Cheryl Anne Frye

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. ncbi request reprint Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats
    Cheryl A Frye
    Department of Psychology, Social Science 220, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:531-40. 2004
  2. ncbi request reprint Prenatal stress alters reproductive responses of rats in behavioral estrus and paced mating of hormone-primed rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Horm Behav 42:472-83. 2002
  3. ncbi request reprint Posttraining androgens' enhancement of cognitive performance is temporally distinct from androgens' increases in affective behavior
    C A Frye
    Department of Psychology, Biological Sciences, Center for Neuroscience Research, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Cogn Affect Behav Neurosci 1:172-82. 2001
  4. ncbi request reprint Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats
    C A Frye
    Department of Psychology, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA
    Cogn Affect Behav Neurosci 1:371-81. 2001
  5. ncbi request reprint Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Ave, Albany, NY 12222, USA
    Brain Res 956:285-93. 2002
  6. ncbi request reprint Testosterone enhances aggression of wild-type mice but not those deficient in type I 5alpha-reductase
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 948:165-70. 2002
  7. ncbi request reprint The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolites
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 74:119-27. 2002
  8. ncbi request reprint Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats
    Cheryl Frye
    Department of Psychology, State University of New York Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Physiol Behav 76:151-8. 2002
  9. ncbi request reprint Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5alpha-reductase
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsia 43:14-7. 2002
  10. ncbi request reprint Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters
    Cheryl A Frye
    Department of Psychology, The University of Albany, SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 28:310-6. 2003

Detail Information

Publications99

  1. ncbi request reprint Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats
    Cheryl A Frye
    Department of Psychology, Social Science 220, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:531-40. 2004
    ..Together, these data suggest that 3alpha,5alpha-THP in the hippocampus may mediate antidepressive behavior of female rats...
  2. ncbi request reprint Prenatal stress alters reproductive responses of rats in behavioral estrus and paced mating of hormone-primed rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Horm Behav 42:472-83. 2002
    ....
  3. ncbi request reprint Posttraining androgens' enhancement of cognitive performance is temporally distinct from androgens' increases in affective behavior
    C A Frye
    Department of Psychology, Biological Sciences, Center for Neuroscience Research, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Cogn Affect Behav Neurosci 1:172-82. 2001
    ..These findings suggest posttraining androgens can enhance consolidation and cognitive performance, independent of their anxiolytic actions...
  4. ncbi request reprint Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats
    C A Frye
    Department of Psychology, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA
    Cogn Affect Behav Neurosci 1:371-81. 2001
    ..Together, these data demonstrate that endogenous T or administration of T produced analgesia and enhanced affect and cognitive performance of adult male rats...
  5. ncbi request reprint Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Ave, Albany, NY 12222, USA
    Brain Res 956:285-93. 2002
    ....
  6. ncbi request reprint Testosterone enhances aggression of wild-type mice but not those deficient in type I 5alpha-reductase
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 948:165-70. 2002
    ..2 suggest that the inability to metabolize T to its 5alpha-reduced products may attenuate some aggression-enhancing effects of mice in the resident intruder test of aggression...
  7. ncbi request reprint The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolites
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 74:119-27. 2002
    ..These data are consistent with the hypothesis that the hedonic effects of T may be due to actions of its metabolites in the NA...
  8. ncbi request reprint Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats
    Cheryl Frye
    Department of Psychology, State University of New York Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Physiol Behav 76:151-8. 2002
    ....
  9. ncbi request reprint Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5alpha-reductase
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsia 43:14-7. 2002
    ..To investigate the importance of progesterone (P4) metabolism by the 5alpha-reductase type I enzyme in mitigating P4 antiseizure effects...
  10. ncbi request reprint Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters
    Cheryl A Frye
    Department of Psychology, The University of Albany, SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 28:310-6. 2003
    ..These data confirm previous findings that sexual dysfunction can be induced by SSRIs and extend the current knowledge to suggest that administration of a PDE-5 inhibitor can override SSRI-induced deficits in sexual functioning...
  11. ncbi request reprint Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 77:71-82. 2003
    ..These data suggest that neurosteroidogenesis involving MBRs in the VTA mediates lordosis of hormone-primed or behavioral estrous rats...
