Mark A Frye

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Use of health care services among persons who screen positive for bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
    Psychiatr Serv 56:1529-33. 2005
  2. ncbi request reprint Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    CNS Spectr 11:704-10; quiz 719. 2006
  3. ncbi request reprint Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
  4. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
  5. ncbi request reprint Unmet needs in bipolar depression
    Mark A Frye
    UCLA Bipolar Disorder Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Depress Anxiety 19:199-208. 2004
  6. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
  7. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
  8. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
  9. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
  10. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Use of health care services among persons who screen positive for bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
    Psychiatr Serv 56:1529-33. 2005
    ..This study examined patterns of diagnosis, consultation, and treatment of persons who screened positive for bipolar disorder...
  2. ncbi request reprint Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    CNS Spectr 11:704-10; quiz 719. 2006
    ..This study examined healthcare utilization in the past year by subjects who screened positive for bipolar versus unipolar depression...
  3. ncbi request reprint Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
    ..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...
  4. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  5. ncbi request reprint Unmet needs in bipolar depression
    Mark A Frye
    UCLA Bipolar Disorder Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Depress Anxiety 19:199-208. 2004
    ....
  6. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  7. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  8. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  9. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  10. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  11. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  12. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  13. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  14. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  15. doi request reprint Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute of Neuroscience and Human Behavior, UCLA, USA
    Am J Psychiatry 167:708-15. 2010
    ..The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder...
  16. doi request reprint Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
    ..This study examined the correlates associated with treatment-emergent mania in patients receiving adjunctive antidepressant treatment for bipolar depression...
  17. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  18. ncbi request reprint Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    Mark A Frye
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
    Neuropsychopharmacology 32:2490-9. 2007
    ..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response...
  19. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  20. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  21. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  22. ncbi request reprint Modal subcomponents of metabolic syndrome in patients with bipolar disorder
    Jeffrey Cardenas
    Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States
    J Affect Disord 106:91-7. 2008
    ..The metabolic syndrome is a growing global public health problem...
  23. pmc An olfactory circuit increases the fidelity of visual behavior
    Dawnis M Chow
    Molecular, Cellular and Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:15035-47. 2011
    ..Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification of a visual reflex that is critical for flight control...
  24. ncbi request reprint Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, Calif, USA
    J Clin Psychiatry 65:1057-63. 2004
    ..This study was conducted to evaluate comparative response rates to lithium and divalproex sodium in adolescent mania with and without this comorbidity...
  25. pmc Flies dynamically anti-track, rather than ballistically escape, aversive odor during flight
    Sara Wasserman
    Howard Hughes Medical Institute, Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles Young Drive East, Los Angeles, CA 90095 7239, USA
    J Exp Biol 215:2833-40. 2012
    ..We show that in-flight aversive flight behavior shares all of the key features of attraction such that flies continuously 'anti-track' the noxious source...
  26. ncbi request reprint Impact of bipolar disorder on a U.S. community sample
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:425-32. 2003
    ..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample...
  27. doi request reprint Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1363-70. 2010
    ..To evaluate the efficacy and safety of armodafinil, the longer-lasting isomer of modafinil, when used adjunctively in patients with bipolar depression...
  28. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  29. ncbi request reprint Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence
    James W McKowen
    UCLA Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 7:377-81. 2005
    ..This report evaluates preliminary data of alcohol consumption patterns utilizing the Alcohol Timeline Followback (TLFB) method in actively drinking patients with bipolar disorder...
  30. pmc Dynamics of optomotor responses in Drosophila to perturbations in optic flow
    Jamie C Theobald
    Howard Hughes Medical Institute, The Department of Integrative Biology and Physiology, University of California Los Angeles, 621 Charles Young Drive South, Los Angeles, CA 90095 1606, USA
    J Exp Biol 213:1366-75. 2010
    ..Finally, the linear filters at least partly explain the optomotor responses to superimposed and decomposed compound flow fields...
  31. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
    ..The primary objective of this study was to assess the rate of bipolar disorder (BPD) risk among patients unsuccessfully treated for major depression and to identify predictors of bipolarity...
  32. ncbi request reprint Subsyndromal depression is associated with functional impairment in patients with bipolar disorder
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 63:807-11. 2002
    ..The purpose of this study was to assess whether a relationship exists between mild depressive symptoms and overall functioning in subjects with bipolar disorder...
  33. ncbi request reprint Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  34. ncbi request reprint Acceleration and augmentation strategies for treating bipolar depression
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 53:691-700. 2003
    ..This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches...
