Kai Fu

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma
    Kai Fu
    Nebraska Medical Center, Department of Pathology and Microbiology, Omaha, NE 68198 3135, USA
    Expert Rev Mol Diagn 5:397-408. 2005
  2. pmc Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 106:4315-21. 2005
  3. doi request reprint SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
    Kai Fu
    Department of Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Arterioscler Thromb Vasc Biol 28:665-71. 2008
  4. doi request reprint Relationship Between Rosai-Dorfman Disease and IgG4-Related Disease: Study of 32 Cases
    Liping Liu
    Dept of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135 e mail
    Am J Clin Pathol 140:395-402. 2013
  5. doi request reprint Gene arrays in lymphoma: Where will they fit in?
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Curr Hematol Malig Rep 1:129-36. 2006
  6. doi request reprint Cell of origin fails to predict survival in patients with diffuse large B-cell lymphoma treated with autologous hematopoietic stem cell transplantation
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hematol Oncol 30:143-9. 2012
  7. pmc Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 29:200-7. 2011
  8. doi request reprint A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    William W L Choi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Clin Cancer Res 15:5494-502. 2009
  9. pmc A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 120:2290-6. 2012
  10. doi request reprint CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma
    Zdravko Mitrovic
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Haematol 162:87-92. 2013

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma
    Kai Fu
    Nebraska Medical Center, Department of Pathology and Microbiology, Omaha, NE 68198 3135, USA
    Expert Rev Mol Diagn 5:397-408. 2005
    ..The future development of this field and its applications in the clinical arena will also be discussed...
  2. pmc Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 106:4315-21. 2005
    ..In conclusion, cases of cyclin D1-negative MCL do exist and are part of the spectrum of MCL. Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL...
  3. doi request reprint SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
    Kai Fu
    Department of Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Arterioscler Thromb Vasc Biol 28:665-71. 2008
    ..TGF-beta plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of ALK5/ALK4 kinase, in the rat carotid injury model of vascular fibrosis...
  4. doi request reprint Relationship Between Rosai-Dorfman Disease and IgG4-Related Disease: Study of 32 Cases
    Liping Liu
    Dept of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, NE 68198 3135 e mail
    Am J Clin Pathol 140:395-402. 2013
    ..There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases. Conclusions: Our study suggests that RDD does not belong in the spectrum of IgG4-RD. ..
  5. doi request reprint Gene arrays in lymphoma: Where will they fit in?
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Curr Hematol Malig Rep 1:129-36. 2006
    ..Future treatments are likely to be founded on effective, individualized, and mechanism-based therapies with the least toxicity...
  6. doi request reprint Cell of origin fails to predict survival in patients with diffuse large B-cell lymphoma treated with autologous hematopoietic stem cell transplantation
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hematol Oncol 30:143-9. 2012
    ..However, no significant differences were found in the 5-year overall or event-free survivals using any of these approaches. In conclusion, cell of origin fails to predict survival of DLBCL patients treated with AHSCT...
  7. pmc Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 29:200-7. 2011
    ..Various immunohistochemical algorithms have been developed to replicate these microarray results and/or stratify patients according to survival. This study compares some of those algorithms and also proposes some modifications...
  8. doi request reprint A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    William W L Choi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Clin Cancer Res 15:5494-502. 2009
    ..Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm...
  9. pmc A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 120:2290-6. 2012
    ..This new biologic prognostic model could be used with the International Prognostic Index to stratify patients for novel or risk-adapted therapies...
  10. doi request reprint CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma
    Zdravko Mitrovic
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Haematol 162:87-92. 2013
    ..The dismal outcome of CD43(+) cases in the non-GCB subgroup may be explained, at least in part, by a less favourable microenvironment...
  11. doi request reprint B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: study of 39 cases
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Br J Haematol 162:40-9. 2013
    ..This B-cell lymphoma is a morphologically-recognizable entity with a spectrum of genetic abnormalities. New and better treatments are needed for this aggressive lymphoma...