  12. ncbi request reprint Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats
    Cheryl A Frye
    The University at Albany SUNY, Department of Psychology, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 28:657-73. 2003
    ..Together, these data are consistent with the hypothesis that olanzapine reduces fear, has anxiolytic effects, and may enhance social interaction in part due to increasing progestin concentrations...
  13. ncbi request reprint Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats
    Cheryl A Frye
    Department of Psychology, State University of New York at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:473-81. 2004
    ..These data indicate that T's 5alpha-reduced metabolite, DHT, can reduce anxiety behavior and that blocking metabolism to 3alpha-diol in the hippocampus can attenuate these effects...
  14. ncbi request reprint Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:405-18. 2004
    ..Thus, 3alpha,5alpha-THP's actions in the VTA for lordosis may involve D1 and/or D2 receptors...
  15. ncbi request reprint 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 29:1019-27. 2004
    ..These results suggest that 5alpha-reduced androgens may have actions in the hippocampus to improve cognitive performance...
  16. ncbi request reprint Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats
    Cheryl A Frye
    Department of Psychology, University at Albany State University of New York, Albany, NY 12222, USA
    Behav Neurosci 118:306-13. 2004
    ..Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses...
  17. ncbi request reprint Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase
    Cheryl A Frye
    Department of Psychology and Center for Neurobiology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 1004:116-24. 2004
    ..Thus, these data suggest metabolism by the 5 alpha-reductase type I enzyme may mitigate P(4)'s effects on some tasks of motor, anxiety, nociception, and depression behavior...
  18. ncbi request reprint Fluoxetine may influence lordosis of rats through effects on midbrain 3 alpha,5 alpha-THP concentrations
    Cheryl A Frye
    Departments of Psychology, Biological Sciences, and The Center for Neuroscience Research, The University at Albany State University of New York, 1400 Washington Avenue, Albany, New York 12222, USA
    Ann N Y Acad Sci 1007:37-41. 2003
    ..3alpha,5alpha-THP, but not vehicle, to the VTA reversed acute fluoxetine's inhibitory effects on lordosis. Together, these data suggest fluoxetine may alter lordosis in part through actions of 3alpha-THP in the midbrain...
  19. ncbi request reprint Effects of olanzapine infusions to the ventral tegmental area on lordosis and midbrain 3alpha,5alpha-THP concentrations in rats
    Cheryl Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 170:132-9. 2003
    ..Olanzapine, an atypical antipsychotic, may exert some of its actions by increasing 3alpha,5alpha-THP levels...
  20. ncbi request reprint Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters
    C A Frye
    Departments of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 15:677-86. 2003
    ..Together, these findings indicate that manipulating actions of mitochondrial benzodiazepine receptors in the VTA can augment and inhibit neurosteroidogenesis and sexual responsiveness of hormone-primed and naturally receptive hamsters...
  21. pmc 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors
    C A Frye
    Department of Psychology, Social Science 369, The University at Albany SUNY, NY 12222, USA
    Neuroscience 138:1007-14. 2006
    ..Given 3alpha-hydroxy-5alpha-pregnan-20-one's involvement in stress responses, its putative role as a homeostatic regulator and in the pathophysiology and treatment of neuropsychiatric disorders is discussed...
  22. ncbi request reprint Prenatal stress produces deficits in socio-sexual behavior of cycling, but not hormone-primed, Long-Evans rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, 12222, USA
    Pharmacol Biochem Behav 73:53-60. 2002
    ..Thus, hormone priming may override or mask effects of PNS on some aspects of socio-sexual behavior...
  23. ncbi request reprint Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male rats and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats
    C A Frye
    Department of Psychology, Biological Sciences and The Neurobiology Research Center, The University at Albany SUNY, 1400 Washington Street, Albany, NY 12222, USA
    Brain Res 889:358-63. 2001
    ..These findings suggest that estradiol's effects on inhibitory avoidance and pyknosis in the dentate gyrus may be independent of each other...
  24. ncbi request reprint Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP
    C A Frye
    Department of Psychology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 67:587-96. 2000
    ..These data demonstrate that proestrous increases in anxiolytic-like behavior coincide with elevated circulating and hippocampal progestin concentrations...
  25. ncbi request reprint Infusion of 3alpha,5alpha-THP to the pontine reticular formation attenuates PTZ-induced seizures
    C A Frye
    Department of Psychology, Biological Sciences and The Neurobiology Research Center, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 881:98-102. 2000
    ..Infusions that missed the PRF were not effective. These data suggest 3alpha,5alpha-THP has anti-seizure effects in part through actions in the PRF...
