E M Frohman

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Multiple sclerosis--the plaque and its pathogenesis
    Elliot M Frohman
    Department of Neurology and Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    N Engl J Med 354:942-55. 2006
  2. doi request reprint Multifocal visual evoked potentials are influenced by variable contrast stimulation in MS
    Audrey R Frohman
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    Neurology 79:797-801. 2012
  3. ncbi request reprint The neuro-ophthalmology of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Lancet Neurol 4:111-21. 2005
  4. ncbi request reprint Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Arch Neurol 62:1345-56. 2005
  5. ncbi request reprint Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations
    Elliot M Frohman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Neurol 62:1519-30. 2005
  6. ncbi request reprint Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mult Scler 12:108-11. 2006
  7. ncbi request reprint Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis
    E M Frohman
    Departments of Neurology and Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Arch Neurol 63:614-9. 2006
  8. ncbi request reprint Optical coherence tomography in multiple sclerosis
    Elliot Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Lancet Neurol 5:853-63. 2006
  9. ncbi request reprint W. Ian McDonald, MB, ChB, PhD (1933-2006): the multiple sclerosis physician-scientist of the 20th century
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:452-4. 2007
  10. ncbi request reprint Is neuromyelitis optica distinct from multiple sclerosis?: something for "lumpers" and "splitters"
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:903-5. 2007

Detail Information

Publications76

  1. ncbi request reprint Multiple sclerosis--the plaque and its pathogenesis
    Elliot M Frohman
    Department of Neurology and Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    N Engl J Med 354:942-55. 2006
  2. doi request reprint Multifocal visual evoked potentials are influenced by variable contrast stimulation in MS
    Audrey R Frohman
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    Neurology 79:797-801. 2012
    ....
  3. ncbi request reprint The neuro-ophthalmology of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Lancet Neurol 4:111-21. 2005
    ..The commonness of visual sensory and eye movement abnormalities in MS highlights the importance of understanding the principles addressed in this review...
  4. ncbi request reprint Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Arch Neurol 62:1345-56. 2005
    ....
  5. ncbi request reprint Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations
    Elliot M Frohman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Neurol 62:1519-30. 2005
    ....
  6. ncbi request reprint Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mult Scler 12:108-11. 2006
    ..We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders...
  7. ncbi request reprint Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis
    E M Frohman
    Departments of Neurology and Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Arch Neurol 63:614-9. 2006
  8. ncbi request reprint Optical coherence tomography in multiple sclerosis
    Elliot Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Lancet Neurol 5:853-63. 2006
    ..In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis...
  9. ncbi request reprint W. Ian McDonald, MB, ChB, PhD (1933-2006): the multiple sclerosis physician-scientist of the 20th century
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:452-4. 2007
  10. ncbi request reprint Is neuromyelitis optica distinct from multiple sclerosis?: something for "lumpers" and "splitters"
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:903-5. 2007
  11. ncbi request reprint Corticosteroids for multiple sclerosis: I. Application for treating exacerbations
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Neurotherapeutics 4:618-26. 2007
    ..This review discusses the pharmacology of these agents, to better understand how they may act to mitigate attacks and to provide some practical formulations for how to use them in the clinic for the benefit of patients...
  12. ncbi request reprint Corticosteroids for multiple sclerosis: II. Application for disease-modifying effects
    Anjali Shah
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Neurotherapeutics 4:627-32. 2007
    ..Nevertheless, we will focus on the rationale and practical schemes that can be considered for using corticosteroids (CS) (and perhaps even ACTH) in an attempt to modify various domains of ongoing disease activity...
  13. doi request reprint Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis
    Elliot M Frohman
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Arch Neurol 65:26-35. 2008
    ..Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies...
  14. doi request reprint Pearls & Oy-sters: The medial longitudinal fasciculus in ocular motor physiology
    T C Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX75235, USA
    Neurology 70:e57-67. 2008
    ..To review the role played by the medial longitudinal fasciculus (MLF) in ocular motor physiology and to characterize a number of syndromes that result from lesions in this eloquent brainstem tract system...
  15. pmc Optical coherence tomography: a window into the mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Nat Clin Pract Neurol 4:664-75. 2008
    ....
  16. doi request reprint Immunologic mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Neuroimaging Clin N Am 18:577-88, ix. 2008
    ....
  17. doi request reprint Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    J Neurol Sci 282:96-105. 2009
    ..Measurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention...
