MARC R contact FREEMAN

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration
    Michelle A Avery
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 184:501-13. 2009
  2. doi request reprint Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years
    Marc R Freeman
    University of Massachusetts, and Howard Hughes Medical Institute, Worcester, MA 01605, USA Electronic address
    Neuron 80:613-23. 2013
  3. doi request reprint Specification and morphogenesis of astrocytes
    Marc R Freeman
    Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 330:774-8. 2010
  4. ncbi request reprint Glial cell biology in Drosophila and vertebrates
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Trends Neurosci 29:82-90. 2006
  5. ncbi request reprint Sculpting the nervous system: glial control of neuronal development
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 16:119-25. 2006
  6. ncbi request reprint Glia got rhythm
    Patrick Emery
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 55:337-9. 2007
  7. ncbi request reprint Glial (and neuronal) cells missing
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 48:163-5. 2005
  8. ncbi request reprint The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
    Jennifer M MacDonald
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Neuron 50:869-81. 2006
  9. pmc Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
  10. pmc Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
    Jennifer S Ziegenfuss
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
    Nature 453:935-9. 2008

Collaborators

  • Patrick Emery
  • Jing Wang
  • Chris Doe
  • David H Rowitch
  • E H Baehrecke
  • Mary A Logan
  • Michelle A Avery
  • Amy E Sheehan
  • Christina K McPhee
  • Johnna Doherty
  • Yuly Fuentes-Medel
  • Jennifer S Ziegenfuss
  • Jennifer M MacDonald
  • Vivian Budnik
  • James Ashley
  • Kimberly S Kerr
  • Ozge E TaƟdemir
  • Bulent Ataman
  • E Richard Stanley
  • Yee Guide Yeung
  • Romi Biswas
  • Kyoungja Hong
  • Margaret G Beach
  • Ryan J Watts
  • Ermelinda Porpiglia

Detail Information

Publications14

  1. pmc Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration
    Michelle A Avery
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 184:501-13. 2009
    ..Thus, nuclear Nmnat activity does not appear to be essential for Wld(S)-like axon protection...
  2. doi request reprint Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years
    Marc R Freeman
    University of Massachusetts, and Howard Hughes Medical Institute, Worcester, MA 01605, USA Electronic address
    Neuron 80:613-23. 2013
    ....
  3. doi request reprint Specification and morphogenesis of astrocytes
    Marc R Freeman
    Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 330:774-8. 2010
    ..A major challenge for the field is to understand how astrocytes talk to each other, and to neurons, during development to establish appropriate astrocytic and neuronal network architectures...
  4. ncbi request reprint Glial cell biology in Drosophila and vertebrates
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Trends Neurosci 29:82-90. 2006
    ..The striking parallels that emerge from this comparison argue that invertebrate model organisms such as Drosophila have excellent potential to add to our understanding of fundamental aspects of glial biology...
  5. ncbi request reprint Sculpting the nervous system: glial control of neuronal development
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 16:119-25. 2006
    ..These recent insights provide further compelling evidence that glial cells, through their diverse cellular actions, are essential contributors to the construction of a functionally mature nervous system...
  6. ncbi request reprint Glia got rhythm
    Patrick Emery
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 55:337-9. 2007
    ....
  7. ncbi request reprint Glial (and neuronal) cells missing
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 48:163-5. 2005
    ..A study by Chotard et al. in this issue of Neuron reveals that this "master regulator" of glial cell fate specification is also required (gasp!) to generate neurons...
  8. ncbi request reprint The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
    Jennifer M MacDonald
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Neuron 50:869-81. 2006
    ..Thus Draper appears to act as a glial receptor for severed axon-derived molecular cues that drive recruitment of glial processes to injured axons for engulfment...
  9. pmc Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
    ....
  10. pmc Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
    Jennifer S Ziegenfuss
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
    Nature 453:935-9. 2008
    ..Thus, Draper seems to be an ancient immunoreceptor with an extracellular domain tuned to modified self, and an intracellular domain promoting phagocytosis through an ITAM-domain-SFK-Syk-mediated signalling cascade...
  11. pmc Ensheathing glia function as phagocytes in the adult Drosophila brain
    Johnna Doherty
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 29:4768-81. 2009
    ....
  12. pmc Activation of autophagy during cell death requires the engulfment receptor Draper
    Christina K McPhee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 465:1093-6. 2010
    ..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival...
  13. ncbi request reprint Glial control of synaptogenesis
    Marc R Freeman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell 120:292-3. 2005
    ..In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation...
  14. ncbi request reprint Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function
    Marc R Freeman
    Institutes of Neuroscience and Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Neuron 38:567-80. 2003
    ..80% of these Drosophila glial genes have mammalian homologs; these are now excellent candidates for regulating human glial development, function, or disease...

Research Grants11

  1. The Draper signaling pathway in Drosophila glial immune functions
    Marc R Freeman; Fiscal Year: 2010
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..
  2. Role of glia in sculpting synpatic fields during development and plasticity
    MARC R contact FREEMAN; Fiscal Year: 2010
    ..Our work will provide fundamental knowledge regarding how neurons and glia communicate during the modification of synapses, and is expected to provide important insights into how glial dysfunction might cause disease. ..
  3. How does Wlds protect severed axons?
    MARC FREEMAN; Fiscal Year: 2009
    ..Our work will identify many new molecules that will be targets for treatment of patients after brain injury or during neurological disease. ..
  4. How does Wlds protect severed axons?
    Marc R Freeman; Fiscal Year: 2010
    ..Our work will identify many new molecules that will be targets for treatment of patients after brain injury or during neurological disease. ..
  5. The Draper signaling pathway in Drosophila glial immune functions
    MARC FREEMAN; Fiscal Year: 2007
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..
  6. The Draper signaling pathway in Drosophila glial immune functions
    MARC FREEMAN; Fiscal Year: 2009
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..
  7. Role of glia in sculpting synpatic fields during development and plasticity
    MARC FREEMAN; Fiscal Year: 2009
    ..Our work will provide fundamental knowledge regarding how neurons and glia communicate during the modification of synapses, and is expected to provide important insights into how glial dysfunction might cause disease. ..
  8. Draper pathway in Drosophila glial immune functions
    MARC FREEMAN; Fiscal Year: 2006
    ..Characterizing genes that regulate neuronal and glial function in response to CNS trauma is essential to identify new avenues for the treatment of CNS injury and neurological disease. ..