C A Frye

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. pmc 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY Albany, NY, USA
    Front Aging Neurosci 2:15. 2010
  2. pmc Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review
    Cheryl A Frye
    Department of Psychology, University at Albany State University of New York Albany, NY, USA
    Front Psychiatry 2:52. 2011
  3. pmc Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY Albany, NY, USA
    Front Neurosci 5:136. 2011
  4. pmc Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our Thirteenth Conference for Neuroscience Trainees and Educators
    Jay P McLaughlin
    Behavioral Neuroscience Program and Psychology Department, Northeastern University, Boston, MA
    J Undergrad Neurosci Educ 7:A65-8. 2009
  5. pmc Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 24:144-59. 2012
  6. ncbi request reprint ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1598-609. 2005
  7. ncbi request reprint Progesterone's 5 alpha-reduced metabolite, 3 alpha,5 alpha-THP, mediates lateral displacement of hamsters
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1038:59-68. 2005
  8. pmc Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1036:101-8. 2005
  9. ncbi request reprint Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:17-26. 2008
  10. pmc Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways
    Cheryl A Frye
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Steroids 73:906-13. 2008

Detail Information

Publications164 found, 100 shown here

  1. pmc 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY Albany, NY, USA
    Front Aging Neurosci 2:15. 2010
    ..Thus, age is associated with a decrease in 3alpha-diol production and 3alpha-diol administration reinstates cognitive and affective performance of aged male rats...
  2. pmc Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review
    Cheryl A Frye
    Department of Psychology, University at Albany State University of New York Albany, NY, USA
    Front Psychiatry 2:52. 2011
    ..This review explores the notion that allopregnanolone may effect, or be influenced by, PNS, with consequences for neurodevelopmental-, neuropsychiatric-, and/or neurodegenerative- relevant processes, such as addiction...
  3. pmc Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY Albany, NY, USA
    Front Neurosci 5:136. 2011
    ..Thus, further understanding of 3α,5α-THP's role and mechanisms to enhance affective and motivated processes is essential...
  4. pmc Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our Thirteenth Conference for Neuroscience Trainees and Educators
    Jay P McLaughlin
    Behavioral Neuroscience Program and Psychology Department, Northeastern University, Boston, MA
    J Undergrad Neurosci Educ 7:A65-8. 2009
    ..Conferences are supported by an NIH R13 grant, and serve as a valuable experience for both students and mentors with a passion for neuroscience. This paper describes the proceedings of the fall 2007 meeting at Northeastern University...
  5. pmc Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 24:144-59. 2012
    ....
  6. ncbi request reprint ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1598-609. 2005
    ..Coadministration of tamoxifen (10 mg/kg) blocked the antianxiety behavior produced by 17beta-E2, DPN, or coumestrol. Together, these data suggest that actions at ERbeta may underlie some of E2's antianxiety effects...
  7. ncbi request reprint Progesterone's 5 alpha-reduced metabolite, 3 alpha,5 alpha-THP, mediates lateral displacement of hamsters
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1038:59-68. 2005
    ..These data suggest that lateral displacement is progestin-sensitive and requires the formation of 3 alpha,5 alpha-THP in the midbrain VTA...
  8. pmc Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1036:101-8. 2005
    ..These findings suggest that E2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task...
  9. ncbi request reprint Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:17-26. 2008
    ....
  10. pmc Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways
    Cheryl A Frye
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Steroids 73:906-13. 2008
    ..Thus, in the VTA, progestins have rapid membrane-mediated actions via D(1), GBRs, NMDARs and their downstream signal transduction pathways...
  11. pmc Conjugated equine estrogen enhances rats' cognitive, anxiety, and social behavior
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 19:789-92. 2008
    ..Thus, CEE can enhance cognitive, antianxiety, and social behavior of middle-aged rats...
  12. pmc Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY, USA
    Neurobiol Learn Mem 90:171-7. 2008
    ..Compared to vehicle, P(4) treatment increased freezing in contextual and cued fear testing. Thus, acute P(4) treatment to OVX mice can improve cognitive performance across a variety of tasks...