  35. ncbi request reprint Comorbid substance use disorder in women with bipolar disorder associated with criminal arrest
    Barbara E McDermott
    Division of Psychiatry and the Law, Department of Psychiatry and Behavioral Sciences, University of California at Davis, Davis, CA, USA
    Bipolar Disord 9:536-40. 2007
    ..This study was conducted to further evaluate possible gender differences in substance use and risk of criminality in BPD...
  36. pmc Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly
    Yan Zhu
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 19:613-9. 2009
    ....
  37. doi request reprint Context-dependent olfactory enhancement of optomotor flight control in Drosophila
    Dawnis M Chow
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Exp Biol 211:2478-85. 2008
    ....
  38. ncbi request reprint Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  39. ncbi request reprint Clinical and legal characteristics of inmates with bipolar disorder
    Cameron D Quanbeck
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry and the Law, University of California, Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    Curr Psychiatry Rep 7:478-84. 2005
    ..Psychiatric advance directives, new developments in civil commitment law, and mental health courts are legal mechanisms that may be critical in preventing the criminalization of those with bipolar disorder...
  40. doi request reprint Higher-order figure discrimination in fly and human vision
    Jacob W Aptekar
    Howard Hughes Medical Institute, Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 23:R694-700. 2013
    ....
  41. pmc Drosophila tracks carbon dioxide in flight
    Sara Wasserman
    Department of Integrative Biology and Physiology, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 23:301-6. 2013
    ....
  42. ncbi request reprint Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest
    Cameron D Quanbeck
    Department of Psychiatry, Forensic Division, University of California Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    J Clin Psychiatry 65:198-203. 2004
    ....
  43. ncbi request reprint Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Clin Psychiatry 63:1012-9. 2002
    ..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
  44. ncbi request reprint Bipolar depression: best practices for the hospitalized patient
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    CNS Spectr 12:1-13. 2007
    ..The onset and severity of bipolar depression, prevalence of substance abuse, psychosocial treatment options, and clinical issues for the long-term treatment of bipolar depression are also discussed...
  45. doi request reprint Improving the design of maintenance studies for bipolar disorder
    Michael J Gitlin
    Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Curr Med Res Opin 26:1835-42. 2010
    ..Over the past 15 years, the design of monotherapy maintenance studies in bipolar disorder has evolved significantly, but recent study designs continue to differ in important ways...
  46. pmc Flies require bilateral sensory input to track odor gradients in flight
    Brian J Duistermars
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 19:1301-7. 2009
    ..We additionally show that sensory signals from the left antenna contribute disproportionately more to odor tracking than signals from the right, providing further evidence of sensory lateralization in invertebrates...
  47. ncbi request reprint International consensus group on depression prevention in bipolar disorder
    Mark A Frye
    Department of Psychiatry, The Mayo Clinic, Rochester, Minnesota, USA
    J Clin Psychiatry 72:1295-310. 2011
    ..This special Commentary was prepared by the CME Institute of Physicians Postgraduate Press, Inc., and was supported by an educational grant from GlaxoSmithKline...
  48. pmc Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection
    Hao Fei
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Exp Biol 213:1717-30. 2010
    ..These results demonstrate that visual behaviors are segregated by the level of GABA signaling in flies, and more generally establish dVGAT as a model to study the contribution of GABA release to other complex behaviors...
  49. ncbi request reprint Visual edge orientation shapes free-flight behavior in Drosophila
    Mark A Frye
    Department of Physiological Science, University of California, Los Angeles, California 90095 1606, USA
    Fly (Austin) 1:153-4. 2007
    ..The disruption of flight behavior by horizontal edges provides insight into the structure of visually-mediated control algorithms...
  50. ncbi request reprint Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
    Bipolar Disord 8:677-85. 2006
    ..A number of add-on, adjunctive medications, such as naltrexone, acamprosate, topiramate, and the atypical antipsychotics quetiapine and clozapine, may be candidates for further testing...
  51. ncbi request reprint Treating acute mania
    Mark A Frye
    UCLA Bipolar Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    J Fam Pract . 2003
  52. ncbi request reprint Free T4 index and clinical outcome in patients with depression
    Osama Abulseoud
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Affect Disord 100:271-7. 2007
    ..This study evaluated baseline thyroid function and its relationship to rapidity of treatment response as measured by hospital length of stay (HLOS)...
