Research Topics
| Nathaniel M FriedSummaryAffiliation: University of North Carolina at Charlotte Country: USA Publications
| Collaborators
|
Detail Information
Publications
Laser stimulation of the cavernous nerves in the rat prostate, in vivo: optimization of wavelength, pulse energy, and pulse repetition rateNathaniel M Fried
Department of Physics and Optical Science at the University of North Carolina at Charlotte, NC 28223, USA
Conf Proc IEEE Eng Med Biol Soc 2008:2777-80. 2008..Optical nerve stimulation may represent a potential intra-operative diagnostic technique for use in laparoscopic and robotic nerve-sparing prostate cancer surgery...- Noncontact stimulation of the cavernous nerves in the rat prostate using a tunable-wavelength thulium fiber laserNathaniel M Fried
Department of Physics and Optical Science, University of North Carolina at Charlotte, North Carolina 28223 0001, USA
J Endourol 22:409-13. 2008..This study explored laser stimulation of the rat cavernous nerves as a potential alternative to electrical nerve mapping during nerve-sparing radical prostatectomy... 
New laser treatment approaches for benign prostatic hyperplasiaNathaniel M Fried
Department of Physics and Optical Science, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223 0001, USA
Curr Urol Rep 8:47-52. 2007..This article reviews the latest developments in laser treatment of BPH over the past 2 years and provides a view toward the future of lasers in the treatment of BPH...- Imaging the cavernous nerves in the rat prostate using optical coherence tomographyNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Lasers Surg Med 39:36-41. 2007..The rat prostate serves as an excellent model for studying the use of OCT for imaging the CNs, as the rat CN is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation... - Optical coherence tomography of cavernous nerves: a step toward real-time intraoperative imaging during nerve-sparing radical prostatectomySoroush Rais-Bahrami
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Bethesda, Maryland 21287, USA
Urology 72:198-204. 2008..OCT is an imaging modality that allows for real-time, high-resolution, cross-sectional imaging of tissues... - Noninvasive thermal coagulation of deep subsurface tissue structures using a laser probe with integrated contact coolingChristopher M Cilip
Department of Physics and Optical Science, University of North Carolina at Charlotte, NC 28223, USA
Conf Proc IEEE Eng Med Biol Soc 2008:3657-60. 2008..Liver lesions of 5.8-mm-diameter were created, while preserving the tissue surface to a depth of 1.5 mm. In vivo animal studies are planned to optimize the laser and cooling parameters for potential clinical applications... - Side-firing germanium oxide optical fibers for use with erbium:YAG laserAnthony K Ngo
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland, USA
J Endourol 20:475-8. 2006..Sufficient pulse energies were transmitted through the side-firing fibers to produce contact tissue ablation... - Comparison of germanium oxide fibers with silica and sapphire fiber tips for transmission of erbium: YAG laser radiationTravis J Polletto
Department of Urology, Johns Hopkins University, Baltimore, Maryland 21224, USA
Lasers Surg Med 38:787-91. 2006.... - High-power thulium fiber laser ablation of urinary tissues at 1.94 micromNathaniel M Fried
Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
J Endourol 19:25-31. 2005..This paper describes the preliminary testing of a new laser, the thulium fiber laser, as a potential replacement for the holmium:YAG laser for multiple applications in urology... - Wavelet denoising during optical coherence tomography of the prostate nerves using the complex wavelet transformShahab Chitchian
Department of Physics and Optical Science, University of North Carolina at Charlotte, NC 28223, USA
Conf Proc IEEE Eng Med Biol Soc 2008:3016-9. 2008..Image quality metrics of the cavernous nerves and signal-to-noise ratio (SNR) were improved significantly using this complex wavelet denoising technique... 