  18. doi request reprint Pearls: multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Semin Neurol 30:97-101. 2010
    ..This article summarizes some of the pearls and pitfalls associated with the evaluation and management of patients with relapsing-remitting multiple sclerosis...
  19. ncbi request reprint Mycophenolate mofetil in multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas, Southwestern Medical Center at Dallas, USA
    Clin Neuropharmacol 27:80-3. 2004
    ..To describe experience with the use of mycophenolate mofetil (MMF) in the treatment of multiple sclerosis (MS)...
  20. ncbi request reprint Horizontal monocular saccadic failure: an unusual clinically isolated syndrome progressing to multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Mult Scler 9:55-8. 2003
    ..Four years later, the subject developed a partial sensory transverse myelitis, confirming clinically definite multiple sclerosis (MS). This paper extends the range of isolated syndromes associated with MS...
  21. ncbi request reprint An unusual variant of the dorsal midbrain syndrome in MS: clinical characteristics and pathophysiologic mechanisms
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mult Scler 10:322-5. 2004
    ..We consider the pathophysiologic mechanisms responsible for our observations and review important details of the dorsal midbrain ocular motor circuitry...
  22. ncbi request reprint Multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Med Clin North Am 87:867-97, viii-ix. 2003
    ....
  23. ncbi request reprint Disease modifying agent related skin reactions in multiple sclerosis: prevention, assessment, and management
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mult Scler 10:302-7. 2004
    ..Our experience with these patients, and the challenges they face in continuing long-term treatment, constitutes the basis of our proposed treatment strategies...
  24. ncbi request reprint The utility of MRI in suspected MS: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    E M Frohman
    University of Texas Southwestern Medical Center at Dallas, USA
    Neurology 61:602-11. 2003
    ..By contrast, normal results on MRI at the time of clinical presentation makes the future development of CDMS considerably less likely...
  25. ncbi request reprint Accuracy of clinical detection of INO in MS: corroboration with quantitative infrared oculography
    T C Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Neurology 61:848-50. 2003
    ..Intermediate dysconjugacy was not detected by 25% of the evaluators. In the most severe cases, INO was not identified by only 6%. Oculographic techniques significantly enhance the precision of INO detection compared to the clinical exam...
  26. ncbi request reprint A new measure of dysconjugacy in INO: the first-pass amplitude
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    J Neurol Sci 210:65-71. 2003
    ....
  27. doi request reprint Retinal architecture predicts pupillary reflex metrics in MS
    A R Salter
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Mult Scler 15:479-86. 2009
    ..To study the relation of retinal nerve fiber layer thinning to clinical and physiologic measures of visual function in patients with MS or neuromyelitis optica and unilateral optic neuropathy...
  28. pmc Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis
    S B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurol Sci 302:19-24. 2011
    ..To identify and characterize cup to disc ratio (CDR) and related optic nerve head abnormalities in multiple sclerosis (MS) using spectral domain optical coherence tomography (OCT)...
  29. ncbi request reprint MRI characteristics of the MLF in MS patients with chronic internuclear ophthalmoparesis
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas 02115, USA
    Neurology 57:762-8. 2001
    ....
  30. ncbi request reprint Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis
    E Gordon-Lipkin
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 69:1603-9. 2007
    ..Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy...
  31. pmc Quantitative oculographic characterisation of internuclear ophthalmoparesis in multiple sclerosis: the versional dysconjugacy index Z score
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Neurol Neurosurg Psychiatry 73:51-5. 2002
    ..There is a poor correlation between multiple sclerosis disease activity, as measured by magnetic resonance imaging, and clinical disability...
  32. pmc Immunologic, clinical, and radiologic status 14 months after cessation of natalizumab therapy
    O Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, TX 75216, USA
    Neurology 72:396-401. 2009
    ....
  33. ncbi request reprint Vertigo in MS: utility of positional and particle repositioning maneuvers
    E M Frohman
    Departments of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Neurology 55:1566-9. 2000
    ..All patients diagnosed with benign paroxysmal positioning vertigo were treated successfully with particle repositioning maneuvers...
  34. pmc Ocular contrapulsion in multiple sclerosis: clinical features and pathophysiological mechanisms
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA
    J Neurol Neurosurg Psychiatry 70:688-92. 2001
    ..In conclusion, ocular contrapulsion can be seen in patients with multiple sclerosis and results from a lesion in the region of the SCP, involving the uncinate fasciculus...
  35. doi request reprint Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis
    Maulik S Zaveri
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Neurol 65:924-8. 2008
    ....
