Reginald Frye

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Effect of St John's wort on imatinib mesylate pharmacokinetics
    Reginald F Frye
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, USA
    Clin Pharmacol Ther 76:323-9. 2004
  2. doi request reprint Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days
    Veronika Butterweck
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Planta Med 75:1196-202. 2009
  3. pmc Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry
    Kyung Mee Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009
  4. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
  5. pmc A summer research training program to foster PharmD students' interest in research
    Julie A Johnson
    Department of Pharmacy Practice, College of Pharmacy, Health Science Center, University of Florida, Gainesville, FL 32610 0486, USA
    Am J Pharm Educ 72:23. 2008
  6. ncbi request reprint Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping
    Jang Ik Lee
    Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
    Clin Pharmacol Ther 72:718-28. 2002
  7. ncbi request reprint Rapid microtiter plate assay for determination of inulin in human plasma and dialysate
    Thomas D Nolin
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Pharm Biomed Anal 28:209-15. 2002
  8. ncbi request reprint Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry
    Thomas D Nolin
    Pharmacodynamic Research Center, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, 15261, Pittsburgh, PA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 783:265-71. 2003
  9. ncbi request reprint Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS)
    Christopher A Bolcato
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 794:363-72. 2003
  10. ncbi request reprint Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies
    Thomas D Nolin
    Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Pharmacol Ther 74:555-68. 2003

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Effect of St John's wort on imatinib mesylate pharmacokinetics
    Reginald F Frye
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, USA
    Clin Pharmacol Ther 76:323-9. 2004
    ..Thus we examined the effects of St John's wort on imatinib pharmacokinetics...
  2. doi request reprint Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days
    Veronika Butterweck
    College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Planta Med 75:1196-202. 2009
    ....
  3. pmc Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry
    Kyung Mee Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009
    ..The new method was used to show that smoking, which can induce oxidative stress, is associated with elevated triuret levels in urine. Thus, the method may be helpful in identifying pathways of oxidative stress in biological samples...
  4. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
    ..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard...
  5. pmc A summer research training program to foster PharmD students' interest in research
    Julie A Johnson
    Department of Pharmacy Practice, College of Pharmacy, Health Science Center, University of Florida, Gainesville, FL 32610 0486, USA
    Am J Pharm Educ 72:23. 2008
    ..To establish and assess the effectiveness of a 10-week summer research program on increasing doctor of pharmacy (PharmD) students' interest in research, particularly as it related to future career choices...
  6. ncbi request reprint Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping
    Jang Ik Lee
    Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
    Clin Pharmacol Ther 72:718-28. 2002
    ....
  7. ncbi request reprint Rapid microtiter plate assay for determination of inulin in human plasma and dialysate
    Thomas D Nolin
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Pharm Biomed Anal 28:209-15. 2002
    ..This method is well suited for the rapid analysis of large numbers of samples and is currently being used for in vitro investigations of solute removal by hemodialysis...
  8. ncbi request reprint Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry
    Thomas D Nolin
    Pharmacodynamic Research Center, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, 15261, Pittsburgh, PA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 783:265-71. 2003
    ..This method is well suited for the phenotypic evaluation of CYP2C19 activity using mephenytoin...
  9. ncbi request reprint Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS)
    Christopher A Bolcato
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 794:363-72. 2003
    ..5+/-39.8 pmol/min per mg; kidney K(m) and V(max): 47.6+/-8.5 microM and 1933+/-151 pM/min per mg). This paper demonstrates HPLC-MS as an efficient method for quantitating 20-HETE enzyme kinetics in microsomes from rat tissues...
  10. ncbi request reprint Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies
    Thomas D Nolin
    Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Pharmacol Ther 74:555-68. 2003
    ....
  11. ncbi request reprint Simplified method for determination of rosiglitazone in human plasma
    Matthew W Hruska
    Department of Pharmaceutical Sciences, Pharmacodynamic Research Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 803:317-20. 2004
    ..The assay is simple, economical, precise, and is directly applicable to human pharmacokinetic studies involving single dose rosiglitazone administration...
  12. pmc Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities
    Mohamed Eslam F Mohamed
    Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Gainesville, FL 32610, USA
    Drug Metab Dispos 39:1522-8. 2011
    ..These results highlight the possibility of herb-drug interactions through modulation of UGT enzyme activities. Further clinical studies are warranted to investigate the in vivo extent of the observed interactions...
  13. ncbi request reprint Validation of incorporating flurbiprofen into the Pittsburgh cocktail
    Nathalie K Zgheib
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15219 3138, USA
    Clin Pharmacol Ther 80:257-63. 2006
    ..This study evaluated the possibility of incorporating flurbiprofen into the current 5-drug Pittsburgh cocktail...
  14. ncbi request reprint Bioequivalence revisited: influence of age and sex on CYP enzymes
    Zourab Bebia
    Center for Clinical Pharmacology and Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15219, USA
    Clin Pharmacol Ther 76:618-27. 2004
    ..Our objectives were to determine whether in vivo activity of selected CYP enzymes is affected by age or sex and to evaluate sex bioequivalence in a large sample size...
  15. ncbi request reprint Determination of trimethoprim in low-volume human plasma by liquid chromatography
    Matthew W Hruska
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 807:301-5. 2004
    ..Intra- and inter-day precision ranged from 1.1 to 1.9 and 0.9 to 4.1%, respectively. The assay is simple, economical, precise, and is directly applicable to human studies involving steady state trimethoprim pharmacokinetics...
  16. ncbi request reprint Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics
    Khalid M Alkharfy
    Department of Pharmaceutical Sciences, University of Pittsburgh, 807 Salk Hall, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 774:33-8. 2002
    ..Overall, the assay described is a sensitive and reproducible method for the determination of estradiol glucuronides in liver microsomal preparations...
  17. pmc Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects
    Reginald F Frye
    Department of Pharmaceutical Sciences, School of Pharmacy, 807 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Br J Clin Pharmacol 53:155-62. 2002
    ..The purpose of this study was to evaluate the effects of disulfiram given for 11 days on selected drug metabolizing enzyme activities...
  18. ncbi request reprint Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites
    Stephan A Chalon
    Department of Clinical Pharmacology, Lilly Research Laboratories, Lilly Development Centre SA, Parc Scientifique de Louvain La Neuve, rue Granbonpre 11, 1348 Mont Saint Guibert, France
    Clin Pharmacol Ther 73:178-91. 2003
    ....
  19. ncbi request reprint Liver disease selectively modulates cytochrome P450--mediated metabolism
    Reginald F Frye
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, USA
    Clin Pharmacol Ther 80:235-45. 2006
    ..The purpose of this study was to assess the effect of liver disease on multiple CYP enzymes by use of a validated cocktail approach...
  20. ncbi request reprint Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes
    Craig R Lee
    Division of Pharmacotherapy, University of North Carolina at Chapel Hill, NC 27599 7360, Chapel Hill, USA
    Eur J Clin Pharmacol 58:791-4. 2003
    ..This study was conducted to examine differences in flurbiprofen metabolism among individuals with the CYP2C9*1/*1, *1/*2, and *1/*3 genotypes...

Research Grants3

  1. St. John's Wort and CYP3A Metabolism in Men & Women
    Reginald Frye; Fiscal Year: 2003
    ..v. and oral midazolam administration (oral midazolam followed by i.v. at 6 hr after oral dosing) and comparing this to separate day administration of i.v. and oral midazolam (Specific Aim 3). ..