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Genomes and Genes | Ellen W FreemanSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Luteal phase administration of agents for the treatment of premenstrual dysphoric disorderEllen W Freeman
Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
CNS Drugs 18:453-68. 2004..Progesterone has consistently failed to show efficacy for severe PMS/PMDD in large, randomised, placebo-controlled trials...
Associations of hormones and menopausal status with depressed mood in women with no history of depressionEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Arch Gen Psychiatry 63:375-82. 2006..Whether depressed mood reported in the transition to menopause by women with no history of depression is associated with menopausal status and changes in reproductive hormones is controversial and lacks scientific information...
Association of physical activity with reproductive hormones: the Penn Ovarian Aging StudyKathryn H Schmitz
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 423 Guardian Drive, 921 Blockley Hall, Philadelphia, PA 19104, USA
Cancer Epidemiol Biomarkers Prev 16:2042-7. 2007..Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels...
Body size affects measures of ovarian reserve in late reproductive age womenH Irene Su
Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Menopause 15:857-61. 2008..To examine the association between obesity and serum and ultrasound measures of ovarian reserve in late reproductive age women...
Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age womenSamantha F Butts
Division of Infertility and Reproductive Endocrinology, Perelman School of Medicine, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 97:E1032-42. 2012..It is currently not known whether the impact of smoking on hot flashes is modified by the presence of such variants...
Temporal associations of hot flashes and depression in the transition to menopauseEllen W Freeman
Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA19104 5509, USA
Menopause 16:728-34. 2009..The aim of this study was to evaluate associations between hot flashes and depressed mood in the menopausal transition and associations of these symptoms with reproductive hormone changes...
Predictors of sleep quality in women in the menopausal transitionGrace W Pien
Division of Sleep Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Sleep 31:991-9. 2008..To determine associations between menopausal status, reproductive hormone levels, menopausal symptoms, and poor sleep quality...
Factors that influence entry into stages of the menopausal transitionMary D Sammel
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Menopause 16:1218-27. 2009..The aim of this study was to estimate the probabilities and identify risk factors for entering the menopausal transition and moving into each subsequent transition stage...
The relationship between obesity and race on inhibin B during the menopause transitionClarisa R Gracia
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Menopause 12:559-66. 2005..The purpose of this study was to determine the relationship among inhibin B levels, body mass index (BMI), and race during the menopause transition...
Contribution of the rate of change of antimüllerian hormone in estimating time to menopause for late reproductive-age womenEllen W Freeman
Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 98:1254-9.e1-2. 2012..We hypothesized that the rate of change between two measures of AMH reflects follicular atresia and varies among women independent of age...
Effects of reproductive history on symptoms of menopause: a brief reportDeborah B Nelson
Department of Public Health and Obstetrics and Gynecology, Temple University, Philadelphia, PA, USA
Menopause 18:1143-8. 2011..The aim of this study was to examine the relationship between reproductive history and menopausal symptoms among urban women...
Associations of depression with the transition to menopauseEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
Menopause 17:823-7. 2010....
Tubal ligation does not affect hormonal changes during the early menopausal transitionDeborah B Nelson
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Contraception 71:104-10. 2005..To determine if women with a bilateral tubal ligation (BTL) were more likely to experience hormonal changes indicative of the transition to menopause or an increase in menopausal symptoms compared to women without a BTL...
Symptoms associated with menopausal transition and reproductive hormones in midlife womenEllen W Freeman
Departments of Obstetrics Gynecology, Psychiatry, University of Pennsylvania, 3701 Market Street, Philadelphia, PA 19104, USA
Obstet Gynecol 110:230-40. 2007....
Obesity and reproductive hormone levels in the transition to menopauseEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
Menopause 17:718-26. 2010..The aim of this study was to estimate associations of obesity with reproductive hormone levels as women progress from premenopausal to postmenopausal status...
Symptoms in the menopausal transition: hormone and behavioral correlatesEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Obstet Gynecol 111:127-36. 2008..To estimate the association of headache, irritability, mood swings, anxiety, and concentration difficulties with menopausal stage and with reproductive hormones in the menopausal transition...
Investigating the associations between nocturia and sleep disorders in perimenopausal womenManish Gopal
Division of Urogynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Urol 180:2063-7. 2008..We determined the associations between nocturia and sleep disorders in perimenopausal women...
Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
J Womens Health (Larchmt) 17:657-65. 2008..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)...
The role of anxiety and hormonal changes in menopausal hot flashesEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
Menopause 12:258-66. 2005..To estimate the association of anxiety with menopausal hot flashes in the early transition to menopause...
Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transitionTimothy R Rebbeck
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Menopause 17:1026-34. 2010..This study evaluated whether genes involved in the metabolism of steroid hormones are associated with hormone levels or menopausal symptoms...
Time to relapse after short- or long-term treatment of severe premenstrual syndrome with sertralineEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 5509, USA
Arch Gen Psychiatry 66:537-44. 2009..The duration of treatment after achieving a satisfactory response is unknown in the treatment of premenstrual syndrome. This information is needed in view of the improvement provided by medication vs the adverse effects and costs of drugs...
Hormones and sexuality during transition to menopauseClarisa R Gracia
Department of Obstetrics Gynecology, Center for Clinical Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 109:831-40. 2007..To examine the relationship between reproductive hormonal dynamics and sexual dysfunction assessed in a cohort of women approaching menopause...
A preliminary study of luteal phase versus symptom-onset dosing with escitalopram for premenstrual dysphoric disorderEllen W Freeman
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
J Clin Psychiatry 66:769-73. 2005..This preliminary study compared the efficacy and tolerability of escitalopram administered at symptom onset or throughout the luteal phase in premenstrual dysphoric disorder (PMDD)...
Predicting participation in prospective studies of ovarian agingDeborah B Nelson
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, USA
Menopause 11:543-8. 2004....
Predictors of decreased libido in women during the late reproductive yearsClarisa R Gracia
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Menopause 11:144-50. 2004..To identify risk factors for decreased libido among women in the late reproductive years...
Defining menopause status: creation of a new definition to identify the early changes of the menopausal transitionClarisa R Gracia
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Menopause 12:128-35. 2005..The objective of this study was to determine which definition captures the earliest hormonal changes in the menopausal transition...
Effect of physical activity on menopausal symptoms among urban womenDeborah B Nelson
Department of Public Health, College of Health Professions, Temple University, Philadelphia, PA 19122, USA
Med Sci Sports Exerc 40:50-8. 2008..To determine whether physical activity, measured by expended kilocalories per week (kcal.wk), decreases the risk of menopausal symptoms among African American and Caucasian women...
Anti-mullerian hormone as a predictor of time to menopause in late reproductive age womenEllen W Freeman
Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 97:1673-80. 2012..Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and a possible surrogate measure of reproductive aging...
Association of change in estradiol to lower urinary tract symptoms during the menopausal transitionManish Gopal
Division of Urogynecology, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 112:1045-52. 2008..To estimate the relationship between changes in estradiol (E2) levels over time and lower urinary tract symptoms in premenopausal women as they transition to menopause...
Clinical subtypes of premenstrual syndrome and responses to sertraline treatmentEllen W Freeman
Department of Obstetrics Gynecology, the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 118:1293-300. 2011..To estimate response of diagnosis and symptom-based subtypes to sertraline treatment...
Core symptoms that discriminate premenstrual syndromeEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Womens Health (Larchmt) 20:29-35. 2011..To identify core symptoms that discriminate premenstrual syndrome (PMS) in prospective daily diary ratings and determine the association of these symptoms with functional impairment...
Association of anti-mullerian hormone levels with obesity in late reproductive-age womenEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 87:101-6. 2007..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trialEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, USA
JAMA 305:267-74. 2011..Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes...
Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivorsH Irene Su
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer 116:592-9. 2010....
Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging StudyMary Frances Morrison
Department of Psychiatry, Temple University School of Medicine, Philadelphia, PA, 19140, USA
Arch Womens Ment Health 14:375-82. 2011..These findings suggest that taking DHEA supplements may increase depressive symptoms for some women, and women and their physicians should be cautious about instituting DHEA replacement therapy during the menopausal transition...
Hot flashes during pregnancy: a comparative studyLaura J Hanisch
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
Eur J Obstet Gynecol Reprod Biol 151:38-40. 2010..To conduct a preliminary study assessing the association of hot flashes with pregnancy...
Duration of menopausal hot flushes and associated risk factorsEllen W Freeman
Department of Obstetrics Gynecology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Obstet Gynecol 117:1095-104. 2011..To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration...
Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorderEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104 5509, USA
Am J Psychiatry 161:343-51. 2004....
Weight gain among women in the late reproductive yearsMary D Sammel
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 605 Blockly Hall, Philadelphia, PA 19104, USA
Fam Pract 20:401-9. 2003..Given the impact of obesity on mortality and morbidity in women, we evaluated correlates of weight gain in women ages 35-47 years...
