Itzhak Fried

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Human hippocampal theta activity during virtual navigation
    Arne D Ekstrom
    Division of Brain Mapping and Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, 90095, USA
    Hippocampus 15:881-9. 2005
  2. pmc Internally generated preactivation of single neurons in human medial frontal cortex predicts volition
    Itzhak Fried
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 69:548-62. 2011
  3. ncbi request reprint Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note
    I Fried
    Department of Psychiatry, University of California at Los Angeles School of Medicine, 90095 7039, USA
    J Neurosurg 91:697-705. 1999
  4. ncbi request reprint Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects
    Itzhak Fried
    Division of Neurosurgery, UCLA School of Medicine, 90095 7039, USA
    Cereb Cortex 12:575-84. 2002
  5. doi request reprint Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    JAMA 307:922-30. 2012
  6. ncbi request reprint Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients
    Richard J Staba
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 48:2130-8. 2007
  7. ncbi request reprint Single neuron burst firing in the human hippocampus during sleep
    Richard J Staba
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Hippocampus 12:724-34. 2002
  8. pmc Sleep spindles in humans: insights from intracranial EEG and unit recordings
    Thomas Andrillon
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 31:17821-34. 2011
  9. ncbi request reprint Analysis of seizure onset on the basis of wideband EEG recordings
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 46:59-63. 2005
  10. pmc Memory enhancement and deep-brain stimulation of the entorhinal area
    Nanthia Suthana
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 7039, USA
    N Engl J Med 366:502-10. 2012

Detail Information

Publications65

  1. ncbi request reprint Human hippocampal theta activity during virtual navigation
    Arne D Ekstrom
    Division of Brain Mapping and Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, 90095, USA
    Hippocampus 15:881-9. 2005
    ..Our findings demonstrate the existence of movement-related theta oscillations in human hippocampus, and suggest that both cortical and hippocampal oscillations play a role in attention and sensorimotor integration...
  2. pmc Internally generated preactivation of single neurons in human medial frontal cortex predicts volition
    Itzhak Fried
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 69:548-62. 2011
    ..We implement a computational model whereby volition emerges once a change in internally generated firing rate of neuronal assemblies crosses a threshold...
  3. ncbi request reprint Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note
    I Fried
    Department of Psychiatry, University of California at Los Angeles School of Medicine, 90095 7039, USA
    J Neurosurg 91:697-705. 1999
    ..The technique described here could be used in developing novel approaches for evaluation and treatment in a variety of neurological conditions such as head injury, subarachnoid hemorrhage, epilepsy, and movement disorders...
  4. ncbi request reprint Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects
    Itzhak Fried
    Division of Neurosurgery, UCLA School of Medicine, 90095 7039, USA
    Cereb Cortex 12:575-84. 2002
    ..These findings suggest that a large population of cells with inhibitory responses is engaged in the hippocampal memory network, but primarily cells with excitatory responses process feature-specific information...
  5. doi request reprint Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    JAMA 307:922-30. 2012
    ..Despite reported success, surgery for pharmacoresistant seizures is often seen as a last resort. Patients are typically referred for surgery after 20 years of seizures, often too late to avoid significant disability and premature death...
  6. ncbi request reprint Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients
    Richard J Staba
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 48:2130-8. 2007
    ..To determine whether hippocampal sclerosis might form an anatomical substrate for pathological high-frequency oscillations in patients with temporal lobe epilepsy (TLE)...
  7. ncbi request reprint Single neuron burst firing in the human hippocampus during sleep
    Richard J Staba
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Hippocampus 12:724-34. 2002
    ....
  8. pmc Sleep spindles in humans: insights from intracranial EEG and unit recordings
    Thomas Andrillon
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 31:17821-34. 2011
    ..Overall, anatomical considerations can account well for regional spindle characteristics, while variable hyperpolarization levels can explain differences in spindle frequency...
  9. ncbi request reprint Analysis of seizure onset on the basis of wideband EEG recordings
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 46:59-63. 2005
    ..The absence of phase reversal of the initial slow wave in white matter or at the border of deep temporal areas indicates a possible nonneuronal mechanism of generation...
  10. pmc Memory enhancement and deep-brain stimulation of the entorhinal area
    Nanthia Suthana
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 7039, USA
    N Engl J Med 366:502-10. 2012
    ..We tested the hypothesis that deep-brain stimulation of the hippocampus or entorhinal cortex alters memory performance...
