Randall S Frey

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
    Randall S Frey
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Antioxid Redox Signal 11:791-810. 2009
  2. ncbi Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
    Randall S Frey
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 281:16128-38. 2006
  3. ncbi LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
    Ximing Zhou
    Department of Pharmacology, College of Medicine, University of Illinois, 835 So Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 288:L655-62. 2005
  4. ncbi FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression
    Muhammad K Mirza
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Exp Med 207:1675-85. 2010
  5. ncbi Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation
    Xiao Pei Gao
    Department of Pharmacology and Center of Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:6116-25. 2007
  6. ncbi TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Invest 112:1234-43. 2003
  7. ncbi PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells
    Randall S Frey
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612-7343, USA
    Circ Res 90:1012-9. 2002
  8. ncbi Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury
    Xiao Pei Gao
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 21:230-42. 2005
  9. ncbi Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1
    Kamran Javaid
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, Ill 60612, USA
    Circ Res 92:1089-97. 2003
  10. ncbi E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
    Kurt Bachmaier
    Department of Pharmacology, College of Medicine, University of Illinois, E403, Medical Science Building, M C 868, 835 S Wolcott Avenue, Chicago, Illinois 60612, USA
    Nat Med 13:920-6. 2007

Collaborators

Detail Information

Publications15

  1. ncbi NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
    Randall S Frey
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Antioxid Redox Signal 11:791-810. 2009
    ..Understanding these mechanisms may provide insight into the NADPH oxidase and oxidant signaling components as potential therapeutic targets...
  2. ncbi Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
    Randall S Frey
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 281:16128-38. 2006
    ..Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase-dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression...
  3. ncbi LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
    Ximing Zhou
    Department of Pharmacology, College of Medicine, University of Illinois, 835 So Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 288:L655-62. 2005
    ..Our data suggest an important role of TLR4-activated CD11b expression in the mechanism of the PMN host-defense response to LPS...
  4. ncbi FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression
    Muhammad K Mirza
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Exp Med 207:1675-85. 2010
    ..Therefore, means of activating FoxM1-mediated endothelial repair represent a new therapeutic strategy for the treatment of inflammatory vascular diseases associated with persistent vascular barrier leakiness such as acute lung injury...
  5. ncbi Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation
    Xiao Pei Gao
    Department of Pharmacology and Center of Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:6116-25. 2007
    ....
  6. ncbi TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Invest 112:1234-43. 2003
    ..Thus, PMN NADPH oxidase-derived oxidant signaling is an important determinant of the cross talk between TLR4 and TLR2 and the control of endothelial cell activation...
  7. ncbi PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells
    Randall S Frey
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612-7343, USA
    Circ Res 90:1012-9. 2002
    ..These data demonstrate a novel function of PKCzeta in signaling oxidant generation in endothelial cells by the activation of NADPH oxidase, which may be important in mediating endothelial activation responses...
  8. ncbi Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury
    Xiao Pei Gao
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 21:230-42. 2005
    ..The NIF(+/+) mouse model, in which CD11b is inactivated by binding to NIF, is a potentially useful model for in vivo assessment of the role of PMN CD11b in the mechanism of vascular inflammation...
  9. ncbi Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1
    Kamran Javaid
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, Ill 60612, USA
    Circ Res 92:1089-97. 2003
    ..The rapid ICAM-1 expression represents a novel mechanism for promoting the stable adhesion of PMN to endothelial cells that is needed to facilitate the early-onset transendothelial migration of PMN...
  10. ncbi E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
    Kurt Bachmaier
    Department of Pharmacology, College of Medicine, University of Illinois, E403, Medical Science Building, M C 868, 835 S Wolcott Avenue, Chicago, Illinois 60612, USA
    Nat Med 13:920-6. 2007
    ..The downregulation of TLR4 expression on the cell surface of neutrophils is impaired in the absence of Cblb. Our data reveal that Cblb regulates the TLR4-mediated acute inflammatory response that is induced by sepsis...
  11. ncbi Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury
    You Yang Zhao
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Invest 116:2333-43. 2006
    ..These data suggest that impairment in FoxM1 activation may be an important determinant of the persistent vascular barrier leakiness and edema formation associated with inflammatory diseases...
  12. ncbi Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:3404-11. 2002
    ..Thus, oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of TNFalpha-induced NF-kappaB activation and ICAM-1 expression in endothelial cells...
  13. ncbi Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
    Manjula Karpurapu
    Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Illinois, Chicago, 60612, USA
    Blood 118:5255-66. 2011
    ..1-deficient mice, establishing a novel protective mechanistic role for the lineage-specific transcription factor PU.1...
  14. ncbi SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling
    Yijie Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:6820-30. 2004
    ..Finally, fetal liver-derived macrophages from SHIP2 gene knockout mice enhanced activation of Akt in response to M-CSF treatment. These data suggest a novel regulatory role for SHIP2 in M-CSF-stimulated myeloid cells...
  15. ncbi Oxidant signaling in lung cells
    Randall S Frey
    Am J Physiol Lung Cell Mol Physiol 286:L1-3. 2004