Robert D Frisina

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Age-related hearing loss: ear and brain mechanisms
    Robert D Frisina
    Otolaryngology Department, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
    Ann N Y Acad Sci 1170:708-17. 2009
  2. pmc Multivariate search for differentially expressed gene combinations
    Yuanhui Xiao
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    BMC Bioinformatics 5:164. 2004
  3. ncbi request reprint Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in mice
    Xiaoxia Zhu
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
    J Comp Neurol 503:593-604. 2007
  4. pmc Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain
    Nathan Christensen
    Otolaryngology Department, University of Rochester Medical School, Rochester, NY 14642 8629, USA
    Brain Res 1253:27-34. 2009
  5. pmc Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice
    Mary D'Souza
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    J Neurosci Methods 171:279-87. 2008
  6. pmc Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis
    Olga N Vasilyeva
    Otolaryngology Department, University of Rochester Medical School and Dentistry, 601 Elmwood Ave, Rochester, NY 14642 8629, USA
    Hear Res 249:44-53. 2009
  7. pmc Glutamate-related gene expression changes with age in the mouse auditory midbrain
    Sherif F Tadros
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Brain Res 1127:1-9. 2007
  8. pmc Hormone replacement therapy diminishes hearing in peri-menopausal mice
    Katharine Price
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Hear Res 252:29-36. 2009
  9. pmc F1 (CBA×C57) mice show superior hearing in old age relative to their parental strains: hybrid vigor or a new animal model for "golden ears"?
    Robert D Frisina
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA robert
    Neurobiol Aging 32:1716-24. 2011
  10. pmc Murine intracochlear drug delivery: reducing concentration gradients within the cochlea
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Hear Res 268:2-11. 2010

Research Grants

  1. Core--Coordination
    Robert Frisina; Fiscal Year: 2007

Collaborators

  • DAVID A BORKHOLDER
  • Joseph P Walton
  • Dean G Johnson
  • Anne E Luebke
  • WILLIAM E O'NEILL
  • Sunghee Kim
  • M L Zettel
  • Scott K Thompson
  • H J Federoff
  • Emily A Desmet
  • Xiaoxia Zhu
  • Sherif F Tadros
  • Susan T Frisina
  • Olga N Vasilyeva
  • D Robert Frisina
  • Mary D'Souza
  • Frances Mapes
  • Patricia Guimaraes
  • Masoumeh Haghpanahi
  • Michael Jacobson
  • Oksana Polesskaya
  • Katharine Price
  • Nathan Christensen
  • George I Varghese
  • Joshua Romney
  • Henry Simon
  • Yuanhui Xiao
  • William J Bowers
  • Miriam B Gladstone
  • Stephen Dewhurst
  • Shimon P Francis
  • David Collins
  • Sanjay B Maggirwar
  • Lisa L Cunningham
  • Harris A Gelbard
  • Julie Sahler
  • Patricia F Guimaraes
  • Martha Lynch-Erhardt
  • Nicole C Waxmonsky
  • David Tuttle
  • Marjorie S Waterman
  • Trinitia Cannon
  • Lev Klebanov
  • Andrei Yakovlev
  • Alexander Gordon
  • Xiaowei Chen
  • Huang Guo

