Hermann B Frieboes

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
    Christopher G England
    Department of Bioengineering, Lutz Hall 419, University of Louisville, Louisville, KY 40292, USA
    Curr Drug Targets 16:1057-87. 2015
  2. pmc An integrated computational/experimental model of lymphoma growth
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003008. 2013
  3. pmc A computational model for predicting nanoparticle accumulation in tumor vasculature
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 8:e56876. 2013
  4. pmc Physical oncology: a bench-to-bedside quantitative and predictive approach
    Hermann B Frieboes
    Department of Bioengineering and James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40208, USA
    Cancer Res 71:298-302. 2011
  5. doi Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States of America
    PLoS ONE 10:e0129172. 2015
  6. doi An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity
    Louis T Curtis
    Department of Bioengineering, University of Louisville, KY, USA
    Nanomedicine (Lond) 11:197-216. 2016
  7. doi Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 10:e0144888. 2015
  8. doi Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, KY, 40202, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, United States of America Department of Pathology, University of New Mexico, Albuquerque, NM, 87131, United States of America
    PLoS ONE 10:e0129433. 2015
  9. pmc Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography
    Shanice V Hudson
    Department of Medicine, University of Louisville, Kentucky
    Cancer Res 74:6271-9. 2014
  10. doi Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles
    Christopher G England
    Dept of Pharmacology and Toxicology, University of Louisville, KY, USA James Graham Brown Cancer Center, University of Louisville, KY, USA
    Eur J Pharm Biopharm 92:120-9. 2015

Collaborators

  • Vittorio Cristini
  • Min Wu
  • Lacey R McNally
  • Paolo Decuzzi
  • Jun Yan
  • Christopher G England
  • Louis T Curtis
  • John Lowengrub
  • Justin S Huang
  • Shanice V Hudson
  • Victor Van Berkel
  • Guandong Zhang
  • Andre M Gobin
  • James J Lee
  • Kurtis T James
  • Ashani Kuttan
  • M Clarke Miller
  • John O Trent
  • Chin F Ng
  • Jamie Rush
  • Wenyuan Yin
  • Sabrin Albeituni
  • Brian P Ceresa
  • Anil Khanal
  • Justin Huang
  • Xinghua Sun
  • Dhruvinkumar N Patel
  • Thomas Priest

Detail Information

Publications13

  1. ncbi A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
    Christopher G England
    Department of Bioengineering, Lutz Hall 419, University of Louisville, Louisville, KY 40292, USA
    Curr Drug Targets 16:1057-87. 2015
    ..To this end, nanotherapeutic options currently in clinical trials offer hope to help address some of these critical issues. ..
  2. pmc An integrated computational/experimental model of lymphoma growth
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003008. 2013
    ..We conclude that computational modeling tightly integrated with experimental data gives insight into the dynamics of Non-Hodgkin's lymphoma and provides a platform to generate confirmable predictions of tumor growth...
  3. pmc A computational model for predicting nanoparticle accumulation in tumor vasculature
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 8:e56876. 2013
    ..The computational tool described here can effectively select an optimal NP formulation presenting high accumulation doses and uniform spatial intra-tumor distributions as a function of the development stage of the malignancy...
  4. pmc Physical oncology: a bench-to-bedside quantitative and predictive approach
    Hermann B Frieboes
    Department of Bioengineering and James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40208, USA
    Cancer Res 71:298-302. 2011
    ....
  5. doi Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States of America
    PLoS ONE 10:e0129172. 2015
    ..06 in the spleen, and 0.20 ± 0.04 in the tumor. Hyperspectral imaging of histology sections enables analysis of phosphatidylcholine-coated gold-based nanoparticles in pancreatic tumors with the goal to improve nanotherapeutic efficacy...
  6. doi An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity
    Louis T Curtis
    Department of Bioengineering, University of Louisville, KY, USA
    Nanomedicine (Lond) 11:197-216. 2016
    ..We develop an interdisciplinary approach modeling diffusive transport of drug-loaded gold nanoparticles in heterogeneously-vascularized tumors...
  7. doi Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 10:e0144888. 2015
    ..This model system enables evaluation of efficacy for vascular-targeted drug-loaded NPs as a function of critical NP, drug, and tumor parameters. ..
  8. doi Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, KY, 40202, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, United States of America Department of Pathology, University of New Mexico, Albuquerque, NM, 87131, United States of America
    PLoS ONE 10:e0129433. 2015
    ..Lastly, tissue blood volume fraction was determined to be the most sensitive model parameter and a primary contributor to drug resistance. ..
  9. pmc Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography
    Shanice V Hudson
    Department of Medicine, University of Louisville, Kentucky
    Cancer Res 74:6271-9. 2014
    ..These studies demonstrate the utility of MSOT to obtain volumetric images of ligand probe biodistribution in vivo to detect orthotopic pancreatic tumor lesions through active targeting of the EGF receptor...
  10. doi Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles
    Christopher G England
    Dept of Pharmacology and Toxicology, University of Louisville, KY, USA James Graham Brown Cancer Center, University of Louisville, KY, USA
    Eur J Pharm Biopharm 92:120-9. 2015
    ....
  11. pmc Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, KY, USA
    Int J Nanomedicine 8:3603-17. 2013
    ..This multilayer formulation may help overcome transport barriers presented by tumor vasculature, and could be further investigated in vivo as a platform for targeted cancer therapies. ..
  12. doi Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville Louisville, KY, USA
    JOP 15:189-97. 2014
    ..We hypothesize that treating metastatic cells with chloroquine, an inhibitor of autophagy, in hypoxia will decrease cell viability and induce cell death...
  13. pmc Predictive modeling of in vivo response to gemcitabine in pancreatic cancer
    James J Lee
    School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003231. 2013
    ....