Errol Friedberg

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Suffering in silence: the tolerance of DNA damage
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Nat Rev Mol Cell Biol 6:943-53. 2005
  2. ncbi request reprint The eureka enzyme: the discovery of DNA polymerase
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 79503 9072, USA
    Nat Rev Mol Cell Biol 7:143-7. 2006
  3. doi request reprint The molecular basis of mutagenesis - 40 years of research on genomic integrity
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    S Afr Med J 103:982-3. 2013
  4. ncbi request reprint The role of endogenous and exogenous DNA damage and mutagenesis
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Curr Opin Genet Dev 14:5-10. 2004
  5. ncbi request reprint Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage (Version 6)
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 3:1617-38. 2004
  6. ncbi request reprint Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 5:189-209. 2006
  7. ncbi request reprint Hot news: temperature-sensitive humans explain hereditary disease
    E C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Bioessays 23:671-3. 2001
  8. ncbi request reprint A brief history of the DNA repair field
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Cell Res 18:3-7. 2008
  9. ncbi request reprint New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mol Cell 26:162-4. 2007
  10. ncbi request reprint Error-prone DNA polymerases: novel structures and the benefits of infidelity
    E C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 107:9-12. 2001

Research Grants

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Suffering in silence: the tolerance of DNA damage
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Nat Rev Mol Cell Biol 6:943-53. 2005
    ..A second category of tolerance mechanism involves alternative replication strategies that obviate the need to replicate directly across sites of template-strand damage...
  2. ncbi request reprint The eureka enzyme: the discovery of DNA polymerase
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 79503 9072, USA
    Nat Rev Mol Cell Biol 7:143-7. 2006
    ..At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell...
  3. doi request reprint The molecular basis of mutagenesis - 40 years of research on genomic integrity
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    S Afr Med J 103:982-3. 2013
    ..This article reviews the multiple mechanisms by which both prokaryotes and eukaryotes remove or tolerate various types of naturally occurring and exogenously generated base damage in DNA.  ..
  4. ncbi request reprint The role of endogenous and exogenous DNA damage and mutagenesis
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Curr Opin Genet Dev 14:5-10. 2004
    ..This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation...
  5. ncbi request reprint Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage (Version 6)
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 3:1617-38. 2004
    ..We present Version 6 of a database of mouse mutant strains that affect biological responses to DNA damage. This database is also electronically available at http://pathcuric1.swmed.edu/research/research.htm...
  6. ncbi request reprint Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 5:189-209. 2006
    ..We present Version 7 of a database of mouse mutant strains that affect biological responses to DNA damage. This database is also electronically available at http://pathcuricl.swmed.edu/research/research.htm...
  7. ncbi request reprint Hot news: temperature-sensitive humans explain hereditary disease
    E C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Bioessays 23:671-3. 2001
    ..1) Specifically, several patients have been shown to carry a mutation in the XPD gene, which encodes a thermolabile form of XPD protein, resulting in loss of hair during febrile episodes...
  8. ncbi request reprint A brief history of the DNA repair field
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Cell Res 18:3-7. 2008
    ..Since then multiple DNA repair mechanisms, as well as other biological responses to DNA damage, have been discovered and their regulation has been studied. This article briefly recounts the early history of this field...
  9. ncbi request reprint New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mol Cell 26:162-4. 2007
    ..2007], this issue of Molecular Cell). This observation likely explains some of the clinical features of individuals with both defective DNA repair and development...
  10. ncbi request reprint Error-prone DNA polymerases: novel structures and the benefits of infidelity
    E C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 107:9-12. 2001
    ....
  11. ncbi request reprint How nucleotide excision repair protects against cancer
    E C Friedberg
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9072, USA
    Nat Rev Cancer 1:22-33. 2001
    ..How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?..
  12. ncbi request reprint Specialized DNA polymerases, cellular survival, and the genesis of mutations
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 296:1627-30. 2002
    ..The low fidelity of some of these specialized polymerases when copying undamaged DNA may be physiologically functional, including generating immunoglobulin diversity...
  13. ncbi request reprint Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage. Version 5
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 2:501-30. 2003
    ..Most of the mice listed in the database were generated by conventional targeted gene replacement technologies...
  14. doi request reprint Nucleotide excision repair of DNA: The very early history
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 10:668-72. 2011
    ..This article, taken largely from the book Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms, summarizes the very early history of the discovery of nucleotide excision repair...
