Hong Fu

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver
    Jonathan Schug
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    BMC Genomics 14:264. 2013
  2. pmc Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver
    Logan J Everett
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 14:337. 2013
  3. pmc Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
    Rodrigo N Lamounier
    Laboratory for Cellular and Molecular Endocrinology LIM 25, University of Sao Paulo Medical School, Av, Dr, Arnaldo 455 4305, 01246 903, Sao Paulo, Brazil
    Diabetol Metab Syndr 5:1. 2013
  4. doi request reprint Following the cycle: finally, a transgenic mouse to sort live replicating cells
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 23:676-7. 2012
  5. pmc Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets
    Sebastian Rieck
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, 12 126 Translational Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 5156, USA
    Mol Endocrinol 26:1590-602. 2012
  6. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
  7. pmc The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
    Ke Zheng
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    BMC Dev Biol 9:38. 2009
  8. pmc Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development
    Keith R Anderson
    Department of Biochemistry and Program in Molecular Biology, University of Colorado Health Science Center, Denver, CO 80045, USA
    BMC Dev Biol 9:65. 2009
  9. pmc Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas
    Jonathon T Hill
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 12:62. 2011
  10. pmc The FoxA factors in organogenesis and differentiation
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, United States
    Curr Opin Genet Dev 20:527-32. 2010

Research Grants

  1. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
  2. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    KLAUS KAESTNER; Fiscal Year: 2007
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  5. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    KLAUS KAESTNER; Fiscal Year: 2009
  6. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    Klaus H Kaestner; Fiscal Year: 2010
  7. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    Klaus H Kaestner; Fiscal Year: 2010
  8. Epigenomic Profiling of Normal and Diabetic Pancreatic Beta-Cells
    Klaus H Kaestner; Fiscal Year: 2010
  9. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    Klaus H Kaestner; Fiscal Year: 2010
  10. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006

Detail Information

Publications95

  1. pmc Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver
    Jonathan Schug
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    BMC Genomics 14:264. 2013
    ..Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs...
  2. pmc Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver
    Logan J Everett
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 14:337. 2013
    ..The precise molecular mechanisms by which CREB specifically targets these genes in response to alternating hormonal cues remain to be elucidated...
  3. pmc Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
    Rodrigo N Lamounier
    Laboratory for Cellular and Molecular Endocrinology LIM 25, University of Sao Paulo Medical School, Av, Dr, Arnaldo 455 4305, 01246 903, Sao Paulo, Brazil
    Diabetol Metab Syndr 5:1. 2013
    ....
  4. doi request reprint Following the cycle: finally, a transgenic mouse to sort live replicating cells
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 23:676-7. 2012
    ..By sorting and analyzing proliferating hepatocytes, they provide evidence for their transient dedifferentiation...
  5. pmc Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets
    Sebastian Rieck
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, 12 126 Translational Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 5156, USA
    Mol Endocrinol 26:1590-602. 2012
    ..The DNA damage response is a barrier to efficient β-cell proliferation in vitro, and we suggest its evaluation in all attempts to stimulate β-cell replication as an approach to diabetes treatment...
  6. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
    ..Current treatment regimens rely on dietary management and, in severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype...
  7. pmc The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
    Ke Zheng
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    BMC Dev Biol 9:38. 2009
    ....
  8. pmc Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development
    Keith R Anderson
    Department of Biochemistry and Program in Molecular Biology, University of Colorado Health Science Center, Denver, CO 80045, USA
    BMC Dev Biol 9:65. 2009
    ..2 during the major wave of endocrine and exocrine cell differentiation, we assessed gene expression changes that occur in the absence of Nkx2.2 at the onset of the secondary transition in the developing pancreas...
  9. pmc Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas
    Jonathon T Hill
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 12:62. 2011
    ..Generation of new prediction methods that are based on protein binding data, but do not rely on these models may improve prediction sensitivity and specificity...