  12. pmc Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
    Karen E Deffenbacher
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 3135, USA
    Blood 119:3757-66. 2012
    ..Elucidation of the underlying target genes may provide insight into factors that modulate outcome and could provide potential novel therapeutic targets with less toxicity for pediatric patients with B-cell non-Hodgkin lymphoma...
  13. doi request reprint The stromal cell marker SPARC predicts for survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    Dept of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA
    Am J Clin Pathol 135:54-61. 2011
    ..More aggressive chemotherapy protocols should be considered for patients with ABC DLBCL without SPARC+ stromal cells. CD68 expression by cells in the microenvironment did not predict survival...
  14. doi request reprint Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks
    Radha M Golla
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Hematol Oncol 30:175-9. 2012
    ..These results suggest that PARPi may enhance the therapeutic efficacy of DNA damaging agents on MCL through TP53-independent mechanisms without requiring the inhibition of either ATM or BRCA2...
  15. pmc Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 119:4939-48. 2012
    ..The other clusters showed enrichment of stroma-associated miRNAs, and also had higher expression of stroma-associated genes. Our clinical outcome analysis in the present study suggested that miRNAs can serve as prognosticators...
  16. pmc Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma
    Timothy C Greiner
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 103:2352-7. 2006
    ..This information on molecular phenotypes may provide new areas of investigation for ATM function or may be exploited by designing specific therapies for MCL cases with p53 aberrations...
  17. pmc Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma
    Xin Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Am J Pathol 181:26-33. 2012
    ..Taken together, our results reveal a novel target involved in miR-155 biological characteristics and provide a molecular link between the overexpression of miR-155 and the activation of PI3K-AKT in DLBCL...
  18. doi request reprint Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution
    Francesco D'Amore
    Department of Pathology and Microbiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Clin Cancer Res 14:7180-7. 2008
    ....
  19. ncbi request reprint Clinical implication of genome-wide profiling in diffuse large B-cell lymphoma and other subtypes of B-cell lymphoma
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Indian J Cancer 44:72-86. 2007
    ..In this review, important discoveries made by genome-wide GEP in understanding the biology of lymphoma and additionally the diagnostic and prognostic value of microarrays are discussed...
  20. doi request reprint Recurrent chromosomal alterations in molecularly classified AIDS-related lymphomas: an integrated analysis of DNA copy number and gene expression
    Karen E Deffenbacher
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    J Acquir Immune Defic Syndr 54:18-26. 2010
    ..1 locus and showed gene silencing or truncated transcript in 9 of 16 cases. These data demonstrate the ability to molecularly classify B-ARL lymphomas by gene expression and identified DNA copy number alterations targeted in B-ARL...
  21. doi request reprint Differences in the cytogenetic alteration profiles of diffuse large B-cell lymphoma among Chinese and American patients
    Yan Chen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet 206:183-90. 2013
    ..Non-GCB-DLBCL in both the Chinese and American patients was characterized by recurrent gains of 3/3q and 18/18q. The incidences of both BCL6 rearrangement and t(14;18) were similar in Chinese and American non-GCB-DLBCL cases. ..
  22. pmc t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 22:1251-7. 2009
    ..Therefore, it is important to perform FISH analysis with ABR to determine possible involvement of BCL6 rearrangement in follicular lymphoma, especially in t(14;18)-negative cases...
  23. doi request reprint Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7680, USA
    J Clin Oncol 26:4587-94. 2008
    ..However, with the addition of rituximab to standard chemotherapy, the prognostic significance of this subclassification of DLBCL is unclear...
  24. pmc ISPTM: An Iterative Search Algorithm for Systematic Identification of Post-translational Modifications from Complex Proteome Mixtures
    Xin Huang
    Department of Pathology and Microbiology, Department of Environmental, Agricultural and Occupational Health, and Mass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States
    J Proteome Res 12:3831-42. 2013
    ..In summary, ISPTM is a new and powerful tool for unbiased identification of many different PTMs with high confidence from complex proteome mixtures. ..