  53. doi request reprint Maintenance therapies in bipolar disorders
    Michael Gitlin
    Department of Psychiatry, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Bipolar Disord 14:51-65. 2012
    ..The authors review the data on maintenance treatments in bipolar disorder, highlighting the controlled trial literature...
  54. pmc Odor identity influences tracking of temporally patterned plumes in Drosophila
    Parthasarathy Krishnan
    UCLA Department of Integrative Biology and Physiology, 621 Charles E Young Dr South, Box 951606, Los Angeles, CA 90095 1606, USA
    BMC Neurosci 12:62. 2011
    ....
  55. ncbi request reprint Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Psychiatry Res 154:259-65. 2007
    ..Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder...
  56. ncbi request reprint Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Am J Psychiatry 159:918-25. 2002
  57. ncbi request reprint The neuro-ecology of resource localization in Drosophila: behavioral components of perception and search
    Dawnis M Chow
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
    Fly (Austin) 3:50-61. 2009
    ..Here we synthesize a broad perspective that integrates across ultimate and proximate mechanisms of odor tracking in Drosophila...
  58. pmc Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors
    Michael Gitlin
    Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Psychiatry Neurosci 29:383-6. 2004
    ..To examine the relation between baseline measurements of thyroid function and response to selective serotonin reuptake inhibitors (SSRIs) and to consider the effect of these antidepressants on thyroid hormone levels...
  59. ncbi request reprint Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up
    Lori Altshuler
    Stanley Bipolar Treatment Network, USA
    Am J Psychiatry 160:1252-62. 2003
    ..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode...
  60. ncbi request reprint Behavioral neurobiology: a vibrating gyroscope controls fly steering maneuvers
    Mark A Frye
    Department of Physiological Science, University of California, 621 Charles E Young Drive, Los Angeles, California 90095, USA
    Curr Biol 17:R134-6. 2007
    ..A clever 'virtual reality' experiment reveals that specialized mechanosensory organs, rather than the eyes, orchestrate the high-performance staccato turns that characterize the flight behavior of a fly...
  61. ncbi request reprint Closing the loop between neurobiology and flight behavior in Drosophila
    Mark A Frye
    Department of Physiological Science, University of California, 621 Charles E Young Drive South, Los Angeles, CA 90095 1606, USA
    Curr Opin Neurobiol 14:729-36. 2004
    ..Olfactory stimuli elicit tonic increases in wingbeat amplitude and frequency but do not alter the time course or magnitude of visual reflexes...
  62. doi request reprint Figure tracking by flies is supported by parallel visual streams
    Jacob W Aptekar
    Howard Hughes Medical Institute, Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 22:482-7. 2012
    ..This analysis requires an extension of the model that fly motion vision is based on simple elementary motion detectors and provides a novel method to characterize the subsystems responsible for the pursuit of visual figures...
  63. doi request reprint Trazodone and alcohol relapse: a retrospective study following residential treatment
    Bhanu Prakash Kolla
    Department of Psychiatry, Mayo Clinic, Rochester, Minnesota, USA
    Am J Addict 20:525-9. 2011
    ..Our retrospective study of a complex patient population discharged from a residential treatment setting did not find an association between trazodone use at discharge and relapse rates at 6 months...
  64. doi request reprint Crossmodal visual input for odor tracking during fly flight
    Brian J Duistermars
    Department of Physiological Science, University of California, Los Angeles, California 90095 1606, USA
    Curr Biol 18:270-5. 2008
    ..We show that flies are unable to use a small-field object or landmark to assist plume tracking, whereas odor activates wide-field optomotor course control to enable accurate orientation toward an attractive food odor...
  65. pmc Multisensory systems integration for high-performance motor control in flies
    Mark A Frye
    Howard Hughes Medical Institute, Department of Physiological Science, University of California, Los Angeles, 90095, USA
    Curr Opin Neurobiol 20:347-52. 2010
    ..Thus, the fly is motivating new conceptual frameworks for how low-level multisensory circuits and functional algorithms produce high-performance motor control...
  66. ncbi request reprint The spatial, temporal and contrast properties of expansion and rotation flight optomotor responses in Drosophila
    Brian J Duistermars
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Exp Biol 210:3218-27. 2007
    ....
  67. pmc Visual stabilization dynamics are enhanced by standing flight velocity
    Jamie C Theobald
    Department of Physiological Science, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
    Biol Lett 6:410-3. 2010
    ..This implies that for flies stabilizing in sideslip, the control effort is strongly affected by the direction of background motion...