  13. pmc Effects of manipulating progesterone and NMDA receptors in the ventral tegmental area for lordosis of hamsters and rats
    Cheryl A Frye
    Departments of Psychology, The University at Albany SUNY, Albany, NY, USA
    Psychopharmacology (Berl) 200:71-80. 2008
    ..There are N-methyl-D: -aspartate receptors (NMDARs) in the VTA that may be a substrate for P4's effects...
  14. pmc Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 193:269-76. 2008
    ..These findings suggest that actions of 3alpha,5alpha-THP in the VTA are important for mediating aspects of exploration, anxiety, and social behavior related to mating...
  15. pmc In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C
    Cheryl A Frye
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res 1230:218-23. 2008
    ..Thus, progestogens' non-traditional actions in the VTA to enhance lordosis through D1 and/or GABA(A) include activity of PLC...
  16. ncbi request reprint Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Horm Behav 50:237-44. 2006
    ..Progestin- or progestin plus SKF38393-or muscimol-mediated increases in lordosis were blocked by DDA pretreatment. Thus, in the VTA, progestins' membrane action may involve adenylyl cyclase...
  17. pmc Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, NY 12222, USA
    Horm Behav 54:726-34. 2008
    ..Thus, actions at ERbeta may be required for T's anxiety-reducing and cognitive-enhancing effects...
  18. pmc Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 91:261-70. 2008
    ..Thus, actions of 3alpha,5alpha-THP in the VTA to enhance social and sexual behaviors were reliant on E(2) but increases in exploratory and anti-anxiety behavior were not...
  19. pmc Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats
    Cheryl A Frye
    Department of Psychology, The Centers for Neuroscience Life Sciences Research 1058, The University at Albany SUNY, Albany, New York 12222, USA
    Reproduction 137:119-28. 2009
    ..These findings suggest that 3alpha,5alpha-THP formation in the midbrain VTA may influence appetitive, as well as consummatory, aspects of mating behavior...
  20. pmc Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, United States
    Behav Brain Res 187:88-99. 2008
    ..Thus, 3alpha,5alpha-THP infusions to the VTA, but not SN or CG, can enhance socio-sexual behaviors and increase levels in midbrain, hippocampus, and diencephalon...
  21. ncbi request reprint In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C
    C A Frye
    Departments of Psychology and Biological Sciences, and the Centers for Neurosience and Life Sciences Research, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    J Neuroendocrinol 19:717-24. 2007
    ..Thus, the actions of progestins in the VTA to enhance lordosis through D(1) and/or GABA(A) may include downstream activity of PLC and PKC...
  22. ncbi request reprint Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 81:907-16. 2005
    ..BDNF levels in the hippocampus were increased by estrogen-priming, but reduced by progesterone administration. Thus, estrogen may have anti-seizure effects by enhancing formation of allopregnanolone...
  23. pmc Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 83:336-47. 2006
    ..Whether endogenous levels of 3alpha,5alpha-THP modulate and/or are increased in response to affective and/or reproductively-relevant behaviors was investigated...
  24. pmc Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse
    Cheryl A Frye
    Department of Psychology, Centers for Neuroscience and Life Sciences Research, The University at Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:209-19. 2007
    ..How progestins' effects on these processes may underlie response to drugs of abuse is considered and new findings which demonstrate interactions between progestins and cocaine are presented...
  25. ncbi request reprint Role of androgens in epilepsy
    Cheryl A Frye
    University of New York, Life Sciences Research Building, Room 01058, The University at Albany SUNY, 1400 Washington Avenue Albany, NY 12222, USA
    Expert Rev Neurother 6:1061-75. 2006
    ..Considerations for therapeutic management and future directions for research and drug discovery are summarized...
  26. ncbi request reprint Self-administration of 3alpha-androstanediol increases locomotion and analgesia and decreases aggressive behavior of male hamsters
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:415-21. 2007
    ..Together, these data suggest that 3alpha-diol may have rewarding effects...
  27. ncbi request reprint Progestins' effects on sexual behaviour of female rats and hamsters involving D1 and GABA(A) receptors in the ventral tegmental area may be G-protein-dependent
    Cheryl A Frye
    Department of Psychology, Life Sciences 1058, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 172:286-93. 2006
    ..Thus, progestins' actions in the VTA for lordosis that involve D(1) and/or GBRs may also include recruitment of G-proteins...
