Norma Frizzell

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. doi request reprint Succination of proteins in diabetes
    Norma Frizzell
    Department of Exercise Science, School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Free Radic Res 45:101-9. 2011
  2. pmc Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin
    Norma Frizzell
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA
    J Biol Chem 284:25772-81. 2009
  3. doi request reprint Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity
    Norma Frizzell
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Biochem J 445:247-54. 2012
  4. doi request reprint Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes
    Sonia A Thomas
    Department of Exercise Science, University of South Carolina, Columbia, South Carolina, USA
    Obesity (Silver Spring) 20:263-9. 2012
  5. pmc Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress
    Matthew Blatnik
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    Diabetes 57:41-9. 2008
  6. ncbi request reprint Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress
    Ryoji Nagai
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    J Biol Chem 282:34219-28. 2007

Collaborators

Detail Information

Publications6

  1. doi request reprint Succination of proteins in diabetes
    Norma Frizzell
    Department of Exercise Science, School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Free Radic Res 45:101-9. 2011
    ..2SC serves as a biomarker of mitochondrial stress and recent studies suggest that succination is the mechanistic link between mitochondrial and ER stress in diabetes...
  2. pmc Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin
    Norma Frizzell
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA
    J Biol Chem 284:25772-81. 2009
    ....
  3. doi request reprint Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity
    Norma Frizzell
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Biochem J 445:247-54. 2012
    ..We propose that increased succination of proteins is an early marker of glucotoxicity and mitochondrial stress in adipose tissue in diabetes...
  4. doi request reprint Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes
    Sonia A Thomas
    Department of Exercise Science, University of South Carolina, Columbia, South Carolina, USA
    Obesity (Silver Spring) 20:263-9. 2012
    ..We conclude that 2SC is a biomarker of nutrient excess and mitochondrial stress in adipose tissue, increasing under the hyperglycemic and insulin resistant conditions associated with type 2 diabetes and obesity...
  5. pmc Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress
    Matthew Blatnik
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    Diabetes 57:41-9. 2008
    ..We investigated the role of fumarate in chemical modification and inhibition of the sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), in vitro and in tissues of diabetic rats...
  6. ncbi request reprint Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress
    Ryoji Nagai
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    J Biol Chem 282:34219-28. 2007
    ..We propose that the increase in fumarate and 2SC is the result of mitochondrial stress in the adipocyte during adipogenesis and that 2SC may be a useful biomarker of mitochondrial stress in obesity, insulin resistance, and diabetes...