Application of optical coherence tomography and high-frequency ultrasound imaging during noninvasive laser vasectomyChristopher M Cilip
University of North Carolina at Charlotte, Department of Physics and Optical Science, North Carolina 28223, USA
J Biomed Opt 17:046006. 2012..Both OCT and high HFUS are promising imaging modalities for real-time confirmation of vas occlusion during noninvasive laser vasectomy...- High-frequency ultrasound imaging of noninvasive laser coagulation of the canine vas deferensChristopher M Cilip
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Lasers Surg Med 43:838-42. 2011..In this study, high-frequency ultrasound is used to confirm successful laser thermal coagulation and scarring of the vas in a short-term canine model... - Denoising during optical coherence tomography of the prostate nerves via wavelet shrinkage using dual-tree complex wavelet transformShahab Chitchian
University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223, USA
J Biomed Opt 14:014031. 2009..The cavernous nerve and prostate gland can be separated from discontinuities due to noise, and image quality metrics improvements with a signal-to-noise ratio increase of 14 dB are attained... - Combined image-processing algorithms for improved optical coherence tomography of prostate nervesShahab Chitchian
University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223, USA
J Biomed Opt 15:046014. 2010.... - Erbium:YAG laser lithotripsy using hybrid germanium/silica optical fibersYubing Yang
Department of Urology, Johns Hopkins Medical School, JH Bayvuew Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
J Endourol 18:830-5. 2004..05). CONCLUSIONS: A prototype hybrid germanium/silica optical fiber demonstrated better performance than both germanium oxide and sapphire fibers for transmission of Er:YAG laser radiation during in vitro lithotripsy... - Application of an optical clearing agent during noninvasive laser coagulation of the canine vas deferensChristopher M Cilip
University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223, USA
J Biomed Opt 15:048001. 2010..This technique may result in use of a less expensive laser and eliminate the formation of scrotal skin burns during the procedure... - Noninvasive laser coagulation of the human vas deferens: optical and thermal simulationsGino R Schweinsberger
Department of Physics and Optical Science, University of North Carolina at Charlotte, North Carolina, USA
Lasers Surg Med 43:443-9. 2011..In this study, Monte Carlo (MC) simulations of light transport through tissue and heat transfer simulations are performed to determine the feasibility of noninvasive laser vasectomy in humans... - Subsurface tissue lesions created using an Nd:YAG laser and a sapphire contact cooling probeRahayu Ramli
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
Lasers Surg Med 35:392-6. 2004..In vivo animal studies are currently in development to optimize the laser and cooling parameters for potential clinical applications... - Holmium:YAG (lambda = 2,120 nm) versus thulium fiber (lambda = 1,908 nm) laser lithotripsyRichard L Blackmon
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223 000, USA
Lasers Surg Med 42:232-6. 2010..We hypothesize that this should translate into more efficient laser lithotripsy using the thulium fiber laser. This study directly compares stone vaporization rates for holmium and thulium fiber lasers... - Thulium fiber laser lithotripsy using tapered fibersRichard L Blackmon
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223 0001, USA
Lasers Surg Med 42:45-50. 2010..This study explores use of a short taper for expanding the Thulium fiber laser beam at the distal tip of a small-core fiber... - High-intensity focused ultrasound ablation of the epididymis in a canine model: a potential alternative to vasectomyWilliam W Roberts
Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Endourol 16:621-5. 2002..The epididymis may be a better target than the vas deferens because it is larger, more easily positioned in the HIFU focal zone, and more susceptible to occlusive injury at lower energy levels, thus reducing collateral damage... - Comparison of erbium:yttrium-aluminum-garnet and holmium:yttrium-aluminum-garnet lasers for incision of urethra and bladder neck in an in vivo porcine modelIoannis M Varkarakis
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 65:191-5. 2005..CONCLUSIONS: In this in vivo animal study, incisions in the urethra and bladder neck made with the Er:YAG laser healed faster and with less scar formation than incisions made with the Ho:YAG laser... - Enhanced thulium fiber laser lithotripsy using micro-pulse train modulationRichard L Blackmon
University of North Carolina at Charlotte, Department of Physics and Optical Science, 9201 University City Avenue, Charlotte, North Carolina 28223 0001, USA
J Biomed Opt 17:028002. 2012..TFL operation in MPT mode results in increased stone ablation rates which, with further optimization, may approach levels comparable to Ho:YAG laser lithotripsy in the clinic... - Continuous-wave laser stimulation of the rat prostate cavernous nerves using a compact and inexpensive all single mode optical fiber systemSerhat Tozburun
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
J Endourol 25:1727-31. 2011..This study demonstrates the feasibility of optical stimulation of the rat CN, in vivo, using a compact, inexpensive all-single-mode fiberoptic system... - Noninvasive laser vasectomy: preliminary ex vivo tissue studiesChristopher M Cilip
Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223 0001, USA
Lasers Surg Med 41:203-7. 2009..The development of a completely noninvasive vasectomy technique may eliminate these concerns... - Comparison of holmium:YAG and thulium fiber laser lithotripsy: ablation thresholds, ablation rates, and retropulsion effectsRichard L Blackmon
University of North Carolina at Charlotte, Department of Physics and Optical Science, 9201 University City Avenue, Charlotte, North Carolina 28223 0001, USA
