Ellen W Freeman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Luteal phase administration of agents for the treatment of premenstrual dysphoric disorder
    Ellen W Freeman
    Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    CNS Drugs 18:453-68. 2004
  2. pmc Body size affects measures of ovarian reserve in late reproductive age women
    H Irene Su
    Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 15:857-61. 2008
  3. ncbi request reprint Associations of hormones and menopausal status with depressed mood in women with no history of depression
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Gen Psychiatry 63:375-82. 2006
  4. ncbi request reprint Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study
    Kathryn H Schmitz
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 423 Guardian Drive, 921 Blockley Hall, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 16:2042-7. 2007
  5. pmc Contribution of the rate of change of antim├╝llerian hormone in estimating time to menopause for late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 98:1254-9.e1-2. 2012
  6. pmc Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women
    Samantha F Butts
    Division of Infertility and Reproductive Endocrinology, Perelman School of Medicine, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:E1032-42. 2012
  7. pmc Factors that influence entry into stages of the menopausal transition
    Mary D Sammel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 16:1218-27. 2009
  8. ncbi request reprint The relationship between obesity and race on inhibin B during the menopause transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 12:559-66. 2005
  9. pmc Predictors of sleep quality in women in the menopausal transition
    Grace W Pien
    Division of Sleep Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 31:991-9. 2008
  10. pmc Temporal associations of hot flashes and depression in the transition to menopause
    Ellen W Freeman
    Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA19104 5509, USA
    Menopause 16:728-34. 2009

Detail Information

Publications61

  1. ncbi request reprint Luteal phase administration of agents for the treatment of premenstrual dysphoric disorder
    Ellen W Freeman
    Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    CNS Drugs 18:453-68. 2004
    ..Progesterone has consistently failed to show efficacy for severe PMS/PMDD in large, randomised, placebo-controlled trials...
  2. pmc Body size affects measures of ovarian reserve in late reproductive age women
    H Irene Su
    Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 15:857-61. 2008
    ..To examine the association between obesity and serum and ultrasound measures of ovarian reserve in late reproductive age women...
  3. ncbi request reprint Associations of hormones and menopausal status with depressed mood in women with no history of depression
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Gen Psychiatry 63:375-82. 2006
    ..Whether depressed mood reported in the transition to menopause by women with no history of depression is associated with menopausal status and changes in reproductive hormones is controversial and lacks scientific information...
  4. ncbi request reprint Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study
    Kathryn H Schmitz
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 423 Guardian Drive, 921 Blockley Hall, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 16:2042-7. 2007
    ..Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels...
  5. pmc Contribution of the rate of change of antim├╝llerian hormone in estimating time to menopause for late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 98:1254-9.e1-2. 2012
    ..We hypothesized that the rate of change between two measures of AMH reflects follicular atresia and varies among women independent of age...
  6. pmc Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women
    Samantha F Butts
    Division of Infertility and Reproductive Endocrinology, Perelman School of Medicine, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:E1032-42. 2012
    ..It is currently not known whether the impact of smoking on hot flashes is modified by the presence of such variants...
  7. pmc Factors that influence entry into stages of the menopausal transition
    Mary D Sammel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 16:1218-27. 2009
    ..The aim of this study was to estimate the probabilities and identify risk factors for entering the menopausal transition and moving into each subsequent transition stage...
  8. ncbi request reprint The relationship between obesity and race on inhibin B during the menopause transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 12:559-66. 2005
    ..The purpose of this study was to determine the relationship among inhibin B levels, body mass index (BMI), and race during the menopause transition...
  9. pmc Predictors of sleep quality in women in the menopausal transition
    Grace W Pien
    Division of Sleep Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 31:991-9. 2008
    ..To determine associations between menopausal status, reproductive hormone levels, menopausal symptoms, and poor sleep quality...
  10. pmc Temporal associations of hot flashes and depression in the transition to menopause
    Ellen W Freeman
    Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA19104 5509, USA
    Menopause 16:728-34. 2009
    ..The aim of this study was to evaluate associations between hot flashes and depressed mood in the menopausal transition and associations of these symptoms with reproductive hormone changes...
