L F Fried

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
  2. ncbi request reprint Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
    Linda F Fried
    Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
    J Am Coll Cardiol 41:1364-72. 2003
  3. ncbi request reprint Effect of lipid reduction on the progression of renal disease: a meta-analysis
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 59:260-9. 2001
  4. ncbi request reprint Lipid modulation in insulin-dependent diabetes mellitus: effect on microvascular outcomes
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, 938 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    J Diabetes Complications 15:113-9. 2001
  5. ncbi request reprint Comparison of the Charlson Comorbidity Index and the Davies score as a predictor of outcomes in PD patients
    Linda Fried
    Renal Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    Perit Dial Int 23:568-73. 2003
  6. ncbi request reprint Duodenal obstruction in polycystic kidney disease. Case report and review of the literature
    L F Fried
    Department of Medicine, University of Pittsburgh School of Medicine, Veterans Affairs Medical Center, PA, USA
    Am J Nephrol 18:318-20. 1998
  7. ncbi request reprint Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
  8. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006
  9. ncbi request reprint Cystatin C and subclinical brain infarction
    Stephen L Seliger
    Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
    J Am Soc Nephrol 16:3721-7. 2005
  10. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008

Detail Information

Publications41

  1. ncbi request reprint Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  2. ncbi request reprint Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
    Linda F Fried
    Renal Section, VA Pittsburgh Healthcare System, Pennsylvania 15240, USA
    J Am Coll Cardiol 41:1364-72. 2003
    ..This study was designed to evaluate the relationship between elevated creatinine levels and cardiovascular events...
  3. ncbi request reprint Effect of lipid reduction on the progression of renal disease: a meta-analysis
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 59:260-9. 2001
    ..We examined the effects of antilipemic agents on glomerular filtration rate and proteinuria or albuminuria in patients with renal disease...
  4. ncbi request reprint Lipid modulation in insulin-dependent diabetes mellitus: effect on microvascular outcomes
    L F Fried
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, 938 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    J Diabetes Complications 15:113-9. 2001
    ..In conclusion, treatment with simvastatin may have a beneficial effect on early nephropathy and diabetic neuropathy, justifying a fully powered trial. However, this would be difficult under current treatment guidelines...
  5. ncbi request reprint Comparison of the Charlson Comorbidity Index and the Davies score as a predictor of outcomes in PD patients
    Linda Fried
    Renal Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    Perit Dial Int 23:568-73. 2003
    ..Previous studies have shown that the Charlson Comorbidity Index (CCI) and the Davies score predict mortality in peritoneal dialysis (PD) patients. However, there are few data on the comparison of comorbidity scores...
  6. ncbi request reprint Duodenal obstruction in polycystic kidney disease. Case report and review of the literature
    L F Fried
    Department of Medicine, University of Pittsburgh School of Medicine, Veterans Affairs Medical Center, PA, USA
    Am J Nephrol 18:318-20. 1998
    ..Duodenal obstruction should be considered in the differential diagnosis of a patient with polycystic kidney disease and intermittent or persistent nausea and vomiting...
  7. ncbi request reprint Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
    ..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
  8. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006
    ..73 m2)...
  9. ncbi request reprint Cystatin C and subclinical brain infarction
    Stephen L Seliger
    Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
    J Am Soc Nephrol 16:3721-7. 2005
    ..Compared with creatinine, CysC, a novel marker of renal function, has a stronger and more direct association with SBI in the elderly...
  10. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008
    ..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
  11. ncbi request reprint Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study
    Rajat Deo
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 155:62-8. 2008
    ..We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events...
  12. ncbi request reprint Cystatin-C and mortality in elderly persons with heart failure
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, 4150 Clement Street, University of California San Francisco, San Francisco, CA 94121, USA
    J Am Coll Cardiol 45:268-71. 2005
    ..We sought to evaluate cystatin-C, a novel measure of renal function, as a predictor of mortality in elderly persons with heart failure (HF) and to compare it with creatinine...
  13. pmc A physiologic index of comorbidity: relationship to mortality and disability
    Anne B Newman
    Center for Aging and Population Health, University of Pittsburgh, Graduate School of Public Health, 130 N Bellefield Ave Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 63:603-9. 2008
    ..We developed a simple physiologic index of comorbidity by scoring five noninvasive tests across the full range of values. We examined the predictive validity of this index for mortality and disability...