  28. pmc Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, New York, USA
    Reproduction 133:663-74. 2007
    ..Thus, paced mating enhances concentrations of 5alpha-reduced progestins in brain areas associated with reproduction (midbrain), as well as exploration/anxiety (hippocampus and striatum) and social behavior (cortex)...
  29. ncbi request reprint In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABA A receptors
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Horm Behav 50:332-7. 2006
    ..There were no effects on motor behavior. Thus, in the VTA, GBR activity modulates D1-mediated actions for lordosis of hamsters and rats...
  30. pmc Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, United States
    Neurobiol Learn Mem 88:208-16. 2007
    ..Thus, performance in the object placement task is better when E(2) and/or P are naturally elevated or when E(2), the ERalpha selective ER modulator PPT, P, or its metabolite, 3alpha,5alpha-THP, are administered post-training...
  31. ncbi request reprint Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    Psychopharmacology (Berl) 185:423-32. 2006
    ....
  32. ncbi request reprint Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors
    C A Frye
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Psychopharmacology (Berl) 186:312-22. 2006
    ..Some of P's antianxiety effects may be due to its conversion to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) and its subsequent actions as a positive modulator at GABAA receptor complexes (GBRs)...
  33. pmc Early postnatal stimulation alters pregnane neurosteroids in the hippocampus
    Cheryl A Frye
    Department of Psychology, University at Albany, Albany, NY 12222, and Division of Neurology, The Children s Hospital of Philadelphia, PA, USA
    Psychopharmacology (Berl) 186:343-50. 2006
    ..Early postnatal stimulation is a developmental stressor that can produce pervasive endocrine effects...
  34. ncbi request reprint Administration of estrogen to ovariectomized rats promotes conditioned place preference and produces moderate levels of estrogen in the nucleus accumbens
    Cheryl A Frye
    Department of Psychology, The University at Albany, 1400 Washington Avenue, Life Sciences Research Building 1058, Albany, NY 12222, USA
    Brain Res 1067:209-15. 2006
    ..Together, these data suggest that regimen of E2 that can produce a CPP result in moderate levels of E2 in the nucleus accumbens...
  35. pmc Some rewarding effects of androgens may be mediated by actions of its 5alpha-reduced metabolite 3alpha-androstanediol
    Cheryl A Frye
    Department of Psychology, Centers for Neuroscience and Life Sciences Research Building, Room 1058, The University at Albany State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:354-67. 2007
    ..This review provides a comprehensive examination of the hedonic properties and abuse/addiction potential of androgens and the putative mechanisms underlying these effects...
  36. ncbi request reprint Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in th
    C A Frye
    Department of Psychology, The University of Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 18:960-75. 2006
    ....
  37. pmc Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 33:1049-61. 2008
    ..Similar patterns were seen among young, adult GDX but not in intact mice. Thus, 3alpha-diol can enhance affective and cognitive behavior of male mice...
  38. pmc Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites
    Cheryl A Frye
    Department of Psychology, Research, The University at Albany, State University of New York, Albany, New York 12222, USA
    Physiol Behav 97:266-9. 2009
    ..Together, these data suggest that T and its 5alpha-reduced and aromatized metabolites have anti-depressant-like effects in aged male and female mice...
  39. pmc Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY, 12222, USA
    Age (Dordr) 31:143-53. 2009
    ..Thus, the APPswe+PSEN1Delta9 mutation alters affective behavior, and P(4) treatment reversed depressive-like behavior...
  40. pmc Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Behav Pharmacol 21:530-9. 2010
    ..Therefore, effects of CEE to reduce anxiety-like behavior of middle-aged rats may be owing, in part, to its capacity to enhance levels of 3alpha,5alpha-THP in the hippocampus...