  10. pmc The FoxA factors in organogenesis and differentiation
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, United States
    Curr Opin Genet Dev 20:527-32. 2010
    ....
  11. ncbi request reprint Transcriptional program of the endocrine pancreas in mice and humans
    Klaus H Kaestner
    Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA
    Diabetes 52:1604-10. 2003
    ..We show that this PancChip is highly enriched for genes expressed in the endocrine pancreas. The mouse and human clone sets and corresponding arrays will be important resources for diabetes research...
  12. ncbi request reprint The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104 6145, USA
    Genes Dev 11:1583-95. 1997
    ....
  13. pmc Beta cell transplantation and immunosuppression: can't live with it, can't live without it
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:2380-2. 2007
    ..Their new mouse model should aid in the development of improved immunoregulatory strategies and in the elucidation of the molecular pathways that govern beta cell regeneration...
  14. pmc Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
    L Li
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA
    Genes Dev 14:147-51. 2000
    ..pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes...
  15. doi request reprint A two-step pathway to resist fasting
    Klaus H Kaestner
    Institute for Diabetes, Obesity and Metabolism, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:449-51. 2008
    ..A recent letter to Nature suggests that a switch from early gluconeogenic gene activation via CRTC2 (also known as TORC2) to late action of FOXO1 is critical to this process...
  16. pmc Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Genes Dev 13:495-504. 1999
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
  17. ncbi request reprint The making of the liver: developmental competence in foregut endoderm and induction of the hepatogenic program
    Klaus H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cell Cycle 4:1146-8. 2005
    ..The Foxa1/Foxa2 model is the first of a completely "liver-less mouse" and provides strong evidence for the competence model of hepatic induction...
  18. ncbi request reprint The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6145, USA
    Trends Endocrinol Metab 11:281-5. 2000
    ..HNF3 alpha is required for the full activation of glucagon in the pancreas, whereas HNF3 gamma induces the activation of gluconeogenic enzymes to prevent hypoglycemia during fasting...
  19. pmc Foxa2 regulates multiple pathways of insulin secretion
    Kristen A Lantz
    Department of Genetics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Invest 114:512-20. 2004
    ..Thus, we have established Foxa2 as an essential activator of genes that function in multiple pathways governing insulin secretion...
  20. pmc Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2
    Nir E Rubins
    Department of Genetics, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Cell Biol 25:7069-77. 2005
    ..Overall, our studies demonstrate that HNF6 binds to and regulates its target promoters in vivo in the presence and absence of Foxa2...
  21. pmc Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Genes Dev 16:1488-97. 2002
    ..In addition, ngn3(-/-) mice display intestinal metaplasia of the gastric epithelium. Thus, ngn3 is required for the differentiation of enteroendocrine cells in the stomach and the maintenance of gastric epithelial cell identity...
  22. pmc The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion
    Rana K Gupta
    Department of Genetics, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:1006-15. 2005
    ..Our data provide genetic evidence that HNF-4alpha is required in the pancreatic beta cell for regulation of the pathway of insulin secretion dependent on the ATP-dependent potassium channel...
  23. ncbi request reprint Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice
    Fang Xiao
    Gastroenterology Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 4:669-75. 2005
    ..Alteration in the composition of the gastric epithelium may play a role in influencing the microenvironment to engender susceptibility to carcinogens...
  24. ncbi request reprint Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Diabetes 51:2546-51. 2002
    ..These data represent the first in vivo demonstration that Foxa2 acts upstream of Pdx1 in the differentiated beta-cell...
  25. ncbi request reprint Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity
    Shamina M Rangwala
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 5:657-63. 2003
    ..Compounds that prevent PPARgamma phosphorylation or ligands that induce the conformation of nonphosphorylated PPARgamma may selectively enhance insulin sensitivity without increasing body weight...
  26. ncbi request reprint Winged-helix transcription factors and pancreatic development
    Kristen A Lantz
    Department of Genetics, University of Pennsylvania Medical School, 560 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Clin Sci (Lond) 108:195-204. 2005
    ..An additional winged-helix protein, Foxo1, contributes to pancreatic beta-cell function by regulating the Pdx1 gene, which is required for pancreatic development in cooperation with Foxa2...