  14. ncbi request reprint Individual and neighborhood socioeconomic status and progressive chronic kidney disease in an elderly population: The Cardiovascular Health Study
    Sharon Stein Merkin
    Johns Hopkins Bloomberg School of Public Health, The Welch Center for Prevention, Epidemiology and Clinical Research, Blatimore, MD 21205, USA
    Soc Sci Med 65:809-21. 2007
    ..As such, living in a low SES area is associated with greater risk of pCKD in an elderly US population...
  15. pmc Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    BMC Nephrol 9:9. 2008
    ..Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort...
  16. ncbi request reprint Associations of race with depression and symptoms in patients on maintenance haemodialysis
    Steven D Weisbord
    VA Pittsburgh Healthcare System, Mailstop 111F U, Pittsburgh, PA 15240, USA
    Nephrol Dial Transplant 22:203-8. 2007
    ..The aim of this study was to compare these domains between African American and White patients on chronic haemodialysis...
  17. ncbi request reprint Cystatin C and measures of physical function in elderly adults: the Health, Aging, and Body Composition (HABC) Study
    Michelle C Odden
    General Internal Medicine Section, San Francisco VA Medical Center, Department of Nephrology, University of California, San Francisco, CA 94121, USA
    Am J Epidemiol 164:1180-9. 2006
    ..73 m2. In these older adults, mild decrements in kidney function, as measured by cystatin C concentration, were associated with poorer physical function...
  18. ncbi request reprint Association of kidney function with incident hip fracture in older adults
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Am Soc Nephrol 18:282-6. 2007
    ..Further studies are needed to evaluate potential mediators of this relationship and to assess whether interventions can decrease this risk...
  19. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
    ..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated...
  20. pmc Cardiovascular risk factors and incident acute renal failure in older adults: the cardiovascular health study
    Anuja Mittalhenkle
    Division of Nephrology and Hypertension, Department of Medicine, Mail Code MQ360, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Clin J Am Soc Nephrol 3:450-6. 2008
    ..Although the elderly are at increased risk for acute renal failure, few prospective studies have identified risk factors for acute renal failure in the elderly...
  21. ncbi request reprint Kidney function, electrocardiographic findings, and cardiovascular events among older adults
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Clin J Am Soc Nephrol 2:501-8. 2007
    ..Associations seemed stronger for participants with CKD; however, no significant interactions were detected. Resting electrocardiographic abnormalities are common in CKD and independently predict future clinical CV events in this setting...
  22. pmc Cystatin C and aging success
    Mark J Sarnak
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Arch Intern Med 168:147-53. 2008
    ..To our knowledge, the effect of kidney function on successful aging has not been examined...
  23. ncbi request reprint Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition study
    Linda F Fried
    Renal Section, Veterans Affairs Pittsburgh Healthcare System Pittsburgh, Pennsylvania 15240, USA
    J Am Geriatr Soc 55:1578-84. 2007
    ..To assess the association between kidney function and change in body composition in older individuals...
  24. pmc Associations of race and ethnicity with anemia management among patients initiating renal replacement therapy
    Steven D Weisbord
    Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Mailstop 111F U, 7E Room 120, Pittsburgh, PA 15240, USA
    J Natl Med Assoc 99:1218-26. 2007
    ..The factors contributing to this remain largely unknown. The aim of this study was to assess the associations of race and ethnicity with anemia care prior to the initiation of renal replacement therapy...
  25. ncbi request reprint Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Gerontol A Biol Sci Med Sci 61:743-8. 2006
    ....
  26. ncbi request reprint Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
    Arch Intern Med 166:1396-402. 2006
    ..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites...
  27. ncbi request reprint Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
    Michael G Shlipak
    Department of Medicine, University of California, San Francisco, and the Veterans Affairs Medical Center, San Francisco 94121, USA
    Circulation 107:87-92. 2003
    ..Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease...
