Jacob E Friedman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum
    Jacob E Friedman
    Department of Pediatrics, University of Colorado Denver, P O Box 6511, MS 8106, Aurora, CO 80045, USA
    Diabetes 57:606-13. 2008
  2. pmc Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle
    Stephanie R Thorn
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:3021-30. 2009
  3. pmc CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice
    Shaikh M Rahman
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 287:34349-60. 2012
  4. pmc Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin
    Stephanie R Thorn
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes 62:65-73. 2013
  5. pmc Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Lipid Res 50:2193-202. 2009
  6. pmc Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 287:37340-51. 2012
  7. pmc Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep
    Laura D Brown
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 303:E352-64. 2012
  8. pmc Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus
    Laura D Brown
    UCD Perinatal Research Center, F441, 13243 East 23rd Ave, PO Box 6508, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 296:E56-63. 2009
  9. ncbi request reprint CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Hepatology 45:1108-17. 2007
  10. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009

Research Grants

  1. MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE (NHP)
    Jacob Friedman; Fiscal Year: 2007
  2. CORE--METABOLIC
    Jacob Friedman; Fiscal Year: 2007

Detail Information

Publications44

  1. ncbi request reprint Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum
    Jacob E Friedman
    Department of Pediatrics, University of Colorado Denver, P O Box 6511, MS 8106, Aurora, CO 80045, USA
    Diabetes 57:606-13. 2008
    ..However, the cellular mechanisms underlying this insulin resistance are unknown...
  2. pmc Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle
    Stephanie R Thorn
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:3021-30. 2009
    ....
  3. pmc CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice
    Shaikh M Rahman
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 287:34349-60. 2012
    ..Reducing C/EBPβ in macrophages confers protection from HFD-induced systemic inflammation and insulin resistance, suggesting it may be an attractive therapeutic target for ameliorating obesity-induced inflammatory responses...
  4. pmc Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin
    Stephanie R Thorn
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes 62:65-73. 2013
    ..These data are consistent with a novel mechanism involving persistent transcriptional activation in the liver that seems to be unique in the fetus with IUGR...
  5. pmc Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Lipid Res 50:2193-202. 2009
    ....
  6. pmc Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β
    Ishtiaq Qadri
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 287:37340-51. 2012
    ....
  7. pmc Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep
    Laura D Brown
    Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 303:E352-64. 2012
    ....
  8. pmc Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus
    Laura D Brown
    UCD Perinatal Research Center, F441, 13243 East 23rd Ave, PO Box 6508, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 296:E56-63. 2009
    ..Furthermore, the effect of amino acids is dependent on a concomitant increase in fetal insulin concentrations, because amino acid infusion upregulates p70(S6k) and Erk only when amino acid-stimulated increase in insulin occurs...
  9. ncbi request reprint CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Hepatology 45:1108-17. 2007
    ....
  10. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
    ..These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this may increase the risk of pediatric NAFLD...
  11. pmc Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum
    Linda A Barbour
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 96:1431-41. 2011
    ....
  12. ncbi request reprint Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
    ..These results demonstrate that chronic fetal hypoglycemia triggers signals that can activate gluconeogenesis in the fetal liver...
  13. pmc C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells
    Mahua Choudhury
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Cell Endocrinol 331:102-8. 2011
    ..Understanding how ER stress suppresses AMPK activation and increases C/EBPβ expression could lead to a potentially novel pathway for treatment of diabetes...
  14. pmc Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes 61:2495-505. 2012
    ....
  15. doi request reprint CCAAT/enhancer binding protein β deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis
    Shaikh M Rahman
    Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 430:336-9. 2013
    ..Inactivation of C/EBPβ might therefore be an important therapeutic strategy to prevent LXR activation-mediated adverse effects on liver TG metabolism without disrupting its beneficial effects on cholesterol metabolism...
  16. pmc Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues
    Hong Wang
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
    Diabetes 58:116-24. 2009
    ..Skeletal muscle-specific LPL knockout mouse (SMLPL(-/-)) were created to study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin sensitivity, body weight, and composition...
  17. ncbi request reprint Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Diabetes Care 30:S112-9. 2007
  18. ncbi request reprint CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice
    Jill M Schroeder-Gloeckler
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 282:15717-29. 2007
    ..These data provide novel evidence linking C/EBPbeta expression to lipogenesis and energy balance with important implications for the treatment of obesity and fatty liver disease...
  19. ncbi request reprint Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction
    James S Barry
    Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, The Children s Hospital, 1056 East 19th Avenue, Box B070, Denver, CO 80218, USA
    Exp Biol Med (Maywood) 231:566-75. 2006
    ....
  20. pmc Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
    Agnieszka A Kendrick
    Nutrition and Obesity Research Center, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, 80045, USA
    Biochem J 433:505-14. 2011
    ....
  21. pmc Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat
    Mahua Choudhury
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Aging (Albany NY) 3:175-8. 2011
    ....
  22. ncbi request reprint Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 145:1144-50. 2004
    ....
  23. ncbi request reprint Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle
    Marianne S Anderson
    Pediatrics Neonatology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 288:R473-81. 2005
    ....
  24. pmc Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice
    Margaret J R Heerwagen
