Leonid E Fridlyand

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi A computational systems analysis of factors regulating α cell glucagon secretion
    Leonid E Fridlyand
    The Kovler Diabetes Center, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA
    Islets 4:262-83. 2012
  2. ncbi Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis
    Leonid E Fridlyand
    Department of Medicine and Pediatrics, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA
    Prog Biophys Mol Biol 107:293-303. 2011
  3. ncbi Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 293:C1924-33. 2007
  4. ncbi Mechanisms of glucose sensing in the pancreatic β-cell: A computational systems-based analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 3:224-30. 2011
  5. ncbi Glucose sensing in the pancreatic beta cell: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Theor Biol Med Model 7:15. 2010
  6. ncbi Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms
    L E Fridlyand
    Dept of Medicine, MC 1027, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E517-32. 2010
  7. ncbi Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions
    Leonid E Fridlyand
    Dept. of Medicine, The Univ. of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E839-48. 2005
  8. ncbi Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling
    Natalia A Tamarina
    Dept of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E578-85. 2005
  9. ncbi Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 53:1942-8. 2004
  10. ncbi Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, MC-1027, 5841 S. Maryland Ave, Chicago, IL 60637, USA
    Curr Diabetes Rev 2:241-59. 2006

Collaborators

Detail Information

Publications12

  1. ncbi A computational systems analysis of factors regulating α cell glucagon secretion
    Leonid E Fridlyand
    The Kovler Diabetes Center, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA
    Islets 4:262-83. 2012
    ..We also reviewed and analyzed dysfunctional mechanisms in α-cells to determine key pharmacological targets for modulating glucagon secretion in type 1 and 2 diabetes...
  2. ncbi Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis
    Leonid E Fridlyand
    Department of Medicine and Pediatrics, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA
    Prog Biophys Mol Biol 107:293-303. 2011
    ..The model may be important in the identification of pharmacological targets for improving insulin secretion in type 2 diabetes...
  3. ncbi Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 293:C1924-33. 2007
    ..Our results reveal important differences in the effects of glucose/TEA and GLP-1 on cAMP dynamics in MIN6 beta-cells...
  4. ncbi Mechanisms of glucose sensing in the pancreatic β-cell: A computational systems-based analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 3:224-30. 2011
    ..This computational systems analysis aids in providing a more complete understanding of the complex process of β-cell glucose sensing...
  5. ncbi Glucose sensing in the pancreatic beta cell: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Theor Biol Med Model 7:15. 2010
    ..The goal of this work is to uncover contributions of the cytoplasmic and mitochondrial processes in this secretory coupling mechanism using mathematical modeling in a systems biology approach...
  6. ncbi Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms
    L E Fridlyand
    Dept of Medicine, MC 1027, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E517-32. 2010
    ..Further studies supported by improved mathematical models are necessary to understand oscillatory phenomena in β-cell physiology...
  7. ncbi Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions
    Leonid E Fridlyand
    Dept. of Medicine, The Univ. of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E839-48. 2005
    ..The results demonstrate the utility of comprehensive mathematical modeling in understanding the ramifications of potential defects in beta-cell function in diabetes...
  8. ncbi Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling
    Natalia A Tamarina
    Dept of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E578-85. 2005
    ..The results underscore the importance of K(V)2.1 channel in repolarization of the pancreatic beta-cell plasma membrane and its role in regulating insulin secretion...
  9. ncbi Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 53:1942-8. 2004
    ..We propose that therapeutic strategies targeting enhancement of GDIS should be carefully considered in light of possible loss of beta-cell function and mass...
  10. ncbi Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, MC-1027, 5841 S. Maryland Ave, Chicago, IL 60637, USA
    Curr Diabetes Rev 2:241-59. 2006
    ..Pharmacological or other approaches that result in the activation of mitochondrial biogenesis could be beneficial for both IRe and T2D...
  11. ncbi Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 285:E138-54. 2003
    ..Simulations also show that filling the ER Ca2+ stores leads to faster electrical bursting and Ca2+ oscillations. Specific Ca2+ oscillations in isolated beta-cell lines can also be simulated...
  12. ncbi Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches
    Leonid E Fridlyand
    Department of Medicine, MC-1027, The University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1066:136-51. 2005
    ..An improved understanding of these mechanisms should facilitate development of antioxidant intervention strategies leading to reduction in diseases associated with oxidative stress...