  26. ncbi request reprint Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats
    C A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 115:55-64. 2000
    ..These data suggest that in the VMH, PRs are important for P-facilitated lordosis, whereas in the VTA, GABAergic neurons may be an important substrate for mediating P's actions on lordosis of rodents...
  27. ncbi request reprint Anti-seizure effects of progesterone and 3alpha,5alpha-THP in kainic acid and perforant pathway models of epilepsy
    C A Frye
    Department of Psychology, The University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 25:407-20. 2000
    ..Data suggest anti-seizure effects of progesterone may be due, in part, to metabolism to 3alpha,5alpha-THP and subsequent actions at GABA(A) receptor complexes...
  28. ncbi request reprint Mating stimuli influence endogenous variations in the neurosteroids 3alpha,5alpha-THP and 3alpha-Diol
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 11:839-47. 1999
    ..The neurosteroids, 3alpha,5alpha-THP and 3alpha-Diol, vary with mating in the hypothalamus and midbrain of rats...
  29. ncbi request reprint Progestins' rapid facilitation of lordosis when applied to the ventral tegmentum corresponds to efficacy at enhancing GABA(A)receptor activity
    C A Frye
    Neuroscience Program, Connecticut College, New London, CT, USA
    J Neuroendocrinol 11:829-37. 1999
    ..These findings suggest that progesterone lordosis enhancing effects in the rodent VTA may be via GBRs...
  30. ncbi request reprint GABA(A), D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis
    C A Frye
    Neuroscience Program, Connecticut College, New London, USA
    Behav Brain Res 103:23-34. 1999
    ..These data suggest that in the VTA GABAergic and dopaminergic neurons may be more important in the mediation of sexual receptivity than neurons containing intracellular PRs...
  31. ncbi request reprint The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state
    C A Frye
    Neuroscience Program, Connecticut College, New London 06320, USA
    Physiol Behav 66:85-92. 1999
    ..These findings suggest that DHEA and DHEAS may alter performance on cognitive tasks due to motor or anxiety effects...
  32. ncbi request reprint Inhibition of 5alpha-reductase enzyme or GABA(A) receptors in the VMH and the VTA attenuates progesterone-induced sexual behavior in rats and hamsters
    C A Frye
    Department of Psychology, Biological Sciences, and Center for Neurobiology, University at Albany, SUNY, NY, USA
    J Endocrinol Invest 24:399-407. 2001
    ..These data suggest that 5alpha-reductase and GBRs are present in the VMH and VTA, and that inhibiting 5alpha-reductase activity or blocking GBRs in the VMH and the VTA attenuates EB+P-primed sexual receptivity of OVX rats and hamsters...
  33. ncbi request reprint The neurosteroids, progesterone and 3alpha,5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats
    C A Frye
    Department of Psychology, The University of Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 808:72-83. 1998
    ..These studies suggest that P and 3alpha,5alpha-THP may have some common effects on reproductive behavior, e.g., sexual motivation, receptivity, and proceptivity...
  34. ncbi request reprint Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, New York, 12222, USA
    Horm Behav 41:306-15. 2002
    ..Together these data suggest that variations in 3alpha,5alpha-THP levels in the hippocampus may mitigate proestrous changes in anxiety and depressive behavior of cycling rats...
  35. ncbi request reprint The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany, SUNY, Albany, NY 12222, USA
    Brain Res Brain Res Rev 37:201-22. 2001
    ....
  36. ncbi request reprint Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3alpha,5alpha-THP attenuate lordosis of hormone-primed and behavioural oestrous rats and hamsters
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany SUNY, Albany, New York 12222, USA
    J Neuroendocrinol 13:1076-86. 2001
    ..These data suggest that biosynthesis of progestins, and the metabolism of progesterone to 3alpha,5alpha-THP in the VTA, are important for progestin-facilitated sexual receptivity of rats and hamsters...
  37. ncbi request reprint Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase
    C A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 918:182-6. 2001
    ..These data are consistent with T having anti-convulsant effects and that 5alpha-reduced metabolites may mitigate some of T's anti-seizure effects...
