Marc R FreemanSummaryAffiliation: University of Oregon Country: USA Publications
| Collaborators
|
Detail Information
Publications
Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and functionMarc R Freeman
Institutes of Neuroscience and Molecular Biology, University of Oregon, Eugene, OR 97403, USA
Neuron 38:567-80. 2003..80% of these Drosophila glial genes have mammalian homologs; these are now excellent candidates for regulating human glial development, function, or disease...- Glial (and neuronal) cells missingMarc R Freeman
Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Neuron 48:163-5. 2005..A study by Chotard et al. in this issue of Neuron reveals that this "master regulator" of glial cell fate specification is also required (gasp!) to generate neurons... - Glia got rhythmPatrick Emery
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Neuron 55:337-9. 2007.... - Glial control of synaptogenesisMarc R Freeman
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cell 120:292-3. 2005..In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation... - Glial cell biology in Drosophila and vertebratesMarc R Freeman
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Trends Neurosci 29:82-90. 2006..The striking parallels that emerge from this comparison argue that invertebrate model organisms such as Drosophila have excellent potential to add to our understanding of fundamental aspects of glial biology... - Sculpting the nervous system: glial control of neuronal developmentMarc R Freeman
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Curr Opin Neurobiol 16:119-25. 2006..These recent insights provide further compelling evidence that glial cells, through their diverse cellular actions, are essential contributors to the construction of a functionally mature nervous system... - The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axonsJennifer M MacDonald
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Neuron 50:869-81. 2006..Thus Draper appears to act as a glial receptor for severed axon-derived molecular cues that drive recruitment of glial processes to injured axons for engulfment... 
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signallingJennifer S Ziegenfuss
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
Nature 453:935-9. 2008..Thus, Draper seems to be an ancient immunoreceptor with an extracellular domain tuned to modified self, and an intracellular domain promoting phagocytosis through an ITAM-domain-SFK-Syk-mediated signalling cascade...