  41. doi request reprint Effects and mechanisms of progestogens and androgens in ictal activity
    Cheryl A Frye
    Department of Psychology and Biology, Centers for Life Sciences and Neuroscience Research, Albany State University of New York, Albany, New York 12222, USA
    Epilepsia 51:135-40. 2010
    ..The evidence implicating sex steroids in differences associated with hormonal, reproductive, developmental, stress, seizure type, and/or therapeutics are discussed...
  42. doi request reprint Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 16:418-22. 2009
    ..Estrogens with activity at ERbeta, but not those selective for ERalpha, produced antiseizure effects. Actions at ERbeta may underlie some antiseizure effects of T's metabolites...
  43. ncbi request reprint Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults
    C A Frye
    Department of Psychology, University at Albany, State University of New York, Albany, NY 12222, USA
    Behav Neurosci 120:281-9. 2006
    ..Thus, levels of 3 alpha,5 alpha-THP in the midbrain are associated with differences in sexual behavior of these rats...
  44. pmc Fluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3α,5α-THP
    Cheryl A Frye
    Departments of Psychology and Biology, Centers for Neuroscience and Life Sciences Research, University at Albany, SUNY, Albany, NY, USA
    J Sex Med 7:2670-80. 2010
    ..SSRIs can alter activity of catabolic enzymes that are involved in progesterone's conversion to 5 α-pregnan-3 α-ol-20-one (3 α,5 α-THP). 3 α,5 α-THP plays a key role in female reproductive physiology and behavior...
  45. pmc Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice
    Cheryl A Frye
    Department of Psychology and Biology, University at Albany, State University of New York, Albany, NY, USA
    Behav Brain Res 209:59-65. 2010
    ..P(4) increased the number of central entries made by DATKO and wildtype mice. Thus, P(4) administration to DATKO female or male mice partially attenuated their hyperactive phenotype...
  46. pmc Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP
    Cheryl A Frye
    Department of Psychology, University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 21:590-5. 2010
    ..Thus, formation of 3alpha,5alpha-THP may be required for progesterone's cognitive-enhancing effects...
  47. ncbi request reprint Steroids, reproductive endocrine function, and affect. A review
    C A Frye
    Departments of Psychology, University of Albany SUNY, Albany, NY, USA
    Minerva Ginecol 61:541-62. 2009
    ....
  48. ncbi request reprint Steroids, reproductive endocrine function, and cognition. A review
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    Minerva Ginecol 61:563-85. 2009
    ....
  49. pmc Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate lordosis
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, Albany, NY 12222, United States
    Behav Brain Res 206:286-92. 2010
    ..Together, these findings suggest that, in the midbrain VTA, P4's actions to facilitate sexual behavior of female rodents, involving D1 receptors, may require DARPP-32...
  50. pmc Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, New York 12222, USA
    Dev Neurobiol 71:142-52. 2011
    ..Thus, these data suggest that a physiological regimen of P₄ can prevent some of the deficits in water maze performance produced by kainic acid...
  51. pmc 6-hydroxydopamine lesions enhance progesterone-facilitated lordosis of rats and hamsters, independent of effects on motor behavior
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Physiol Behav 99:218-24. 2010
    ..This suggests that the dopaminergic output neurons of midbrain VTA may play an important role in modulation of P(4)-facilitated sexual lordosis among rodents...
  52. pmc Novel substrates for, and sources of, progestogens for reproduction
    Cheryl Anne Frye
    Department of Psychology, University at Albany, Albany, NY 12222, USA
    J Neuroendocrinol 23:961-73. 2011
    ..Finally, the potential role of the pregnane xenobiotic receptor in mediating 3α,5α-THP biosynthesis in the midbrain is introduced...
  53. pmc Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 99:525-31. 2011
    ..Together these data demonstrate that P decreases depressive behavior of young and older adult C57/BL6, wildtype and PRKO mice, which suggest that acute anti-depressant effects of P may occur independent of actions at "classic" PRs...
  54. doi request reprint Progestogens influence cognitive processes in aging
    Cheryl A Frye
    Department of Psychology, The University at Albany, SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Future Med Chem 1:1215-31. 2009
    ..Progestogens may therefore influence cognitive processes...
