Henry F Frierson

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming
    Henry F Frierson
    University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 123:2783-5. 2013
  2. ncbi request reprint Frozen-section diagnosis by wireless telepathology and ultra portable computer: use in pathology resident/faculty consultation
    Henry F Frierson
    Department of Pathology, University of Virginia Medical Center, Box 800214, Charlottesville, VA 22908, USA
    Hum Pathol 38:1330-4. 2007
  3. pmc Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0214, USA
    Am J Pathol 161:1315-23. 2002
  4. ncbi request reprint Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas
    Andy Beckler
    Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer 98:1547-51. 2003
  5. pmc Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas
    Charles A Fox
    Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 7:407-16. 2005
  6. pmc CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated
    Jonathan B Overdevest
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 109:E3588-96. 2012
  7. pmc Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis
    Adam H Johnson
    Digestive Health Center of Excellence, University of Virginia Health System, P O Box 800708, Charlottesville, VA 22908 0708, USA
    Am J Pathol 167:577-84. 2005
  8. pmc Clustering of molecular alterations in gastroesophageal carcinomas
    Natalie Koon
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Neoplasia 6:143-9. 2004
  9. ncbi request reprint Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays
    Yongtao Yu
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 87:430-9. 2007
  10. ncbi request reprint Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
    Brian Titus
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 65:7320-7. 2005

Collaborators

Detail Information

Publications70

  1. pmc Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming
    Henry F Frierson
    University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 123:2783-5. 2013
    ....
  2. ncbi request reprint Frozen-section diagnosis by wireless telepathology and ultra portable computer: use in pathology resident/faculty consultation
    Henry F Frierson
    Department of Pathology, University of Virginia Medical Center, Box 800214, Charlottesville, VA 22908, USA
    Hum Pathol 38:1330-4. 2007
    ..We conclude that a telepathology system using an ultra portable computer and wireless telecommunications is useful for frozen-section consultation between an experienced resident and a faculty member in pathology...
  3. pmc Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0214, USA
    Am J Pathol 161:1315-23. 2002
    ....
  4. ncbi request reprint Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas
    Andy Beckler
    Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer 98:1547-51. 2003
    ..Recently, DARPP-32 and a truncated isoform, t-DARPP, have been cloned in gastric carcinoma. The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown...
  5. pmc Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas
    Charles A Fox
    Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 7:407-16. 2005
    ..These potential biomarkers, as well as the relative expression of genes from BE1 versus those from BE2, may be validated in the future to aid in risk stratification and guide treatment protocols in patients with BE and associated AC...
  6. pmc CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated
    Jonathan B Overdevest
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 109:E3588-96. 2012
    ....
  7. pmc Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis
    Adam H Johnson
    Digestive Health Center of Excellence, University of Virginia Health System, P O Box 800708, Charlottesville, VA 22908 0708, USA
    Am J Pathol 167:577-84. 2005
    ..001). These results suggest that Cldn7 expression is an early event in gastric tumorigenesis that is maintained throughout tumor progression...
  8. pmc Clustering of molecular alterations in gastroesophageal carcinomas
    Natalie Koon
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Neoplasia 6:143-9. 2004
    ..The observed phenomenon of the presence of large amplification areas, yet clustering of overexpressed genes to relatively small loci, may suggest a high organization of chromatin and cancer-related genes in the nucleus...
  9. ncbi request reprint Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays
    Yongtao Yu
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 87:430-9. 2007
    ..Our data suggest that gene mutation and/or epigenetic events that cannot be detected by assay of gross alteration of chromosomal structure are likely to underlie the malignant transformation events of this tumor type...
  10. ncbi request reprint Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
    Brian Titus
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 65:7320-7. 2005
    ..The data also suggest that blockade of the ET-1 axis may prevent lung metastasis, a new therapeutic concept that warrants clinical evaluation...
  11. pmc CD24 is an effector of HIF-1-driven primary tumor growth and metastasis
    Shibu Thomas
    Departments of Urology, University of Virginia, Charlottesville, Virginia, USA
    Cancer Res 72:5600-12. 2012
    ....
  12. ncbi request reprint Comprehensive analysis of HE4 expression in normal and malignant human tissues
    Mary T Galgano
    Department of Pathology, Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Mod Pathol 19:847-53. 2006
    ....
  13. ncbi request reprint Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma
    Sue Rutherford
    Department of Pathology, University of Virginia, P O Box 800214 Health Sciences Center, Charlottesville VA 22908, USA
    Cancer Lett 236:309-17. 2006
    ..Analysis of gene expression showed no substantial differences between samples of normal salivary gland and ACC, eliminating the most obvious candidate genes in this locus as tumor suppressors in ACC...
  14. pmc Development and characterization of xenograft model systems for adenoid cystic carcinoma
    Christopher A Moskaluk
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 91:1480-90. 2011
    ....