  28. ncbi request reprint Development of a symptom assessment instrument for chronic hemodialysis patients: the Dialysis Symptom Index
    Steven D Weisbord
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Medical Center, A919 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Pain Symptom Manage 27:226-40. 2004
    ..Overall kappa statistic was 0.48+/-0.22. These steps allowed the systematic development of a 30-item symptom assessment index for hemodialysis patients. Additional reliability and validity testing is needed prior to its widespread use...
  29. ncbi request reprint Chronic renal insufficiency and cardiovascular events in the elderly: findings from the Cardiovascular Health Study
    Michael G Shlipak
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Am J Geriatr Cardiol 13:81-90. 2004
    ..The identification of CRI in the elderly and the use of cardiovascular prevention therapies represent a major opportunity to reduce their burden of cardiovascular morbidity...
  30. ncbi request reprint The presence of frailty in elderly persons with chronic renal insufficiency
    Michael G Shlipak
    Epidemiology and Biostatistics, University of California, San Francisco, General Internal Medicine Section, Medical Service, San Francisco Veterans Affairs Medical Center San Francisco, CA 94121, USA
    Am J Kidney Dis 43:861-7. 2004
    ..We hypothesized that chronic renal insufficiency (CRI) would be associated with a greater prevalence of frailty and disability in the elderly...
  31. ncbi request reprint Bleeding complications associated with peritoneal dialysis catheter insertion
    Sangeeta Mital
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Perit Dial Int 24:478-80. 2004
    ..To identify the incidence of bleeding complications associated with peritoneal dialysis catheter insertion...
  32. ncbi request reprint Cystatin C concentration as a risk factor for heart failure in older adults
    Mark J Sarnak
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 142:497-505. 2005
    ..Previous studies that evaluated the association of kidney function with incident heart failure may be limited by the insensitivity of serum creatinine concentration for detecting abnormal kidney function...
  33. ncbi request reprint Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco 94121, USA
    JAMA 293:1737-45. 2005
    ..Elderly persons with chronic kidney disease have substantial risk for cardiovascular mortality, but the relative importance of traditional and novel risk factors is unknown...
  34. ncbi request reprint Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study
    Manjula Kurella
    Division of Nephrology, University of California San Francisco, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
    J Am Soc Nephrol 16:2127-33. 2005
    ..Studies aimed at understanding the mechanism(s) responsible for cognitive impairment in CKD and efforts to interrupt this decline are warranted...
  35. ncbi request reprint Prevalence, severity, and importance of physical and emotional symptoms in chronic hemodialysis patients
    Steven D Weisbord
    Center for Health Equity Research and Promotion and Renal Section, VA Pittsburgh Healthcare System, Renal Section 7E, Room 120, Mailstop 111F U, Pittsburgh, PA 15240, USA
    J Am Soc Nephrol 16:2487-94. 2005
    ..Incorporating a standard assessment of symptoms into the care provided to maintenance hemodialysis patients may provide a means to improve quality of life in this patient population...
  36. ncbi request reprint Associations between retinal microvascular abnormalities and declining renal function in the elderly population: the Cardiovascular Health Study
    Matthew S Edwards
    Department of Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Kidney Dis 46:214-24. 2005
    ..We hypothesized that retinal microvascular abnormalities, when present, would be associated with progressive renal dysfunction in elderly individuals...
  37. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  38. ncbi request reprint Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, and General Internal Medicine Section, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Faancisco, CA 94121, USA
    Arch Intern Med 165:2666-70. 2005
    ..The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined...
  39. ncbi request reprint Chronic kidney disease and functional limitation in older people: health, aging and body composition study
    Linda F Fried
    Department of Veterans Affairs Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
    J Am Geriatr Soc 54:750-6. 2006
    ..To assess whether chronic kidney disease (CKD) is independently associated with incident physical-function limitation...
  40. ncbi request reprint Statins for improving renal outcomes: a meta-analysis
    Sabrina Sandhu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2006-16. 2006
    ..17 to 0.98). Statin therapy seems to reduce proteinuria modestly and results in a small reduction in the rate of kidney function loss, especially in populations with cardiovascular disease...
  41. ncbi request reprint Cardiovascular disease risk status in elderly persons with renal insufficiency
    Michael G Shlipak
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    Kidney Int 62:997-1004. 2002
    ..We determined the prevalence of elevated cardiovascular disease risk status among elderly persons with renal insufficiency...