Affiliation: University of Alabama at Birmingham
Urakova N, Kuznetsova V, Crossman D, Sokratian A, Guthrie D, Kolykhalov A, et al
. β-d-N 4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome. J Virol. 2018;92: pubmed publisher
..Even low levels of resistance require acquisition of multiple mutations in the gene of the VEEV-specific RNA-dependent RNA polymerase nsP4. ..
Frolov I, Frolova E. Molecular Virology of Chikungunya Virus. Curr Top Microbiol Immunol. 2019;: pubmed publisher
..The available data suggest that our knowledge about alphavirus replication contains numerous gaps that potentially hamper the development of new therapeutic means against CHIKV and other pathogenic alphaviruses. ..
Atasheva S, Kim D, Frolova E, Frolov I. Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. J Virol. 2015;89:71-82 pubmed publisher
..Similar methodologies can be applied for attenuation of other encephalitogenic New World alphaviruses. ..
Meshram C, Agback P, Shiliaev N, Urakova N, Mobley J, Agback T, et al
. Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode. J Virol. 2018;92: pubmed publisher
..To date, the disordered protein fragments have been identified in the nonstructural proteins of many other viruses. They may also interact with a variety of cellular factors that determine critical aspects of virus-host interactions. ..
Reynaud J, Lulla V, Kim D, Frolova E, Frolov I. The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. J Virol. 2016;90:2008-20 pubmed publisher
..It functions synergistically with the following SD2 (helix I) and appears to form a core in the center of nucleocapsid. The core formation is one of the driving forces of alphavirus particle assembly. ..
Frolova E, Gorchakov R, Pereboeva L, Atasheva S, Frolov I. Functional Sindbis virus replicative complexes are formed at the plasma membrane. J Virol. 2010;84:11679-95 pubmed publisher