  15. pmc Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers
    Masayoshi Iizuka
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908 0734, USA
    Gene 436:108-14. 2009
    ..Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder...
  16. ncbi request reprint Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas
    Andrew D Beckler
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Cancer 98:2184-91. 2003
    ..As loss of trefoil factor 1 (TFF1) expression leads to neoplastic growth in the antropyloric mucosa of mice, the authors sought to comprehensively study the human TFF1 gene in primary gastric carcinomas...
  17. ncbi request reprint The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer
    Steven C Smith
    Department of Molecular Physiology, University of Virginia, Charlottesville, Virginia, USA
    Cancer Res 66:1917-22. 2006
    ..We suggest that these insights may lead to future therapeutic approaches that seek to eliminate CD24 function in cancer cells...
  18. pmc PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma
    Mary T Galgano
    Robert E Fechner Laboratory of Surgical Pathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hum Pathol 40:1434-40. 2009
    ....
  19. ncbi request reprint Initial assessment of fine-needle aspiration specimens by telepathology: validation for use in pathology resident-faculty consultations
    Sarah E Kerr
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Clin Pathol 130:409-13. 2008
    ..Our telepathology system is efficient and accurate for the initial assessment and preliminary diagnosis of FNA specimens, but we recommend its use by more senior and experienced trainees...
  20. pmc Loss of SPARC in bladder cancer enhances carcinogenesis and progression
    Neveen Said
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 123:751-66. 2013
    ..These results indicate that SPARC is produced by benign and malignant compartments of bladder carcinomas where it functions to suppress bladder carcinogenesis, progression, and metastasis...
  21. ncbi request reprint Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays
    Christopher A Moskaluk
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mod Pathol 16:913-9. 2003
    ..Cdx2 shows a limited range of expression in the spectrum of human tissues and neoplasia and thus may have utility in determining the site of origin of tumors in certain clinical situations...
  22. ncbi request reprint PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    Oncogene 23:6788-97. 2004
    ....
  23. ncbi request reprint Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
    Roy W Phillips
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 27:1442-7. 2003
    ..Acid mucin in non-goblet columnar cells is a common feature of Barrett's and junctional-type epithelium and may not always be indicative of intestinal metaplasia...
  24. pmc Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function
    Yimin Wu
    Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 106:5807-12. 2009
    ..Our findings also suggest caution in using Src inhibitors in the hope of delaying progression in patients with bladder cancer...
  25. ncbi request reprint Cyclin D1 and FADD as biomarkers in head and neck squamous cell carcinoma
    Jk J Rasamny
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0713, USA
    Otolaryngol Head Neck Surg 146:923-31. 2012
    ..This study evaluates these proteins as predictors of clinical outcomes for HNSCC...
  26. ncbi request reprint Gastric cancers overexpress S100A calcium-binding proteins
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:6823-6. 2002
    ..Our results indicate that S100A proteins may be important for gastric tumorigenesis. Additional investigations are required to elucidate the biological role of calcium-binding proteins in cancer...
  27. ncbi request reprint Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma
    Sue Rutherford
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Lab Invest 85:1076-85. 2005
    ..This combined genetic and genomic analysis provides several candidate genes to test for functional tumor suppressor activity in ACC...
  28. doi request reprint Integrin agonists as adjuvants in chemotherapy for melanoma
    Martin A Schwartz
    Department of Microbiology, Robert M Berne Cardiovascular Research Center, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA
    Clin Cancer Res 14:6193-7. 2008
    ..Thus, reduced integrin-dependent adhesion to ECM could mediate therapy resistance. The goal of this study was to test whether stimulation of integrin signaling could increase chemotherapeutic efficacy...
  29. pmc Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination
    Steven Christopher Smith
    Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Pathol 174:371-9. 2009
    ..In summary, LAMC2 is a novel biomarker of bladder cancer metastasis that reflects the propensity of cells to metastasize via either lymphatic or hematogenous routes...
  30. pmc Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas
    Helen P Cathro
    Department of Pathology, University of Virginia Health System, Charlottesville, 22908, USA
    Cancer Immunol Immunother 59:465-72. 2010
    ..The goal of this study was to analyze protein expression of antigen processing machinery (APM) components in bladder carcinoma (BC), and to assess the clinical significance of defects in their expression...
  31. ncbi request reprint Profiling the evolution of human metastatic bladder cancer
    Brian E Nicholson
    Department of Molecular Physiology and Biological Physics, Division of Biostatistics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 64:7813-21. 2004
    ....
  32. ncbi request reprint Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
    Dan Theodorescu
    Department of Molecular Physiology, Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA, USA
    Lancet Oncol 7:230-40. 2006
    ..We aimed to use mass spectrometry and bioinformatics to define and validate a cancer-specific proteomic pattern...