  55. doi request reprint Neurosteroids for a successful pregnancy
    Cheryl A Frye
    Department of Psychology, and Biological Sciences, Centers for Life Science and Neuroscience Research, The University at Albany SUNY, Albany, NY 12222, USA
    Stress 14:1-5. 2011
    ..The 6(th) International Meeting on Steroids and the Nervous System will be held in Torino, Italy in February 2011...
  56. pmc Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, USA
    J Endocrinol Invest 34:e188-99. 2011
    ..Aim: To elucidate whether actions of 3α,5α-THP in the midbrain ventral tegmental area (VTA) are both necessary and sufficient to enhance non-sexual and sexual social behaviors, affect, and central 3α,5α-THP metabolism...
  57. pmc Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, NY 12222, USA
    Pharmacol Biochem Behav 93:474-81. 2009
    ..Thus, actions at GABA(A) receptors in the midbrain VTA are essential for appetitive and consummatory aspects of sexual receptivity among rats...
  58. pmc Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 213:93-103. 2011
    ..Some actions of 3α,5α-THP may occur via positive modulation of GABA(A) receptors (GBRs), or negative modulation of N-methyl-D: -aspartate receptors (NMDARs), to influence anxiety-like behavior; but this is not known...
  59. pmc Oxytocin and/or steroid hormone binding globulin infused into the ventral tegmental area modulates progestogen-mediated lordosis
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropharmacology 58:44-9. 2010
    ..There were no effects of these manipulations in E(2)-primed rats. Thus, SHBG and/or oxytocin may have actions in the VTA for progestogen-facilitated lordosis...
  60. pmc Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:S143-61. 2009
    ..Further understanding of these neurobiological and/or behavioral factors may lead to findings that ultimately can promote health and prevent disease...
  61. ncbi request reprint Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1288-301. 2005
    ..Together, these data suggest that E(2) may have dose-dependent effects on anxiety and depressive behavior of female rodents, which may depend on the tone of the hypothalamic-pituitary-adrenal axis...
  62. ncbi request reprint Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins
    Madeline E Rhodes
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Epilepsy Behav 6:320-7. 2005
    ..These data suggest that actions of progesterone at GABA(A) receptors in the hippocampus are important for progesterone's antiseizure effects...
  63. ncbi request reprint Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Neurosci 118:1352-64. 2004
    ..Only 3alpha-diol levels in the hippocampus were consistently elevated in conjunction with these behavioral effects...
  64. pmc Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze
    Alicia A Walf
    Dept of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Behav Brain Res 196:254-60. 2009
    ..Thus, enhanced performance in cognitive tasks and anti-anxiety-like behavior of proestrous mice may require actions of ERbeta in the hippocampus and/or cortex...
  65. ncbi request reprint Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects
    Alicia A Walf
    Department of Psychology, Research, The University at Albany SUNY, Albany, NY 12222, USA
    Stress 10:251-60. 2007
    ..Thus, estradiol and gestational stress can have opposite effects on anxiety and inhibitory avoidance performance...
  66. ncbi request reprint Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Epilepsia 45:1531-8. 2004
    ..The present studies were designed to characterize the effects of progestins to modulate pentylenetetrazole (PTZ)-induced seizures in female rats...
  67. ncbi request reprint Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase
    C A Frye
    Department of Psychology, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 918:182-6. 2001
    ..These data are consistent with T having anti-convulsant effects and that 5alpha-reduced metabolites may mitigate some of T's anti-seizure effects...
  68. ncbi request reprint The neurosteroids, progesterone and 3alpha,5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats
    C A Frye
    Department of Psychology, The University of Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Brain Res 808:72-83. 1998
    ..These studies suggest that P and 3alpha,5alpha-THP may have some common effects on reproductive behavior, e.g., sexual motivation, receptivity, and proceptivity...
  69. pmc Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice
    Alicia A Walf
    Department of Psychology, University at Albany State University of New York, USA
    Behav Neurosci 122:974-81. 2008
    ..This pattern was neither seen in motor activity nor pain threshold measures. Thus, actions of ERss may be important for modulating anxiety-like behavior of mice...
