Research Topics
Genomes and Genes
| Henry F FriersonSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Frozen-section diagnosis by wireless telepathology and ultra portable computer: use in pathology resident/faculty consultationHenry F Frierson
Department of Pathology, University of Virginia Medical Center, Box 800214, Charlottesville, VA 22908, USA
Hum Pathol 38:1330-4. 2007..We conclude that a telepathology system using an ultra portable computer and wireless telecommunications is useful for frozen-section consultation between an experienced resident and a faculty member in pathology...
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinomaHenry F Frierson
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0214, USA
Am J Pathol 161:1315-23. 2002....- Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomasAndy Beckler
Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer 98:1547-51. 2003..Recently, DARPP-32 and a truncated isoform, t-DARPP, have been cloned in gastric carcinoma. The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown... - Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomasCharles A Fox
Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
Neoplasia 7:407-16. 2005..These potential biomarkers, as well as the relative expression of genes from BE1 versus those from BE2, may be validated in the future to aid in risk stratification and guide treatment protocols in patients with BE and associated AC... - Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesisAdam H Johnson
Digestive Health Center of Excellence, University of Virginia Health System, P O Box 800708, Charlottesville, VA 22908 0708, USA
Am J Pathol 167:577-84. 2005..001). These results suggest that Cldn7 expression is an early event in gastric tumorigenesis that is maintained throughout tumor progression... - CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulatedJonathan B Overdevest
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 109:E3588-96. 2012.... - Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arraysYongtao Yu
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Lab Invest 87:430-9. 2007..Our data suggest that gene mutation and/or epigenetic events that cannot be detected by assay of gross alteration of chromosomal structure are likely to underlie the malignant transformation events of this tumor type... - Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2Brian Titus
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
Cancer Res 65:7320-7. 2005..The data also suggest that blockade of the ET-1 axis may prevent lung metastasis, a new therapeutic concept that warrants clinical evaluation... - Comprehensive analysis of HE4 expression in normal and malignant human tissuesMary T Galgano
Department of Pathology, Robert E. Fechner Laboratory of Surgical Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
Mod Pathol 19:847-53. 2006.... - Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancersMasayoshi Iizuka
Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908 0734, USA
Gene 436:108-14. 2009..Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder... - Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinomaSue Rutherford
Department of Pathology, University of Virginia, P.O. Box 800214 Health Sciences Center, Charlottesville VA 22908, USA
Cancer Lett 236:309-17. 2006..Analysis of gene expression showed no substantial differences between samples of normal salivary gland and ACC, eliminating the most obvious candidate genes in this locus as tumor suppressors in ACC... 
Development and characterization of xenograft model systems for adenoid cystic carcinomaChristopher A Moskaluk
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Lab Invest 91:1480-90. 2011....- Clustering of molecular alterations in gastroesophageal carcinomasNatalie Koon
Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908-0708, USA
Neoplasia 6:143-9. 2004..The observed phenomenon of the presence of large amplification areas, yet clustering of overexpressed genes to relatively small loci, may suggest a high organization of chromatin and cancer-related genes in the nucleus... - The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancerSteven C Smith
Department of Molecular Physiology, University of Virginia, Charlottesville, Virginia, USA
Cancer Res 66:1917-22. 2006..We suggest that these insights may lead to future therapeutic approaches that seek to eliminate CD24 function in cancer cells... - Initial assessment of fine-needle aspiration specimens by telepathology: validation for use in pathology resident-faculty consultationsSarah E Kerr
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Clin Pathol 130:409-13. 2008..Our telepathology system is efficient and accurate for the initial assessment and preliminary diagnosis of FNA specimens, but we recommend its use by more senior and experienced trainees... - PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinomaMary T Galgano
Robert E Fechner Laboratory of Surgical Pathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Hum Pathol 40:1434-40. 2009.... - Src phosphorylation of RhoGDI2 regulates its metastasis suppressor functionYimin Wu
Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 106:5807-12. 2009..Our findings also suggest caution in using Src inhibitors in the hope of delaying progression in patients with bladder cancer... - PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activityJohn J Gildea
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
Oncogene 23:6788-97. 2004.... - Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarraysChristopher A Moskaluk
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Mod Pathol 16:913-9. 2003..Cdx2 shows a limited range of expression in the spectrum of human tissues and neoplasia and thus may have utility in determining the site of origin of tumors in certain clinical situations... - Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomasAndrew D Beckler
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Cancer 98:2184-91. 2003..Dysregulation of TFF1 expression at the transcript level was a critical event in the development of most gastric carcinomas... - Cdx2 as a marker of epithelial intestinal differentiation in the esophagusRoy W Phillips
Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
Am J Surg Pathol 27:1442-7. 2003..Acid mucin in non-goblet columnar cells is a common feature of Barrett's and junctional-type epithelium and may not always be indicative of intestinal metaplasia... - Cyclin D1 and FADD as biomarkers in head and neck squamous cell carcinomaJk J Rasamny
Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0713, USA
Otolaryngol Head Neck Surg 146:923-31. 2012..This study evaluates these proteins as predictors of clinical outcomes for HNSCC... - Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinomaSue Rutherford
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908-0708, USA
Lab Invest 85:1076-85. 2005..This combined genetic and genomic analysis provides several candidate genes to test for functional tumor suppressor activity in ACC... - Profiling the evolution of human metastatic bladder cancerBrian E Nicholson
Department of Molecular Physiology and Biological Physics, Division of Biostatistics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Cancer Res 64:7813-21. 2004.... - Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous disseminationSteven Christopher Smith
Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Pathol 174:371-9. 2009..In summary, LAMC2 is a novel biomarker of bladder cancer metastasis that reflects the propensity of cells to metastasize via either lymphatic or hematogenous routes... - Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysisDan Theodorescu
Department of Molecular Physiology, Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA, USA
Lancet Oncol 7:230-40. 2006..We aimed to use mass spectrometry and bioinformatics to define and validate a cancer-specific proteomic pattern... - Integrin agonists as adjuvants in chemotherapy for melanomaMartin A Schwartz
Department of Microbiology, Robert M Berne Cardiovascular Research Center, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA
Clin Cancer Res 14:6193-7. 2008..Thus, reduced integrin-dependent adhesion to ECM could mediate therapy resistance. The goal of this study was to test whether stimulation of integrin signaling could increase chemotherapeutic efficacy... - Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomasHelen P Cathro
Department of Pathology, University of Virginia Health System, Charlottesville, 22908, USA
Cancer Immunol Immunother 59:465-72. 2010..The goal of this study was to analyze protein expression of antigen processing machinery (APM) components in bladder carcinoma (BC), and to assess the clinical significance of defects in their expression... - Gastric cancers overexpress S100A calcium-binding proteinsWa el El-Rifai
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer Res 62:6823-6. 2002..Our results indicate that S100A proteins may be important for gastric tumorigenesis. Additional investigations are required to elucidate the biological role of calcium-binding proteins in cancer... - Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferationYanmei Zhang
Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
Cancer Discov 2:598-607. 2012..SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression... - Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cellsPaul D Deeble
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908, USA
Cancer Res 67:3663-72. 2007..These results suggest that neuroendocrine-like cells of prostatic tumors have the potential to enhance androgen-independent tumor growth in a paracrine manner, thereby contributing to progression of the disease... - Comprehensive evaluation of CDX2 in invasive cervical adenocarcinomas: immunopositivity in the absence of overt colorectal morphologyLisa M Sullivan
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Surg Pathol 32:1608-12. 2008.... - Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomasHenry F Frierson
Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
Hum Pathol 34:605-9. 2003.... - Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinomaSeung Mo Hong