  33. doi request reprint Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation
    Yanmei Zhang
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Discov 2:598-607. 2012
    ..Our results suggest that gene fusions can arise from cis-splicing of adjacent genes without corresponding DNA changes...
  34. ncbi request reprint Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 30:744-9. 2006
    ....
  35. ncbi request reprint Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells
    Paul D Deeble
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:3663-72. 2007
    ..These results suggest that neuroendocrine-like cells of prostatic tumors have the potential to enhance androgen-independent tumor growth in a paracrine manner, thereby contributing to progression of the disease...
  36. ncbi request reprint Comprehensive evaluation of CDX2 in invasive cervical adenocarcinomas: immunopositivity in the absence of overt colorectal morphology
    Lisa M Sullivan
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 32:1608-12. 2008
    ....
  37. ncbi request reprint Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    Hum Pathol 34:605-9. 2003
    ....
  38. doi request reprint EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma
    Akeesha A Shah
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Surg Pathol 37:571-8. 2013
    ....
  39. pmc Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cancer Ther 8:2470-7. 2009
    ....
  40. doi request reprint Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer
    Shibu Thomas
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA
    Cancer Res 71:832-41. 2011
    ..Clinical evaluation of personalized therapy to suppress metastasis development based on Cav-1 and Src profiles seems warranted...
  41. doi request reprint Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms
    Louis B Brill
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Mod Pathol 24:1169-76. 2011
    ..In addition to being a diagnostically useful biomarker for adenoid cystic carcinoma, MYB and its downstream effectors are also novel potential therapeutic targets...
  42. ncbi request reprint When is a negative lymph node really negative? Molecular tools for the detection of lymph node metastasis from urological cancer
    Dan Theodorescu
    Department of Urology, Molecular Physiology, University of Virginia Health System, Charlottesville, VA 22908 0422, USA
    Urol Oncol 22:256-9. 2004
  43. ncbi request reprint AP-2gamma protein expression in intratubular germ cell neoplasia of testis
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    Am J Clin Pathol 124:873-7. 2005
    ..All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region forAP-2gamma in the PLAP and c-kit genes might explain the concordance of protein expression...
  44. ncbi request reprint MMTV-EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone-responsive tissues
    Nadzeya V Marozkina
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 103:2010-8. 2008
    ....
  45. doi request reprint Human papillomavirus profile of women in Belize City, Belize: correlation with cervical cytopathologic findings
    Helen P Cathro
    Department of Pathology, PO Box 800214, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hum Pathol 40:942-9. 2009
    ....
  46. doi request reprint Analysis of immunohistochemical stain usage in different pathology practice settings
    Akeesha A Shah
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Clin Pathol 138:831-6. 2012
    ..The average number of stains ordered per case was similar among all groups. We suggest that the use of IHC may reflect both the degree of experience of the pathologist and the pathology practice setting...
  47. ncbi request reprint Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers
    Leah E Morris
    Department of Biology, University of Virginia, Charlottesville, Virginia 22908 0708, USA
    Genes Chromosomes Cancer 42:280-6. 2005
    ..Additional studies analyzing other proteins involved in cell adhesion may lead to a better molecular understanding of the histopathologic appearance of diffuse gastric cancers...
  48. ncbi request reprint RhoGDI2 is an invasion and metastasis suppressor gene in human cancer
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 62:6418-23. 2002
    ..These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human cancer, and a promising target for therapy...
  49. ncbi request reprint Unusual case of recurrent low-grade invasive and endophytic squamous cell carcinoma of the penis
    Caroline D Ames
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Scand J Urol Nephrol 38:258-9. 2004
    ..We present a case of low-grade yet recurrent and invasive squamous cell carcinoma that may constitute a new biological variant of penile cancer...
  50. ncbi request reprint Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines
    V Anne Westbrook
    Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia, USA
    Clin Cancer Res 10:101-12. 2004
    ....
  51. ncbi request reprint CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, USA
    Am J Clin Pathol 124:361-70. 2005
    ..05). Expression of CDX2 and MUC2 supports that intestinal differentiation is present in specific subtypes of EBD carcinomas, and their expression status correlates with patients' overall survival...
  52. ncbi request reprint Defining the region(s) of deletion at 6q16-q22 in human prostate cancer
    Eija Riitta Hyytinen
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Genes Chromosomes Cancer 34:306-12. 2002
    ..These findings suggest that deletion of 6q16 - q22 is a frequent event in prostate cancer, and that the deletion originates from two distinct regions. These results should be useful in identifying the target gene(s) of deletion at 6q...
  53. ncbi request reprint Rosai-Dorfman disease presenting as a pulmonary artery mass
    Dustin M Walters
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 89:300-2. 2010
    ..We present a case of Rosai-Dorfman disease affecting the pulmonary arteries in a 22-year-old woman with severe, symptomatic right heart failure...
