Jianping Fu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction
    Yue Shao
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Integr Biol (Camb) 6:300-11. 2014
  2. pmc Continuous-flow bioseparation using microfabricated anisotropic nanofluidic sieving structures
    Jianping Fu
    Research Laboratories of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Protoc 4:1681-98. 2009
  3. doi request reprint Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA
    Small 9:81-9. 2013
  4. doi request reprint Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
  5. pmc Mechanics regulates fate decisions of human embryonic stem cells
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e37178. 2012
  6. doi request reprint Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis
    Raymond H W Lam
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Lab Chip 12:1865-73. 2012
  7. doi request reprint UV-modulated substrate rigidity for multiscale study of mechanoresponsive cellular behaviors
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States
    Langmuir 28:10789-96. 2012
  8. ncbi request reprint Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane
    Raymond H W Lam
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Integr Biol (Camb) 4:1289-98. 2012
  9. pmc Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 6:4094-103. 2012
  10. doi request reprint Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood
    Bo Ram Oh
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Nano 8:2667-76. 2014

Collaborators

Detail Information

Publications28

  1. doi request reprint Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction
    Yue Shao
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Integr Biol (Camb) 6:300-11. 2014
    ....
  2. pmc Continuous-flow bioseparation using microfabricated anisotropic nanofluidic sieving structures
    Jianping Fu
    Research Laboratories of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Protoc 4:1681-98. 2009
    ..The ANA is physically robust and can be reused repeatedly. Compared with the conventional gel-based separation techniques, ANA offers the potential for faster separation, higher throughput and more convenient sample recovery...
  3. doi request reprint Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA
    Small 9:81-9. 2013
    ..The capability to control and further predict cellular responses to nanoroughness might suggest novel methods for developing biomaterials mimicking nanotopographic structures in vivo for functional tissue engineering...
  4. doi request reprint Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
    ....
  5. pmc Mechanics regulates fate decisions of human embryonic stem cells
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e37178. 2012
    ....
  6. doi request reprint Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis
    Raymond H W Lam
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Lab Chip 12:1865-73. 2012
    ....
  7. doi request reprint UV-modulated substrate rigidity for multiscale study of mechanoresponsive cellular behaviors
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States
    Langmuir 28:10789-96. 2012
    ..Together, we demonstrated the potential of photoPDMS as a photosensitive and rigidity-tunable material for mechanobiology studies...
  8. ncbi request reprint Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane
    Raymond H W Lam
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Integr Biol (Camb) 4:1289-98. 2012
    ....
  9. pmc Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 6:4094-103. 2012
    ....
  10. doi request reprint Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood
    Bo Ram Oh
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Nano 8:2667-76. 2014
    ..We achieved cellular functional immunoanalysis with a minimal blood sample volume (3 μL) and a total assay time 3 times shorter than that of the conventional enzyme-linked immunosorbent assay (ELISA). ..
  11. doi request reprint Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 7:566-75. 2013
    ....
  12. doi request reprint Mechanobiology: a new frontier for human pluripotent stem cells
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Integr Biol (Camb) 5:450-7. 2013
    ....
  13. doi request reprint Microengineered synthetic cellular microenvironment for stem cells
    Yubing Sun
    Department of Mechanical Engineering, Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:414-27. 2012
    ..This review provides insights into how these micro/nanoengineering approaches, particularly microcontact printing and elastomeric micropost array, are applied to create dynamic and complex environment for stem cells culture...
  14. doi request reprint A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response
    Jennifer M Mann
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48105, USA
    Lab Chip 12:731-40. 2012
    ..Our mPAM device and live-cell subcellular contractile measurements will help elucidate the mechanotransductive system in VSMCs and thus contribute to our understanding of pressure-induced vascular disease processes...
  15. doi request reprint Artificial molecular sieves and filters: a new paradigm for biomolecule separation
    Jianping Fu
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Biotechnol 26:311-20. 2008
    ....
  16. doi request reprint Decreasing effective nanofluidic filter size by modulating electrical double layers: separation enhancement in microfabricated nanofluidic filters
    Hansen Bow
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Electrophoresis 29:4646-51. 2008
    ..We characterize this method by comparing the selectivity with that achieved in devices with different dimensions. The results of this study are relevant to the optimization of chip-based gel-free biomolecule separation and analysis...
  17. doi request reprint Photolithographic surface micromachining of polydimethylsiloxane (PDMS)
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Lab Chip 12:391-5. 2012
    ..To illustrate the general application of our method, we demonstrated fabrication of large microfiltration membranes and free-standing beam structures in PDMS...
  18. pmc Emerging microfluidic tools for functional cellular immunophenotyping: a new potential paradigm for immune status characterization
    Weiqiang Chen
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan Ann Arbor, MI, USA Department of Mechanical Engineering, University of Michigan Ann Arbor, MI, USA
    Front Oncol 3:98. 2013
    ..We envision that such microfluidic immunophenotyping tools will allow for comprehensive and systems-level immunomonitoring, unlocking the potential to transform experimental clinical immunology into an information-rich science...
  19. doi request reprint Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment
    Yubing Sun
    Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Annu Rev Biophys 41:519-42. 2012
    ....
  20. pmc A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins
    Jianping Fu
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Nanotechnol 2:121-8. 2007
    ....
  21. pmc Rapid quantification of disease-marker proteins using continuous-flow immunoseparation in a nanosieve fluidic device
    Masumi Yamada
    Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Anal Chem 81:7067-74. 2009
    ..The presented nanofluidic device will be a useful tool for the rapid quantification and the preparative immunoseparation of the target proteins...
  22. pmc An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping
    Nien Tsu Huang
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Lab Chip 12:4093-101. 2012
    ....
  23. pmc Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility
    Zhenzhen Fan
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Sci Rep 3:2176. 2013
    ..Our results demonstrated the great potential of ultrasound tweezing cytometry technique using functionalized microbubbles as an actuatable, biocompatible, and multifunctional agent for biomechanical stimulations of cells. ..
  24. doi request reprint Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective
    Yue Shao
    Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, 48109, USA
    Adv Mater 26:1494-533. 2014
    ..The impact of integrated micro/nanoengineered functional biomaterials for future in vitro studies of regenerative medicine, cell biology, as well as human development and disease models are discussed. ..
  25. pmc Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions
    Yue Shao
    Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    Rev Sci Instrum 84:114304. 2013
    ....
  26. doi request reprint Synergistic regulation of cell function by matrix rigidity and adhesive pattern
    Shinuo Weng
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Biomaterials 32:9584-93. 2011
    ..Our study here had determined key aspects of the biomechanical responses of adherent cells to independent and collective changes of substrate rigidity and adhesive ECM pattern...
  27. pmc Molecular sieving using nanofilters: past, present and future
    Jongyoon Han
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 36 841, 77 Mass Ave, Cambridge, MA 02139, USA
    Lab Chip 8:23-33. 2008
    ..Reviewing past theoretical developments (often scattered across different fields) and connecting them to the most recent advances in the field would be essential to get a full, unified view on this important engineering question...
  28. pmc Molecular sieving in periodic free-energy landscapes created by patterned nanofilter arrays
    Jianping Fu
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 97:018103. 2006
    ..We further show experimental evidence of the crossover from Ogston-like sieving to entropic trapping, depending on the ratio between nanofilter constriction size and DNA size...