  68. doi request reprint Animal behavior: flying back to front
    Jamie Carroll Theobald
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    Curr Biol 18:R169-70. 2008
    ....
  69. ncbi request reprint Spatial organization of visuomotor reflexes in Drosophila
    Lance F Tammero
    Bioengineering Graduate Group, University of California, Berkeley, CA 94720, USA
    J Exp Biol 207:113-22. 2004
    ..The spatial heterogeneity of visuomotor responses explains a seemingly peculiar behavior in which flies robustly fixate the contracting pole of a translating flow field...
  70. pmc Binocular interactions underlying the classic optomotor responses of flying flies
    Brian J Duistermars
    Department of Physiological Science, Howard Hughes Medical Institute, University of California Los Angeles Los Angeles, CA, USA
    Front Behav Neurosci 6:6. 2012
    ....
  71. ncbi request reprint Low CSF somatostatin associated with response to nimodipine in patents with affective illness
    Mark A Frye
    UCLA Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 53:180-3. 2003
    ..This study was conducted to assess whether a low baseline level of CSF SRIF was associated with response to nimodipine treatment...
  72. ncbi request reprint Dynamic properties of large-field and small-field optomotor flight responses in Drosophila
    Brian J Duistermars
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:787-99. 2007
    ....
  73. ncbi request reprint Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 4400, USA
    J Affect Disord 69:1-14. 2002
    ..Understanding the mechanisms of anticonvulsant mood stabilizers, integrated with clinical observations, may ultimately provide important new insights into the pathophysiology and treatment of bipolar disorders...
  74. ncbi request reprint Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on design
    Barbara Hummel
    Stanley Foundation Bipolar Network Centers, Department of Psychiatry, LMU Munich, Germany
    Bipolar Disord 4:412-7. 2002
    ..OXC is not metabolized to the 10, 11-epoxide, which seems to be responsible for several undesirable side-effects of carbamazepine and furthermore OXC has less enzyme-inducing properties...
  75. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  76. ncbi request reprint Odor localization requires visual feedback during free flight in Drosophila melanogaster
    Mark A Frye
    Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA
    J Exp Biol 206:843-55. 2003
    ..A simple model based on the statistics of flight behavior supports the hypothesis that a subtle influence on these behaviors is sufficient to lead a fly to its food...
  77. ncbi request reprint Validity of the mood disorder questionnaire: a general population study
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
    Am J Psychiatry 160:178-80. 2003
    ..The Mood Disorder Questionnaire has been validated in a psychiatric outpatient study group...
  78. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  79. ncbi request reprint Screening for bipolar disorder in the community
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
    J Clin Psychiatry 64:53-9. 2003
    ..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States...
  80. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  81. ncbi request reprint A signature of salience in the Drosophila brain
    Mark A Frye
    Nat Neurosci 6:544-6. 2003
  82. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  83. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  84. ncbi request reprint Longitudinal evaluation of reproductive function in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, 401 Quarry Road, Palo Alto, Ca 94305 5723 Stanford, California, United States
    J Affect Disord 89:217-25. 2005
    ..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...
  85. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  86. ncbi request reprint Relationship between criminal arrest and community treatment history among patients with bipolar disorder
    Cameron D Quanbeck
    Forensic Division of the Department of Psychiatry at the University of California Davis, Sacramento, 95817, USA
    Psychiatr Serv 56:847-52. 2005
    ..This study examined the relationship between criminal arrest and gender, substance use disorder, and use of community mental health services among patients with bipolar I disorder...
  87. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  88. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  89. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  90. ncbi request reprint Motor output reflects the linear superposition of visual and olfactory inputs in Drosophila
    Mark A Frye
    Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 207:123-31. 2004
    ..Based on the physiology of the flight motor system and recent free-flight analyses, we present a hypothetical model to account for the summation or superposition of sensorimotor responses during flight...
  91. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  92. doi request reprint Aripiprazole efficacy in irritability and disruptive-aggressive symptoms: young mania rating scale line analysis from two, randomized, double-blind, placebo-controlled trials
    Mark A Frye
    J Clin Psychopharmacol 28:243-5. 2008
  93. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  94. ncbi request reprint Diagnostic dilemmas and clinical correlates of mixed states in bipolar disorder
    Mark A Frye
    Mayo Clinic, Rochester, Minnesota, USA
    J Clin Psychiatry 69:e13. 2008
    ..Inconsistent diagnostic criteria can be problematic for clinicians when treating patients...
  95. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  96. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  97. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
    ..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse...