Gregory K Friedman

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Targeting pediatric cancer stem cells with oncolytic virotherapy
    Gregory K Friedman
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Res 71:500-10. 2012
  2. ncbi request reprint Changing trends of research and treatment in infant neuroblastoma
    Gregory K Friedman
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 49:1060-5. 2007
  3. pmc Herpes simplex virus oncolytic therapy for pediatric malignancies
    Gregory K Friedman
    Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
    Mol Ther 17:1125-35. 2009
  4. doi request reprint Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111
    Gregory K Friedman
    Brain Tumor Research Program, Department of Pediatrics, University of Alabama at Birmingham, 1046 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Neurooncol 95:199-209. 2009
  5. pmc CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV
    Joseph G Pressey
    Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Blood Cancer 60:45-52. 2013
  6. pmc Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy
    Gregory K Friedman
    Brain Tumor Research Program, Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Oncol 3:28. 2013
  7. doi request reprint Treatment of children with glioblastoma with conformal radiation, temozolomide, and bevacizumab as adjuncts to surgical resection
    Gregory K Friedman
    Departments of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr Hematol Oncol 35:e123-6. 2013
  8. pmc Hypoxia Moderates γ(1)34.5-Deleted Herpes Simplex Virus Oncolytic Activity in Human Glioma Xenoline Primary Cultures
    Gregory K Friedman
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
    Transl Oncol 5:200-7. 2012

Detail Information

Publications8

  1. pmc Targeting pediatric cancer stem cells with oncolytic virotherapy
    Gregory K Friedman
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Res 71:500-10. 2012
    ..We highlight advantages and limitations of each virus and potential ways in which next-generation engineered viruses may target resilient CSCs...
  2. ncbi request reprint Changing trends of research and treatment in infant neuroblastoma
    Gregory K Friedman
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 49:1060-5. 2007
    ..Thus the categorization of children up to 18 months of age into risk category is critically dependent on biologic characterization and assignment to appropriate treatment intensity categories...
  3. pmc Herpes simplex virus oncolytic therapy for pediatric malignancies
    Gregory K Friedman
    Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
    Mol Ther 17:1125-35. 2009
    ....
  4. doi request reprint Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111
    Gregory K Friedman
    Brain Tumor Research Program, Department of Pediatrics, University of Alabama at Birmingham, 1046 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294 0006, USA
    J Neurooncol 95:199-209. 2009
    ..However, virotherapy with HSV may be very effective against CD111+ GPC resistant to traditional therapies...
  5. pmc CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV
    Joseph G Pressey
    Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Blood Cancer 60:45-52. 2013
    ..Cancer stem cells or cancer-initiating cells (CIC) represent a theorized population of cells that give rise to tumors and are responsible for treatment resistance...
  6. pmc Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy
    Gregory K Friedman
    Brain Tumor Research Program, Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Oncol 3:28. 2013
    ....
  7. doi request reprint Treatment of children with glioblastoma with conformal radiation, temozolomide, and bevacizumab as adjuncts to surgical resection
    Gregory K Friedman
    Departments of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr Hematol Oncol 35:e123-6. 2013
    ..Two patients remain disease free at 38 and 49 months from diagnosis. One patient recurred 14 months off therapy and currently receives salvage therapy 48 months from diagnosis. These results support further investigation of this regimen...
  8. pmc Hypoxia Moderates γ(1)34.5-Deleted Herpes Simplex Virus Oncolytic Activity in Human Glioma Xenoline Primary Cultures
    Gregory K Friedman
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
    Transl Oncol 5:200-7. 2012
    ....