  11. pmc Effects of reproductive history on symptoms of menopause: a brief report
    Deborah B Nelson
    Department of Public Health and Obstetrics and Gynecology, Temple University, Philadelphia, PA, USA
    Menopause 18:1143-8. 2011
    ..The aim of this study was to examine the relationship between reproductive history and menopausal symptoms among urban women...
  12. ncbi request reprint Tubal ligation does not affect hormonal changes during the early menopausal transition
    Deborah B Nelson
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Contraception 71:104-10. 2005
    ..To determine if women with a bilateral tubal ligation (BTL) were more likely to experience hormonal changes indicative of the transition to menopause or an increase in menopausal symptoms compared to women without a BTL...
  13. doi request reprint Associations of depression with the transition to menopause
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 17:823-7. 2010
    ....
  14. ncbi request reprint Symptoms associated with menopausal transition and reproductive hormones in midlife women
    Ellen W Freeman
    Departments of Obstetrics Gynecology, Psychiatry, University of Pennsylvania, 3701 Market Street, Philadelphia, PA 19104, USA
    Obstet Gynecol 110:230-40. 2007
    ....
  15. pmc Obesity and reproductive hormone levels in the transition to menopause
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 17:718-26. 2010
    ..The aim of this study was to estimate associations of obesity with reproductive hormone levels as women progress from premenopausal to postmenopausal status...
  16. doi request reprint Symptoms in the menopausal transition: hormone and behavioral correlates
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obstet Gynecol 111:127-36. 2008
    ..To estimate the association of headache, irritability, mood swings, anxiety, and concentration difficulties with menopausal stage and with reproductive hormones in the menopausal transition...
  17. pmc Investigating the associations between nocturia and sleep disorders in perimenopausal women
    Manish Gopal
    Division of Urogynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Urol 180:2063-7. 2008
    ..We determined the associations between nocturia and sleep disorders in perimenopausal women...
  18. pmc Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 17:657-65. 2008
    ..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)...
  19. pmc Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Menopause 17:1026-34. 2010
    ..This study evaluated whether genes involved in the metabolism of steroid hormones are associated with hormone levels or menopausal symptoms...
  20. ncbi request reprint Hormones and sexuality during transition to menopause
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Center for Clinical Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 109:831-40. 2007
    ..To examine the relationship between reproductive hormonal dynamics and sexual dysfunction assessed in a cohort of women approaching menopause...
  21. pmc Time to relapse after short- or long-term treatment of severe premenstrual syndrome with sertraline
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 5509, USA
    Arch Gen Psychiatry 66:537-44. 2009
    ..The duration of treatment after achieving a satisfactory response is unknown in the treatment of premenstrual syndrome. This information is needed in view of the improvement provided by medication vs the adverse effects and costs of drugs...
  22. ncbi request reprint A preliminary study of luteal phase versus symptom-onset dosing with escitalopram for premenstrual dysphoric disorder
    Ellen W Freeman
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    J Clin Psychiatry 66:769-73. 2005
    ..This preliminary study compared the efficacy and tolerability of escitalopram administered at symptom onset or throughout the luteal phase in premenstrual dysphoric disorder (PMDD)...
  23. ncbi request reprint Predicting participation in prospective studies of ovarian aging
    Deborah B Nelson
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, USA
    Menopause 11:543-8. 2004
    ....
  24. ncbi request reprint The role of anxiety and hormonal changes in menopausal hot flashes
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Menopause 12:258-66. 2005
    ..To estimate the association of anxiety with menopausal hot flashes in the early transition to menopause...
  25. pmc Duration of menopausal hot flushes and associated risk factors
    Ellen W Freeman
    Department of Obstetrics Gynecology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obstet Gynecol 117:1095-104. 2011
    ..To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration...
  26. ncbi request reprint Predictors of decreased libido in women during the late reproductive years
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 11:144-50. 2004
    ..To identify risk factors for decreased libido among women in the late reproductive years...
