Research Topics
Species | JAMES DUNCAN FRYSummaryAffiliation: University of Rochester Country: USA Publications
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Detail Information
Publications
The genetic architecture of fitness in a seed beetle: assessing the potential for indirect genetic benefits of female choiceT Bilde
Animal Ecology Department of Ecology and Evolution, Evolutionary Biology Centre, University of Uppsala, Uppsala SE 753 32, Sweden
BMC Evol Biol 8:295. 2008..From reciprocal crosses of inbred lines, we assayed egg production, egg-to-adult survival, and lifetime offspring production of the outbred F1 daughters (F1 productivity)...
The genomic location of sexually antagonistic variation: some cautionary commentsJames D Fry
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Evolution 64:1510-6. 2010..Although more work is needed to resolve the issue, it is premature to conclude that the X chromosome is a "hot spot" for the accumulation of sexually antagonistic variation...
A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selection mediated by dietary ethanolJames D Fry
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Evolution 62:66-75. 2008..We present evidence that this is likely to be the result of a trade-off in catalytic activity, with the advantage of the derived allele in acetaldehyde detoxification being offset by a disadvantage in detoxification of other aldehydes...- On the rate and linearity of viability declines in Drosophila mutation-accumulation experiments: genomic mutation rates and synergistic epistasis revisitedJames D Fry
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Genetics 166:797-806. 2004..Because different genotypes may show very different mutational behavior, only studies using many founding genotypes can determine the average rate and distribution of effects of mutations relevant to natural populations... - Genotype-environment interaction for total fitness in DrosophilaJames D Fry
Department of Biology, University of Rochester, Rochester NY 14627 0211, USA
J Genet 87:355-62. 2008.... - Multilocus models of sympatric speciation: Bush versus Rice versus FelsensteinJames D Fry
Department of Biology, University of Rochester, Rochester, New York 14627 0211, USA
Evolution 57:1735-46. 2003..This indicates that documenting instances of sympatric species that are reproductively isolated only by host or habitat preference would provide evidence for the plausibility of sympatric speciation in nature... - Dominance of mutations affecting viability in Drosophila melanogasterJames D Fry
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Genetics 163:1357-64. 2003.... - Environment dependence of mutational parameters for viability in Drosophila melanogasterJames D Fry
Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
Genetics 161:1155-67. 2002..Possible reasons for this discrepancy are discussed. Regardless of the interpretation, the results show that assay conditions can have a large effect on estimates of mutational parameters for fitness traits... - Rapid mutational declines of viability in DrosophilaJ D Fry
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Genet Res 77:53-60. 2001.... - Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogasterJames D Fry
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Genet Res 87:87-92. 2006..The results refute the view that ALDH plays only a minor role in ethanol detoxification in larvae, and suggest that Aldh and Adh may be equally important players in the evolution of ethanol resistance in fruit-breeding Drosophila... - New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogasterJ D Fry
Department of Biology, Utah State University, Logan, UT 84322 5305, USA
Proc Natl Acad Sci U S A 96:574-9. 1999..01 in these lines), but the results also are consistent with models that include many mutations with very small effects... - Environment-dependent reversal of a life history trade-off in the seed beetle Callosobruchus maculatusF J Messina
Department of Biology, Utah State University, Logan, UT 84322 5305, USA
J Evol Biol 16:501-9. 2003..Despite their common dependence on resources acquired during larval stages, fecundity and lifespan in C. maculatus do not appear to be tightly coupled in a physiological or genetic sense... - Widespread correlations between dominance and homozygous effects of mutations: implications for theories of dominanceNitin Phadnis
Department of Biology, University of Rochester, Rochester, New York 14627 0211, USA
Genetics 171:385-92. 2005..A complete explanation of dominance therefore requires either a generalization of Kacser and Burns' theory to nonenzyme genes or a new theory... - How common are overdominant mutations?James D Fry
Genetics 167:1031-2. 2004
Research Grants
- Genetic basis of clinal variation in ethanol tolerance in Drosophila melanogasterJames Fry; Fiscal Year: 2007..These insights could potentially be used to develop drug or other treatments for alcoholism. ..
- Genetic basis of clinal variation in ethanol tolerance in Drosophila melanogasterJAMES DUNCAN FRY; Fiscal Year: 2010..These insights could potentially be used to develop drug or other treatments for alcoholism. ..