  36. ncbi request reprint Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    Olaf Stuve
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, USA
    Arch Neurol 63:1383-7. 2006
    ....
  37. doi request reprint Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity
    Laura J Balcer
    Department of Neurology, 3 East Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 74:S16-23. 2010
    ..Lesions associated with these impairments frequently involve the afferent visual pathway...
  38. ncbi request reprint Diagnosis and management of multiple sclerosis: case studies
    Douglas A Woo
    Multiple Sclerosis Program, Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Neurol Clin 24:199-214. 2006
    ....
  39. doi request reprint Depletion of B lymphocytes from cerebral perivascular spaces by rituximab
    Maria del Pilar Martin
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Arch Neurol 66:1016-20. 2009
    ..We and other investigators previously demonstrated that rituximab therapy depletes B lymphocytes from peripheral blood and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis...
  40. doi request reprint Break in binocular fusion during head turning in MS patients with INO
    D A Mills
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neurology 71:458-60. 2008
  41. pmc A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis
    A J Ligocki
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroimmunol 226:192-3. 2010
    ..Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF...
  42. ncbi request reprint Benign paroxysmal positioning vertigo in multiple sclerosis: diagnosis, pathophysiology and therapeutic techniques
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Mult Scler 9:250-5. 2003
    ..To report on the most common causes of vertigo in patients with multiple sclerosis (MS) and emphasize appropriate diagnostic techniques and treatment interventions...
  43. pmc Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
    Lauren S Talman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 67:749-60. 2010
    ..We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON)...
  44. pmc Translational research in neurology and neuroscience 2010: multiple sclerosis
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Arch Neurol 67:1307-15. 2010
    ..This model has served clinician-scientists for many decades to enable understanding the inflammatory cascade that underlies clinical disease activity and disease surrogate markers detected in patients...
  45. ncbi request reprint Pharmacological treatment of early multiple sclerosis
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, Texas 75216, USA
    Drugs 68:73-83. 2008
    ....
  46. pmc Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Clin Invest 109:641-9. 2002
    ....
  47. ncbi request reprint Potential risk of progressive multifocal leukoencephalopathy with natalizumab therapy: possible interventions
    Olaf Stuve
    Neurology Section, Medical Service, Veterans Affairs North Texas Health Care System, Dallas, TX, USA
    Arch Neurol 64:169-76. 2007
    ..Because it is currently impossible to identify patients at risk, and thus to prevent PML as a consequence of natalizumab therapy, it is important that neurologists be aware of possible therapeutic interventions...
  48. ncbi request reprint Urodynamic distinctions between idiopathic detrusor overactivity and detrusor overactivity secondary to multiple sclerosis
    Gary E Lemack
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Urology 67:960-4. 2006
    ....
  49. ncbi request reprint Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis
    Nancy L Monson
    Department of Neurology and Center for Immunology, The University of Texas Southwestern Medical Center, Dallas 75390, USA
    Arch Neurol 62:258-64. 2005
    ..Whether this efficacy can be translated to neurological diseases of the central nervous system with possible autoimmune B-cell involvement remains unknown...
  50. ncbi request reprint Immune surveillance in multiple sclerosis patients treated with natalizumab
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, USA
    Ann Neurol 59:743-7. 2006
    ....
  51. doi request reprint Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
    Maria del Pilar Martin
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Neurology Section, Veterans Affairs North Texas Health Care System, Medical Service, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Arch Neurol 65:1596-603. 2008
    ..We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS...
  52. pmc Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis
    Elizabeth M Cameron
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas TX 75154, USA
    J Neuroimmunol 213:123-30. 2009
    ..If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system...
  53. pmc Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein
    Christopher T Harp
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Immunol 40:2942-56. 2010
    ..Our results demonstrate for the first time that the memory B-cell pool in RRMS harbors neuro-Ag specific B cells that can activate T cells...
  54. doi request reprint Direct and consensual murine pupillary reflex metrics: establishing normative values
    Rehana Z Hussain
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Auton Neurosci 151:164-7. 2009
    ..Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods...
  55. doi request reprint Expansion of CD27(high) plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation
    A J Ligocki
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Genes Immun 14:291-301. 2013
    ..These characteristics unique to TM patients may impact disease severity and progression. ..
  56. ncbi request reprint Autonomic regulation of neuroimmunological responses: implications for multiple sclerosis
    E M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    J Clin Immunol 21:61-73. 2001
    ..These studies may have relevance for a number of inflammatory conditions in humans, including multiple sclerosis...
