Research Topics
| J A FrenchSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
A workshop on antiepileptic drug monotherapy indicationsJacqueline A French
The Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 43:3-27. 2002- Dose-response trial of pregabalin adjunctive therapy in patients with partial seizuresJ A French
University of Pennsylvania Medical Center Epilepsy Center, Philadelphia, USA
Neurology 60:1631-7. 2003..Pregabalin is an alpha(2)-delta ligand that has anxiolytic, analgesic, and anticonvulsant properties... - A systematic review of the safety profile of levetiracetam: a new antiepileptic drugJ French
Department of Neurology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Epilepsy Res 47:77-90. 2001..This report provides detailed review of safety information on levetiracetam (LEV) (Keppra), a new antiepileptic drug... - Use of levetiracetam in special populationsJ French
Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA
Epilepsia 42:40-3. 2001..Additional studies will refine the recommendations for use of levetiracetam in these special populations... - Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies... - First-choice drug for newly diagnosed epilepsyJacqueline A French
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Lancet 369:970-1. 2007 - Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American EpileJ A French
University of Pennsylvania, Philadelphia, USA
Neurology 62:1261-73. 2004..The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes where more evidence is necessary... - Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American EpilepsJ A French
University of Pennsylvania, Philadelphia, USA
Neurology 62:1252-60. 2004..CONCLUSIONS: The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with newly diagnosed epilepsy and identify those seizure types and syndromes where more evidence is necessary... - Postmarketing experience with topiramate and cognitionW O Tatum
Department of Neurology, Tampa General Hospital, University of South Florida, Tampa, Florida, USA
Epilepsia 42:1134-40. 2001..Psychomotor slowing was the most common complaint, yet most patients elect to continue treatment, with "better" or "much better" ratings of both seizure and global improvement during treatment... - Levetiracetam safety profiles and tolerability in epilepsy patientsDeborah E Briggs
Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Expert Opin Drug Saf 3:415-24. 2004..Adjustments in dosing are required for decreases in renal clearance... - Refractory epilepsy: clinical overviewJacqueline A French
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Epilepsia 48:3-7. 2007.... - Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004.... - Likelihood of seizure remission in an adult population with refractory epilepsyBrian C Callaghan
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 62:382-9. 2007..We aimed to determine the likelihood of remission and its clinical predictors in adult patients meeting a strict definition of refractory epilepsy. We also wanted to investigate the influence of treatment regimen on remission... - Can evidence-based guidelines and clinical trials tell us how to treat patients?Jacqueline A French
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 48:1264-7. 2007 
Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...- Historical control monotherapy design in the treatment of epilepsyJacqueline A French
Department of Neurology, New York University, New York, New York, USA
Epilepsia 51:1936-43. 2010..Such an approach reduces patient risk that would result from exposure to pseudo-placebo. In this article, we present the data submitted to the FDA to justify a historical control... - Effects of intermittent levetiracetam dosing in a patient with refractory daily seizuresDaniel Friedman
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA
Neurology 66:590-1. 2006..These results suggest a useful treatment strategy for patients with refractory epilepsy who have developed resistance to AEDs... - Ventricular asystole during vagus nerve stimulation for epilepsy in humansW O Tatum
Department of Neurology, Tampa General Hospital, University of South Florida, USA
Neurology 52:1267-9. 1999..Acute intraoperative vagus nerve stimulation may create ventricular asystole in humans. Extracorporeal cervical vagus nerve stimulation testing with continuous EKG monitoring intraoperatively before generator implantation is warranted... - Medical causes of seizuresN Delanty
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
Lancet 352:383-90. 1998..Only those patients with recurrent seizures and uncorrectable predisposing factors need long-term treatment with anticonvulsant medication... - Proof of efficacy trials: endpointsJ A French
The Neurological Institute, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Epilepsy Res 45:53-6; discussion 57-9. 2001..Other useful endpoints are time to nth seizure, number of seizure-free days, proportion of seizure-free patients, and assessment of seizure severity using rating scales. The choice of endpoint(s) will depend upon the design of the study... - Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalinDeborah E Briggs
Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA, United States
Epilepsy Res 82:86-92. 2008..To determine whether pregabalin reduces SGTC seizures in clinically refractory epilepsy... - Guidelines for new antiepileptic drug evaluationJohn D Hixson