  15. doi request reprint A comprehensive catalogue of somatic mutations in cancer genomes
    Errol C Friedberg
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390, USA
    DNA Repair (Amst) 9:468-9. 2010
    ..Among other observations the studies suggest the operation of novel DNA repair mechanisms or modes...
  16. ncbi request reprint REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 23:265-71. 2006
    ..In vivo studies in both chicken DT40 cells and yeast directly support the requirement of the BRCT domain of REV1 for cell survival and DNA damage-induced mutagenesis...
  17. pmc Celebrating 40 years of biochemistry in Europe
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genome Biol 5:344. 2004
  18. ncbi request reprint Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Biol Chem 283:4658-64. 2008
    ..However, the ubiquitin-binding motifs do not affect Polkappa half-life. Finally, we have examined levels of Polkappa expression following the exposure of mouse cells to benzo[a]pyrene-dihydrodiol epoxide or UVB radiation...
  19. ncbi request reprint Trading places: how do DNA polymerases switch during translesion DNA synthesis?
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 18:499-505. 2005
    ..This review addresses recent advances in our understanding of DNA polymerase switching during TLS in bacteria such as E. coli and in lower and higher eukaryotes...
  20. ncbi request reprint Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides
    Paula L Fischhaber
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Biol Chem 277:37604-11. 2002
    ..Our findings suggest a role for polkappa in both nonmutagenic and mutagenic bypass of oxidative damage...
  21. ncbi request reprint Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer
    Lisiane B Meira
    Laboratory of Molecular Pathology, Department of Pathology, Southwestern Medical Center, University of Texas, Dallas, TX 75235, USA
    DNA Repair (Amst) 1:929-34. 2002
    ....
  22. ncbi request reprint Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 2:639-52. 2003
  23. ncbi request reprint Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 22:150-2. 2006
    ..Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation...
  24. pmc Mapping of a single locus capable of complementing the defective heterochromatin phenotype of Roberts syndrome cells
    Lisa D McDaniel
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    Am J Hum Genet 77:132-9. 2005
    ..The results are consistent with the notion that the single gene defect responsible for heterochromatic splaying and developmental abnormalities maps to chromosome 8p21...
  25. ncbi request reprint How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?
    Paula L Fischhaber
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 4:279-83. 2005
    ..Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication...
  26. ncbi request reprint Maurice Wilkins (1916-2004)
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Cell 16:671-2. 2004
  27. ncbi request reprint DNA damage and repair
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072
    Nature 421:436-40. 2003
    ..Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution...
  28. ncbi request reprint TERF2-XPF: caught in the middle; beginnings from the end
    Lisa D McDaniel
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    DNA Repair (Amst) 5:868-72. 2006
    ..Here, we review these exciting findings that suggest new roles for the TERF2-XPF complex and point out several questions that remain to be addressed...
  29. doi request reprint Y-family DNA polymerases in mammalian cells
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Cell Mol Life Sci 66:2363-81. 2009
    ....
  30. ncbi request reprint The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75390 9072, USA
    DNA Repair (Amst) 3:183, 195. 2004
    ..This discovery by James Cleaver had an important impact on our understanding of nucleotide excision repair in mammals...
  31. ncbi request reprint DNA polymerases for translesion DNA synthesis: enzyme purification and mouse models for studying their function
    Paula L Fischhaber
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Methods Enzymol 408:355-78. 2006
    ..It also describes some of the methods employed in the evaluation of mouse strains defective in genes that encode these enzymes...
  32. ncbi request reprint Validation of XP-C pathogenic variations in archival material from a live XP patient
    Lisa D McDaniel
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 6:115-20. 2007
    ....
  33. pmc Polk mutant mice have a spontaneous mutator phenotype
    J Nicole Kosarek Stancel
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 8:1355-62. 2009
    ..These results are consistent with the notion that Pol kappa is required for accurate translesion DNA synthesis past naturally occurring polycyclic guanine adducts, possibly generated by cholesterol and/or its metabolites...
  34. ncbi request reprint The intersection between the birth of molecular biology and the discovery of DNA repair
    Errol C Friedberg
    Department of Pathology, Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 1:855-67. 2002
    ....
  35. ncbi request reprint Obituary: Arthur Kornberg (1918-2007)
    Errol C Friedberg
    University of Texas Southwestern Medical Center, Laboratory of Molecular Pathology, Department of Pathology, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 7:135. 2008
  36. ncbi request reprint Inroads into base excision repair II. The discovery of DNA glycosylases. "An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues," Proc. Nat. Acad. Sci. USA, 1974
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    DNA Repair (Amst) 3:1532-6; discussion 1531-2. 2004
    ..The discovery of a DNA glycosylase that specifically removes uracil from DNA, opened the door for uncovering a large class of such enzymes that are fundamental to the process of base excision repair of DNA...
  37. pmc Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mol Cell Biol 26:8892-900. 2006
    ..In cells exposed to UV radiation, the association of REV1 with replication foci is dependent on functional UBMs. The UBMs of REV1 are shown to contribute to DNA damage tolerance and damage-induced mutagenesis in vivo...
  38. ncbi request reprint A novel XPC pathogenic variant detected in archival material from a patient diagnosed with Xeroderma Pigmentosum: a case report and review of the genetic variants reported in XPC
    Amanda Rivera-Begeman
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 6:100-14. 2007
    ....
  39. pmc Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    EMBO J 22:6621-30. 2003
    ..Our observations suggest that Rev1 plays a role(s) in mediating protein-protein interactions among DNA polymerases required for TLS. The precise function(s) of these interactions during TLS remains to be determined...
  40. ncbi request reprint Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process
    Dorit Nahari
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 3:379-86. 2004
    ....
  41. ncbi request reprint The 3rd Japan-US DNA Repair Meeting, Sendai, Japan, May 7-11, 2007
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 6:1545-55. 2007
  42. ncbi request reprint TB or Not TB: how Mycobacterium tuberculosis may evade drug treatment
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 113:139-40. 2003
    ..This may be an important mechanism for generating drug-resistant strains of M. tuberculosis...
  43. ncbi request reprint DNA repair: from molecular mechanism to human disease
    Errol C Friedberg
    Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA
    DNA Repair (Amst) 5:986-96. 2006
  44. ncbi request reprint Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa
    Susana Velasco-Miguel
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 73590 9013, USA
    DNA Repair (Amst) 2:91-106. 2003
    ..The mouse (but not the human) Polkappa gene is primarily regulated by the p53 gene and is upregulated in response to exposure to various DNA-damaging agents in a p53-dependent manner...
  45. pmc Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts
    J Nicole Kosarek
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 7:439-51. 2008
    ..The results of this study suggest that special consideration should be exercised when making mechanistic extrapolations regarding translesion DNA synthesis from one eukaryotic system to another...
  46. ncbi request reprint Reminiscences of a long-time colleague and friend, Philip C. Hanawalt
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mutat Res 577:9-13. 2005
    ..Philip Hanawalt is a long time contributor to many areas of the DNA repair field. This article summarizes aspect of his relationship with the author over the past 36 years...
  47. ncbi request reprint Multiple PolK (POLK) transcripts in mammalian testis
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9072, USA
    DNA Repair (Amst) 4:397-402. 2005
    ..The multiple mouse/human (PolK/POLK) transcripts may encode multiple Polkappa isoforms in testis...
  48. pmc Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome
    Ingrid van der Pluijm
    Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Biol 5:e2. 2007
    ..Importantly, wild-type mice exposed to a low dose of chronic genotoxic stress recapitulated this response, thereby pointing to a novel link between genome instability and the age-related decline of the somatotroph axis...
  49. ncbi request reprint Mouse mutant database relevant to cellular responses to DNA damage
    Errol C Friedberg
    DNA Repair (Amst) 1:341. 2002
  50. ncbi request reprint The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line
    Laurent Miccoli
    Commissariat a l Energie Atomique, Laboratoire de Génétique de la Radiosensibilité, Institut de Radiobiologie Cellulaire et Moleculaire, Direction des Sciences du Vivant, Fontenay aux Roses, France
    Cancer Res 67:4695-9. 2007
    ....
  51. ncbi request reprint Mutagenesis in the spotlight
    Errol C Friedberg
    DNA Repair (Amst) 1:109. 2002
  52. ncbi request reprint Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer
    David L Cheo
    Life Technologies Division, Invitrogen Corporation, Rockville, MD, USA
    Methods Mol Med 74:481-91. 2003
  53. ncbi request reprint Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa
    Sharon Avkin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 279:53298-305. 2004
    ..These results indicate that BP-G is bypassed in mammalian cells with relatively high efficiency and that polkappa bypasses BP-G in vivo with higher efficiency and higher accuracy than other DNA polymerases...