  27. pmc CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis
    John Le Lay
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 10:55-62. 2009
    ..Collectively, these results provide genetic evidence supporting a role for CRTC2 in the transcriptional response to fasting, but indicate only a limited contribution of this cofactor to the maintenance of glucose homeostasis...
  28. ncbi request reprint Foxa2 is required for the differentiation of pancreatic alpha-cells
    Catherine S Lee
    Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 560 Philadelphia, PA 19104, USA
    Dev Biol 278:484-95. 2005
    ..By marker gene analysis, we show that the expression of the alpha-cell transcription factors Arx, Pax6, and Brn4 does not require Foxa2 in the transcriptional hierarchy governing alpha-cell differentiation...
  29. pmc Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    Nan Gao
    Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 16:588-99. 2009
    ..We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code...
  30. ncbi request reprint An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells
    Amelie Calmont
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Dev Cell 11:339-48. 2006
    ..The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation...
  31. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ....
  32. pmc FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine
    Blair B Madison
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:5936-44. 2009
    ..Furthermore, expression of both Foxf1 and Foxl1 is reduced in the Gli2/Gli3 mutant gut. These results provide compelling evidence that Foxf1 and Foxl1 are mediators of the Hh (endoderm) to mesoderm signaling pathway...
  33. ncbi request reprint Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Gastroenterology 128:935-45. 2005
    ..The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon...
  34. ncbi request reprint Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment
    Diva D De Leon
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 24:133-43. 2006
    ..Our data suggest molecular pathways that may regulate pancreatic growth and offer a unique set of candidate genes to target in the development of therapies aimed at improving pancreatic growth and function...
  35. pmc EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes
    Joan M Mazzarelli
    Department of Genetics, School of Medicine, Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 35:D751-5. 2007
    ..EPConDB provides database queries and tools to examine the relationship between a gene, its transcriptional regulation, protein function and expression in pancreatic tissues...
  36. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..Thus, the regulation of Pdx1 expression by Foxa1 and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia...
  37. ncbi request reprint SnapShot: forkhead transcription factors I
    Geetu Tuteja
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 130:1160. 2007
  38. pmc The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania School of Medicine, 560 Clinical Research Building, 415 Curie Blvd, Philadelphia 19104 6145, USA
    Development 129:2619-28. 2002
    ..All other epithelial cell types are present in the colon of Klf4(-/-) mice. In summary, Klf4 plays a crucial role in colonic epithelial cell differentiation in vivo...
  39. ncbi request reprint Foxa2 integrates the transcriptional response of the hepatocyte to fasting
    Liping Zhang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Metab 2:141-8. 2005
    ..We conclude that Foxa2 is required for execution of the hepatic gluconeogenic program by integrating the transcriptional response of the hepatocyte to hormonal stimulation...
  40. ncbi request reprint Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research
    L Marie Scearce
    Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadephia, PA 19104, USA
    Diabetes 51:1997-2004. 2002
    ..5 through adulthood in mice. The clone set and corresponding array are useful resources for diabetes research...
  41. ncbi request reprint Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake
    Jonathan P Katz
    Dept of Genetics, Univ of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6145, USA
    Am J Physiol Gastrointest Liver Physiol 287:G856-64. 2004
    ..Thus we identified, for the first time, a link between a mesenchymal factor, Foxl1, and the regulation of a specific epithelial transport process...
  42. pmc The evolution of Fox genes and their role in development and disease
    Sridhar Hannenhalli
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 10:233-40. 2009
    ..We summarize the salient features of the evolution of the Fox gene family and highlight the diverse contribution of various Fox subfamilies to developmental processes, from organogenesis to speech acquisition...