  11. ncbi request reprint High-frequency oscillations recorded in human medial temporal lobe during sleep
    Richard J Staba
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Neurol 56:108-15. 2004
    ....
  12. pmc Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus
    Jennifer A Ogren
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7169, USA
    Ann Neurol 66:783-91. 2009
    ..It is hypothesized that morphological changes associated with hippocampal atrophy (HA) contribute to the generation of FR, yet there is limited evidence that hippocampal FR-generating sites correspond with local areas of atrophy...
  13. pmc Correlation between BOLD fMRI and theta-band local field potentials in the human hippocampal area
    Arne Ekstrom
    Center for Cognitive Neuroscience, Semel Institute, Department of Psychiatry, University of California, Davis, 1544 Newton Ct, Davis, CA 95618, USA
    J Neurophysiol 101:2668-78. 2009
    ..Together, our results suggest that the BOLD signal in the human hippocampal area has a more heterogenous relationship with underlying neural activity than has been described previously in other brain regions...
  14. doi request reprint Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes
    Kristen Upchurch
    Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Seizure 19:120-8. 2010
    ..On the basis of these postoperative seizure control results, we recommend consideration of concurrent resection of mesial temporal structures with EL for certain temporal CM...
  15. ncbi request reprint Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study
    Jamie M Zeitzer
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Sleep 29:455-61. 2006
    ..To examine the pattern of extracellular adenosine in the human brain during sleep deprivation, sleep, and normal wake...
  16. pmc Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction
    Ashley M Blouin
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Commun 4:1547. 2013
    ..Levels of these two peptides in humans are not simply linked to arousal, but rather to specific emotions and state transitions. Other arousal systems may be similarly emotionally specialized...
  17. pmc Single-neuron responses in humans during execution and observation of actions
    Roy Mukamel
    Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 20:750-6. 2010
    ..These findings suggest that multiple systems in humans may be endowed with neural mechanisms of mirroring for both the integration and differentiation of perceptual and motor aspects of actions performed by self and others...
  18. pmc Human medial temporal lobe neurons respond preferentially to personally relevant images
    Indre V Viskontas
    Department of Psychology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:21329-34. 2009
    ....
  19. ncbi request reprint Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex
    Richard J Staba
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurophysiol 88:1743-52. 2002
    ..The strong association between FR and regions of seizure initiation supports the view that FR reflects pathological hypersynchronous events crucially associated with seizure genesis...
  20. pmc Contrasting roles of neural firing rate and local field potentials in human memory
    Arne Ekstrom
    Department of Psychiatry and Biobehavioral Sciences, Center for Cognitive Neurosciences, Semel Institute, UCLA School of Medicine, Los Angeles, California, USA
    Hippocampus 17:606-17. 2007
    ..Our findings suggest that neuronal firing and ensemble activity can be dissociated during encoding, item-maintenance, and retrieval in the human hippocampal area, likely relating to functional properties unique to this region...
  21. pmc High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy
    Arne Ekstrom
    Center for Cognitive Neurosciences, Semel Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095 7039, USA
    J Neurosurg 108:812-5. 2008
    ..Such methods may be extended to therapeutic procedures targeting specific neuronal circuitry in subfields of structures deep in the human brain...
  22. ncbi request reprint Characterizing interneuron and pyramidal cells in the human medial temporal lobe in vivo using extracellular recordings
    Indre V Viskontas
    Department of Psychology, University of California, Los Angeles, California 90095 7039, USA
    Hippocampus 17:49-57. 2007
    ....
  23. pmc Coding of information in the phase of local field potentials within human medial temporal lobe
    Beth A Lopour
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Neuron 79:594-606. 2013
    ..These findings highlight the importance of phase coding in human medial temporal lobe and suggest that different brain regions may represent information in diverse ways...
  24. doi request reprint Percepts to recollections: insights from single neuron recordings in the human brain
    Nanthia Suthana
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Trends Cogn Sci 16:427-36. 2012
    ..Representation of information by these neurons is highly explicit, suggesting abstraction of information for future conscious recall...
  25. pmc Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone
    Richard J Staba
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Epilepsia 53:25-34. 2012
    ..We hypothesized that gray matter (GM) loss could have important effects on neuronal firing, and quantifying these effects would reveal significant differences in neuronal firing inside versus outside the SOZ...
  26. pmc Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy
    Jerome Engel
    Department of Neurology, UCLA, Los Angeles, California 90095 1769, USA
    Epilepsia 51:1978-86. 2010
    ..ERSET was designed to assess the safety and efficacy of early surgical intervention compared to continued pharmacotherapy...