  57. doi request reprint Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided?
    Clemens Warnke
    Neurology Section, VA North Texas Health Care System, Medical Service, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Arch Neurol 67:923-30. 2010
    ..In addition, recent data indicate that risk of PML might increase beyond 24 months of treatment...
  58. ncbi request reprint Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patients
    Nancy L Monson
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroimmunol 158:170-81. 2005
    ..These observations are consistent with the presence of intense specific B cell stimulation and expansion in the CNS of MS patients early in the disease process...
  59. doi request reprint Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mult Scler 16:829-39. 2010
    ..Specific procedures for OCT acquisition and analysis of retinal imaging metrics using SD-OCT technology may improve the application of this novel technology in multiple sclerosis...
  60. doi request reprint Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  61. doi request reprint Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis
    Christopher T Harp
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Immunol 128:382-91. 2008
    ..CNS-antigen specific CD8(+) T cell proliferation was also blocked by HLA-DR, suggesting that CD8(+) proliferation is in part dependent on CD4(+) help...
  62. doi request reprint Factors that influence adherence with disease-modifying therapy in MS
    Katherine Treadaway
    Dept of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    J Neurol 256:568-76. 2009
    ..The aim of this investigation was to identify which factors most influenced nonadherent behavior with the available disease-modifying injection therapies for multiple sclerosis (MS)...
  63. ncbi request reprint Isolated relative afferent pupillary defect secondary to contralateral midbrain compression
    Cheun Ju Chen
    Departments of Neurology and Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Arch Neurol 61:1451-3. 2004
    ..Relative afferent pupillary defects are typically related to ipsilateral lesions within the anterior visual pathways...
  64. ncbi request reprint Acquired sexual paraphilia in patients with multiple sclerosis
    Elliot M Frohman
    Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 59:1006-10. 2002
    ..In contrast, hypersexual behavior and paraphilias are distinctly uncommon in this population of patients, but have been associated with various focal brain lesions...
  65. ncbi request reprint Sexual dysfunction in neurologic disease
    Elliot M Frohman
    UT Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Clin Neuropharmacol 25:126-32. 2002
  66. ncbi request reprint Spinal neurosarcoidosis mimicking an idiopathic inflammatory demyelinating syndrome
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Arch Neurol 61:586-9. 2004
    ..Intramedullary neurosarcoidosis may be the first and only manifestation of the disease and may mimic an idiopathic inflammatory demyelinating syndrome both clinically and on neuroimaging results...
  67. pmc Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis
    Rodney Stuart
    Department of Neurology, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States
    J Neuroimmunol 191:45-50. 2007
    ....
  68. doi request reprint Reproducibility of optical coherence tomography in multiple sclerosis
    Deanna Cettomai
    Pathology Bldg, Ste 627, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 65:1218-22. 2008
    ..Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers...
  69. ncbi request reprint Autologous HSCT for advanced MS: is the glass half-empty or really half-full?
    Richard A Nash
    Brain 131:e89; author reply e90. 2008
  70. ncbi request reprint High incidence of post-lumbar puncture headaches in patients with multiple sclerosis treated with natalizumab: role of intrathecal leukocytes
    Olaf Stuve
    Arch Neurol 64:1055-6. 2007
  71. ncbi request reprint Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis
    Jennifer B Fisher
    Division of Neuro ophthalmology, Departments of Neurology, Ophthalmology, and Biostatistics, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Ophthalmology 113:324-32. 2006
    ....
  72. ncbi request reprint Fatigue in multiple sclerosis: is the picture getting simpler or more complex?
    Michael K Racke
    Arch Neurol 61:176-7. 2004
  73. ncbi request reprint Overdiagnosis of multiple sclerosis by magnetic resonance imaging
    Douglas S Goodin
    Ann Neurol 59:575-6; author reply 576. 2006
  74. ncbi request reprint The effects of horizontal head position (yaw axis) and step velocity on the vestibulo-ocular reflex
    Phillip Kramer
    The New Jersey Neuroscience Institute, Edison, New Jersey 08818, USA
    Ann N Y Acad Sci 956:530-2. 2002
  75. ncbi request reprint DNA plasmid vaccination for multiple sclerosis
    Olaf Stuve
    Arch Neurol 64:1385-6. 2007
  76. ncbi request reprint What you see is what you get: coupling function with structure in the visual system
    Elliot M Frohman
    Neurology 69:2119-20. 2007