  43. doi request reprint Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast
    Karen M Berkowitz
    Center for Research on Reproduction and Women s Health, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Mol Hum Reprod 14:143-50. 2008
    ..We suggest a unique biological role for CTF18 in mammalian germ cell development based on its mammalian germline expression, high degree of evolutionary conservation, and role in DNA replication and chromosomal stability in yeast...
  44. pmc Foxl1 is a marker of bipotential hepatic progenitor cells in mice
    Sara D Sackett
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hepatology 49:920-9. 2009
    ..These results demonstrate that the early Foxl1-Cre lineage cell gives rise to both cholangiocytes and hepatocytes after liver injury and suggest the potential for progenitor-portal fibroblast cell interactions...
  45. doi request reprint Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development
    Xinping Tan
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Hepatology 47:1667-79. 2008
    ..CONCLUSION: Beta-catenin regulates multiple, critical events during the process of hepatic morphogenesis, including hepatoblast maturation, expansion, and survival, making it indispensable to survival...
  46. pmc Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha
    Rana K Gupta
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:756-69. 2007
    ..Together, these results indicate that HNF-4alpha is essential for the physiological expansion of adult beta-cell mass in response to increased metabolic demand...
  47. ncbi request reprint Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation
    Marko Z Vatamaniuk
    Department of Genetics and Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6145, USA
    Diabetes 55:2730-6. 2006
    ..Chromatin immunoprecipitation assays indicate that UCP2 is a direct transcriptional target of Foxa1 in vivo. Thus, we have identified a novel function for Foxa1 in the regulation of oxidative phosphorylation in pancreatic beta-cells...
  48. ncbi request reprint Developmental and cell type-specific expression of the zinc finger transcription factor Krüppel-like factor 4 (Klf4) in postnatal mouse testis
    Rüdiger Behr
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Mech Dev 115:167-9. 2002
    ..These findings suggest that Klf4 might play an important role in testicular differentiation in mammals...
  49. ncbi request reprint Comparison of different labeling methods for two-channel high-density microarray experiments
    Elisabetta Manduchi
    Center for Bioinformatics, Univ of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Physiol Genomics 10:169-79. 2002
    ..These findings are helping to guide our decisions on what labeling method to use for subsequent studies, based on the purpose of a specific study and its limitations in terms of available material...
  50. pmc Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Mol Endocrinol 24:1594-604. 2010
    ..These data demonstrate that Foxa1 and Foxa2 play crucial roles in the development and maintenance of beta-cell-specific secretory and metabolic pathways...
  51. ncbi request reprint Identification of transcriptional networks during liver regeneration
    Peter White
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:3715-22. 2005
    ..This allowed us to identify a large cluster of genes controlling mitotic spindle assembly and checkpoint control at the 40-h time point as regulated at the mRNA level in vivo...
  52. ncbi request reprint The initiation of liver development is dependent on Foxa transcription factors
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 435:944-7. 2005
    ..Thus, Foxa1 and Foxa2 are required for the establishment of competence within the foregut endoderm and the onset of hepatogenesis...
  53. ncbi request reprint Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3
    Catherine S Lee
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 611 B, Philadelphia, 19104, USA
    Diabetes 55:269-72. 2006
    ....
  54. pmc Foxa1 and Foxa2 regulate bile duct development in mice
    Zhaoyu Li
    Department of Genetics and Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    J Clin Invest 119:1537-45. 2009
    ..Our data suggest that Foxa1/2 function as terminators of bile duct expansion in the adult liver through inhibition of IL-6 expression...
  55. ncbi request reprint Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets
    Nicolai M Doliba
    Dept of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 291:E525-35. 2006
    ....
  56. ncbi request reprint Novel genes identified by manual annotation and microarray expression analysis in the pancreas
    Joan M Mazzarelli
    Center for Bioinformatics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genomics 88:752-61. 2006
    ..Interestingly, when we investigated the novel transcripts for their overlap with noncoding microRNAs, we found that 1 of the novel transcripts overlapped a known microRNA gene...