Psychometric properties of a menopausal symptom listEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia 19104, USA
Menopause 10:258-65. 2003..To determine psychometric properties of a brief menopause symptom list and its sensitivity to menopausal status in a population-based cohort of late reproductive-age women...
An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndromeEllen W Freeman
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Contraception 85:437-45. 2012....
Therapeutic management of premenstrual syndromeEllen W Freeman
Departments of Obstetrics Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Expert Opin Pharmacother 11:2879-89. 2010..Premenstrual syndrome (PMS) is among the most common health problems reported by reproductive-age women. Estimates indicate that up to 25% of women may warrant treatment for the distress or impaired functioning associated with the symptoms...
Acute consequences of the menopausal transition: the rise of common menopausal symptomsClarisa R Gracia
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Endocrinol Metab Clin North Am 33:675-89. 2004..This article re-views the current evidence regarding the acute symptoms of the menopausal transition, including vasomotor symptoms, mood changes, sleep problems, and changes in sexual functioning...
Allopregnanolone levels and symptom improvement in severe premenstrual syndromeEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia 19104, USA
J Clin Psychopharmacol 22:516-20. 2002....
Effects of antidepressants on quality of life in women with premenstrual dysphoric disorderEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5509, USA
Pharmacoeconomics 23:433-44. 2005..Greater awareness of the effectiveness of treatments and reliable measures of the direct and indirect healthcare costs of the disorder when it remains untreated are needed...
Premenstrual syndrome (PMS) in adolescents: severity and impairmentMichelle Vichnin
Departments of Obstetrics/Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Pediatr Adolesc Gynecol 19:397-402. 2006..Further study is warranted to confirm these results with prospective assessment of PMS and to evaluate treatments for adolescents who have clinically significant PMS...
Citalopram in PMS patients with prior SSRI treatment failure: a preliminary studyEllen W Freeman
Departments of Obstetrics/Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
J Womens Health Gend Based Med 11:459-64. 2002..CONCLUSIONS: These results from a small number of subjects with open-label treatment must be viewed as preliminary but suggest that citalopram treatment is effective for PMS patients who failed previous SSRI treatment...
Current update of hormonal and psychotropic drug treatment of premenstrual dysphoric disorderEllen W Freeman
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, 3400 Spruce Street, 2 Dulles, Mudd Suite, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 4:435-40. 2002..The results of a meta-analysis of the published trials of progesterone and progestins further indicate that these hormones are not effective in the management of PMDD...
Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Technol Ther 9:176-82. 2007..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes...
Hormones and menopausal status as predictors of depression in women in transition to menopauseEllen W Freeman
Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Mudd Suite, 3701 Market Street, Philadelphia, PA 19104 5509, USA
Arch Gen Psychiatry 61:62-70. 2004..Associations between depressed mood and hormonal changes during transition to menopause are controversial. To our knowledge, there has been no prospective study of these associations in women commencing when they are premenopausal...
Premenstrual syndrome and premenstrual dysphoric disorder: definitions and diagnosisEllen W Freeman
Department of Obstetrics/Gynecology, Mudd Suite, 3701 Market Street, Philadelphia, PA 19104-5509, USA
Psychoneuroendocrinology 28:25-37. 2003..Diagnostic criteria for PMS must recognize the broad range of symptoms, the temporal pattern of the symptoms and the critical issue of symptom severity, which differentiates clinically significant PMS from normal menstrual cycle changes...
Hot flashes and panic attacks: a comparison of symptomatology, neurobiology, treatment, and a role for cognitionLaura J Hanisch
Department of Psychiatry, University of Pennsylvania, USA
Psychol Bull 134:247-69. 2008..This model yields readily testable hypotheses and may provide a template for exploring the role of cognition in the frequency and severity of hot flashes and, in turn, a basis for the development of nonpharmacological treatments...
Are there differential symptom profiles that improve in response to different pharmacological treatments of premenstrual syndrome/premenstrual dysphoric disorder?Uriel Halbreich
Biobehavior Program, Department of Psychiatry, State University of New York at Buffalo, New York 14214, USA
CNS Drugs 20:523-47. 2006..Such information would also improve understanding of the putative pathophysiological mechanisms underlying PMS and PMDD, and may point to a more specific diagnosis of these conditions...
Pilot study of racial differences and longitudinal changes in inhibin B in the late reproductive yearsMichelle Battistini
Fertil Steril 77:193-5. 2002
A pilot naturalistic follow-up of extended sertraline treatment for severe premenstrual syndromeEllen W Freeman
J Clin Psychopharmacol 24:351-3. 2004