  54. ncbi request reprint Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature
    Maria Luisa Policarpio-Nicolas
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Diagn Cytopathol 36:115-9. 2008
    ..The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT...
  55. ncbi request reprint Interobserver variability with the interpretation of thyroid FNA specimens showing predominantly Hürthle cells
    Edward B Stelow
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Clin Pathol 126:580-3. 2006
    ....
  56. ncbi request reprint Cysteinyl leukotrienes in chronic hyperplastic rhinosinusitis
    Pablo Arango
    Department of Otolaryngology, Division of Allergy Immunology, University of Virginia Health Sciences Center, Charlottesville, VA 22903, USA
    Otolaryngol Head Neck Surg 127:512-5. 2002
    ..Our study was designed to demonstrate that, similar to asthma, eosinophilic chronic rhinosinusitis is a disease characterized by activation and the expression of cysteinyl leukotrienes (LTs)...
  57. ncbi request reprint Reassessment of the usefulness of frozen section analysis for hip and knee joint revisions
    William A Kanner
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Am J Clin Pathol 130:363-8. 2008
    ..We suggest that FS examination be used more selectively in conjunction with other studies, namely erythrocyte sedimentation rate and C-reactive protein...
  58. ncbi request reprint Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:4061-4. 2002
    ..Our results reveal for the first time the presence of these signaling molecules in human cancer and suggest that they may be important for gastric tumorigenesis...
  59. ncbi request reprint Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: is there evidence for systematic upgrading?
    Emily B Smith
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer 94:2282-7. 2002
    ..In contrast, grade has shifted heavily toward moderate differentiation. The authors sought to test the hypothesis that such changes in grade in part may be because of trends among pathologists to upgrade similar specimens over time...
  60. pmc Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
    John B Welsh
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3410-5. 2003
    ....
  61. pmc Deletion, mutation, and loss of expression of KLF6 in human prostate cancer
    Ceshi Chen
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Pathol 162:1349-54. 2003
    ..These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers...
  62. ncbi request reprint Classifying human cancer by analysis of gene expression
    Garret M Hampton
    Genomics Institute of the Novartis Research Foundation, 10 675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Trends Mol Med 9:5-10. 2003
    ..If substantiated in larger studies, this might form a basis for stratifying patients so that they receive optimal therapeutic treatment and follow-up...
  63. ncbi request reprint Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression
    Mohammad H Razvi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Genes Chromosomes Cancer 46:914-28. 2007
    ..ANPEP is a secreted protein that may have diagnostic and/or prognostic significance for Barrett's progression. The use of genomic approaches in this study provided useful information about the molecular pathobiology of BAs...
  64. ncbi request reprint Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer
    Xiaodong Sun
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Genet 37:407-12. 2005
    ..Furthermore, ATBF1 inhibited cell proliferation. Hence, loss of ATBF1 is one mechanism that defines the absence of growth control in prostate cancer...
  65. ncbi request reprint Expression of focal adhesion kinase in normal and pathologic human prostate tissues
    Joshua D Rovin
    Department of Surgery, University of Virginia, Charlottesville 22908, USA
    Prostate 53:124-32. 2002
    ..In tumor cells, including prostate adenocarcinoma, FAK overexpression has been linked to cancer progression...
  66. ncbi request reprint Tissues from population-based cancer registries: a novel approach to increasing research potential
    Marc T Goodman
    Etiology Program, Hawaii Tumor Registry, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Hum Pathol 36:812-20. 2005
    ..SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country...
  67. ncbi request reprint CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray
    Brenda Y Hernandez
    Hawaii Tumor Registry Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Hum Pathol 36:275-81. 2005
    ..This well-characterized TMA offers a powerful tool for testing hypotheses regarding colorectal carcinogenesis, including the identification of potential markers of neoplastic development and progression...
  68. ncbi request reprint Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin
    Klaus W Wagner
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Oncogene 23:6621-9. 2004
    ..Together, these data demonstrate that UbcH10 plays an important role in tumor development and that its inhibition in combination with agonists of the TRAIL receptor may provide an enhanced therapeutic index...
  69. doi request reprint Array comparative genomic hybridization analysis of olfactory neuroblastoma
    Mohamed Guled
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Mod Pathol 21:770-8. 2008
    ..In addition, our results indicate that gains in 20q and 13q may be important in the progression of this cancer, and that these regions possibly harbor genes with functional relevance in olfactory neuroblastoma...
  70. ncbi request reprint The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts
    Aylin M Ozyildirim
    Department of Cell Biology, UVA Health System, University of Virginia, Charlottesville, VA 22908 USA
    Invest Ophthalmol Vis Sci 46:1572-80. 2005
    ..To sequence and comprehensively analyze human and mouse lacrimal gland transcriptomes as part of the NEIBank project...