  27. ncbi request reprint Effect of physical activity on menopausal symptoms among urban women
    Deborah B Nelson
    Department of Public Health, College of Health Professions, Temple University, Philadelphia, PA 19122, USA
    Med Sci Sports Exerc 40:50-8. 2008
    ..To determine whether physical activity, measured by expended kilocalories per week (kcal.wk), decreases the risk of menopausal symptoms among African American and Caucasian women...
  28. ncbi request reprint Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 12:128-35. 2005
    ..The objective of this study was to determine which definition captures the earliest hormonal changes in the menopausal transition...
  29. pmc Methods for the design of vasomotor symptom trials: the menopausal strategies: finding lasting answers to symptoms and health network
    Katherine M Newton
    From the 1Group Health Research Institute, Seattle, WA 2School of Nursing, Indiana University, Indianapolis, IN 3Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA 4Division of Research, Kaiser Permanente of Northern California, Oakland, CA 5Massachusetts General Hospital Harvard Medical School, Boston, MA 6VA Medical Center University of Minnesota, Minneapolis, MN 7Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 8Department of Obstetrics Gynecology and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 9National Institute on Aging, US National Institutes of Health, Bethesda, MD 10Center for Clinical Epidemiology and Statistics, University of Pennsylvania School of Medicine, Philadelphia, PA and 11VA Center of Excellence for Implementing Evidence Based Practice and Indiana University School of Medicine, Indianapolis, IN
    Menopause 21:45-58. 2014
    ..This report describes the Menopausal Strategies: Finding Lasting Answers to Symptoms and Health network and methodological issues addressed in designing and implementing vasomotor symptom trials...
  30. pmc Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:1673-80. 2012
    ..Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and a possible surrogate measure of reproductive aging...
  31. pmc Association of change in estradiol to lower urinary tract symptoms during the menopausal transition
    Manish Gopal
    Division of Urogynecology, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 112:1045-52. 2008
    ..To estimate the relationship between changes in estradiol (E2) levels over time and lower urinary tract symptoms in premenopausal women as they transition to menopause...
  32. pmc Efficacy of yoga for vasomotor symptoms: a randomized controlled trial
    Katherine M Newton
    From the 1Group Health Research Institute, Seattle, WA 2Departments of Obstetrics Gynecology and Epidemiology, University of Washington School of Medicine, Seattle, WA 3Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA 4School of Nursing, University of Washington, Seattle, WA 5Division of Research, Kaiser Permanente Medical Program of Northern California, Oakland, CA 6School of Nursing, Indiana University, Indianapolis, IN 7Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 8Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 9Massachusetts General Hospital, Boston, MA 10Department of Medicine, VA Medical Center, Minneapolis, MN and 11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN
    Menopause 21:339-46. 2014
    ..This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother...
  33. pmc Menopause effects on verbal memory: findings from a longitudinal community cohort
    C Neill Epperson
    Department of Psychiatry, Penn Center for Women s Behavioral Wellness, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 98:3829-38. 2013
    ..Although cognitive complaints are common among menopausal women, it is debatable whether there is an objective decline in cognition with menopause that exceeds what is expected with normal aging...
  34. pmc Clinical subtypes of premenstrual syndrome and responses to sertraline treatment
    Ellen W Freeman
    Department of Obstetrics Gynecology, the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 118:1293-300. 2011
    ..To estimate response of diagnosis and symptom-based subtypes to sertraline treatment...
  35. pmc Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, USA
    JAMA 305:267-74. 2011
    ..Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes...
  36. pmc Core symptoms that discriminate premenstrual syndrome
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Womens Health (Larchmt) 20:29-35. 2011
    ..To identify core symptoms that discriminate premenstrual syndrome (PMS) in prospective daily diary ratings and determine the association of these symptoms with functional impairment...