  70. pmc Estradiol reduces anxiety- and depression-like behavior of aged female mice
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Physiol Behav 99:169-74. 2010
    ..Thus, an acute E(2) regimen produced specific anti-anxiety and anti-depressant effects, independent of effects on motor behavior, when administered to aged female C57BL/6 mice...
  71. ncbi request reprint The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference
    C A Frye
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 26:731-50. 2001
    ..Hence, whether the effects of 3 alpha-diol on CPP are mediated by differential actions at ARs or GABA(A) receptors in particular brain regions needs to be determined...
  72. pmc Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice
    Carolyn J Koonce
    Department of aPsychology, University at Albany SUNY, Albany, New York 12222, USA
    Neuroreport 20:1047-50. 2009
    ..Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects...
  73. pmc Nociceptive and anxiety-like behavior in reproductively competent and reproductively senescent middle-aged rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York 12222, USA
    Gend Med 6:235-46. 2009
    ..Changes in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect...
  74. ncbi request reprint Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat
    D Bitran
    Department of Psychology, College of the Holy Cross, Worcester, MA 01602, USA
    Psychopharmacology (Berl) 151:64-71. 2000
    ..Allopregnanolone is a potent anxiolytic, anticonvulsant, sedative and hypnotic GABAergic neurosteroid. The anxiolytic-like effects of FGIN 1-27, an MBR agonist, were determined after microinjection into the dorsal hippocampus...
  75. ncbi request reprint Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3alpha,5alpha-THP attenuate lordosis of hormone-primed and behavioural oestrous rats and hamsters
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany SUNY, Albany, New York 12222, USA
    J Neuroendocrinol 13:1076-86. 2001
    ..These data suggest that biosynthesis of progestins, and the metabolism of progesterone to 3alpha,5alpha-THP in the VTA, are important for progestin-facilitated sexual receptivity of rats and hamsters...
  76. ncbi request reprint Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus
    S M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 17:545-52. 2005
    ..These data suggest that, in the VTA, both central biosynthesis of progesterone and metabolism of progesterone (from central and/or peripheral sources) to 3alpha,5alpha-THP are important for mediating lordosis of rats...
  77. pmc Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats
    Cheryl A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Brain Res Bull 77:91-7. 2008
    ..Effects on lordosis were not solely due to changes in general motor behavior. Thus, 3alpha,5alpha-THP's actions in the ventral tegmental area through membrane receptors may require activity of protein kinase C...
  78. ncbi request reprint Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Epilepsy Behav 6:140-6. 2005
    ..These data suggest that formation of 3alpha,5alpha-THP in the hippocampus is important for progesterone's antiseizure effects...
  79. ncbi request reprint Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP
    C A Frye
    Department of Psychology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Pharmacol Biochem Behav 67:587-96. 2000
    ..These data demonstrate that proestrous increases in anxiolytic-like behavior coincide with elevated circulating and hippocampal progestin concentrations...
  80. ncbi request reprint Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors
    M E Rhodes
    State University of New York, Albany, New York, USA
    Cogn Affect Behav Neurosci 1:287-96. 2001
    ....
  81. ncbi request reprint In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3alpha,5alpha-THP's actions at dopamine type 1 receptors for lordosis of rats
    Sandra M Petralia
    Department of Psychology, University at Albany SUNY, Albany, NY 12222, USA
    Neuroendocrinology 80:233-43. 2004
    ..Thus, in the VTA, 3alpha,5alpha-THP's actions for lordosis may involve activation of D1 and initiation of the G-protein-mediated second messenger cAMP...
  82. pmc Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of naturally cycling and ovariectomized rats
    Danielle C Llaneza
    Dept of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 93:337-42. 2009
    ..Thus, progesterone and/or estrogen may mediate impulsive and/or avoidant behavior...
  83. ncbi request reprint Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area
    Kanako Sumida
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Behav Brain Res 161:1-7. 2005
    ..The D(2) agonist, quinpirole and the D(2) antagonist, sulpiride, had no significant effects on P-facilitated lordosis. These data suggest that, in hamsters, P's actions for lordosis may involve D(1) receptors in the VTA...