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Surg Pathol 30:744-9. 2006.... - MMTV-EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone-responsive tissuesNadzeya V Marozkina
Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Cell Biochem 103:2010-8. 2008.... - Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancerShibu Thomas
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA
Cancer Res 71:832-41. 2011..Clinical evaluation of personalized therapy to suppress metastasis development based on Cav-1 and Src profiles seems warranted... - Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasmsLouis B Brill
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
Mod Pathol 24:1169-76. 2011..In addition to being a diagnostically useful biomarker for adenoid cystic carcinoma, MYB and its downstream effectors are also novel potential therapeutic targets... - Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate modelJill K Slack-Davis
Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
Mol Cancer Ther 8:2470-7. 2009.... - When is a negative lymph node really negative? Molecular tools for the detection of lymph node metastasis from urological cancerDan Theodorescu
Department of Urology, Molecular Physiology, University of Virginia Health System, Charlottesville, VA 22908 0422, USA
Urol Oncol 22:256-9. 2004 - AP-2gamma protein expression in intratubular germ cell neoplasia of testisSeung-Mo Hong
Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
Am J Clin Pathol 124:873-7. 2005..All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region forAP-2gamma in the PLAP and c-kit genes might explain the concordance of protein expression... - Human papillomavirus profile of women in Belize City, Belize: correlation with cervical cytopathologic findingsHelen P Cathro
Department of Pathology, PO Box 800214, University of Virginia Health System, Charlottesville, VA 22908, USA
Hum Pathol 40:942-9. 2009.... - Analysis of immunohistochemical stain usage in different pathology practice settingsAkeesha A Shah
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Clin Pathol 138:831-6. 2012..The average number of stains ordered per case was similar among all groups. We suggest that the use of IHC may reflect both the degree of experience of the pathologist and the pathology practice setting... - RhoGDI2 is an invasion and metastasis suppressor gene in human cancerJohn J Gildea
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Cancer Res 62:6418-23. 2002..These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human cancer, and a promising target for therapy... - Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancersLeah E Morris
Department of Biology, University of Virginia, Charlottesville, Virginia 22908-0708, USA
Genes Chromosomes Cancer 42:280-6. 2005..Additional studies analyzing other proteins involved in cell adhesion may lead to a better molecular understanding of the histopathologic appearance of diffuse gastric cancers... - EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinomaAkeesha A Shah
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Am J Surg Pathol 37:571-8. 2013.... - Unusual case of recurrent low-grade invasive and endophytic squamous cell carcinoma of the penisCaroline D Ames
Department of Urology, University of Virginia, Charlottesville, VA, USA
Scand J Urol Nephrol 38:258-9. 2004..We present a case of low-grade yet recurrent and invasive squamous cell carcinoma that may constitute a new biological variant of penile cancer... - Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell linesV Anne Westbrook
Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia, USA
Clin Cancer Res 10:101-12. 2004..CONCLUSIONS: The data herein suggest that the SPAN-X protein may be a useful target in cancer immunotherapy... - CDX2 and MUC2 protein expression in extrahepatic bile duct carcinomaSeung-Mo Hong
Department of Pathology, University of Virginia Health System, Charlottesville, USA
Am J Clin Pathol 124:361-70. 2005..05). Expression of CDX2 and MUC2 supports that intestinal differentiation is present in specific subtypes of EBD carcinomas, and their expression status correlates with patients' overall survival... - Defining the region(s) of deletion at 6q16-q22 in human prostate cancerEija-Riitta Hyytinen
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908-0214, USA
Genes Chromosomes Cancer 34:306-12. 2002..These findings suggest that deletion of 6q16 - q22 is a frequent event in prostate cancer, and that the deletion originates from two distinct regions. These results should be useful in identifying the target gene(s) of deletion at 6q... - Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPPWa el El-Rifai
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer Res 62:4061-4. 2002..Our results reveal for the first time the presence of these signaling molecules in human cancer and suggest that they may be important for gastric tumorigenesis... - Cysteinyl leukotrienes in chronic hyperplastic rhinosinusitisPablo Arango
Department of Otolaryngology, Division of Allergy/Immunology, University of Virginia Health Sciences Center, Charlottesville, VA 22903, USA
