of LTbetaR plays an important role in the regulation of central tolerance in an Aire-dependent manner...
  34. ncbi request reprint Membrane lymphotoxin is required for resistance to Theiler's virus infection
    Xiaoqi Lin
    Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    Int Immunol 15:955-62. 2003
    ..There was relatively little demyelination associated with inflammation in LT-alpha(-/-) and LT-beta-R(-/-) mice compared to susceptible SJL mice, suggesting the possibility that LT plays a role in mediating demyelination...
  35. doi request reprint Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition
    Yugang Wang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 184:1589-95. 2010
    ..Our data collectively suggest that LIGHT might be a critical cytokine involved in the development of autoimmune inflammatory diseases and that LIGHT-targeted immunotherapy might be useful in the treatment of these diseases...
  36. pmc Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    Daniel R Clayburgh
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:2682-94. 2006
    ..These data demonstrate the necessity of coordinated Na+ malabsorption and barrier dysfunction in TNF-induced diarrhea and provide insight into mechanisms of intestinal water transport...
  37. pmc T cell-derived lymphotoxin regulates liver regeneration
    Alexei V Tumanov
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Gastroenterology 136:694-704.e4. 2009
    ..The role of adaptive immune system in liver regeneration was investigated in lymphocyte-deficient mice and in conditional lymphotoxin-deficient mice...
  38. pmc Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    Ping Yu
    The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 201:779-91. 2005
    ....
  39. ncbi request reprint Secondary lymphoid organs are important but not absolutely required for allograft responses
    Ping Zhou
    Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 3:259-66. 2003
    ..These results suggest that immunologic events capable of leading to allograft rejection can successfully occur at sites other than classical secondary lymphoid organs...
  40. pmc Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection
    Yugang Wang
    The University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Immunity 32:403-13. 2010
    ..These results support a model wherein LT from RORgammat(+) cells orchestrates the innate immune response against mucosal microbial infection...
  41. pmc B and T lymphocyte attenuator tempers early infection immunity
    Yonglian Sun
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 183:1946-51. 2009
    ..These results provide the first evidence that a coinhibitory pathway plays a critical role in regulating early host innate immunity against infection...
  42. ncbi request reprint Lymphotoxin beta receptor-dependent control of lipid homeostasis
    James C Lo
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Science 316:285-8. 2007
    ..These results suggest that the immune system directly influences lipid metabolism and that LT modulating agents may represent a novel therapeutic route for the treatment of dyslipidemia...
  43. pmc LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells
    Bijoy Chellan
    Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e54719. 2013
    ..Therefore, our data argues that interaction of LIGHT with LTβR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function...
  44. pmc Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
    Alexei V Tumanov
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 10:44-53. 2011
    ..Taken together, our data show that LTβR signaling in gut lymphoid follicles regulates IL-22 production by ILCs in response to mucosal pathogen challenge...
  45. pmc Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
    Salvatore Papa
    Ben May Department for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1911-23. 2008
    ..These data provide a basis for JNK suppression during liver regeneration and identify Gadd45beta as a potential therapeutic target in liver diseases...
  46. ncbi request reprint A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development
    Rebecca H Lian
    The Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Eur J Immunol 34:2699-707. 2004
    ..These data suggest that LTbetaR-mediated signals regulate Ly49 expression at least in part through the activation of IL-15...
  47. ncbi request reprint Recognition of host immune activation by Pseudomonas aeruginosa
    Licheng Wu
    Department of Surgery, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    Science 309:774-7. 2005
    ..These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host...
  48. pmc Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    Ju Qiu
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Immunity 39:386-99. 2013
    ..Innate expression of Ahr played a protective role in T-cell-mediated experimental colitis by suppressing pathogenic Th17 cells. Our data reveal an intricate balance between ILCs and Th17 cells regulated by Ahr and commensal flora. ..
  49. doi request reprint Equilibrium between host and cancer caused by effector T cells killing tumor stroma
    Bin Zhang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, Illinois, USA
    Cancer Res 68:1563-71. 2008
    ..These findings show the effectiveness of adoptive CTL therapy directed against tumor stroma and open a new avenue for cancer treatments...
  50. ncbi request reprint Co-stimulation agonists as a new immunotherapy for autoimmune diseases
    Yonglian Sun
    Department of Pathology and Committee in Immunology, University of Chicago, Chicago, IL 60637, USA
    Trends Mol Med 9:483-9. 2003
    ..These findings imply that signaling through co-stimulatory molecules can have diametric outcomes in modulating immune responses, thereby providing a novel approach to the treatment of autoimmune diseases...
