MARC R contact FREEMAN

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Specification and morphogenesis of astrocytes
    Marc R Freeman
    Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 330:774-8. 2010
  2. ncbi Sculpting the nervous system: glial control of neuronal development
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 16:119-25. 2006
  3. ncbi Glial cell biology in Drosophila and vertebrates
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Trends Neurosci 29:82-90. 2006
  4. ncbi Glia got rhythm
    Patrick Emery
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 55:337-9. 2007
  5. ncbi Glial (and neuronal) cells missing
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 48:163-5. 2005
  6. ncbi The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
    Jennifer M MacDonald
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Neuron 50:869-81. 2006
  7. ncbi Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
  8. ncbi Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
    Jennifer S Ziegenfuss
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
    Nature 453:935-9. 2008
  9. ncbi Glial control of synaptogenesis
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell 120:292-3. 2005
  10. ncbi Ensheathing glia function as phagocytes in the adult Drosophila brain
    Johnna Doherty
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 29:4768-81. 2009

Research Grants

  1. The Draper signaling pathway in Drosophila glial immune functions
    Marc R Freeman; Fiscal Year: 2010
  2. How does Wlds protect severed axons?
    MARC FREEMAN; Fiscal Year: 2009
  3. Role of glia in sculpting synpatic fields during development and plasticity
    MARC R contact FREEMAN; Fiscal Year: 2010
  4. The Draper signaling pathway in Drosophila glial immune functions
    MARC FREEMAN; Fiscal Year: 2007
  5. How does Wlds protect severed axons?
    Marc R Freeman; Fiscal Year: 2010

Collaborators

  • Patrick Emery
  • Jing Wang
  • Chris Doe
  • E H Baehrecke
  • Mary A Logan
  • Michelle A Avery
  • Amy E Sheehan
  • Christina K McPhee
  • Yuly Fuentes-Medel
  • Johnna Doherty
  • Jennifer S Ziegenfuss
  • Jennifer M MacDonald
  • Ozge E Taşdemir
  • Vivian Budnik
  • James Ashley
  • Kimberly S Kerr
  • Bulent Ataman
  • Yee Guide Yeung
  • Kyoungja Hong
  • Yee-Guide Yeung
  • Romi Biswas
  • E Richard Stanley
  • Ermelinda Porpiglia
  • Margaret G Beach
  • Ryan J Watts

Detail Information

Publications13

  1. ncbi Specification and morphogenesis of astrocytes
    Marc R Freeman
    Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 330:774-8. 2010
    ..A major challenge for the field is to understand how astrocytes talk to each other, and to neurons, during development to establish appropriate astrocytic and neuronal network architectures...
  2. ncbi Sculpting the nervous system: glial control of neuronal development
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 16:119-25. 2006
    ..These recent insights provide further compelling evidence that glial cells, through their diverse cellular actions, are essential contributors to the construction of a functionally mature nervous system...
  3. ncbi Glial cell biology in Drosophila and vertebrates
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Trends Neurosci 29:82-90. 2006
    ..The striking parallels that emerge from this comparison argue that invertebrate model organisms such as Drosophila have excellent potential to add to our understanding of fundamental aspects of glial biology...
  4. ncbi Glia got rhythm
    Patrick Emery
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 55:337-9. 2007
    ....
  5. ncbi Glial (and neuronal) cells missing
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 48:163-5. 2005
    ..A study by Chotard et al. in this issue of Neuron reveals that this "master regulator" of glial cell fate specification is also required (gasp!) to generate neurons...
  6. ncbi The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
    Jennifer M MacDonald
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Neuron 50:869-81. 2006
    ..Thus Draper appears to act as a glial receptor for severed axon-derived molecular cues that drive recruitment of glial processes to injured axons for engulfment...
  7. ncbi Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
    ....
  8. ncbi Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
    Jennifer S Ziegenfuss
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
    Nature 453:935-9. 2008
    ..Thus, Draper seems to be an ancient immunoreceptor with an extracellular domain tuned to modified self, and an intracellular domain promoting phagocytosis through an ITAM-domain-SFK-Syk-mediated signalling cascade...
  9. ncbi Glial control of synaptogenesis
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell 120:292-3. 2005
    ..In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation...
  10. ncbi Ensheathing glia function as phagocytes in the adult Drosophila brain
    Johnna Doherty
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 29:4768-81. 2009
    ....
  11. ncbi Activation of autophagy during cell death requires the engulfment receptor Draper
    Christina K McPhee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 465:1093-6. 2010
    ..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival...
  12. ncbi Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration
    Michelle A Avery
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 184:501-13. 2009
    ..Thus, nuclear Nmnat activity does not appear to be essential for Wld(S)-like axon protection...
  13. ncbi Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function
    Marc R Freeman
    Institutes of Neuroscience and Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Neuron 38:567-80. 2003
    ..80% of these Drosophila glial genes have mammalian homologs; these are now excellent candidates for regulating human glial development, function, or disease...

Research Grants11

  1. The Draper signaling pathway in Drosophila glial immune functions
    Marc R Freeman; Fiscal Year: 2010
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..
  2. How does Wlds protect severed axons?
    MARC FREEMAN; Fiscal Year: 2009
    ..Our work will identify many new molecules that will be targets for treatment of patients after brain injury or during neurological disease. ..
  3. Role of glia in sculpting synpatic fields during development and plasticity
    MARC R contact FREEMAN; Fiscal Year: 2010
    ..Our work will provide fundamental knowledge regarding how neurons and glia communicate during the modification of synapses, and is expected to provide important insights into how glial dysfunction might cause disease. ..
  4. The Draper signaling pathway in Drosophila glial immune functions
    MARC FREEMAN; Fiscal Year: 2007
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..
  5. How does Wlds protect severed axons?
    Marc R Freeman; Fiscal Year: 2010
    ..Our work will identify many new molecules that will be targets for treatment of patients after brain injury or during neurological disease. ..