M G Frid

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling
    M G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Arterioscler Thromb Vasc Biol 19:2884-93. 1999
  2. ncbi Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities
    Maria G Frid
    Pediatric Critical Care, University of Colorado Health Sciences Center, Box B131, 4200 E 9th Avenue, Denver, CO 80262, USA
    Paediatr Respir Rev 5:S253-7. 2004
  3. ncbi Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
  4. ncbi Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis
    Maria G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Circ Res 90:1189-96. 2002
  5. ncbi Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling
    Maria G Frid
    University of Colorado Health Sciences Center, Developmental Lung Biology Research Laboratory, Denver, CO 80262, USA
    Chest 128:583S-584S. 2005
  6. ncbi Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
    M G Frid
    Developmental Lung Biology Research, University of Colorado Health Sciences Center, Denver 80262, USA
    Circ Res 81:940-52. 1997
  7. ncbi cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration
    D J Klemm
    Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Denver, Colorado 80220, USA
    J Biol Chem 276:46132-41. 2001
  8. ncbi Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities
    Leopold Stiebellehner
    Developmental Lung Biology Research, Univ. of Colorado Health Sciences Center, 4200 E. 9th Ave, Box B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 285:L819-28. 2003
  9. ncbi Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts
    Mark F Banks
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol 98:732-8. 2005
  10. ncbi Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol 98:715-21. 2005

Collaborators

Detail Information

Publications13

  1. ncbi Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling
    M G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    Arterioscler Thromb Vasc Biol 19:2884-93. 1999
    ..Our data suggest that unique arterial cells with autonomous growth potential and constitutively activated signaling pathways exist in normal arteries and may contribute selectively to the pathogenesis of vascular diseases...
  2. ncbi Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities
    Maria G Frid
    Pediatric Critical Care, University of Colorado Health Sciences Center, Box B131, 4200 E 9th Avenue, Denver, CO 80262, USA
    Paediatr Respir Rev 5:S253-7. 2004
  3. ncbi Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
    ..We conclude that circulating mesenchymal precursors of a monocyte/macrophage lineage, including fibrocytes, are essential contributors to hypoxia-induced pulmonary vascular remodeling...
  4. ncbi Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis
    Maria G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Circ Res 90:1189-96. 2002
    ....
  5. ncbi Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling
    Maria G Frid
    University of Colorado Health Sciences Center, Developmental Lung Biology Research Laboratory, Denver, CO 80262, USA
    Chest 128:583S-584S. 2005
  6. ncbi Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
    M G Frid
    Developmental Lung Biology Research, University of Colorado Health Sciences Center, Denver 80262, USA
    Circ Res 81:940-52. 1997
    ....
  7. ncbi cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration
    D J Klemm
    Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Denver, Colorado 80220, USA
    J Biol Chem 276:46132-41. 2001
    ..Our data suggest a unique mode of cellular phenotype determination at the level of the nuclear content of CREB...
  8. ncbi Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities
    Leopold Stiebellehner
    Developmental Lung Biology Research, Univ. of Colorado Health Sciences Center, 4200 E. 9th Ave, Box B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 285:L819-28. 2003
    ..We thus speculate that distinct SMC phenotypes present in distal vs. proximal PA may confer different response mechanisms during remodeling in conditions such as hypertension...
  9. ncbi Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts
    Mark F Banks
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol 98:732-8. 2005
    ..We conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells...
  10. ncbi Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol 98:715-21. 2005
    ....
  11. ncbi Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
    Neil J Davie
    Developmental Lung Biology Group, UCHSC, 4200 East 9 th Ave, Rm 3419, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 286:L668-78. 2004
    ..From these observations, we suggest that the vasa vasorum and circulating progenitor cells could be involved in vessel wall thickening in the setting of hypoxia-induced PH...
  12. ncbi Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..This review provides perspectives on each of the aforementioned areas...
  13. ncbi Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension
    Enrique Arciniegas
    Laboratorio de Microscopía Electrónica, Servicio Autónomo Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela
    Am J Physiol Lung Cell Mol Physiol 293:L1-8. 2007
    ..Thus insights into the mechanisms controlling endothelial-mesenchymal transition are relevant to vascular remodeling and are important as we consider new therapies aimed at reversing pulmonary vascular remodeling...