  38. ncbi request reprint Progesterone and 3alpha,5alpha-THP enhance sexual receptivity in mice
    C A Frye
    Department of Psychology and Center for Neuroscience Research, University at Albany, State University of New York, 12222, USA
    Behav Neurosci 115:1118-28. 2001
    ..Thus, P-facilitated receptivity in mice involves P and 3alpha,5alpha-THP and their actions at PRs and GABAA receptors...
  39. ncbi request reprint The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents
    C A Frye
    Department of Psychology, Biological Sciences and The Neurobiology Research Center, Social Sciences 112, The University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Horm Behav 40:226-33. 2001
    ..In the VTA, P(4) may facilitate lordosis following metabolism to and/or biosynthesis of 3 alpha,5 alpha-THP, which may have subsequent actions at GBRs and/or MBRs to acutely modulate female sexual behavior in rodents...
  40. ncbi request reprint 3alpha,5alpha-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures
    C A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 911:146-51. 2001
    ..These data suggest that progestins' anti-seizure effects in the NRM may be involve actions of 3alpha,5alpha-THP...
  41. ncbi request reprint The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference
    C A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 26:731-50. 2001
    ..Hence, whether the effects of 3 alpha-diol on CPP are mediated by differential actions at ARs or GABA(A) receptors in particular brain regions needs to be determined...
  42. ncbi request reprint Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1288-301. 2005
    ..Together, these data suggest that E(2) may have dose-dependent effects on anxiety and depressive behavior of female rodents, which may depend on the tone of the hypothalamic-pituitary-adrenal axis...
  43. pmc Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze
    Alicia A Walf
    Dept of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Behav Brain Res 196:254-60. 2009
    ..Thus, enhanced performance in cognitive tasks and anti-anxiety-like behavior of proestrous mice may require actions of ERbeta in the hippocampus and/or cortex...
  44. ncbi request reprint Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Neurosci 118:1352-64. 2004
    ..Only 3alpha-diol levels in the hippocampus were consistently elevated in conjunction with these behavioral effects...
  45. ncbi request reprint Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 6:320-7. 2005
    ..These data suggest that actions of progesterone at GABA(A) receptors in the hippocampus are important for progesterone's antiseizure effects...
  46. ncbi request reprint Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects
    Alicia A Walf
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Stress 10:251-60. 2007
    ..Thus, estradiol and gestational stress can have opposite effects on anxiety and inhibitory avoidance performance...
  47. ncbi request reprint Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Epilepsia 45:1531-8. 2004
    ..The present studies were designed to characterize the effects of progestins to modulate pentylenetetrazole (PTZ)-induced seizures in female rats...
  48. pmc Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice
    Alicia A Walf
    Department of Psychology, University at Albany State University of New York, USA
    Behav Neurosci 122:974-81. 2008
    ..This pattern was neither seen in motor activity nor pain threshold measures. Thus, actions of ERss may be important for modulating anxiety-like behavior of mice...
  49. pmc Estradiol reduces anxiety- and depression-like behavior of aged female mice
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Physiol Behav 99:169-74. 2010
    ..Thus, an acute E(2) regimen produced specific anti-anxiety and anti-depressant effects, independent of effects on motor behavior, when administered to aged female C57BL/6 mice...
  50. pmc Nociceptive and anxiety-like behavior in reproductively competent and reproductively senescent middle-aged rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Gend Med 6:235-46. 2009
    ..Changes in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect...
  51. pmc Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice
    Carolyn J Koonce
    Department of aPsychology, University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 20:1047-50. 2009
    ..Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects...
  52. pmc Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res Bull 77:91-7. 2008
    ..Effects on lordosis were not solely due to changes in general motor behavior. Thus, 3alpha,5alpha-THP's actions in the ventral tegmental area through membrane receptors may require activity of protein kinase C...
  53. ncbi request reprint Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsy Behav 6:140-6. 2005
    ..These data suggest that formation of 3alpha,5alpha-THP in the hippocampus is important for progesterone's antiseizure effects...
  54. pmc Raloxifene and/or estradiol decrease anxiety-like and depressive-like behavior, whereas only estradiol increases carcinogen-induced tumorigenesis and uterine proliferation among ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany, State University of New York, Albany, NY 12222, USA
    Behav Pharmacol 21:231-40. 2010
    ..As well, E2, with or without raloxifene, can also have clear trophic actions in peripheral tissues, such as carcinogen-induced tumors, uterus, and pituitary glands...