Detail Information

Publications31

  1. doi request reprint Age-related hearing loss: ear and brain mechanisms
    Robert D Frisina
    Otolaryngology Department, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
    Ann N Y Acad Sci 1170:708-17. 2009
    ....
  2. pmc Multivariate search for differentially expressed gene combinations
    Yuanhui Xiao
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    BMC Bioinformatics 5:164. 2004
    ..Such tests are essentially univariate and disregard the multidimensional structure of microarray data. A more general two-sample hypothesis is formulated in terms of the joint distribution of any sub-vector of expression signals...
  3. ncbi request reprint Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in mice
    Xiaoxia Zhu
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
    J Comp Neurol 503:593-604. 2007
    ..In conclusion, the C57 mouse has MOC function at 6 weeks, but it declines quickly, preceding the progression of peripheral age-related sensitivity deficits and hearing loss in this mouse strain...
  4. pmc Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain
    Nathan Christensen
    Otolaryngology Department, University of Rochester Medical School, Rochester, NY 14642 8629, USA
    Brain Res 1253:27-34. 2009
    ..In regard to central auditory processing at the level of the auditory midbrain, aquaporin gene expression changes may affect neurotransmitter cycling involving supporting cells, thus impairing complex sound neural processing with age...
  5. pmc Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice
    Mary D'Souza
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    J Neurosci Methods 171:279-87. 2008
    ..Lastly, gene expression measures were correlated with pathway/network relationships relevant to the inner ear using Pathway Architect, to identify key pathways consistent with the gene expression changes observed...
  6. pmc Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis
    Olga N Vasilyeva
    Otolaryngology Department, University of Rochester Medical School and Dentistry, 601 Elmwood Ave, Rochester, NY 14642 8629, USA
    Hear Res 249:44-53. 2009
    ..On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus...
  7. pmc Glutamate-related gene expression changes with age in the mouse auditory midbrain
    Sherif F Tadros
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Brain Res 1127:1-9. 2007
    ..The up-regulation of Slc1a3 gene expression may reflect a cellular compensatory mechanism to protect against age-related glutamate or calcium excitoxicity...
  8. pmc Hormone replacement therapy diminishes hearing in peri-menopausal mice
    Katharine Price
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Hear Res 252:29-36. 2009
    ....
  9. pmc F1 (CBA×C57) mice show superior hearing in old age relative to their parental strains: hybrid vigor or a new animal model for "golden ears"?
    Robert D Frisina
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA robert
    Neurobiol Aging 32:1716-24. 2011
    ..Therefore, F1s might be an optimal model for studying cases where the peripheral hearing is quite good in old age; thereby allowing isolation of central auditory changes due to brain neurodegeneration...
  10. pmc Murine intracochlear drug delivery: reducing concentration gradients within the cochlea
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Hear Res 268:2-11. 2010
    ..Both the C+C approach and a flow rate increase were found to provide enhanced response for lower frequencies, with evidence suggesting the C+C approach reduces concentration gradients within the cochlea...
  11. pmc Age-related decline in Kv3.1b expression in the mouse auditory brainstem correlates with functional deficits in the medial olivocochlear efferent system
    Martha L Zettel
    Department of Otolaryngology, University of Rochester, Rochester, NY 14642, USA
    J Assoc Res Otolaryngol 8:280-93. 2007
    ..Thus, Kv3.1b expression declines in MOC neurons by middle age, and these changes appear to correlate with functional declines in efferent activity in both middle-aged CBA mice and Kv3.1b knockout mice...
  12. doi request reprint Noninvasive Technique for Monitoring Drug Transport Through the Murine Cochlea using Micro-Computed Tomography
    Masoumeh Haghpanahi
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, 79 Lomb Memorial Drive, Rochester, NY, 14623, USA
    Ann Biomed Eng 41:2130-42. 2013
    ..This may permit determination of spatially dependent diffusion and clearance parameters for enhanced models. ..
  13. pmc Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure
    Oksana Polesskaya
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Hear Res 270:21-7. 2010
    ..Rather, other MLK family members such as MLK1, which is also expressed in cochlea, may have a previously unappreciated role in noise- and aminoglycoside-induced ototoxicity...
  14. pmc Progestin negatively affects hearing in aged women
    Patricia Guimaraes
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:14246-9. 2006
    ....
  15. ncbi request reprint Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system
    Sherif F Tadros
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
    Neurobiol Aging 28:1112-23. 2007
    ..We conclude that serotonin 2B receptors may play a role in the pathogenesis of age-related hearing loss...
  16. pmc In-plane biocompatible microfluidic interconnects for implantable microsystems
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY 14623, USA
    IEEE Trans Biomed Eng 58:943-8. 2011
    ..9 N. Each interconnect consumes less than 0.018 mm3 (18 nL) of volume. The low added volume makes this an ideal interconnect technology for medical applications where implant volume is critical...
  17. ncbi request reprint Age-related alterations in the neural coding of envelope periodicities
    Joseph P Walton
    Department of Surgery, Otolaryngology Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
