Research Topics
| Reginald FryeSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Effect of St John's wort on imatinib mesylate pharmacokineticsReginald F Frye
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, USA
Clin Pharmacol Ther 76:323-9. 2004..Thus we examined the effects of St John's wort on imatinib pharmacokinetics...
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 DaysVeronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
Planta Med 75:1196-202. 2009....
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometryKyung Mee Kim
Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009..The new method was used to show that smoking, which can induce oxidative stress, is associated with elevated triuret levels in urine. Thus, the method may be helpful in identifying pathways of oxidative stress in biological samples...- A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acidKyung Mee Kim
Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard... - A summer research training program to foster PharmD students' interest in researchJulie A Johnson
Department of Pharmacy Practice, College of Pharmacy, Health Science Center, University of Florida, Gainesville, FL 32610 0486, USA
Am J Pharm Educ 72:23. 2008..To establish and assess the effectiveness of a 10-week summer research program on increasing doctor of pharmacy (PharmD) students' interest in research, particularly as it related to future career choices... - Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotypingJang-Ik Lee
Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
Clin Pharmacol Ther 72:718-28. 2002..Thus the semisimultaneous midazolam method appears to be a suitable approach to determine hepatic and intestinal CYP3A activity at baseline and with enzyme inhibition... - Rapid microtiter plate assay for determination of inulin in human plasma and dialysateThomas D Nolin
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Pharm Biomed Anal 28:209-15. 2002..This method is well suited for the rapid analysis of large numbers of samples and is currently being used for in vitro investigations of solute removal by hemodialysis... - Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometryThomas D Nolin
Pharmacodynamic Research Center, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, 15261, Pittsburgh, PA, USA
J Chromatogr B Analyt Technol Biomed Life Sci 783:265-71. 2003..This method is well suited for the phenotypic evaluation of CYP2C19 activity using mephenytoin... - Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS)Christopher A Bolcato
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Chromatogr B Analyt Technol Biomed Life Sci 794:363-72. 2003..5+/-39.8 pmol/min per mg; kidney K(m) and V(max): 47.6+/-8.5 microM and 1933+/-151 pM/min per mg). This paper demonstrates HPLC-MS as an efficient method for quantitating 20-HETE enzyme kinetics in microsomes from rat tissues... - Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studiesThomas D Nolin
Pharmacodynamic Research Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
Clin Pharmacol Ther 74:555-68. 2003..The results of this study show that the commonly used plasma-based chlorzoxazone metabolic ratio is dependent on renal function and, therefore, does not provide a reliable index of CYP2E1-mediated metabolism... - Simplified method for determination of rosiglitazone in human plasmaMatthew W Hruska
Department of Pharmaceutical Sciences, Pharmacodynamic Research Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Chromatogr B Analyt Technol Biomed Life Sci 803:317-20. 2004..The assay is simple, economical, precise, and is directly applicable to human pharmacokinetic studies involving single dose rosiglitazone administration... - Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activitiesMohamed Eslam F Mohamed
Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Gainesville, FL 32610, USA
Drug Metab Dispos 39:1522-8. 2011..These results highlight the possibility of herb-drug interactions through modulation of UGT enzyme activities. Further clinical studies are warranted to investigate the in vivo extent of the observed interactions... - Validation of incorporating flurbiprofen into the Pittsburgh cocktailNathalie K Zgheib
Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15219-3138, USA
Clin Pharmacol Ther 80:257-63. 2006.... - Bioequivalence revisited: influence of age and sex on CYP enzymesZourab Bebia
Center for Clinical Pharmacology and Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15219, USA
Clin Pharmacol Ther 76:618-27. 2004..However, we suggest that sex has a limited ability to explain intersubject variation of activity for these phenotypic measures of CYP enzyme activity... - Determination of trimethoprim in low-volume human plasma by liquid chromatographyMatthew W Hruska
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
J Chromatogr B Analyt Technol Biomed Life Sci 807:301-5. 2004..Intra- and inter-day precision ranged from 1.1 to 1.9 and 0.9 to 4.1%, respectively. The assay is simple, economical, precise, and is directly applicable to human studies involving steady state trimethoprim pharmacokinetics... - Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kineticsKhalid M Alkharfy
Department of Pharmaceutical Sciences, University of Pittsburgh, 807 Salk Hall, Pittsburgh, PA 15261, USA
J Chromatogr B Analyt Technol Biomed Life Sci 774:33-8. 2002..Overall, the assay described is a sensitive and reproducible method for the determination of estradiol glucuronides in liver microsomal preparations... - Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjectsReginald F Frye
Department of Pharmaceutical Sciences, School of Pharmacy, 807 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15261, USA
Br J Clin Pharmacol 53:155-62. 2002..The purpose of this study was to evaluate the effects of disulfiram given for 11 days on selected drug metabolizing enzyme activities... - Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolitesStephan A Chalon
Department of Clinical Pharmacology, Lilly Research Laboratories, Lilly Development Centre SA, Parc Scientifique de Louvain La Neuve, rue Granbonpre 11, 1348 Mont Saint Guibert, France
Clin Pharmacol Ther 73:178-91. 2003.... - Liver disease selectively modulates cytochrome P450--mediated metabolismReginald F Frye
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, USA
Clin Pharmacol Ther 80:235-45. 2006..We propose that the data can be explained by the "sequential progressive model of hepatic dysfunction," whereby liver disease severity has a differential effect on the metabolic activity of specific CYP enzymes... - Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypesCraig R Lee
Division of Pharmacotherapy, University of North Carolina at Chapel Hill, NC 27599 7360, Chapel Hill, USA
Eur J Clin Pharmacol 58:791-4. 2003..This study was conducted to examine differences in flurbiprofen metabolism among individuals with the CYP2C9*1/*1, *1/*2, and *1/*3 genotypes...
Research Grants
- St. John's Wort and CYP3A Metabolism in Men & WomenReginald Frye; Fiscal Year: 2003..v. and oral midazolam administration (oral midazolam followed by i.v. at 6 hr after oral dosing) and comparing this to separate day administration of i.v. and oral midazolam (Specific Aim 3). ..