    Division of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 8:e67791. 2013
    ..Our results suggest that reducing excess maternal inflammation may be a promising target for preventing adverse fetal metabolic outcomes in pregnancies complicated by maternal obesity. ..
  25. ncbi request reprint Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells
    Jianhua Shao
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Endocrinol Metab 286:E304-10. 2004
    ..These adaptations in the beta-cell may play an important role in maintaining the basal hyperinsulinemia of pregnancy while limiting the capacity of PRL and PRG to promote glucose-stimulated insulin secretion during late gestation...
  26. ncbi request reprint Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio
    Jianhua Shao
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 54:976-84. 2005
    ....
  27. pmc De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific
    Susan M Majka
    Charles C Gates Regenerative Medicine and Stem Cell Biology Program, Department of Pediatrics, Cardiovascular Pulmonary Research Laboratory, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14781-6. 2010
    ..BMP-derived adipocytes may, therefore, account in part for adipose depot heterogeneity and detrimental changes in adipose metabolism and inflammation with aging and adiposity...
  28. pmc Maternal obesity and fetal metabolic programming: a fertile epigenetic soil
    Margaret J R Heerwagen
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R711-22. 2010
    ....
  29. pmc Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes
    David E Brumbaugh
    Department of Pediatrics, School of Medicine, University of Colorado Denver, Denver, CO, USA
    J Pediatr 162:930-6.e1. 2013
    ....
  30. pmc Epigenetics and microRNAs in preeclampsia
    Mahua Choudhury
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Clin Exp Hypertens 34:334-41. 2012
    ..Translating these basic epigenetic findings to clinical practice could potentially serve as prognostic biomarkers for diagnosis in its early stages and could help in the development of prophylactic strategies...
  31. ncbi request reprint Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
    Jianhua Shao
    Department of Pediatrics, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 51:19-29. 2002
    ..These defects are unique to pregnancy and suggest that redistribution of PI 3-kinase to the insulin receptor may be a primary defect underlying insulin resistance in skeletal muscle during gestational diabetes...
  32. pmc Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation
    Keith E Fox
    Cardiovascular Pulmonary Research Laboratory and Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 283:35096-105. 2008
    ..We conclude that cAMP stimulates phosphorylation and binding of CREB to the cyclin D1 gene promoter. Simultaneously, hypermethylation of the Wnt10b gene promoter suppresses binding of CREB, allowing adipogenesis to proceed...
  33. ncbi request reprint Human placental growth hormone causes severe insulin resistance in transgenic mice
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Obstet Gynecol 186:512-7. 2002
    ..Our aim was to evaluate the effect of placental growth hormone on insulin sensitivity in vivo using transgenic mice that overexpress the human placental growth hormone gene...
  34. ncbi request reprint Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, and MetroHealth Medical Center, Cleveland, Ohio 44106, USA
    Am J Physiol Endocrinol Metab 282:E522-33. 2002
    ..Decreased PPARgamma and its target genes may be part of the molecular mechanism to accelerate fat catabolism to meet fetal nutrient demand in late gestation...
  35. ncbi request reprint Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice
    Yang Sun
    Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:23301-7. 2002
    ....
  36. ncbi request reprint Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X
    Rodney A Velliquette
    Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4906, USA
    J Pharmacol Exp Ther 314:422-30. 2005
    ..Both these novel antidiabetic agents attenuate insulin resistance and hypertriglyceridemia associated with metabolic syndrome but via distinct mechanisms...
  37. ncbi request reprint Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    Linda A Barbour
    Department of Medicine, University Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:37489-94. 2005
    ....
  38. ncbi request reprint Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
    ....
  39. ncbi request reprint Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling
    John P Kirwan
    Departments of Pediatrics, Biochemistry, and Molecular Genetics, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 195, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:4678-84. 2004
    ..These changes may allow for greater p85/p110 binding to IRS-1 and play a significant physiological role in the underlying metabolic adaptation to normal human pregnancy and restoration of insulin sensitivity postpartum...
  40. ncbi request reprint Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice
    Hiroshi Yamashita
    Department of Pediatric, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatr Res 53:411-8. 2003
    ....
  41. ncbi request reprint TNF-alpha is a predictor of insulin resistance in human pregnancy
    John P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Diabetes 51:2207-13. 2002
    ....
  42. pmc Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis
    Victoria A Payne
    Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, United Kingdom
    J Biol Chem 282:21005-14. 2007
    ..Moreover, they further refine the complex and serial roles of the C/EBP family of transcription factors in inducing and maintaining the metabolic properties of mature adipocytes...
  43. ncbi request reprint C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer
    Liping Qiao
    Graduate Center for Nutritional Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
    Diabetes 54:1744-54. 2005
    ..Thus, C/EBPalpha is a key transcription factor for full activation of human adiponectin gene transcription in mature adipocytes through interaction with response elements in the intronic enhancer...
  44. doi request reprint Hepatitis C virus infection: molecular pathways to metabolic syndrome
    Muhammad Y Sheikh
    Division of Gastroenterology and Hepatology, University of California San Francisco Fresno Education Program, Community Regional Medical Center, Fresno, CA 93721, USA
    Hepatology 47:2127-33. 2008
    ..This chain of events may be initiated by HCV-associated IR and provides a direction for future research in the areas of therapeutic intervention...

Research Grants2

  1. MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE (NHP)
    Jacob Friedman; Fiscal Year: 2007
    ....
  2. CORE--METABOLIC
    Jacob Friedman; Fiscal Year: 2007
    ..This core provides a bridge between whole animal/human investigation and an array of molecular and cellular assays of key metabolic targets underlying insulin resistance, weight gain, and maternal-fetal metabolism. ..