Department of Neurology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Rev Neurol Dis 1:S18-26. 2004..Neurologists are encouraged to integrate the AAN guidelines with clinical experience, opinion, and other considerations of special populations until an exhaustive set of guidelines is available for a wide variety of seizure types... - Seizure-free outcome in randomized add-on trials of the new antiepileptic drugsDeana M Gazzola
Hospital of the University of Pennsylvania, Department of Neurology, Philadelphia, Pennsylvania 19104, USA
Epilepsia 48:1303-7. 2007..The goal of this study is to (1) provide clinically useful, previously unpublished comparative analyses of seizure-freedom rates for newer antiepileptic drugs (AEDs), and (2) recommend a standard for data presentation and analysis... - Hemispheric asymmetries in arousal affect outcome of the intracarotid amobarbital testG Glosser
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Neurology 52:1583-90. 1999..To evaluate changes in arousal and their impact on memory performance during the intracarotid amobarbital test (IAT)... - Clinical practice. Initial management of epilepsyJacqueline A French
Department of Neurology, New York University School of Medicine, New York, USA
N Engl J Med 359:166-76. 2008 - Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imagingR L Wolf
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
AJNR Am J Neuroradiol 22:1334-41. 2001..This technique is readily combined with routine structural assessment and potentially offers an inexpensive and noninvasive means of screening for asymmetries in interictal mesial temporal lobe function... - Neurosyphilis and status epilepticus: case report and literature reviewBeau M Ances
Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
Epilepsy Res 59:67-70. 2004..Neurosyphilis should be considered in the differential diagnosis of patients presenting with status epilepticus... - October 2002: 27-year-old female with epilepsyZissimos Mourelatos
Division of Neuropathology, Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA
Brain Pathol 13:233-4, 239. 2003..The treatment of choice is functionally complete hemispherectomy with complete disconnection of the frontal and occipital lobes... - Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsyJohn F Kerrigan
Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
Epilepsia 45:346-54. 2004.... - Fear sensitivity and the psychological profile of patients with psychogenic nonepileptic seizuresJohn D Hixson
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Epilepsy Behav 9:587-92. 2006..This finding may reflect an elevated internal "setpoint" for appraising the intensity of emotional settings... - A past psychiatric history may be a risk factor for topiramate-related psychiatric and cognitive adverse eventsAndres M Kanner
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Rush Medical College, 1653 West Congress Parkway, Chicago, IL 60612, USA
Epilepsy Behav 4:548-52. 2003.... - Guidelines--are they useful?Elinor Ben-Menachem
Department of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Epilepsia 47:62-4. 2006..Although guidelines may not answer all questions it is critical that clinicians using them consider the available evidence, as well as the quality of the evidence, when incorporating the information in their decision making... - Role of levetiracetam in the treatment of epilepsyMartin J Brodie
Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
Epileptic Disord 5:S65-72. 2003..Levetiracetam has specific characteristics that make it an optimal choice for many patient populations... - Postmarketing surveillance of new antiepileptic drugs: the tribulations of trialsJacqueline A French
Epilepsia 43:951-5. 2002 - Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsyChristian Otoul
UCB Pharma, Braine l Alleud, Belgium
Clin Neuropharmacol 28:72-8. 2005..These meta-analyses give only short-term efficacy and safety data. Comparative clinical trials and long-term studies of these agents are needed to confirm these findings... - Antiepileptic drugs for the elderly: using the old to focus on the newJacqueline A French
Neurology 64:1834-5. 2005 - Active control trials for epilepsy: avoiding bias in head-to-head trialsJacqueline A French
Neurology 66:1294-5. 2006 - VNS Therapy versus the latest antiepileptic drugElinor Ben-Menachem
Department of Clinical Neuroscience, Sahlgren University Hospital, Sweden
Epileptic Disord 7:S22-6. 2005.... - Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled studyDorothée G A Kasteleijn Nolst Trenité
University La Sapienza II, Via Vitorchiano 81, 00189 Roma, Italy
Epilepsy Res 74:193-200. 2007.... - Is refractory epilepsy preventable?Santiago Arroyo
Epilepsy Unit, Hospital Clinic i Provincial, Barcelona, Spain
Epilepsia 43:437-44. 2002..The early initiation of aggressive therapy may improve outcome and overall quality of life... - How trial designs impact on guidelinesJacqueline A French
Epilepsy Res 68:56-60. 2006..Understanding of the variables that will be considered for treatment guidelines can improve the methodological strength of studies and lead to recommendations for practice... - New antiepileptic drugs--discovery, development, and updateRoger J Porter
Neurotherapeutics 4:2-3. 2007