Robert Freeman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
    Liang Xie
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Biol 168:911-20. 2005
  2. pmc The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL)
    Y Guo
    University of Rochester School of Medicine, NY 14642, USA
    Oncogene 28:1864-74. 2009
  3. pmc Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway
    Huang Guo
    Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Neurodegener 6:13. 2011
  4. ncbi request reprint SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cells 16:1-12. 2003
  5. ncbi request reprint NGF deprivation-induced gene expression: after ten years, where do we stand?
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Prog Brain Res 146:111-26. 2004
  6. ncbi request reprint Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation
    David J Lomb
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Neurochem 103:1897-906. 2007
  7. ncbi request reprint EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability
    Jian Fu
    Cardiovascular Research Institute and Department of Medicine, Univeristy of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 282:12410-8. 2007
  8. ncbi request reprint A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"
    Paul S Brookes
    Department of Anesthesiology, University of Rochester Medical Center, Box 604, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 41:41-5. 2006
  9. ncbi request reprint Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death
    Jennifer A Straub
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 85:318-28. 2003
  10. ncbi request reprint Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA edu
    Curr Drug Targets CNS Neurol Disord 4:85-92. 2005

Research Grants

  1. GENES THAT REGULATE NEURONAL DEATH
    Robert Freeman; Fiscal Year: 1999
  2. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2005
  3. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2006
  4. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2007
  5. Multidisciplinary Training in Developmental Neuroscience
    Robert Freeman; Fiscal Year: 2007
  6. Prolyl Hydroxylation and Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
  7. Prolyl Hydroxylation and Neuronal Cell Death
    Robert S Freeman; Fiscal Year: 2010
  8. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2005
  9. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2004
  10. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2004

Collaborators

  • Jennifer A Straub
  • Paul S Brookes
  • Jian Fu
  • Gunter Wolf
  • M I Dawson
  • Ying Huang
  • William Kaelin
  • Bruce Carter
  • David J Lomb
  • Huang Guo
  • Zhihui Zhong
  • John H Griffin
  • Theresa M Barrett
  • Jose A Fernandez
  • Berislav V Zlokovic
  • Y Guo
  • Lynette A Desouza
  • Maria Cecilia Barone
  • Sungwoo Lee
  • Liang Xie
  • Lulu Farhana
  • Robert D Bell
  • Yaoming Wang
  • Abhay Sagare
  • James L Franklin
  • M C Schoell
  • Randall S Johnson
  • Susanne Schlisio
  • Haifeng Yang
  • Robert V Farese
  • Eijiro Nakamura
  • Mini P Sajan
  • Michelle S Linggi
  • Wenyi Wei
  • Arun K Rishi
  • Kaladhar B Reddy
  • Joseph A Fontana
  • Yuxiang Zhang

Detail Information

Publications16

  1. pmc Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
    Liang Xie
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Biol 168:911-20. 2005
    ..These data suggest a new model for how O(2) tension can influence apoptotic events that underlie trophic factor deprivation-induced cell death...
  2. pmc The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL)
    Y Guo
    University of Rochester School of Medicine, NY 14642, USA
    Oncogene 28:1864-74. 2009
    ....
  3. pmc Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway
    Huang Guo
    Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Neurodegener 6:13. 2011
    ..abstract:..
  4. ncbi request reprint SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cells 16:1-12. 2003
    ..elegans important for normal egg laying...
  5. ncbi request reprint NGF deprivation-induced gene expression: after ten years, where do we stand?
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Prog Brain Res 146:111-26. 2004
    ..In this chapter, we discuss the evidence that these genes act as regulators of neuronal cell death. We also suggest a hypothesis for how one gene, SM-20, may function to suppress a self-protection mechanism in NGF-deprived neurons...
  6. ncbi request reprint Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation
    David J Lomb
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Neurochem 103:1897-906. 2007
    ..Thus, while HIF prolyl hydroxylase inhibitors can delay cell death in NGF-deprived neurons, they do so through distinct mechanisms that, at least in the case of DHB, are partly independent of HIF stabilization...
  7. ncbi request reprint EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability
    Jian Fu
    Cardiovascular Research Institute and Department of Medicine, Univeristy of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 282:12410-8. 2007
    ..In addition, this report provides evidence for a novel pathway that regulates myogenin expression and skeletal muscle differentiation...
  8. ncbi request reprint A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"
    Paul S Brookes
    Department of Anesthesiology, University of Rochester Medical Center, Box 604, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 41:41-5. 2006
  9. ncbi request reprint Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death
    Jennifer A Straub
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 85:318-28. 2003
    ..These results suggest that SM-20 promotes caspase-dependent cell death through a mechanism involving cytochrome c...
  10. ncbi request reprint Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders
    Robert S Freeman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA edu
    Curr Drug Targets CNS Neurol Disord 4:85-92. 2005
    ....
  11. pmc Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity
    Maria Cecilia Barone
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA
    J Neurochem 106:734-45. 2008
    ..Finally, cell death induced by ectopic Pin1 was largely blocked by expression of dominant negative c-Jun. These results suggest a novel mechanism by which Pin1 promotes cell death involving activation of c-Jun...
  12. pmc Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neur
    David J Lomb
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 75:1198-209. 2009
    ..These results implicate HIF-2alpha in the neuroprotective mechanisms of prolyl hydroxylase inhibitors and in an endogenous cell survival pathway activated by NGF in developing neurons...
  13. pmc Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region
    Zhihui Zhong
    Center for Neurodegenerative and Vascular Brain Disorders, Department of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:15521-34. 2010
    ....
  14. ncbi request reprint Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer
    Sungwoo Lee
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Cell 8:155-67. 2005
    ..Moreover, EglN3 proapoptotic activity requires SDH activity because EglN3 is feedback inhibited by succinate. These studies suggest that failure of developmental apoptosis plays a role in pheochromocytoma pathogenesis...
  15. ncbi request reprint Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Lab Invest 82:1305-17. 2002
    ..This gene apparently plays an important role in the regulatory processes determining whether a cell should undergo differentiation, apoptosis, or proliferation...
  16. ncbi request reprint Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities
    Lulu Farhana
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Oncogene 23:1874-84. 2004
    ..Inhibition of AKT activity by this compound results in the inability of AKT to phosphorylate and inactivate the proapoptotic forkhead transcription factor...