  57. ncbi request reprint Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
    Debra G Silberg
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:689-96. 2002
    ..Cdx2 induces differentiation of intestinal epithelial cells in vitro; therefore, we sought to establish whether a causal relationship exists between Cdx2 activation and intestinal metaplasia...
  58. ncbi request reprint Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage
    Kathleen M Loomes
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hepatology 45:323-30. 2007
    ..Conclusion: These results indicate that Notch signaling in the liver is sensitive to Jag1 gene dosage and suggest a role for the Notch pathway in postnatal growth and morphogenesis of bile ducts...
  59. pmc Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas
    Maria L Golson
    Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mech Dev 126:687-99. 2009
    ..Expression of the Notch modifier Manic Fringe (Mfng) is limited to endocrine precursors, providing a possible explanation for the inhibition of Notch signaling by Jag1 during mid-gestation embryonic pancreas development...
  60. pmc MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function
    Lindsay B McKenna
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19103, USA
    Gastroenterology 139:1654-64, 1664.e1. 2010
    ..We aimed to quantify the complete miRNA expression profile of the mammalian intestinal mucosa and to determine the contribution of miRNAs to intestinal homeostasis using genetic means...
  61. ncbi request reprint PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21)
    Brant R Burkhardt
    Department of Pathology and Laboratory Medicine, 803D Abramson Research Center 3516 Civic Center Blvd, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, United States
    Gene 369:134-41. 2006
    ..PANDER-induced downregulation of CDKN1A expression coupled with induced CASP3-activation may serve a central role in islet cell death and offers further insight into the mechanisms of cytokine-induced beta-cell apoptosis...
  62. ncbi request reprint Defining pancreatic endocrine precursors and their descendants
    Peter White
    University of Pennsylvania, Medical School, Department of Genetics, Institute for Diabetes, Obesity and Metabolism, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 57:654-68. 2008
    ..Efforts to differentiate insulin-producing beta-cells from progenitor or stem cells require knowledge of the transcriptional programs that regulate the development of the endocrine pancreas...
  63. ncbi request reprint Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents
    Olga T Hardy
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, 560 Clinical Research Building, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 21:765-73. 2007
    ..Our results suggest a molecular explanation for the hyperinsulinemia hypoglycemic seen in patients with SCHAD deficiency...
  64. pmc Glucocorticoid receptor-dependent gene regulatory networks
    Phillip Phuc Le
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Genet 1:e16. 2005
    ..Together, our results further our understanding of the GR and its targets, and provide the basis for more targeted glucocorticoid therapies...
  65. ncbi request reprint HNF-4alpha: from MODY to late-onset type 2 diabetes
    Rana K Gupta
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 10:521-4. 2004
    ..This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes...
  66. ncbi request reprint Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency
    Rüdiger Behr
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:41936-41. 2004
    ....
  67. pmc Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3
    Rüdiger Behr
    Department of Genetics, University of Pennsylvania Medical School, 415 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Dev Biol 306:636-45. 2007
    ..In summary, we have identified Foxa3 as a transcriptional regulator with a dominant phenotype in germ cell maintenance and suggest FOXA3 as a potential candidate gene for subfertility in man...
  68. pmc Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice
    Diana Z Ye
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 137:2052-62. 2009
    ..These findings suggest Foxa1/a2 as critical factors in the differentiation of gut epithelial cells...
  69. pmc The transcriptional response of the islet to pregnancy in mice
    Sebastian Rieck
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Mol Endocrinol 23:1702-12. 2009
    ....
  70. pmc Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth
    Catherine E Gleason
    University of Pennsylvania School of Medicine, Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 24:178-92. 2010
    ..This is accentuated during diet-induced obesity, when Igfbp5-deficient mice have increased adiposity compared with wild-type mice on the same diet. These studies reveal a novel role for Igfbp5 in the control of growth and metabolism...
  71. doi request reprint Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion
    Maria L Golson
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 136:1761-71.e1. 2009
    ..Up to 40% of Alagille syndrome patients also display exocrine pancreatic insufficiency, the pathobiology of which is unknown. Additionally, no mouse model recapitulating this aspect of the disease has been reported...
