Genomes and Genes
R A Frye
Affiliation: University of Pittsburgh
- Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activityR A Frye
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15240, USA
Biochem Biophys Res Commun 260:273-9. 1999..These results suggest that the sirtuins may function via mono-ADP-ribosylation of proteins...
- Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteinsR A Frye
Pittsburgh V A Medical Center 132L, University, Pittsburgh, Pennsylvania 15240, USA
Biochem Biophys Res Commun 273:793-8. 2000..The seven human sirtuin genes include all four classes: SIRT1, SIRT2, and SIRT3 are class I, SIRT4 is class II, SIRT5 is class III, and SIRT6 and SIRT7 are class IV...
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseH Vaziri
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 107:149-59. 2001..In contrast, expression of a catalytically inactive hSir2 protein potentiates p53-dependent apoptosis and radiosensitivity. We propose that hSir2 is involved in the regulation of p53 function via deacetylation...