Genomes and Genes
Edward S Friedman
Affiliation: University of Pittsburgh
- Using comparative effectiveness design to improve the generalizability of bipolar treatment trials data: contrasting LiTMUS baseline data with pre-existing placebo controlled trialsE S Friedman
University of Pittsburgh Medical Center, Pittsburgh, PA, USA Electronic address
J Affect Disord 152:97-104. 2014..The LiTMUS trial increased the representation of real-world individuals with bipolar disorder despite the acknowledgment that this compromises assay sensitivity...
- Baseline depression severity as a predictor of single and combination antidepressant treatment outcome: results from the CO-MED trialEdward S Friedman
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Eur Neuropsychopharmacol 22:183-99. 2012..03). These data may help us to understand the impact of baseline features on antidepressant medication effectiveness and to inform the personalization of depression treatment across the spectrum of depressive severity...
- Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trialEdward S Friedman
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 26:612-21. 2009..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention...
- Seasonal changes in clinical status in bipolar disorder: a prospective study in 1000 STEP-BD patientsE Friedman
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Acta Psychiatr Scand 113:510-7. 2006..To investigate seasonal and regional effects on bipolar I and II patients...
- Acceptability of second-step treatments to depressed outpatients: a STAR*D reportStephen R Wisniewski
Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Am J Psychiatry 164:753-60. 2007..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches...
- Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D reportMichael E Thase
Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
Am J Psychiatry 164:739-52. 2007..Cognitive therapy was compared with medication augmentation and switch strategies...
- Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patientsDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Psychiatr Serv 60:888-97. 2009..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
- Concordance between clinician and patient ratings as predictors of response, remission, and recurrence in major depressive disorderBoadie W Dunlop
Department of Psychiatry, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
J Psychiatr Res 45:96-103. 2011..Poor agreement between patient- and clinician-ratings of depression severity is primarily a state phenomenon, although it is trait-like for some patients...
- Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP TrialJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
Arch Gen Psychiatry 66:1178-88. 2009..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
- Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT StudyJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
J Clin Psychiatry 68:1014-23. 2007..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
- The Medication Recommendation Tracking Form: a novel tool for tracking changes in prescribed medication, clinical decision making, and use in comparative effectiveness researchNoreen A Reilly-Harrington
Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA Electronic address
J Psychiatr Res 47:1686-93. 2013..As the first tool in psychiatry to track the types and reasons for medication changes, it has important implications for training new clinicians and examining clinical decision making. (ClinicalTrials.gov number NCT00667745). ..
- Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D ReportRchard C Shelton
Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
CNS Spectr 14:487-98. 2009..Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear...
- Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and designAndrew A Nierenberg
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Trials 6:637-48. 2009..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
- Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristicsGreg J Siegle
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 69:913-24. 2012..Subgenual anterior cingulate activity, in particular, may reflect processes that interfere with treatment (eg, emotion generation) in addition to its putative regulatory role; alternately, its absence may facilitate treatment response...
- Early adverse events and attrition in selective serotonin reuptake inhibitor treatment: a suicide assessment methodology study reportDiane Warden
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychopharmacol 30:259-66. 2010..Neither global ratings nor specific adverse effects at week 2 were related to patient attrition during SSRI treatment. Other factors seem to contribute to patient decisions about continuing with treatment...
- Effects of sertraline on sleep architecture in patients with depressionRipu D Jindal
Department of Psychiatry, University of Pittsburgh School of Medicine WPIC, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Clin Psychopharmacol 23:540-8. 2003..Further studies are needed to examine the effects of SSRIs in acute treatment of depressed patients with severe insomnia, and the relationship of acute changes and relapse prevention of recurrent depression...
- Correlation between patient and clinician assessments of depression severity in the PREVENT studyBoadie W Dunlop
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
Psychiatry Res 177:177-83. 2010..This study analyzed agreement between commonly used depression rating scales in the Prevention of Recurrent Episodes of Depression with Venlafaxine Extended Release (ER) for Two Years (PREVENT) trial...
- Cognitive reactivity, dysfunctional attitudes, and depressive relapse and recurrence in cognitive therapy respondersRobin B Jarrett
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9149, USA
Behav Res Ther 50:280-6. 2012..While findings cannot be generalized beyond CT responders, they emphasize the clinical importance of reducing dysfunctional attitudes in preventing depression...
- Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlatesGreg J Siegle
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 69:726-33. 2011..This study examined 1) whether pretreatment assessment of pupillary responses to negative information were associated with remission in CT and 2) their associated brain mechanisms...
- Complexity of illness and adjunctive benzodiazepine use in outpatients with bipolar I or II disorder: results from the Bipolar CHOICE studyWilliam V Bobo
From the Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN Department of Psychiatry, The Massachusetts General Hospital, Boston, MA Department of Psychiatry and Behavioral Sciences and the Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH Department of Psychiatry, University of Alabama Birmingham School of Medicine, Birmingham, AL Lindner Center of HOPE, Mason, Ohio and Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH Department of Psychiatry and Depression Center, The University of Michigan, Ann Arbor, MI Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX Department of Psychiatry, University of New Mexico, Health Sciences Center, Albuquerque, NM Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA and Department of Psychiatry, Upstate Medical University, State University of New York, Department of Biological Sciences
J Clin Psychopharmacol 35:68-74. 2015..Demographic factors were also important determinants of benzodiazepine use, which may be related to access to care and insurance coverage for benzodiazepines. ..
- Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians StudyAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:382-90. 2009..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
- Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depressionMichael E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
J Clin Psychiatry 63:493-500. 2002..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
- Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
- C'mon get happy: reduced magnitude and duration of response during a positive-affect induction in depressionMichelle S Horner
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Depress Anxiety 31:952-60. 2014..Thus, we examined the time course of affect following exposure to positive stimuli in depressed and healthy individuals...
- Medical monitoring in patients with bipolar disorder: clinical recommendationsEdward S Friedman
Department of Psychiatry, University of Pittsburgh Medical Center and Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
J Clin Psychiatry 70:e27. 2009..Different health tests are needed depending on the type of medication the patient is prescribed...
- Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remissionRipu D Jindal
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 51:230-6. 2002..This study examines whether the observed differences in the sleep patterns during recurrent and single-episode depression persist into remission following nonpharmacologic treatment...
- Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile...
- Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer developmentM Koren-Michowitz
Department of Pediatric Hematology Oncology, Sheba Medical Center, Tel Hashomer, Israel
Am J Hematol 78:203-6. 2005..Coinheritance of FA and/or BS mutations seems to be more prevalent among BRCA mutation carriers, but a larger study encompassing more women may help in clarifying this issue...
- Population attributes affecting the prevalence of BRCA mutation carriers in epithelial ovarian cancer cases in israelG Hirsh-Yechezkel
Cancer Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
Gynecol Oncol 89:494-8. 2003..The objective was to evaluate the prevalence of BRCA1/2 mutations in selected categories of ovarian cancer patients in Israel...
- Codon 72 polymorphism of p53 in Israeli Jewish cervical cancer patients and healthy womenS Arbel-Alon
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel
Int J Gynecol Cancer 12:741-4. 2002..10.8%; P < 0.01). It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism..
- Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorderH Wang
Laboratory of Molecular Pharmacology, MCP Hahnemann School of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USA
Biol Psychiatry 50:364-70. 2001....
- Are Cognitive Therapy's Antidepressant Effects Durable?Edward Friedman; Fiscal Year: 2008..Dependent variables measure response, relapse, recurrence, remission, and recovery. Blind evaluations and survival analysis are planned. ..