  27. ncbi request reprint Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex
    Anatol Bragin
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Ann Neurol 52:407-15. 2002
    ....
  28. pmc Improved P300 speller performance using electrocorticography, spectral features, and natural language processing
    William Speier
    Department of Bioengineering, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Clin Neurophysiol 124:1321-8. 2013
    ..This study was designed to explore the potential improvement from using electrocorticography (ECoG) compared to the more traditional usage of electroencephalography (EEG)...
  29. pmc Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex
    Roy Mukamel
    Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles UCLA, 660 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Hum Brain Mapp 32:1181-93. 2011
    ....
  30. pmc Encoding of speed and direction of movement in the human supplementary motor area
    Ariel Tankus
    Department of Neurosurgery, University of California, Los Angeles, California, USA
    J Neurosurg 110:1304-16. 2009
    ..This is a study of single-neuron activity during a continuous volitional motor task, with the goal of clarifying these relationships for SMA neurons and other frontal lobe regions in humans...
  31. doi request reprint Human intracranial recordings and cognitive neuroscience
    Roy Mukamel
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 90095, USA
    Annu Rev Psychol 63:511-37. 2012
    ..In the current review we discuss the unique contribution of invasive recordings from patients to the field of cognitive neuroscience...
  32. pmc An automatic measure for classifying clusters of suspected spikes into single cells versus multiunits
    Ariel Tankus
    Department of Neurosurgery, University of California, Los Angeles, 90095, USA
    J Neural Eng 6:056001. 2009
    ..The proposed algorithm is suitable for real-time operation and as such may allow brain-computer interfaces to treat single cells differently than multiunits...
  33. doi request reprint Behavioral correlates of human hippocampal delta and theta oscillations during navigation
    Andrew J Watrous
    Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95618, USA
    J Neurophysiol 105:1747-55. 2011
    ..These results extend previous findings in nonhuman mammals and humans, expanding our knowledge of the role of human hippocampal low-frequency oscillations in navigation...
  34. ncbi request reprint Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum
    Richard J Staba
    Department of Neurobiology, David Greffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:5694-704. 2002
    ....
  35. pmc Regional slow waves and spindles in human sleep
    Yuval Nir
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 70:153-69. 2011
    ..Thus, intracerebral communication during sleep is constrained because slow and spindle oscillations often occur out-of-phase in different brain regions...
  36. ncbi request reprint Regional analyses of CNS microdialysate glucose and lactate in seizure patients
    Eain M Cornford
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Epilepsia 43:1360-71. 2002
    ..To correlate glucose (and lactate) results obtained from microdialysate to recent studies suggesting that glucose transporter activity may be significantly altered in seizures...
  37. doi request reprint Structured neuronal encoding and decoding of human speech features
    Ariel Tankus
    Department of Neurosurgery, David Geffen School of Medicine, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    Nat Commun 3:1015. 2012
    ..This structured encoding enables accurate decoding of volitional speech segments and could be applied in the development of brain-machine interfaces for restoring speech in paralysed individuals...
  38. ncbi request reprint Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus
    Lara M Schrader
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Room 1 194, Los Angeles, CA 90095, USA
    Clin Neurophysiol 117:781-8. 2006
    ..We delivered low frequency stimulation through subdural electrodes to suppress seizures in a case of refractory status epilepticus (RSE)...
  39. ncbi request reprint Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience
    Jason T Lerner
    Department of Pediatric Neurology, University of California, Los Angeles, California, USA
    Epilepsia 50:1310-35. 2009
    ..The authors discuss future challenges to identifying and treating medically refractory epilepsy patients with cortical dysplasia...
  40. ncbi request reprint Single-neuron activity in the human supplementary motor area underlying preparation for action
    Nelly Amador
    Division of Neurosurgery, David Geffen School of Medicine, Neuropsychiatric Institute, University of California at Los Angeles, California 90095 7039, USA
    J Neurosurg 100:250-9. 2004
    ....
  41. ncbi request reprint Sparse decoding of multiple spike trains for brain-machine interfaces
    Ariel Tankus
    Technion Israel Institute of Technology, Haifa 32000, Israel
    J Neural Eng 9:054001. 2012
    ..The parameter estimation algorithm is orders of magnitude faster than existing methods and achieves significantly higher accuracies for both simulations and human data, rendering sparse decoding highly attractive for BMIs...