  55. ncbi request reprint ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Social Sciences 369, Albany, NY 12222, USA
    Neurobiol Learn Mem 85:183-91. 2006
    ....
  56. pmc Progesterone enhances performance of aged mice in cortical or hippocampal tasks
    Cheryl A Frye
    Department of Psychology and Centers for Life Science and Neuroscience Research, University at Albany SUNY, Albany, NY 12222, United States
    Neurosci Lett 437:116-20. 2008
    ..Thus, progesterone improved learning and memory in tasks mediated by the prefrontal cortex and/or hippocampus of aged mice...
  57. ncbi request reprint Administration of estrogen receptor beta-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:407-14. 2007
    ..Administration of ERalpha-specific SERMs produced similar effects as vehicle administration. Thus, E(2)'s anti-anxiety and anti-depressive effects may involve ERbeta in the hippocampus...
  58. ncbi request reprint In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3alpha,5alpha-THP's actions at dopamine type 1 receptors for lordosis of rats
    Sandra M Petralia
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 80:233-43. 2004
    ..Thus, in the VTA, 3alpha,5alpha-THP's actions for lordosis may involve activation of D1 and initiation of the G-protein-mediated second messenger cAMP...
  59. pmc Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks
    Alicia A Walf
    Department of Psychology, The University at Albany, State University of New York, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:513-21. 2008
    ..Thus, actions at ERbeta may be important for E(2) or SERMs to enhance cognitive performance of female mice in the object recognition and placement tasks...
  60. pmc Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of naturally cycling and ovariectomized rats
    Danielle C Llaneza
    Dept of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 93:337-42. 2009
    ..Thus, progesterone and/or estrogen may mediate impulsive and/or avoidant behavior...
  61. pmc Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 186:302-11. 2006
    ....
  62. ncbi request reprint Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area
    Kanako Sumida
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 161:1-7. 2005
    ..The D(2) agonist, quinpirole and the D(2) antagonist, sulpiride, had no significant effects on P-facilitated lordosis. These data suggest that, in hamsters, P's actions for lordosis may involve D(1) receptors in the VTA...
  63. ncbi request reprint In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A
    Sandra M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Neuroendocrinology 84:405-14. 2006
    ..Thus, in the VTA, progestins' membrane actions involving D1 or GBRs are mediated, in part, by PKA...
  64. ncbi request reprint Androgens' performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the dorsal hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:201-8. 2007
    ....
  65. ncbi request reprint Sexual experience of male rats influences anxiety-like behavior and androgen levels
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, United States
    Physiol Behav 92:443-53. 2007
    ..Thus, sexual experience is associated with lower levels of anxiety-like behavior and higher levels of androgen secretion...
  66. ncbi request reprint Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 32:522-30. 2007
    ..Thus, E(2)'s rewarding effects may involve actions at ERs in the nucleus accumbens...
  67. ncbi request reprint In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters
    Sandra M Petralia
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 178:174-82. 2005
    ..Thus, if, in the VTA, MBR-mediated increases in 3alpha,5alpha-THP enhance sexual responses via actions at GBRs, then blocking GBRs with picrotoxin will reduce FGIN 1-27-induced increases in sexual behavior of female rodents...
  68. ncbi request reprint Anti-nociception following exposure to trimethylthiazoline, peripheral or intra-amygdala estrogen and/or progesterone
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 144:77-85. 2003
    ..These data suggest that following exposure to predator odor, pain sensitivity in the tailflick task is decreased and that E(2) and/or P may have actions in the amygdala to produce similar anti-nociceptive effects...
  69. pmc Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    Neurobiol Learn Mem 86:35-46. 2006
    ..Together, these results suggest that E2 and progestins can have mnemonic effects through actions in the cortex and/or hippocampus...
  70. pmc Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Life Sciences Research 1058, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:909-16. 2009
    ..Thus, E(2)-replacement reduced anxiety and depression behavior and improved cognitive performance of aged female rats; however, delay in E(2) treatment influenced whether there were favorable effects of E(2) in some tasks...
  71. pmc Parity and estrogen-administration alter affective behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Physiol Behav 93:351-6. 2008
    ..Together, these data suggest that E(2) can alter affective behavior and rats with greater reproductive experience have decreased anxiety-like behavior in the elevated plus maze, irrespective of E(2)-priming...