  72. pmc Foxa2-dependent hepatic gene regulatory networks depend on physiological state
    Irina M Bochkis
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Physiol Genomics 38:186-95. 2009
    ..We show that Foxa2 interacts with different transcription factors to achieve gene expression responses appropriate for each physiologic state...
  73. pmc Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site
    Geetu Tuteja
    Department of Genetics, Genomics and Computational Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:4149-57. 2008
    ..We not only provide a better understanding of the mechanisms of Foxa2 regulation but also introduce a novel method for identification of different cis-regulatory modules involving a single factor...
  74. pmc Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology
    Theresa Alenghat
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 456:997-1000. 2008
    ..These findings indicate that activation of Hdac3 by Ncor1 is a nodal point in the epigenetic regulation of circadian and metabolic physiology...
  75. pmc Species-specific strategies underlying conserved functions of metabolic transcription factors
    Raymond E Soccio
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
    Mol Endocrinol 25:694-706. 2011
    ..Analysis of factor binding in multiple species may be necessary to distinguish apparent species-unique noise and reveal functionally relevant information...
  76. ncbi request reprint Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors
    Hsun Teresa Ku
    Department of Gene and Cell Medicine and Surgery, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Diabetes 56:921-9. 2007
    ..Together, these results demonstrate that progenitors that have the potential to give rise to insulin-expressing cells can be derived from murine embryonic stem cells...
  77. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
    ..Foxa2 regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth...
  78. doi request reprint KLF4 is a FOXO target gene that suppresses B cell proliferation
    Isharat Yusuf
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA
    Int Immunol 20:671-81. 2008
    ..Collectively, our findings indicate that KLF4 has growth-suppressive properties in B cells but might be redundant with other members of the KLF family in maintaining B cell quiescence...
  79. ncbi request reprint Foxa2 regulates alveolarization and goblet cell hyperplasia
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 131:953-64. 2004
    ..FOXA2 is required for alveolarization and regulates airway epithelial cell differentiation in the postnatal lung...
  80. ncbi request reprint Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    Fereshteh Parviz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 34:292-6. 2003
    ..Most importantly, the morphogenetic parameters controlled by Hnf4alpha in hepatocytes are essential for normal liver architecture, including the organization of the sinusoidal endothelium...
  81. pmc Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression
    Yuanfang Liu
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, 101 College Street CCRW3 845, Toronto, Canada M5G 2C4
    Biochem J 366:633-41. 2002
    ..These findings identify Foxa3 as a member of the proglucagon gene G2 element binding-protein family that, unlike Foxa1, is not essential for control of islet or intestinal proglucagon gene expression in vivo...
  82. ncbi request reprint Generation of a conditionally null allele of hnf4alpha
    Fereshteh Parviz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genesis 32:130-3. 2002
  83. ncbi request reprint Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants
    Marc Hallonet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, C U de Strasbourg, Illkirch, France
    Dev Biol 243:20-33. 2002
    ..Foxa2 therefore plays an integral role in the formation of axial mesendoderm, which is required to maintain the specification of the forebrain and the anterior definitive endoderm...
  84. ncbi request reprint beta-Catenin is critical for early postnatal liver growth
    Udayan Apte
    Depts of Pathology and Medicine, Univ of Pittsburgh School of Medicine, 200 Lothrop St, S 421 BST, Pittsburgh, PA 15216, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1578-85. 2007
    ..These data indicate that the activation of beta-catenin is critical for early postnatal liver growth and development...
  85. ncbi request reprint The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ....
  86. pmc Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
    Circ Res 102:1548-57. 2008
    ..Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury...
  87. pmc The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis
    Michael P Hunter
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Dev Biol 308:355-67. 2007
    ..The altered expression of Hnf4alpha, Hnf6 and Hnf1beta in Hhex conditional null mice suggests that Hhex is an essential component of the genetic networks regulating hepatoblast differentiation and intrahepatic bile duct morphogenesis...