    J Neurophysiol 88:565-78. 2002
    ..We postulate that this age-related difference in rate coding of SAM noise carriers is consistent with a loss, or imbalance, of excitatory and inhibitory neural mechanisms known to shape encoding of envelope periodicities in the IC...
  18. ncbi request reprint Effects of age on contralateral suppression of distortion product otoacoustic emissions in human listeners with normal hearing
    Sunghee Kim
    Otolaryngology Division, Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Audiol Neurootol 7:348-57. 2002
    ..These findings suggest that a functional decline of the MOC system with age precedes OHC degeneration. Moreover, the MOC system maintains better function in the 1- to 2-kHz range than in the 4- to 6-kHz range as a function of age...
  19. ncbi request reprint The effects of early bilateral deafening on calretinin expression in the dorsal cochlear nucleus of aged CBA/CaJ mice
    Martha L Zettel
    Department of Surgery, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
    Hear Res 183:57-66. 2003
    ....
  20. ncbi request reprint Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners
    Michael Jacobson
    Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Laryngoscope 113:1707-13. 2003
    ..By studying contralateral suppression on cochlear output in subjects of different ages, it is possible to describe aging effects on the medial olivocochlear system...
  21. ncbi request reprint Sex differences in distortion product otoacoustic emissions as a function of age in CBA mice
    Patricia Guimaraes
    Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Hear Res 192:83-9. 2004
    ..Understanding sex differences in age-related sensory disorders will be quite helpful for the goals of preventing, slowing or curing sensory problems in old age for both women and men...
  22. ncbi request reprint Age reduces response latency of mouse inferior colliculus neurons to AM sounds
    Henry Simon
    International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, New York 14623, USA
    J Acoust Soc Am 116:469-77. 2004
    ..These latency changes will result in age-related timing variations in brainstem responses to stimulus onsets, and therefore affect the encoding of complex sounds...
  23. ncbi request reprint Loss of peripheral right-ear advantage in age-related hearing loss
    Sherif F Tadros
    International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Audiol Neurootol 10:44-52. 2005
    ..On the contrary, HINT results showed a continuous dominance of the right ear (left hemisphere) in both groups, which was consistent with previous reports showing that the right hemisphere is more affected by age than the left hemisphere...
  24. ncbi request reprint Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis
    Sherif F Tadros
    International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, NY 14623, USA
    Hear Res 209:10-8. 2005
    ..We conclude that aldosterone hormone may have a protective effect on hearing in old age. This effect is more peripheral than central, appearing to affect inner hair cells more than outer hair cells...
  25. ncbi request reprint Age-related declines in distortion product otoacoustic emissions utilizing pure tone contralateral stimulation in CBA/CaJ mice
    George I Varghese
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, NY 14642 8629, USA
    Hear Res 209:60-7. 2005
    ..These findings reinforce the idea that age-related changes in the MOC or the operating points of OHCs play a role in the progression of presbycusis - age-related hearing loss in mammals...
  26. pmc Characterization of hearing loss in aged type II diabetics
    Susan T Frisina
    International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, NY, USA
    Hear Res 211:103-13. 2006
    ..Consequences of elevated blood sugar levels as possible underlying physiological mechanisms for the hearing loss are discussed...
  27. ncbi request reprint Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise
    Robert D Frisina
    J Acoust Soc Am 121:EL29-34. 2007
    ..The C57s showed normal hearing, measured with DPOAE amplitudes and auditory brainstem response thresholds, but showed little CS, suggesting a loss of efferent dynamics preceding any deficiencies of the afferent auditory system...
  28. ncbi request reprint Age-related structural and functional changes in the cochlear nucleus
    Robert D Frisina
    Otolaryngology Department, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Hear Res 216:216-23. 2006
    ..To the extent that this sensory deficit resides in the central auditory system, including the cochlear nucleus, future neural therapies will be able to improve hearing in the elderly...
  29. ncbi request reprint Estrogen blockade reduces auditory feedback in CBA mice
    Scott K Thompson
    Department of Otolaryngology Head and Neck Surgery, University of Rochester School of Medicine and Dentistry, 973 East Avenue, Rochester, NY 14607, USA
    Otolaryngol Head Neck Surg 135:100-5. 2006
    ..To examine the effects of estrogen suppression on age-related changes in distortion product otoacoustic emissions (DPOAEs) and contralateral suppression (CS) of DPOAEs in CBA mice...
  30. ncbi request reprint Micro-molded cannulae for intracochlear infusions in small rodents
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY, 14623 USA
    Conf Proc IEEE Eng Med Biol Soc 2007:6617-20. 2007
    ..Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani...
  31. ncbi request reprint Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea
    William J Bowers
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
    Mol Ther 6:12-8. 2002
    ..The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging...

Research Grants2

  1. Core--Coordination
    Robert Frisina; Fiscal Year: 2007
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