  25. pmc The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies
    Ming Ji
    School of Life Science, Nanjing University, Nanjing, China Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
    Am J Pathol 179:1645-56. 2011
    ..Because the miR-17-92 cluster acts as an important oncogene in several cancers and targets genes important in regulating cell proliferation and survival, further studies of its transcriptional control are warranted...
  26. pmc PCR-based generation of shRNA libraries from cDNAs
    Cheng Du
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 0766, USA
    BMC Biotechnol 6:28. 2006
    ..The high cost of chemical synthesis and the low efficiency of the enzymatic approach have hampered the widespread use of screening with shRNA libraries...
  27. ncbi request reprint Molecular diagnostics on lymphoid malignancies
    Wing C Chan
    Department of Pathology Microbiology, University of Nebraska Medical Center, Omaha 68198 3135, USA
    Arch Pathol Lab Med 128:1379-84. 2004
    ....
  28. doi request reprint Racial patterns of extranodal natural killer/T-cell lymphoma, nasal type, in California: a population-based study
    Weiyun Z Ai
    Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Br J Haematol 156:626-32. 2012
    ..In conclusion, ENKTL is more common and clinically more similar among Hispanics and APIs than non-Hispanic whites with poor outcome in all racial groups...
  29. pmc Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis
    Xin Ming Liu
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pharm Res 25:2910-9. 2008
    ..To develop a pH-sensitive dexamethasone (Dex)-containing N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate with well-defined structure for the improved treatment of rheumatoid arthritis (RA)...
  30. pmc Gene- and cell-type-specific effects of signal transduction cascades on metal-regulated gene transcription appear to be independent of changes in the phosphorylation of metal-response-element-binding transcription factor-1
    Huimin Jiang
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7421, USA
    Biochem J 382:33-41. 2004
    ..Instead, protein kinases may exert their interdependent effects on metal-induced gene expression by acting on cofactors that interact with MTF-1...
  31. ncbi request reprint Full clinical recovery after topical acyclovir treatment of Epstein-Barr virus associated cutaneous B-cell lymphoma in patient with mycosis fungoides
    M Sitki Copur
    Saint Francis Cancer Center, 2116 W Faidley Ave, Grand Island, NE 68802 9804, USA
    Croat Med J 46:458-62. 2005
    ....
  32. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  33. ncbi request reprint A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus
    Stefan Gesk
    Blood 108:1109-10. 2006
  34. ncbi request reprint Mantle cell lymphoma with plasma cell differentiation
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Surg Pathol 30:954-61. 2006
    ..These findings indicate that the clonal PC differentiation may occur within GCs in some cases of MCL...
  35. ncbi request reprint Clonal CD8+ lymphocytic proliferation associated with Epstein-Barr virus infection mimicking T-cell leukemia
    Qinglong Hu
    Leuk Lymphoma 48:1651-3. 2007
  36. ncbi request reprint Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features
    Olga Balague
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 31:1310-22. 2007
    ..The distinctive features of these patients suggest that these lesions represent a specific phenomenon in PTCL...
  37. pmc Comprehensive analysis of GST-pi expression in B-cell lymphomas: Correlation with histological subtypes and survival
    Catherine Thieblemont
    Leuk Lymphoma 49:1403-6. 2008
  38. ncbi request reprint CD23 expression in mantle cell lymphoma: clinicopathologic features of 18 cases
    Ellen Schlette
    Dept of Hematopathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 72, Houston, TX 77030, USA
    Am J Clin Pathol 120:760-6. 2003
    ..The frequency of CD23 expression by MCL is method-dependent, being typically dim and most commonly detected by flow cytometry. In this small study group, bone marrow and leukemic involvement were relatively common...