  51. ncbi request reprint The role of LIGHT in T cell-mediated immunity
    Jing Wang
    Department of Pathology, University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Immunol Res 30:201-14. 2004
    ..Here, we review the recent studies about LIGHT mainly in the context of autoimmunity and conclude with a discussion of the potential mechanisms by which LIGHT promotes autoimmunity...
  52. pmc Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine
    Yuru Meng
    Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois, USA
    Mol Ther 20:1046-55. 2012
    ..Applied to human cancers, radiation-inducible immunotherapy may enhance radiotherapy responses to prevent local recurrence and distant metastasis...
  53. pmc Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
    James C Lo
    Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Blood 107:1048-55. 2006
    ....
  54. ncbi request reprint Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development
    X Wu
    Division of Rheumatology, Department of Medicine, and Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 165:3119-27. 2000
    ....
  55. pmc Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses
    Xuanming Yang
    IBP UC Group for Immunotherapy, Chinese Academy of Sciences Key Laboratory for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Cancer Cell 25:37-48. 2014
    ..This study establishes a next-generation Ab-based immunotherapy that targets and eradicates established Ab-resistant tumors. ..
  56. ncbi request reprint Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation
    Michael T Spiotto
    Department of Pathology and Committee on Immunology, The University of Chicago, 5831 S Ellis Avenue, Chicago, Illinois 60637, USA
    Curr Opin Immunol 15:725-30. 2003
    ..Exploiting these conditions to target unique tumor antigens will enable us to develop better cancer immunotherapies...
  57. ncbi request reprint Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 6063, USA
    J Immunol 179:4473-9. 2007
    ..Together, our data suggest that Cbl-b attenuates CD40-mediated NF-kappaB and JNK activation, thereby suppressing B cell responses...
  58. ncbi request reprint Lymphoid microenvironment in the gut for immunoglobulin A and inflammation
    Robert Chin
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunol Rev 195:190-201. 2003
    ..The ability to modulate LTbetaR signaling may alternatively permit the suppression of autoimmune responses and augmentation of gut defenses...
  59. pmc Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing
    Hua Liang
    Department of Radiation and Cellular Oncology, The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
    J Immunol 190:5874-81. 2013
    ..We identify an active interplay between tumor cells and immune cells that occurs in radiation-induced tumor equilibrium and suggest a potential role for disruption of the PD-L1/PD-1 axis in increasing local tumor control...
  60. ncbi request reprint Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
    Michael T Spiotto
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 17:737-47. 2002
    ..Thus, tumor antigens expressed at levels sufficient for crosspresentation by bone marrow-derived stromal cells may overcome immunological "ignorance" to solid tumors...
  61. pmc CD95 promotes tumour growth
    Lina Chen
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Nature 465:492-6. 2010
    ..These results demonstrate that CD95 has a growth-promoting role during tumorigenesis and indicate that efforts to inhibit its activity rather than to enhance it should be considered during cancer therapy...
  62. pmc The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    Ju Qiu
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Immunity 36:92-104. 2012
    ..Our data uncover a previously unrecognized physiological role for Ahr in promoting innate gut immunity by regulating RORγt(+) ILCs...
  63. ncbi request reprint Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development
    Q Wu
    Department of Pathology and Neurology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 166:1684-9. 2001
    ..Together, these results indicate that the signal via LTbetaR on BM stromal cells by membrane LT is an important pathway for early NK cell development...
  64. ncbi request reprint Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells
    Y Wang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 166:330-7. 2001
    ..Thus, the development and maintenance of these lymphoid structures depend on a delicate interaction between TNF and LT from different subsets of lymphocytes...
  65. ncbi request reprint A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α(+) DCs to Promote Long-Term T Cell Responses
    Xuanming Yang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 16:68-80. 2014
    ..This study uncovers a BTLA-mediated strategy used by the host that permits Listeria proliferation to enable increasing T cell responses for long-term protection. ..
  66. doi request reprint Immunoregulation by tumor necrosis factor superfamily member LIGHT
    Yugang Wang
    The Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunol Rev 229:232-43. 2009
    ..Understanding LIGHT interactions offers promising new therapeutic strategies that target LIGHT-engaged pathways to fight against cancer and various infectious diseases...
  67. ncbi request reprint Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla
    Mingzhao Zhu
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 179:8069-75. 2007
    ..Thus, LTbetaR has been revealed to play an important role in thymic negative selection of organ-specific thymocytes through thymic medullary chemokines regulation...