  37. ncbi request reprint Association of anti-mullerian hormone levels with obesity in late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:101-6. 2007
    ..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
  38. pmc Efficacy of exercise for menopausal symptoms: a randomized controlled trial
    Barbara Sternfeld
    From the 1Division of Research, Kaiser Permanente, Oakland, CA 2Fred Hutchison Cancer Research Center, Seattle, WA 3University of Minnesota and Minneapolis VA Health Care System, Minneapolis, MN 4Klein Buendel Inc, Denver, CO 5Division of Nutritional Sciences, Cornell University, Ithaca, NY 6School of Nursing, Indiana University, Indianapolis, IN 7Group Health Research Institute, Seattle, WA 8University of Washington, Seattle, WA 9Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 10Massachusetts General Hospital, Harvard University, Boston, MA and 11National Institute for Fitness and Sport, Indianapolis, IN
    Menopause 21:330-8. 2014
    ..This study aims to determine the efficacy of exercise training for alleviating vasomotor and other menopausal symptoms...
  39. pmc Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging Study
    Mary Frances Morrison
    Department of Psychiatry, Temple University School of Medicine, Philadelphia, PA, 19140, USA
    Arch Womens Ment Health 14:375-82. 2011
    ..These findings suggest that taking DHEA supplements may increase depressive symptoms for some women, and women and their physicians should be cautious about instituting DHEA replacement therapy during the menopausal transition...
  40. pmc Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors
    H Irene Su
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 116:592-9. 2010
    ....
  41. pmc Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial
    Lee S Cohen
    From the 1Massachusetts General Hospital, Boston, MA 2MsFLASH Data Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 3VA Medical Center, University of Minnesota, Minneapolis, MN 4School of Nursing, Indiana University, Indianapolis, IN 5Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 6Group Health Research Institute, Group Health Cooperative, Seattle, WA 7Departments of Obstetrics Gynecology and Epidemiology, University of Washington School of Medicine, Seattle, WA 8Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 9Division of Research, Kaiser Permanente Medical Program of Northern California, Oakland, CA 10Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA and 11School of Nursing, University of Washington, Seattle, WA
    Menopause 21:347-54. 2014
    ..This study aims to determine the efficacy and tolerability of omega-3 fatty acids in reducing vasomotor symptoms (VMS) frequency and bother in perimenopausal and postmenopausal women...
  42. ncbi request reprint Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers
    Samantha F Butts
    From the 1Department of Obstetrics and Gynecology, and 2Center for Clinical Epidemiology and Biostatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 3University of Miami School of Medicine, Miami, FL 4Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA and 5Drexel University School of Medicine, Philadelphia, PA
    Menopause 21:694-701. 2014
    ..This study aims to evaluate associations between variations in genes involved in the metabolism of environmental chemicals and steroid hormones and risk of menopause in smokers...
  43. ncbi request reprint Hot flashes during pregnancy: a comparative study
    Laura J Hanisch
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
    Eur J Obstet Gynecol Reprod Biol 151:38-40. 2010
    ..To conduct a preliminary study assessing the association of hot flashes with pregnancy...
  44. ncbi request reprint Psychometric properties of a menopausal symptom list
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    Menopause 10:258-65. 2003
    ..To determine psychometric properties of a brief menopause symptom list and its sensitivity to menopausal status in a population-based cohort of late reproductive-age women...
  45. ncbi request reprint Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104 5509, USA
    Am J Psychiatry 161:343-51. 2004
    ....
  46. ncbi request reprint Weight gain among women in the late reproductive years
    Mary D Sammel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 605 Blockly Hall, Philadelphia, PA 19104, USA
    Fam Pract 20:401-9. 2003
    ..Given the impact of obesity on mortality and morbidity in women, we evaluated correlates of weight gain in women ages 35-47 years...
  47. doi request reprint An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndrome
    Ellen W Freeman
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Contraception 85:437-45. 2012
    ....
  48. doi request reprint Therapeutic management of premenstrual syndrome
    Ellen W Freeman
    Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 11:2879-89. 2010
    ..Premenstrual syndrome (PMS) is among the most common health problems reported by reproductive-age women. Estimates indicate that up to 25% of women may warrant treatment for the distress or impaired functioning associated with the symptoms...
  49. ncbi request reprint Allopregnanolone levels and symptom improvement in severe premenstrual syndrome
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Psychopharmacol 22:516-20. 2002
    ....