Research Grants22

  1. GENES THAT REGULATE NEURONAL DEATH
    Robert Freeman; Fiscal Year: 1999
    ..This work should further our long-term goals of elucidating the molecular mechanism of neuronal PCD and of developing the means to manipulate the process pharmacologically. ..
  2. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2005
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  3. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2006
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  4. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2007
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  5. Multidisciplinary Training in Developmental Neuroscience
    Robert Freeman; Fiscal Year: 2007
    ..A plan is also in place that will increase the pool of predoctoral applicants from underrepresented racial and ethnic groups. ..
  6. Prolyl Hydroxylation and Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    ..Information gained from this project will further our understanding of normal development and could help identify new targets for therapies aimed at preventing pathological neuronal cell death. ..
  7. Prolyl Hydroxylation and Neuronal Cell Death
    Robert S Freeman; Fiscal Year: 2010
    ..Information gained from this project will further our understanding of normal development and could help identify new targets for therapies aimed at preventing pathological neuronal cell death. ..
  8. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2005
    ..Together these experiments will test the importance of NF-kB for neurotrophinregulated survival and they will uncover important new information concerning the mechanisms by which neurotrophins protect neurons from cell death. ..
  9. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2004
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  10. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2004
    ..Together these experiments will test the importance of NF-kB for neurotrophinregulated survival and they will uncover important new information concerning the mechanisms by which neurotrophins protect neurons from cell death. ..
  11. GENES THAT REGULATE NEURONAL DEATH
    Robert Freeman; Fiscal Year: 2000
    ..This work should further our long-term goals of elucidating the molecular mechanism of neuronal PCD and of developing the means to manipulate the process pharmacologically. ..
  12. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2001
    ..Together these experiments will test the importance of NF-kB for neurotrophinregulated survival and they will uncover important new information concerning the mechanisms by which neurotrophins protect neurons from cell death. ..
  13. GENES THAT REGULATE NEURONAL DEATH
    Robert Freeman; Fiscal Year: 2001
    ..This work should further our long-term goals of elucidating the molecular mechanism of neuronal PCD and of developing the means to manipulate the process pharmacologically. ..
  14. GENES THAT REGULATE NEURONAL DEATH
    Robert Freeman; Fiscal Year: 2002
    ..This work should further our long-term goals of elucidating the molecular mechanism of neuronal PCD and of developing the means to manipulate the process pharmacologically. ..
  15. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2002
    ..Together these experiments will test the importance of NF-kB for neurotrophinregulated survival and they will uncover important new information concerning the mechanisms by which neurotrophins protect neurons from cell death. ..
  16. Mechanisms of Neurotrophin dependent Survival
    Robert Freeman; Fiscal Year: 2003
    ..Together these experiments will test the importance of NF-kB for neurotrophinregulated survival and they will uncover important new information concerning the mechanisms by which neurotrophins protect neurons from cell death. ..
  17. Prolyl Hydroxylation and Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    ..Information gained from this project may help identify new targets for therapies aimed at preventing neuronal loss. ..