  68. ncbi request reprint Innate and adaptive immune cells in the tumor microenvironment
    Thomas F Gajewski
    University of Chicago, Chicago, Illinois, USA
    Nat Immunol 14:1014-22. 2013
    ..These two major phenotypes of tumor microenvironment may require distinct immunotherapeutic interventions for maximal therapeutic effect. ..
  69. ncbi request reprint The role of stroma in immune recognition and destruction of well-established solid tumors
    Ping Yu
    Department of Pathology and Committee on Immunology, The University of Chicago, 5831 S Ellis Avenue, Chicago, IL 60637, USA
    Curr Opin Immunol 18:226-31. 2006
    ..Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence...
  70. pmc Lymphotoxin signalling in immune homeostasis and the control of microorganisms
    Vaibhav Upadhyay
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Immunol 13:270-9. 2013
    ..In this Review, we discuss these newly defined roles for LT, with a particular focus on how the LT receptor pathway regulates innate and adaptive immune responses to microorganisms...
  71. pmc Requirement for membrane lymphotoxin in natural killer cell development
    K Iizuka
    Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6336-40. 1999
    ..They also support a cellular and molecular mechanism by which NK cell precursors themselves deliver essential signals, through the membrane ligand, that induce the microenvironment to promote further NK cell and NK/T cell development...
  72. ncbi request reprint The role of lymphotoxin receptor signaling in diseases
    Alexei V Tumanov
    Department of Pathology, University of Chicago, Chicago, IL 60537, USA
    Curr Mol Med 7:567-78. 2007
    ..This review will discuss recent advances in understanding LTbetaR's role in various human and murine disease models while focusing on its regulation of and implications in various liver related diseases...
  73. pmc The human BCL6 transgene promotes the development of lymphomas in the mouse
    Beverly W Baron
    Department of Pathology, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:14198-203. 2004
    ..Because BCL6 expression has been reported in a number of T cell tumors as well as in the more commonly occurring B cell lymphomas in humans, our transgenic mice provide a model for the study of human lymphomas...
  74. ncbi request reprint The balance of immune responses: costimulation verse coinhibition
    Sumit K Subudhi
    Department of Pathology, University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    J Mol Med (Berl) 83:193-202. 2005
    ..This cautions against using clinical immunotherapeutic reagents targeted against these molecules until we gain a better understanding of the circumstances that regulate the outcomes of the T cell response...
  75. ncbi request reprint Tumor-infiltrating T lymphocytes: friends or foes?
    Ping Yu
    1Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Lab Invest 86:231-45. 2006
    ..This article reviews the antitumor functions of T-lymphocytes, with special attention given to CD4(+) regulatory T-cells within the tumor environment...
  76. pmc Targeting tumors with LIGHT to generate metastasis-clearing immunity
    Ping Yu
    Section of Dermatology, Department of Medicine, University of Chicago, MC5067 Chicago, IL 60637, USA
    Cytokine Growth Factor Rev 19:285-94. 2008
    ..This review summarizes recent findings to support that LIGHT is a promising candidate for an effective cancer immunotherapy...
  77. ncbi request reprint Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin
    Y Wang
    Department of Pathology, The University of Chicago, Chicago 60637, USA
    Eur J Immunol 30:2226-34. 2000
    ..Thus, these data support a model in which prolonged availability of antigen is required for somatic mutation and affinity maturation, and FDC or adjuvants facilitate such processes by slowly releasing antigens...
  78. pmc Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses
    Y X Fu
    Department of Laboratory Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:2111-20. 1997
    ..Rather, expression of LTalpha supports the maturation of spleen follicle structure, including the development and maintenance of FDC clusters, which supports Ig class switching and an effective IgG response...
  79. pmc Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells
    M Matsumoto
    Center for Immunology and the Department of, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 186:1997-2004. 1997
    ..The data in this study demonstrate that FDC organization and GC formation are controlled by both LT-alpha-expressing BM-derived cells and by TNFR-I-expressing non-BM-derived cells...
  80. doi request reprint Coordinating development of medullary thymic epithelial cells
    Mingzhao Zhu
    The Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:386-8. 2008
    ..2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells...
  81. pmc Lymphotoxin regulates commensal responses to enable diet-induced obesity
    Vaibhav Upadhyay
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, Illinois, USA
    Nat Immunol 13:947-53. 2012
    ..Mice deficient in these pathways also resisted DIO, demonstrating that intact mucosal immunity guides diet-induced changes to the microbiota to enable obesity...
  82. pmc The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity
    Byron C Burnette
    Departments of Pathology and Radiation and Cellular Oncology, The Ludwig Center for Metastasis Research, University of Chicago, Chicago, Illinois, USA
    Cancer Res 71:2488-96. 2011
    ..Our study reveals that local high-dose RT can trigger production of type I IFN that initiates a cascading innate and adaptive immune attack on the tumor...