  42. ncbi request reprint Limbic neuromodulation: implications for addiction, posttraumatic stress disorder, and memory
    AUSAF BARI
    Department of Neurosurgery, Geffen School of Medicine, University of California, Los Angeles, Room 18 228 NPI, Box 957039, Los Angeles, CA 90095, USA Electronic address
    Neurosurg Clin N Am 25:137-45. 2014
    ..As the scope of neuromodulation grows to include disorders of mood and thought, new ethical and philosophic challenges that require multidisciplinary discussion and cooperation are emerging. ..
  43. doi request reprint Deep brain stimulation for enhancement of learning and memory
    Nanthia Suthana
    Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA Department of Psychology, University of California, Los Angeles, USA
    Neuroimage 85:996-1002. 2014
    ..Throughout our discussion, we also propose several future directions that will provide the necessary insight into if and how DBS could be used as a therapeutic treatment for memory disorders. ..
  44. ncbi request reprint Effects of topiramate on memory performance on the intracarotid amobarbital (Wada) test
    Svetlana Kipervasser
    EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Epilepsy Behav 5:197-203. 2004
    ..02). We conclude that a possible adverse effect of TPM on memory performance should be considered when evaluating the Wada test memory scores of patients on TPM therapy...
  45. ncbi request reprint Cellular networks underlying human spatial navigation
    Arne D Ekstrom
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 425:184-8. 2003
    ..The former are present primarily in the hippocampus, and the latter in the parahippocampal region. Cells throughout the frontal and temporal lobes responded to the subjects' navigational goals and to conjunctions of place, goal and view...
  46. ncbi request reprint Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas
    Eran Privman
    School of Computer Science, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 27:6234-42. 2007
    ..A plausible interpretation of the fMRI and iEEG results concerns cortical organization in which object categories are organized in a mosaic of narrowly tuned object-selective clusters...
  47. pmc Single-neuron correlates of subjective vision in the human medial temporal lobe
    Gabriel Kreiman
    Computation and Neural Systems Program, California Institute of Technology 139 74, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:8378-83. 2002
    ..Therefore, the activity of most individual neurons in the medial temporal lobe of naive human subjects directly correlates with the phenomenal visual experience...
  48. ncbi request reprint Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset
    Scott Mintzer
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Epilepsia 45:792-802. 2004
    ..To investigate the clinical characteristics and surgical outcomes in patients with unilateral hippocampal sclerosis whose scalp ictal EEG recordings localize to the opposite temporal lobe...
  49. ncbi request reprint Lateralization of deficit in self-awareness of memory in patients with intractable epilepsy
    Fani Andelman
    Functional Neurosurgery Unit, Department of Neurosurgery Tel Aviv Sourasky Medical Center, Tel Aviv
    Epilepsia 45:826-33. 2004
    ..This discrepancy may reflect emotional, cognitive, or self-awareness deficits among these individuals. The aim of the current study was to explore the interference of cerebral dysfunction on accuracy of self-appraisal for memory...
  50. ncbi request reprint Consciousness and neurosurgery
    Francis Crick
    Salk Institute for Biological Studies, La Jolla, California, USA
    Neurosurgery 55:273-281; discussion 281-2. 2004
    ..This article explores the contributions of neurosurgeons to this quest and outlines some of the results that have already been achieved...
  51. ncbi request reprint Brain oscillations control timing of single-neuron activity in humans
    Joshua Jacobs
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:3839-44. 2007
    ..Specifically, they indicate that theta and delta oscillations facilitate phase coding and that gamma oscillations help to decode combinations of simultaneously active neurons...
  52. ncbi request reprint Local field potentials and spikes in the human medial temporal lobe are selective to image category
    Alexander Kraskov
    California Institute of Technology, California, USA
    J Cogn Neurosci 19:479-92. 2007
    ..Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals...
  53. pmc Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe
    Florian Mormann
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:8865-72. 2008
    ....
  54. pmc Internally generated reactivation of single neurons in human hippocampus during free recall
    Hagar Gelbard-Sagiv
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
    Science 322:96-101. 2008
    ..We suggest that this reactivation is an internally generated neuronal correlate for the subjective experience of spontaneous emergence of human recollection...
  55. ncbi request reprint Hippocampal memory function as reflected by the intracarotid sodium methohexital Wada test
    Fani Andelman
    Functional Neurosurgery Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Epilepsy Behav 9:579-86. 2006
    ..IAP scores related better to standard neuropsychological memory test scores than did IMP scores. The anesthetic drug used in Wada testing may affect lateralized memory assessment and prediction of postsurgical memory changes...
