Gregory K Friedman

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy
    Gregory K Friedman
    Brain Tumor Research Program, Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Oncol 3:28. 2013
  2. pmc Response to radiation in renal medullary carcinoma
    Alexandra M Walsh
    Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL
    Rare Tumors 3:e32. 2011
  3. pmc Targeting pediatric cancer stem cells with oncolytic virotherapy
    Gregory K Friedman
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Res 71:500-10. 2012
  4. ncbi Changing trends of research and treatment in infant neuroblastoma
    Gregory K Friedman
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 49:1060-5. 2007
  5. ncbi Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111
    Gregory K Friedman
    Brain Tumor Research Program, Department of Pediatrics, University of Alabama at Birmingham, 1046 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Neurooncol 95:199-209. 2009
  6. pmc Herpes simplex virus oncolytic therapy for pediatric malignancies
    Gregory K Friedman
    Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
    Mol Ther 17:1125-35. 2009
  7. ncbi Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors
    Michael L Megison
    Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 9:e86843. 2014
  8. pmc CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV
    Joseph G Pressey
    Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Blood Cancer 60:45-52. 2013
  9. pmc Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma
    Lauren A Gillory
    Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e77753. 2013
  10. ncbi Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
    Xiaosi Han
    Department of Neurology, The University of Alabama at Birmingham, FOT 1020, 1530 3rd Ave S, Birmingham, AL, 35294 3410, USA
    J Neurooncol 118:61-72. 2014

Collaborators

Detail Information

Publications13

  1. pmc Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy
    Gregory K Friedman
    Brain Tumor Research Program, Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Oncol 3:28. 2013
    ....
  2. pmc Response to radiation in renal medullary carcinoma
    Alexandra M Walsh
    Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL
    Rare Tumors 3:e32. 2011
    ....
  3. pmc Targeting pediatric cancer stem cells with oncolytic virotherapy
    Gregory K Friedman
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Res 71:500-10. 2012
    ..We highlight advantages and limitations of each virus and potential ways in which next-generation engineered viruses may target resilient CSCs...
  4. ncbi Changing trends of research and treatment in infant neuroblastoma
    Gregory K Friedman
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 49:1060-5. 2007
    ..Thus the categorization of children up to 18 months of age into risk category is critically dependent on biologic characterization and assignment to appropriate treatment intensity categories...
  5. ncbi Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111
    Gregory K Friedman
    Brain Tumor Research Program, Department of Pediatrics, University of Alabama at Birmingham, 1046 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Neurooncol 95:199-209. 2009
    ..However, virotherapy with HSV may be very effective against CD111+ GPC resistant to traditional therapies...
  6. pmc Herpes simplex virus oncolytic therapy for pediatric malignancies
    Gregory K Friedman
    Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
    Mol Ther 17:1125-35. 2009
    ....
  7. ncbi Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors
    Michael L Megison
    Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 9:e86843. 2014
    ..We concluded that M002 effectively targeted these rare aggressive tumor types and that M002 may have potential for use in children with unresponsive or relapsed pediatric solid tumors. ..
  8. pmc CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV
    Joseph G Pressey
    Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Blood Cancer 60:45-52. 2013
    ..Cancer stem cells or cancer-initiating cells (CIC) represent a theorized population of cells that give rise to tumors and are responsible for treatment resistance...
  9. pmc Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma
    Lauren A Gillory
    Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e77753. 2013
    ..We concluded that M002 effectively targeted neuroblastoma and that this oHSV may have potential for use in children with unresponsive or relapsed neuroblastoma. ..
  10. ncbi Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
    Xiaosi Han
    Department of Neurology, The University of Alabama at Birmingham, FOT 1020, 1530 3rd Ave S, Birmingham, AL, 35294 3410, USA
    J Neurooncol 118:61-72. 2014
    ..These findings indicate that PRMT5 is a marker of malignant progression in glioma tumors and plays a pivotal role in tumor growth. ..
  11. doi Treatment of children with glioblastoma with conformal radiation, temozolomide, and bevacizumab as adjuncts to surgical resection
    Gregory K Friedman
    Departments of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr Hematol Oncol 35:e123-6. 2013
    ..Two patients remain disease free at 38 and 49 months from diagnosis. One patient recurred 14 months off therapy and currently receives salvage therapy 48 months from diagnosis. These results support further investigation of this regimen...
  12. pmc Hypoxia Moderates γ(1)34.5-Deleted Herpes Simplex Virus Oncolytic Activity in Human Glioma Xenoline Primary Cultures
    Gregory K Friedman
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
    Transl Oncol 5:200-7. 2012
    ....
  13. ncbi The role of Src family kinases in growth and migration of glioma stem cells
    Xiaosi Han
    Division of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
    Int J Oncol 45:302-10. 2014
    ..These results suggest that SFKs represent an effective target for GSC migration but not for their growth...