L A Frohman

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Growth hormone-releasing hormone and pituitary somatotrope proliferation
    L A Frohman
    Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Minerva Endocrinol 27:277-85. 2002
  2. ncbi request reprint Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy
    Lawrence A Frohman
    Section of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL 60608, USA
    Pituitary 10:283-9. 2007
  3. ncbi request reprint Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis
    Lawrence A Frohman
    Section of Endocrinology, Dept of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Trends Endocrinol Metab 13:299-303. 2002
  4. ncbi request reprint The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling
    R D Kineman
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 142:3764-73. 2001
  5. ncbi request reprint Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment
    M Kovacs
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    J Neuroendocrinol 12:335-41. 2000
  6. ncbi request reprint Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid
    J Kamegai
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Endocrinology 139:3554-60. 1998
  7. ncbi request reprint The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback
    X D Peng
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 142:1117-23. 2001
  8. ncbi request reprint Growth hormone physiology in health and disease: insights using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    J Pediatr Endocrinol Metab 9:233-6. 1996
  9. ncbi request reprint Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly
    M Kovacs
    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA
    Endocrinology 138:4536-42. 1997
  10. ncbi request reprint p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation
    L T Teixeira
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Oncogene 19:1875-84. 2000

Collaborators

  • RHONDA KINEMAN
  • M Kovacs
  • J J Kopchick
  • K T Coschigano
  • Vivien Bonert
  • J Kamegai
  • K Rohde
  • R Salvatori
  • Seungjoon Park
  • John P Monson
  • John Ah Wass
  • Akira Matsuno
  • Marta Korbonits
  • Marcello Delano Bronstein
  • Julian R E Davis
  • V Popovic
  • Ashley Grossman
  • Beatriz S Soares
  • Raul M Luque
  • Susan Sam
  • Chrysanthia A Leontiou
  • Soe Naing
  • Kuniki Eguchi
  • Betty Lawrence
  • Maria Alba
  • Sam L Teichman
  • X D Peng
  • Madalina Ionescu
  • Monica R Gadelha
  • Jean Paul Castaigne
  • M R Gadelha
  • Anxo Vidal
  • Douglas C Luccio-Camelo
  • Beatriz Santana Soares
  • L T Teixeira
  • Sonia Krishnan
  • Jose Cordoba-Chacon
  • Xiao ding Peng
  • Madalina Musat
  • Richard N Clayton
  • Dan M Berney
  • David Bishop-Bailey
  • Scott A Akker
  • Helen C Christian
  • Jessica Wray
  • Francesca Lolli
  • J Paul Chapple
  • Gordon Peters
  • Antônio Ribeiro-Oliveira
  • Jacqueline van der Spuy
  • Maria Gueorguiev
  • Janice Rowe
  • Suzanne Jordan
  • Susana C Igreja
  • Richard Quinton
  • Harvinder S Chahal
  • Graeme B Bolger
  • Sevda Hassan
  • Marie Stolbrink
  • Takeo Iwata
  • Daniel Flanagan
  • Katsuhiko Yoshimoto
  • Alessia Sagazio
  • Catherine Gagnon
  • Danilo Fintini
  • Ann Neale
  • Joseph Knowles
  • Filippo Giancotti
  • Daniel D MacDonald
  • Kristian K Jensen
  • David Lyden
  • Carmen de la Hoz
  • Andrew Koff
  • Anna H Bramley
  • Stergios Zacharoulis
  • Wenjun Guo
  • Shahin Rafii
  • Nancy Yeh
  • David Shaffer
  • Daniel Kato
  • Bin Tean Teh
  • Mario Vaisman
  • Berenice B Mendonca
  • Sok Kean Khoo
  • Radoslav Nickolov
  • Rafael E S Ferreira
  • Karina N Une
  • M Vaisman
  • K T Christov
  • K N Une