  84. ncbi request reprint Administration of estrogen receptor beta-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:407-14. 2007
    ..Administration of ERalpha-specific SERMs produced similar effects as vehicle administration. Thus, E(2)'s anti-anxiety and anti-depressive effects may involve ERbeta in the hippocampus...
  85. pmc Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 186:302-11. 2006
    ....
  86. pmc Progesterone enhances performance of aged mice in cortical or hippocampal tasks
    Cheryl A Frye
    Department of Psychology and Centers for Life Science and Neuroscience Research, University at Albany SUNY, Albany, NY 12222, United States
    Neurosci Lett 437:116-20. 2008
    ..Thus, progesterone improved learning and memory in tasks mediated by the prefrontal cortex and/or hippocampus of aged mice...
  87. ncbi request reprint ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Social Sciences 369, Albany, NY 12222, USA
    Neurobiol Learn Mem 85:183-91. 2006
    ....
  88. pmc Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks
    Alicia A Walf
    Department of Psychology, The University at Albany, State University of New York, Albany, NY 12222, USA
    Neurobiol Learn Mem 89:513-21. 2008
    ..Thus, actions at ERbeta may be important for E(2) or SERMs to enhance cognitive performance of female mice in the object recognition and placement tasks...
  89. ncbi request reprint In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A
    Sandra M Petralia
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Neuroendocrinology 84:405-14. 2006
    ..Thus, in the VTA, progestins' membrane actions involving D1 or GBRs are mediated, in part, by PKA...
  90. ncbi request reprint Sexual experience of male rats influences anxiety-like behavior and androgen levels
    Kassandra L Edinger
    Department of Biological Sciences, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, United States
    Physiol Behav 92:443-53. 2007
    ..Thus, sexual experience is associated with lower levels of anxiety-like behavior and higher levels of androgen secretion...
  91. pmc Parity and estrogen-administration alter affective behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Life Sciences Research Building 01058, 1400 Washington Avenue, Albany, NY 12222, USA
    Physiol Behav 93:351-6. 2008
    ..Together, these data suggest that E(2) can alter affective behavior and rats with greater reproductive experience have decreased anxiety-like behavior in the elevated plus maze, irrespective of E(2)-priming...
  92. ncbi request reprint In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters
    Sandra M Petralia
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychopharmacology (Berl) 178:174-82. 2005
    ..Thus, if, in the VTA, MBR-mediated increases in 3alpha,5alpha-THP enhance sexual responses via actions at GBRs, then blocking GBRs with picrotoxin will reduce FGIN 1-27-induced increases in sexual behavior of female rodents...
  93. ncbi request reprint Androgens' performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the dorsal hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neurobiol Learn Mem 87:201-8. 2007
    ....
  94. ncbi request reprint Anti-nociception following exposure to trimethylthiazoline, peripheral or intra-amygdala estrogen and/or progesterone
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Behav Brain Res 144:77-85. 2003
    ..These data suggest that following exposure to predator odor, pain sensitivity in the tailflick task is decreased and that E(2) and/or P may have actions in the amygdala to produce similar anti-nociceptive effects...
  95. ncbi request reprint Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 32:522-30. 2007
    ..Thus, E(2)'s rewarding effects may involve actions at ERs in the nucleus accumbens...
  96. pmc Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Life Sciences Research 1058, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:909-16. 2009
    ..Thus, E(2)-replacement reduced anxiety and depression behavior and improved cognitive performance of aged female rats; however, delay in E(2) treatment influenced whether there were favorable effects of E(2) in some tasks...
  97. ncbi request reprint Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 30:418-30. 2005
    ..These findings suggest that T's anti-anxiety effects may be due in part to actions of its 5alpha-reduced metabolites in the dorsal hippocampus...
  98. pmc Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY, USA
    Neurobiol Learn Mem 86:35-46. 2006
    ..Together, these results suggest that E2 and progestins can have mnemonic effects through actions in the cortex and/or hippocampus...
  99. ncbi request reprint Differences in affective behaviors and hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations
    Betty Zimmerberg
    Department of Psychology, Williams College, 18 Hoxsey Street, Williamstown, MA 01267, USA
    Behav Brain Res 159:301-11. 2005
    ....