J Biomed Opt 16:071403. 2011.... - High-power laser vaporization of the canine prostate using a 110 W Thulium fiber laser at 1.91 micromNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
Lasers Surg Med 36:52-6. 2005..This study describes the preliminary testing of a high-power Thulium fiber laser for vaporization of the canine prostate, ex vivo... - Continuous-wave infrared optical nerve stimulation for potential diagnostic applicationsSerhat Tozburun
University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223 0001, USA
J Biomed Opt 15:055012. 2010.... - Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgeryThomas C Hutchens
University of North Carolina at Charlotte, Department of Physics and Optical Science, Center for Optoelectronics and Optical Communications, Charlotte, North Carolina 28223, USA
J Biomed Opt 17:068004. 2012.... - Subsurface tissue lesions created using an Nd:YAG laser and cryogen coolingRahayu Ramli
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
J Endourol 17:923-6. 2003..Skin lesions measured 4.1 +/- 0.6 mm, while preserving the skin surface to a depth of 1.2 +/- 0.2 mm (N = 4). CONCLUSION: This technique may prove useful to target subsurface anatomic structures in urology... - Transmission of Q-switched erbium:YSGG (lambda=2.79 microm) and erbium:YAG (lambda=2.94 microm) laser radiation through germanium oxide and sapphire optical fibres at high pulse energiesNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, 4940 Eastern Avenue, Building A, Baltimore, Maryland, MD 21224, USA
Lasers Med Sci 19:155-60. 2004..This is the first report of germanium and sapphire fibre optic transmission of Q-switched erbium laser energies of 25-42 mJ per pulse... - Segmentation of optical coherence tomography images for differentiation of the cavernous nerves from the prostate glandShahab Chitchian
University of North Carolina at Charlotte, Department of Physics and Optical Science, 9201 University City Boulevard, Charlotte, North Carolina 28223, USA
J Biomed Opt 14:044033. 2009..058+/-0.019. This algorithm may be useful for implementation in clinical endoscopic OCT systems currently being studied for potential intraoperative diagnostic use in laparoscopic and robotic nerve-sparing prostate cancer surgery... - Selective laser suture lysis with a compact, low-cost, red diode laserPetr Shein
Department of Physics and Optical Science at the University of North Carolina at Charlotte, NC 28223, USA
Conf Proc IEEE Eng Med Biol Soc 2008:4358-60. 2008..The red diode laser may represent an inexpensive, compact, and safer alternative laser for use in laser suture lysis during ophthalmic surgery... - Fiber-optic manipulation of urinary stone phantoms using holmium:YAG and thulium fiber lasersRichard L Blackmon
University of North Carolina at Charlotte, Department of Physics and Optical Science, 9201 University City Avenue, Charlotte, NC 28223 0001, USA
J Biomed Opt 18:28001. 2013..With further development, this novel technique may be useful for manipulating stone fragments in the urinary tract... - Detachable fiber optic tips for use in thulium fiber laser lithotripsyThomas C Hutchens
Optical Science and Engineering Program, University of North Carolina, Charlotte, North Carolina, USA
J Biomed Opt 18:038001. 2013..The 1-mm outer-diameter prototype also functioned comparable to previously tested tapered fiber tips... - Subsurface near-infrared laser stimulation of the periprostatic cavernous nervesSerhat Tozburun
Dept of Physics and Optical Science, University of North Carolina at Charlotte, NC, USA
J Biophotonics 5:793-800. 2012.... - Selective laser vaporization of polypropylene mesh used in treatment of female stress urinary incontinence and pelvic organ prolapse: preliminary studies using a red diode laserDavid Burks
Deparment of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Lasers Surg Med 44:325-9. 2012..This study explores selective laser vaporization of polypropylene suture/mesh materials commonly used in SUI and POP... - Optimization of the Erbium:YAG laser for precise incision of ureteral and urethral tissues: in vitro and in vivo resultsNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Lasers Surg Med 33:108-14. 2003..The Erbium:YAG laser ablates soft tissues with minimal peripheral damage and may be a promising alternative to cold knife and Holmium:YAG laser for precise incision of urological strictures... - Thulium fiber laser lithotripsy: an in vitro analysis of stone fragmentation using a modulated 110-watt Thulium fiber laser at 1.94 micromNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, Hopkins Bayview Medical Center, 4940 Eastern Avenue, Bldg A, Baltimore, MD 21224, USA
Lasers Surg Med 37:53-8. 2005..g., prostate). This is the first preliminary study of a high-power Thulium fiber laser for fragmentation of urinary stones... - Hybrid germanium/silica optical fibers for endoscopic delivery of erbium:YAG laser radiationCharles A Chaney
Biophotonics Laboratory, Department of Urology, Johns Hopkins Medical School, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Lasers Surg Med 34:5-11. 2004..However, significant improvement in the hybrid fibers will be necessary before they can be used for efficient Er:YAG laser lithotripsy... - Therapeutic applications of lasers in urology: an updateNathaniel M Fried
Johns Hopkins University School of Medicine, James Buchanan Brady Urological Institute, Biophotonics Laboratory, Baltimore, MD 21224, USA
Expert Rev Med Devices 3:81-94. 2006..This review provides an update on the most important new clinical and experimental therapeutic applications of lasers in urology over the past 5 years... - Focused ultrasound ablation of the epididymis with use of thermal measurements in a canine modelNathaniel M Fried
Department of Urology, Johns Hopkins Medical School, Baltimore, Maryland 21224, USA
Fertil Steril 78:609-13. 2002..To explore the epididymis as an alternative anatomical target to the vas deferens for noninvasive male sterilization using therapeutic focused ultrasound...