  83. pmc Cetuximab-mediated tumor regression depends on innate and adaptive immune responses
    Xuanming Yang
    Center for Infection and Immunity and National Key Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Mol Ther 21:91-100. 2013
    ..Therefore, this study establishes new models to evaluate immune responses induced by antibody-based treatment, defines molecular mechanisms, and provides new tumor-regression strategies...
  84. pmc Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    Youjin Lee
    Department of Pathology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Blood 114:589-95. 2009
    ..Our findings emphasize the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity...
  85. pmc Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
    Yabing Chen
    Department of Pathology, University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 283:29593-601. 2008
    ..Taken together, PLCgamma2 is essential for RANK signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation...
  86. ncbi request reprint Tumor necrosis factor family members and inflammatory bowel disease
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunol Rev 204:144-55. 2005
    ..Such mechanisms may also apply to other TNF family members...
  87. pmc LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms
    Brad T Schwarz
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Gastroenterology 132:2383-94. 2007
    ..The aim of this study was to determine if LIGHT is capable of signaling directly to intestinal epithelia and to define the mechanisms and consequences of such signaling...
  88. pmc The confluence of radiotherapy and immunotherapy
    Byron Burnette
    Department of Pathology, The Ludwig Center for Metastasis Research, The University of Chicago Chicago, IL, USA
    Front Oncol 2:143. 2012
    ..Below we review principals underlying the concepts of combining both modalities...
  89. doi request reprint Targeting and utilizing primary tumors as live vaccines: changing strategies
    Xuanming Yang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Cell Mol Immunol 9:20-6. 2012
    ....
  90. doi request reprint Cutting edge: B and T lymphocyte attenuator signaling on NKT cells inhibits cytokine release and tissue injury in early immune responses
    Mendy L Miller
    Committee on Immunology and Department of Pathology, University of Chicago, IL 60637, USA
    J Immunol 183:32-6. 2009
    ..Overall, our data demonstrate that coinhibition is active in early immune responses through BTLA regulation of NKT cells...
  91. doi request reprint The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling
    Mingzhao Zhu
    Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Immunol Rev 244:75-84. 2011
    ..In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation...
  92. ncbi request reprint The critical role of LIGHT, a TNF family member, in T cell development
    J Wang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 167:5099-105. 2001
    ..Taken together, these results demonstrate a critical role of LIGHT in thymic negative selection of the T cell repertoire...
  93. pmc The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
    J Wang
    Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 108:1771-80. 2001
    ....
  94. pmc NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors
    Zusen Fan
    National Laboratory of Biomacromolecules and Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China
    Blood 107:1342-51. 2006
    ..Our findings establish a direct role for LIGHT in NK activation/expansion and a critical helper role of activated NK cells in priming CD8+ T cells and breaking T-cell tolerance at the tumor site...
  95. pmc Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid
    Tatjana Marinkovic
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Invest 116:2622-32. 2006
    ..These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3+CD4+ T cells...
  96. ncbi request reprint Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    Zheng Zhang
    Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
    Gastroenterology 134:1938-49, 1949.e1-3. 2008
    ....
  97. ncbi request reprint B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation
    Carsten Krieg
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 8:162-71. 2007
    ..In addition, BTLA negatively regulated antigen-independent homeostatic expansion of CD4(+) and CD8(+) T cells. These results emphasize two central functions of BTLA in limiting T cell activity in vivo...
  98. pmc Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease
    Koji Tamada
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 109:549-57. 2002
    ..Our study provides a potential new approach for the prevention of lethal GVHD...
  99. ncbi request reprint Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice
    Guilian Xu
    Department of Immunology, University of Manitoba, Winnipeg, Canada
    J Immunol 179:5358-66. 2007
    ..These results suggest that membrane lymphotoxin plays critical role in resistance to L. major by promoting effective T cell-mediated anti-Leishmania immunity...
  100. pmc The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells
    Carl De Trez
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:238-48. 2008
    ..These results indicate the HVEM-BTLA pathway provides an inhibitory checkpoint for DC homeostasis in lymphoid tissue. Together, the LTbetaR and HVEM-BTLA pathways form an integrated signaling network regulating DC homeostasis...
  101. ncbi request reprint Blockade of lymphotoxin pathway exacerbates autoimmune arthritis by enhancing the Th1 response
    Shuhua Han
    Baylor College of Medicine, Houston, Texas 77030, USA
    Arthritis Rheum 52:3202-9. 2005
    ....