  50. ncbi request reprint Premenstrual syndrome (PMS) in adolescents: severity and impairment
    Michelle Vichnin
    Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Pediatr Adolesc Gynecol 19:397-402. 2006
    ..Identify the presence of patients with premenstrual syndrome (PMS) in an adolescent gynecology practice, and evaluate the reported severity, impairment and timing of the symptoms in the menstrual cycle...
  51. ncbi request reprint Acute consequences of the menopausal transition: the rise of common menopausal symptoms
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Endocrinol Metab Clin North Am 33:675-89. 2004
    ..This article re-views the current evidence regarding the acute symptoms of the menopausal transition, including vasomotor symptoms, mood changes, sleep problems, and changes in sexual functioning...
  52. ncbi request reprint Effects of antidepressants on quality of life in women with premenstrual dysphoric disorder
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5509, USA
    Pharmacoeconomics 23:433-44. 2005
    ..Greater awareness of the effectiveness of treatments and reliable measures of the direct and indirect healthcare costs of the disorder when it remains untreated are needed...
  53. ncbi request reprint Current update of hormonal and psychotropic drug treatment of premenstrual dysphoric disorder
    Ellen W Freeman
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, 3400 Spruce Street, 2 Dulles, Mudd Suite, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 4:435-40. 2002
    ..The results of a meta-analysis of the published trials of progesterone and progestins further indicate that these hormones are not effective in the management of PMDD...
  54. ncbi request reprint Citalopram in PMS patients with prior SSRI treatment failure: a preliminary study
    Ellen W Freeman
    Departments of Obstetrics Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Womens Health Gend Based Med 11:459-64. 2002
    ..This study examined the effectiveness of half-cycle dosing of citalopram in PMS patients who did not respond to previous SSRI treatment...
  55. ncbi request reprint Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Technol Ther 9:176-82. 2007
    ..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes...
  56. ncbi request reprint Hormones and menopausal status as predictors of depression in women in transition to menopause
    Ellen W Freeman
    Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Mudd Suite, 3701 Market Street, Philadelphia, PA 19104 5509, USA
    Arch Gen Psychiatry 61:62-70. 2004
    ..Associations between depressed mood and hormonal changes during transition to menopause are controversial. To our knowledge, there has been no prospective study of these associations in women commencing when they are premenopausal...
  57. ncbi request reprint Premenstrual syndrome and premenstrual dysphoric disorder: definitions and diagnosis
    Ellen W Freeman
    Department of Obstetrics Gynecology, Mudd Suite, 3701 Market Street, Philadelphia, PA 19104 5509, USA
    Psychoneuroendocrinology 28:25-37. 2003
    ..Diagnostic criteria for PMS must recognize the broad range of symptoms, the temporal pattern of the symptoms and the critical issue of symptom severity, which differentiates clinically significant PMS from normal menstrual cycle changes...
  58. doi request reprint Hot flashes and panic attacks: a comparison of symptomatology, neurobiology, treatment, and a role for cognition
    Laura J Hanisch
    Department of Psychiatry, University of Pennsylvania, USA
    Psychol Bull 134:247-69. 2008
    ..This model yields readily testable hypotheses and may provide a template for exploring the role of cognition in the frequency and severity of hot flashes and, in turn, a basis for the development of nonpharmacological treatments...
  59. ncbi request reprint Are there differential symptom profiles that improve in response to different pharmacological treatments of premenstrual syndrome/premenstrual dysphoric disorder?
    Uriel Halbreich
    Biobehavior Program, Department of Psychiatry, State University of New York at Buffalo, New York 14214, USA
    CNS Drugs 20:523-47. 2006
    ..Such information would also improve understanding of the putative pathophysiological mechanisms underlying PMS and PMDD, and may point to a more specific diagnosis of these conditions...
  60. ncbi request reprint Pilot study of racial differences and longitudinal changes in inhibin B in the late reproductive years
    Michelle Battistini
    Fertil Steril 77:193-5. 2002
  61. ncbi request reprint A pilot naturalistic follow-up of extended sertraline treatment for severe premenstrual syndrome
    Ellen W Freeman
    J Clin Psychopharmacol 24:351-3. 2004