Leonid E Fridlyand

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 5:1-15. 2013
  2. pmc A computational systems analysis of factors regulating α cell glucagon secretion
    Leonid E Fridlyand
    The Kovler Diabetes Center, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA
    Islets 4:262-83. 2012
  3. doi request reprint Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis
    Leonid E Fridlyand
    Department of Medicine and Pediatrics, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA
    Prog Biophys Mol Biol 107:293-303. 2011
  4. ncbi request reprint Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 293:C1924-33. 2007
  5. pmc Mechanisms of glucose sensing in the pancreatic β-cell: A computational systems-based analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 3:224-30. 2011
  6. pmc Glucose sensing in the pancreatic beta cell: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Theor Biol Med Model 7:15. 2010
  7. pmc Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms
    L E Fridlyand
    Dept of Medicine, MC 1027, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E517-32. 2010
  8. ncbi request reprint Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions
    Leonid E Fridlyand
    Dept of Medicine, The Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E839-48. 2005
  9. ncbi request reprint Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling
    Natalia A Tamarina
    Dept of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E578-85. 2005
  10. ncbi request reprint Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 285:E138-54. 2003

Collaborators

Detail Information

Publications13

  1. pmc Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 5:1-15. 2013
    ..This computational system approach provides a framework to analyze the mechanisms of human β cell insulin secretion...
  2. pmc A computational systems analysis of factors regulating α cell glucagon secretion
    Leonid E Fridlyand
    The Kovler Diabetes Center, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA
    Islets 4:262-83. 2012
    ..We also reviewed and analyzed dysfunctional mechanisms in α-cells to determine key pharmacological targets for modulating glucagon secretion in type 1 and 2 diabetes...
  3. doi request reprint Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis
    Leonid E Fridlyand
    Department of Medicine and Pediatrics, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA
    Prog Biophys Mol Biol 107:293-303. 2011
    ..The model may be important in the identification of pharmacological targets for improving insulin secretion in type 2 diabetes...
  4. ncbi request reprint Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 293:C1924-33. 2007
    ..Our results reveal important differences in the effects of glucose/TEA and GLP-1 on cAMP dynamics in MIN6 beta-cells...
  5. pmc Mechanisms of glucose sensing in the pancreatic β-cell: A computational systems-based analysis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 3:224-30. 2011
    ..This computational systems analysis aids in providing a more complete understanding of the complex process of β-cell glucose sensing...
  6. pmc Glucose sensing in the pancreatic beta cell: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Theor Biol Med Model 7:15. 2010
    ..The goal of this work is to uncover contributions of the cytoplasmic and mitochondrial processes in this secretory coupling mechanism using mathematical modeling in a systems biology approach...
  7. pmc Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms
    L E Fridlyand
    Dept of Medicine, MC 1027, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E517-32. 2010
    ..Further studies supported by improved mathematical models are necessary to understand oscillatory phenomena in β-cell physiology...
  8. ncbi request reprint Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions
    Leonid E Fridlyand
    Dept of Medicine, The Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E839-48. 2005
    ..The results demonstrate the utility of comprehensive mathematical modeling in understanding the ramifications of potential defects in beta-cell function in diabetes...
  9. ncbi request reprint Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling
    Natalia A Tamarina
    Dept of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 289:E578-85. 2005
    ..The results underscore the importance of K(V)2.1 channel in repolarization of the pancreatic beta-cell plasma membrane and its role in regulating insulin secretion...
  10. ncbi request reprint Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 285:E138-54. 2003
    ..Simulations also show that filling the ER Ca2+ stores leads to faster electrical bursting and Ca2+ oscillations. Specific Ca2+ oscillations in isolated beta-cell lines can also be simulated...
  11. ncbi request reprint Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 53:1942-8. 2004
    ..We propose that therapeutic strategies targeting enhancement of GDIS should be carefully considered in light of possible loss of beta-cell function and mass...
  12. ncbi request reprint Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis
    Leonid E Fridlyand
    Department of Medicine, University of Chicago, MC 1027, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Curr Diabetes Rev 2:241-59. 2006
    ..Pharmacological or other approaches that result in the activation of mitochondrial biogenesis could be beneficial for both IRe and T2D...
  13. ncbi request reprint Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches
    Leonid E Fridlyand
    Department of Medicine, MC 1027, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1066:136-51. 2005
    ..An improved understanding of these mechanisms should facilitate development of antioxidant intervention strategies leading to reduction in diseases associated with oxidative stress...