  56. ncbi request reprint Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex
    Roy Mukamel
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 309:951-4. 2005
    ..75, P < 10(-47)). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons...
  57. ncbi request reprint Invasive recordings from the human brain: clinical insights and beyond
    Andreas K Engel
    Institute of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Rev Neurosci 6:35-47. 2005
    ..In addition to their clinical relevance, these recordings can provide unique insights into brain functions such as movement control, perception, memory, language and even consciousness...
  58. ncbi request reprint A single-neuron correlate of change detection and change blindness in the human medial temporal lobe
    Leila Reddy
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 16:2066-72. 2006
    ..In contrast, this prediction was at chance for incorrect, unattended trials. The firing rates of visually selective MTL cells thus constitute a neural correlate of change detection...
  59. ncbi request reprint Differences in mnemonic processing by neurons in the human hippocampus and parahippocampal regions
    Indre V Viskontas
    University of California Los Angeles, USA
    J Cogn Neurosci 18:1654-62. 2006
    ..The findings also provide further evidence for the division of labor in the medial-temporal lobe with respect to declarative memory processes...
  60. ncbi request reprint The role of the amygdala in signaling prospective outcome of choice
    Itamar Kahn
    Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel
    Neuron 33:983-94. 2002
    ..These results support a role of the amygdala in choice behavior, both in the appraisal of inherent value of choice and the signaling of prospective negative outcomes...
  61. ncbi request reprint Sparse representation in the human medial temporal lobe
    Stephen Waydo
    Control and Dynamical Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:10232-4. 2006
    ..Here, we used a probabilistic analysis to show that these data are consistent with a sparse code in which neurons respond in a selective manner to a small fraction of stimuli...
  62. ncbi request reprint Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations
    Yuval Nir
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Biol 17:1275-85. 2007
    ....
  63. ncbi request reprint The prognostic significance of interictal epileptiform activity in postoperative EEGs of patients with mesial temporal lobe epilepsy
    Svetlana Kipervasser
    EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Clin EEG Neurosci 38:137-42. 2007
    ..078). IEAs in postoperative EEGs were less frequently demonstrated in patients who were seizure free, but the presence of postoperative IEAs does not preclude successful surgical outcome...
  64. ncbi request reprint Predictive value of Wada memory scores on postoperative learning and memory abilities in patients with intractable epilepsy
    Fani Andelman
    Functional Neurosurgery Unit, Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurosurg 104:20-6. 2006
    ..Evidence for the contribution of deactivating the contralateral healthy hemisphere remains inconclusive...
  65. ncbi request reprint Contribution of neuropsychology to epilepsy surgery
    Fani Andelman
    Functional Neurosurgery Unit, Department of Neurosurgery, Sourasky Medical Center, Tel Aviv, Israel
    Isr J Psychiatry Relat Sci 41:125-32. 2004
    ..The Wada test is used to determine the cerebral speech dominance, to predict postsurgical amnesia and is found to be useful in predicting laterality of seizure focus in candidates for temporal lobectomy...

Research Grants12

  1. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2009
    ..Our studies pave the way to understanding and managing memory impairment in Alzheimer's, temporal lobe epilepsy and other neurological diseases. ..
  2. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2007
    ..Our studies pave the way to understanding and managing memory impairment in Alzheimer's, temporal lobe epilepsy and other neurological diseases. ..
  3. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2004
    ..Our findings promise to be of value in understanding memory impairments in Alzheimer's disease, temporal love epilepsy and other neurological disorders involving memory impairment. ..
  4. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2003
    ..Our findings promise to be of value in understanding memory impairments in Alzheimer's disease, temporal love epilepsy and other neurological disorders involving memory impairment. ..
  5. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2002
    ..Our findings promise to be of value in understanding memory impairments in Alzheimer's disease, temporal love epilepsy and other neurological disorders involving memory impairment. ..
  6. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2001
    ..Our findings promise to be of value in understanding memory impairments in Alzheimer's disease, temporal love epilepsy and other neurological disorders involving memory impairment. ..
  7. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 1999
    ....
  8. NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBE
    Itzhak Fried; Fiscal Year: 2010
    ..Our studies pave the way to understanding and managing memory impairment in Alzheimer's, temporal lobe epilepsy and other neurological diseases. ..