Detail Information

Publications28

  1. ncbi request reprint Growth hormone-releasing hormone and pituitary somatotrope proliferation
    L A Frohman
    Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Minerva Endocrinol 27:277-85. 2002
    ..However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis...
  2. ncbi request reprint Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy
    Lawrence A Frohman
    Section of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL 60608, USA
    Pituitary 10:283-9. 2007
    ..However, increased tumor volume was reported in patients receiving pegvisomant who had not received prior radiotherapy...
  3. ncbi request reprint Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis
    Lawrence A Frohman
    Section of Endocrinology, Dept of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Trends Endocrinol Metab 13:299-303. 2002
    ..However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis...
  4. ncbi request reprint The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling
    R D Kineman
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 142:3764-73. 2001
    ....
  5. ncbi request reprint Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment
    M Kovacs
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    J Neuroendocrinol 12:335-41. 2000
    ..Collectively, our observations demonstrate a complex interplay between transcriptional, translational and post-translational mechanisms within each level of the GH-axis following destruction of GHRH neurones by neonatal MSG treatment...
  6. ncbi request reprint Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid
    J Kamegai
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Endocrinology 139:3554-60. 1998
    ..Finally, this report establishes modulation of GHRH-R synthesis as a component of GH autofeedback regulation...
  7. ncbi request reprint The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback
    X D Peng
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 142:1117-23. 2001
    ..05). Therefore, in the presence of GH negative feedback, both hypothalamic and pituitary expression is altered to favor suppression of GH synthesis and release...
  8. ncbi request reprint Growth hormone physiology in health and disease: insights using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    J Pediatr Endocrinol Metab 9:233-6. 1996
  9. ncbi request reprint Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly
    M Kovacs
    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA
    Endocrinology 138:4536-42. 1997
    ..Our findings, showing the suppression of GH and IGF-I secretion with GHRH antagonists, suggest that this class of analogs could be used for the diagnosis and therapy of disorders characterized by excessive GHRH secretion...
  10. ncbi request reprint p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation
    L T Teixeira
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Oncogene 19:1875-84. 2000
    ....
  11. pmc Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation
    Raul M Luque
    Research and Development Division, Jesse Brown Veterans Affairs Medical Center and Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 150:3177-85. 2009
    ....
  12. ncbi request reprint Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice
    Seungjoon Park
    Section of Endocrinology and Metabolism, Department of Medicine, University of Illinois at Chicago, 820 Damen Avenue, Chicago, IL 60612, USA
    Neuroendocrinology 81:360-71. 2005
    ....
  13. ncbi request reprint New insights into the regulation of somatotrope function using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    Metabolism 45:1-3. 1996
    ..They may provide insights into our understanding of human GH secretory disorders...
  14. ncbi request reprint Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12
    M R Gadelha
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    J Clin Endocrinol Metab 85:707-14. 2000
    ..This report establishes linkage of the tumor suppressor gene involved in the pathogenesis of IFS to chromosome 11q13.1-13.3 and identifies a potential second locus at chromosome 2p16-12...
  15. ncbi request reprint Familial acromegaly
    Lawrence A Frohman
    Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street MC 640, Chicago, IL 60612, USA
    Growth Horm IGF Res 14:S90-6. 2004
    ..Identification of the IFS gene should provide new insight into the pathogenesis of somatotropinomas, not only in IFS but also in sporadic tumors, where there is an up to 40% allelic loss on chromosome 11q13...
  16. ncbi request reprint Isolated familial somatotropinoma
    Beatriz Santana Soares
    Section of Endocrinology and Metabolism, University of Illinois at Chicago, IL 60612, USA
    Pituitary 7:95-101. 2004
    ..Although the gene still remains to be identified there is strong evidence for linkage to a locus of less than 10 Mb on chromosome 11q13.1-13.3...
  17. ncbi request reprint Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas
    Beatriz S Soares
    Section of Endocrinology and Metabolism, University of Illinois at Chicago, 1819 West Polk Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 90:6580-7. 2005
    ..The association between the disease and loss of heterozygosity on chromosome 11q13 as well as its linkage to this region has been well established, but the IFS gene still remains unknown...
  18. ncbi request reprint Who needs growth hormone therapy? Growth hormone helps some, but its use as an "anti-aging" agent is dubious
    Lawrence A Frohman
    University of Illinois at Chicago, USA
    Health News 8:4. 2002
  19. doi request reprint Normal physiology of hypothalamic pituitary regulation
    Susan Sam
    Section of Endocrinology, Diabetes, and Metabolism M C 640, College of Medicine, University of Illinois at Chicago, 1819 West Polk Street, 625 CMW, Chicago, IL 60612, USA
    Endocrinol Metab Clin North Am 37:1-22, vii. 2008
    ..The hormones are secreted in a pulsatile manner, which is distinct for each hormone and reflects the influence of its individual neuroendocrine control mechanisms...
  20. ncbi request reprint The empty sella
    Soe Naing
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60608, USA
    Pediatr Endocrinol Rev 4:335-42. 2007
    ..The ES should not be considered as merely an incidental finding and clinicians should be aware of its varying presentations and ramifications...
  21. ncbi request reprint Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
    Maria Alba
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Physiol Endocrinol Metab 291:E1290-4. 2006
    ..These findings demonstrate that treatment with once-daily administration of CJC-1295 is able to maintain normal body composition and growth in GHRHKO mice. The same dose is less effective when administered every 48 or 72 h...
  22. ncbi request reprint Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
    Madalina Ionescu
    Section of Endocrinology, Metabolism, and Diabetes, University of Illinois at Chicago, 1747 West Roosevelt Road, Room 517, Chicago, Illinois 60608, USA
    J Clin Endocrinol Metab 91:4792-7. 2006
    ..A synthetic GHRH analog (CJC-1295) that binds permanently to endogenous albumin after injection (half-life = 8 d) stimulates GH and IGF-I secretion in several animal species and in normal human subjects and enhances growth in rats...
  23. pmc Isolated familial somatotropinomas: clinical and genetic considerations
    Lawrence A Frohman
    Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street MC 640, Chicago, Illinois 60612, USA
    Trans Am Clin Climatol Assoc 114:165-77. 2003
    ..7 Mb (7.6 cM) on chromosome 11q13.1-13.3. Identification of the IFS gene should provide new insight into the pathogenesis not only of this disorder but also of sporadic somatotropinomas...
  24. doi request reprint The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas
    Chrysanthia A Leontiou
    Department of Endocrinology, Barts and the London School of Medicine, London, United Kingdom
    J Clin Endocrinol Metab 93:2390-401. 2008
    ..Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone is involved in tumorigenesis...
  25. ncbi request reprint Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
    Sam L Teichman
    WinPharm Associates, Alamo, CA 94507, USA
    J Clin Endocrinol Metab 91:799-805. 2006
    ..Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action...
  26. ncbi request reprint Controversy about treatment of growth hormone-deficient adults: a commentary
    Lawrence A Frohman
    Ann Intern Med 137:202-4. 2002
  27. pmc p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
    Anxo Vidal
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:6890-5. 2005
    ..This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events...
  28. ncbi request reprint A meiotic recombination in a new isolated familial somatotropinoma kindred
    Douglas C Luccio-Camelo
    Servico de Endocrinologia, Laboratorio de Neuroendocrinologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Eur J Endocrinol 150:643-8. 2004
    ..These results support the involvement of a tumor suppressor gene at 11q13.1-q13.3 in the pathogenesis of IFS...