Otolaryngol Head Neck Surg 127:512-5. 2002..LT expression occurs in patients who demonstrate few or no mucosal eosinophils, which indicates that cell lines other than eosinophils may be responsible for LT production in chronic rhinosinusitis... - Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literatureMaria Luisa Policarpio-Nicolas
Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
Diagn Cytopathol 36:115-9. 2008..The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT... - Rosai-Dorfman disease presenting as a pulmonary artery massDustin M Walters
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 89:300-2. 2010..We present a case of Rosai-Dorfman disease affecting the pulmonary arteries in a 22-year-old woman with severe, symptomatic right heart failure... - Reassessment of the usefulness of frozen section analysis for hip and knee joint revisionsWilliam A Kanner
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
Am J Clin Pathol 130:363-8. 2008..We suggest that FS examination be used more selectively in conjunction with other studies, namely erythrocyte sedimentation rate and C-reactive protein... - Interobserver variability with the interpretation of thyroid FNA specimens showing predominantly Hürthle cellsEdward B Stelow
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Am J Clin Pathol 126:580-3. 2006.... - Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: is there evidence for systematic upgrading?Emily B Smith
Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Cancer 94:2282-7. 2002..In contrast, grade has shifted heavily toward moderate differentiation. The authors sought to test the hypothesis that such changes in grade in part may be because of trends among pathologists to upgrade similar specimens over time... - Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expressionMohammad H Razvi
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Genes Chromosomes Cancer 46:914-28. 2007..ANPEP is a secreted protein that may have diagnostic and/or prognostic significance for Barrett's progression. The use of genomic approaches in this study provided useful information about the molecular pathobiology of BAs... - Expression of focal adhesion kinase in normal and pathologic human prostate tissuesJoshua D Rovin
Department of Surgery, University of Virginia, Charlottesville 22908, USA
Prostate 53:124-32. 2002..In tumor cells, including prostate adenocarcinoma, FAK overexpression has been linked to cancer progression... - Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serumJohn B Welsh
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 100:3410-5. 2003.... - Deletion, mutation, and loss of expression of KLF6 in human prostate cancerCeshi Chen
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Pathol 162:1349-54. 2003..These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers... - Classifying human cancer by analysis of gene expressionGarret M Hampton
Genomics Institute of the Novartis Research Foundation, 10 675 John Jay Hopkins Drive, San Diego, CA 92121, USA
Trends Mol Med 9:5-10. 2003..If substantiated in larger studies, this might form a basis for stratifying patients so that they receive optimal therapeutic treatment and follow-up... - Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancerXiaodong Sun
Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nat Genet 37:407-12. 2005..Furthermore, ATBF1 inhibited cell proliferation. Hence, loss of ATBF1 is one mechanism that defines the absence of growth control in prostate cancer... - Tissues from population-based cancer registries: a novel approach to increasing research potentialMarc T Goodman
Etiology Program, Hawaii Tumor Registry, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Hum Pathol 36:812-20. 2005..SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country... - CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarrayBrenda Y Hernandez
Hawaii Tumor Registry Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
Hum Pathol 36:275-81. 2005..This well-characterized TMA offers a powerful tool for testing hypotheses regarding colorectal carcinogenesis, including the identification of potential markers of neoplastic development and progression... - Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic originKlaus W Wagner
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
Oncogene 23:6621-9. 2004..Together, these data demonstrate that UbcH10 plays an important role in tumor development and that its inhibition in combination with agonists of the TRAIL receptor may provide an enhanced therapeutic index... - The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcriptsAylin M Ozyildirim
Department of Cell Biology, UVA Health System, University of Virginia, Charlottesville, VA 22908 USA
Invest Ophthalmol Vis Sci 46:1572-80. 2005.... - Array comparative genomic hybridization analysis of olfactory neuroblastomaMohamed Guled
Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Mod Pathol 21:770-8. 2008..In addition, our results indicate that gains in 20q and 13q may be important in the progression of this cancer, and that these regions possibly harbor genes with functional relevance in olfactory neuroblastoma...