  72. ncbi request reprint Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 30:418-30. 2005
    ..These findings suggest that T's anti-anxiety effects may be due in part to actions of its 5alpha-reduced metabolites in the dorsal hippocampus...
  73. pmc Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout, mice
    Danielle M Osborne
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 16:411-4. 2009
    ..Thus, some of the anticonvulsive effects of E(2) may involve formation of 3alpha,5alpha-THP in the hippocampus...
  74. pmc Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice
    Cheryl A Frye
    The Departments of Psychology and Biology and Centers for Life Science and Neuroscience Research, The University at Albany State University of New York, Albany, NY 12222, United States
    Neurosci Lett 472:38-42. 2010
    ..PRKO, compared to wildtype, mice performed better in the inhibitory avoidance task, irrespective of progesterone. Thus, progesterone to aged mice enhances performance across a variety of tasks and this may not require actions at PRs...
  75. pmc Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Physiol Behav 100:264-7. 2010
    ..Levels of 3alpha,5alpha-THP in the hypothalamus of BTBR mice were significantly higher compared to C57/J and 129S1 mice. These findings suggest that neuroendocrine dysregulation among BTBR mice extends to 3alpha,5alpha-THP...
  76. ncbi request reprint Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively
    Alicia A Walf
    Department of Psychology, Research The University at Albany Suny, Albany, NY 12222, USA
    Neuropsychopharmacology 33:431-40. 2008
    ..Thus, ERbeta and ERalpha may be required for E(2)'s modulation of affective and sexual behavior, respectively...
  77. ncbi request reprint Differences in affective behaviors and hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations
    Betty Zimmerberg
    Department of Psychology, Williams College, 18 Hoxsey Street, Williamstown, MA 01267, USA
    Behav Brain Res 159:301-11. 2005
    ....
  78. ncbi request reprint In the ventral tegmental area, G-proteins mediate progesterone's actions at dopamine type 1 receptors for lordosis of rats and hamsters
    Sandra M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY, 12222, USA
    Psychopharmacology (Berl) 186:133-42. 2006
    ..Previous reports indicate that the ventral tegmental area (VTA) and/or progesterone (P) can modulate the reinforcing effects of drugs of abuse, food, and sexual behavior...
  79. pmc MK-801 infusions to the ventral tegmental area and ventromedial hypothalamus produce opposite effects on lordosis of hormone-primed rats
    Sandra M Petralia
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:377-85. 2007
    ..These data suggest NMDARs may be important in the mediation of hormonal actions in both the ventral tegmental area and the ventromedial hypothalamus for sexual receptivity of rodents, but in different ways...
  80. doi request reprint Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta
    Allicia Ryan
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 13:32-5. 2008
    ..This pattern of effects was observed in wild-type or betaERKO mice. Thus, for these mice, the antiseizure effects of 3*-diol for the chemoconvulsant PTZ occur independent of actions at ERbeta...
  81. pmc Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder
    Jason J Paris
    Department of Psychology Research, The University at Albany, SUNY, NY, USA
    Horm Behav 57:35-45. 2010
    ..To address this, cortisol levels among boys and girls with different stress-related experiences, will be the subject of future investigation...
  82. pmc Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats
    Amy S Kohtz
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Horm Behav 57:474-80. 2010
    ..However, cocaine's disruption of sexual behaviors was similar among males and proestrous females. These data suggest a complex interaction between hormonal milieu and the neuroendocrine and behavioral effects of cocaine...
  83. ncbi request reprint Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:551-8. 2004
    ..Together, these data suggest that estrogen can have positive mnemonic effects in the inhibitory avoidance task...
  84. ncbi request reprint Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Horm Behav 50:216-22. 2006
    ..Together, these findings suggest that androgens can decrease anxiety-like behavior of male rats in part through DHT's actions at androgen receptors in the hippocampus...
  85. ncbi request reprint Androgens in the hippocampus can alter, and be altered by, ictal activity
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:483-93. 2004
    ..Thus, this paper will review data in support of androgens' antiseizure effects. Further understanding of androgens' role in seizure processes is important for potential therapeutic effects...
  86. ncbi request reprint Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the conditioned fear and inhibitory avoidance tasks
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 78:559-68. 2004
    ..These data indicate that androgens effects to enhance learning may be mediated in part by actions of 5alpha-reduced metabolites in the hippocampus...