  54. ncbi request reprint The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair
    Shirong Yu
    Department of Pathology, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    DNA Repair (Amst) 3:277-87. 2004
    ..We conclude that in yeast the molecular mechanism of NER includes the generation of superhelical torsion in DNA...
  55. ncbi request reprint Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair
    Julian J Raffoul
    Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, USA
    J Biol Chem 279:18425-33. 2004
    ....
  56. pmc Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice
    Maria Carolina N Marchetto
    Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Proc Natl Acad Sci U S A 101:17759-64. 2004
    ..Thus, efficient adenovirus gene delivery to the skin is a promising tool for reconstitution of specific DNA repair defects in XP patients...
  57. ncbi request reprint Reflections on the 8th international conference on environmental mutagens
    Bryn A Bridges
    Centre for Genome Damage and Stability, University of Sussex, Falmer, Brighton, BN1 9RR, UK
    DNA Repair (Amst) 1:169-74. 2002
  58. pmc Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis
    M Christine Hollander
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13200-5. 2005
    ..Coupled with cigarette carcinogens, decreased DNA repair would lead to additional mutations in genes such as p53 that are frequent targets in lung cancer...
  59. ncbi request reprint UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice
    Gijsbertus T J van der Horst
    Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, The Netherlands
    DNA Repair (Amst) 1:143-57. 2002
    ....
  60. ncbi request reprint Elevated mutation rates in the germline of Polkappa mutant male mice
    Karen L A Burr
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    DNA Repair (Amst) 5:860-2. 2006
    ..We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate...
  61. ncbi request reprint Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage
    Katsuya Takenaka
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 281:2000-4. 2006
    ..These data imply that Polkappa has a function in TLS past alkylated base adducts as well as UV radiation DNA damage in vertebrates...
  62. ncbi request reprint Identification of MMS19 domains with distinct functions in NER and transcription
    Melissa D Hatfield
    Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    DNA Repair (Amst) 5:914-24. 2006
    ..Furthermore, our work associates for the first time specific protein domains with MMS19's role in NER and transcription...
  63. ncbi request reprint How e-mail raises the spectre of a digital Dark Age
    Errol C Friedberg
    Nature 423:801. 2003
  64. ncbi request reprint A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions
    Alberto Inga
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, PO Box 12233, Research Triangle Park, North Carolina, NC 27709, USA
    Oncogene 21:5704-15. 2002
    ..Furthermore, the approach that we have taken also provides for the dissection of functions that may be retained in many p53 tumor alleles...
  65. ncbi request reprint DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
    Dominik Schenten
    Institute for Genetics, University of Cologne, Cologne, Germany
    Eur J Immunol 32:3152-60. 2002
    ..However, pol kappa-deficient embryonic fibroblasts are abnormally sensitive to killing following exposure to ultraviolet (UV) radiation, suggesting a role of pol kappa in translesion DNA synthesis...
  66. ncbi request reprint Report of the Working Group on Integrated Translational Research in DNA Repair
    Leslie Reinlib
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, U S Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    DNA Repair (Amst) 6:145-7. 2007
    ..This report summarizes the rationale for this initiative and the recommendations that emerged...
  67. ncbi request reprint DNA Repair-responses to DNA damage and other aspects of genomic stability. A new journal format
    Errol C Friedberg
    DNA Repair (Amst) 1:1-2. 2002
  68. ncbi request reprint Growth of a journal
    Errol C Friedberg
    DNA Repair (Amst) 4:1. 2005
  69. ncbi request reprint Happy 5th birthday, DNA Repair
    Errol C Friedberg
    DNA Repair (Amst) 6:271-3. 2007
  70. ncbi request reprint Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene
    Jeffrey K Wickliffe
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
    Chem Biol Interact 166:226-31. 2007
    ....

Research Grants28

  1. DNA REPAIR AND ITS RELATIONSHIP TO CARCINOGENESIS
    Errol Friedberg; Fiscal Year: 2001
    ..There is reason to believe that the proteins encoded by these genes operate in a different chromatin-modulating complex, and it is proposed to isolate and characterize this putative complex as well. ..
  2. DNA REPAIR AND CANCER PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 2002
    ....
  3. MOUSE MODELS OF DNA REPAIR - DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2007
    ....
  4. DNA REPAIR AND CANCER-PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 1993
    ....
  5. DNA REPAIR AND CANCER-PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 1992
    ....
  6. MOUSE MODELS OF DNA REPAIR - DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2011
    ..abstract_text> ..