  88. ncbi request reprint Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    David M Keller
    Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:32084-92. 2007
    ..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion...
  89. pmc Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation
    Jettanong Klaewsongkram
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 179:4679-84. 2007
    ..These findings demonstrate that Klf4 regulates B cell number and activation-induced B cell proliferation through directly acting on the promoter of cyclin D2...
  90. pmc Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon
    Wendy D Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53326, USA
    Gastroenterology 130:1207-20. 2006
    ..It has also been implicated in regulating expression of genes that act in the epithelium of the lower gastrointestinal tract. This implied that HNF4alpha might be required for development of the gut...
  91. ncbi request reprint Imaging pancreatic beta-cells in the intact pancreas
    Manami Hara
    Dept of Medicine, University of Chicago, 5841 South Maryland Ave, MC1027, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 290:E1041-7. 2006
    ....
  92. doi request reprint Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    Irina M Bochkis
    Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:828-36. 2008
    ..In addition, we show that expression of FOXA2 is markedly decreased in liver samples from individuals with different cholestatic syndromes, suggesting that reduced FOXA2 abundance could exacerbate the injury...
  93. ncbi request reprint Distinct proliferative and transcriptional effects of the D-type cyclins in vivo
    Lisa K Mullany
    Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    Cell Cycle 7:2215-24. 2008
    ..Further study of the unique targets of cyclin D1 should provide further insight into its prominent role in proliferation, growth and cancer...
  94. ncbi request reprint Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    ..Foxa family members regulate signaling and transcriptional programs required for morphogenesis and cell differentiation during formation of the lung...
  95. pmc Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells
    Maren Godmann
    Institute of Anatomy, Developmental Biology, University of Duisburg Essen Medical School, 45122 Essen, Germany
    Dev Biol 315:552-66. 2008
    ..In summary, KLF4 plays a significant role for proper and timely Sertoli cell differentiation in pubertal mice...

Research Grants33

  1. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  2. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    KLAUS KAESTNER; Fiscal Year: 2007
    ..abstract_text> ..
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ....
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  5. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    KLAUS KAESTNER; Fiscal Year: 2009
    ..Therefore, we will develop and exploit new genetic tools to elucidate fundamental questions regarding the function of transcriptional regulators, or master genes, in proliferation and performance of beta-cells. ..
  6. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    Klaus H Kaestner; Fiscal Year: 2010
    ..Therefore, we will develop and exploit new genetic tools to elucidate fundamental questions regarding the function of transcriptional regulators, or master genes, in proliferation and performance of beta-cells. ..
  7. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    Klaus H Kaestner; Fiscal Year: 2010
    ..Together, this proposal will further our understanding of GI development and cancer, and allow for the development of novel diagnostic and possibly therapeutic tools in the future. ..
  8. Epigenomic Profiling of Normal and Diabetic Pancreatic Beta-Cells
    Klaus H Kaestner; Fiscal Year: 2010
    ..We will determine the "epigenetic", that is not mutation based, changes in the genome of the diabetic beta-cell that cause it to fail. This work will identify new potential drug targets for the treatment of type 2 diabetes. ..
  9. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    Klaus H Kaestner; Fiscal Year: 2010
    ..Therefore, we will develop and exploit new genetic tools to elucidate fundamental questions regarding the function of transcriptional regulators, or master genes, in proliferation and performance of beta-cells. ..
  10. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  11. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  12. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2001
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  13. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    KLAUS KAESTNER; Fiscal Year: 2002
    ..Insights gained about the role of HNF3Beta in Beta-cell function could be incorporated into future therapeutic strategies, including gene therapy. ..
  14. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  15. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    Klaus H Kaestner; Fiscal Year: 2010
    ..Together, this proposal will further our understanding of GI development and cancer, and allow for the development of novel diagnostic and possibly therapeutic tools in the future. ..