  87. ncbi request reprint Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats
    Deborah F Frisone
    Department of Psychology, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA
    Behav Brain Res 128:153-60. 2002
    ..These results are discussed in light of research on the effects of CORT on the developing hippocampus...
  88. pmc Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building Rm 1058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:78-85. 2007
    ..Together, these findings suggest that T's effects to enhance learning and memory may take place, in part, through actions of its metabolite, 3alpha-diol, at ERbeta in the dorsal hippocampus...
  89. pmc Effects of two estradiol regimens on anxiety and depressive behaviors and trophic effects in peripheral tissues in a rodent model
    Alicia A Walf
    Department of Psychology, The Centers for Neuroscience and Life Sciences Research, The University at Albany State University of New York, Albany, New York 12222, USA
    Gend Med 6:300-11. 2009
    ....
  90. pmc A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 31:1097-111. 2006
    ..It is particularly important to investigate the putative receptor mechanisms and brain targets for E2 to determine whether mood-enhancing effects of E2 can occur without deleterious proliferative effects in reproductive tissues...
  91. pmc Novel substrates for, and sources of, progestogens for reproduction
    Cheryl Anne Frye
    Department of Psychology, University at Albany, Albany, NY 12222, USA
    J Neuroendocrinol 23:961-73. 2011
    ..Finally, the potential role of the pregnane xenobiotic receptor in mediating 3α,5α-THP biosynthesis in the midbrain is introduced...
  92. pmc Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats
    Cheryl Anne Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    J Sex Med 10:1692-706. 2013
    ..Of interest is whether 3α,5α-THP formation requires the pregnane xenobiotic receptor (PXR), which is expressed in the midbrain of rats...
  93. ncbi request reprint Seizure exacerbation associated with inhibition of progesterone metabolism
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Neurol 53:390-1. 2003
    ..We report a case in which efficacy was eliminated during concomitant treatment with a reductase inhibitor. The observation suggests that a reduced metabolite, rather than progesterone itself, was responsible for improved seizure control...
  94. pmc Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats
    Madeline E Rhodes
    Department of Biology, University of Hartford, West Hartford, CT 06117, USA
    Epilepsy Behav 7:231-9. 2005
    ..These data suggest that levels of pregnane and androstane neuroactive steroids, or their precursors, may underlie some of the antiseizure effects of KD...
  95. pmc Early postnatal stimulation alters pregnane neurosteroids in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany, Albany, NY 12222, and Division of Neurology, The Children s Hospital of Philadelphia, PA, USA
    Psychopharmacology (Berl) 186:343-50. 2006
    ..Early postnatal stimulation is a developmental stressor that can produce pervasive endocrine effects...
  96. ncbi request reprint Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Epilepsia 47:1945-8. 2006
    ..To compare serum levels of neuroactive steroids among men with epilepsy who take various antiepileptic drugs, untreated men with epilepsy and normal controls (NC)...
  97. pmc Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, New York, USA
    Reproduction 133:663-74. 2007
    ..Thus, paced mating enhances concentrations of 5alpha-reduced progestins in brain areas associated with reproduction (midbrain), as well as exploration/anxiety (hippocampus and striatum) and social behavior (cortex)...
  98. pmc Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Behav Brain Res 187:88-99. 2008
    ..Thus, 3alpha,5alpha-THP infusions to the VTA, but not SN or CG, can enhance socio-sexual behaviors and increase levels in midbrain, hippocampus, and diencephalon...
  99. ncbi request reprint Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile rats
    Cheryl M McCormick
    Neuroscience Program and Department of Psychology, Bates College, Lewiston, ME 04240, USA
    Pharmacol Biochem Behav 73:77-85. 2002
    ..These data indicate that the effects of neonatal isolation persist postweaning and that the effects are most evident in response to stress as opposed to under baseline conditions...

Research Grants9

  1. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2007
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. ..
  2. Progestins non-genomic actions for socio-sexual behavior
    Cheryl Frye; Fiscal Year: 2007
    ..abstract_text> ..
  3. Progestogens' non-classical effects and mechanisms for social & mood processes
    Cheryl Anne Frye; Fiscal Year: 2010
    ..Further understanding of progestogens'effects and mechanisms are vital to provide insight into normative and pathophysiological processes. ..