Ellen Freeman


Affiliation: University of Pennsylvania
Country: USA


  1. Freeman E, Sammel M, Gracia C, Kapoor S, Lin H, Liu L, et al. Follicular phase hormone levels and menstrual bleeding status in the approach to menopause. Fertil Steril. 2005;83:383-92 pubmed
    ..Racial differences in mean levels of E(2) appear strongly mediated by BMI. ..
  2. Freeman E, Rickels K. Characteristics of placebo responses in medical treatment of premenstrual syndrome. Am J Psychiatry. 1999;156:1403-8 pubmed
    ..Patients who sustain improvement for at least 2 consecutive months are likely to remain improved, indicating the importance of nondrug factors in clinical care. ..
  3. Freeman E, Sammel M, Liu L, Martin P. Psychometric properties of a menopausal symptom list. Menopause. 2003;10:258-65 pubmed
    ..The MSL provides a brief questionnaire with acceptable psychometric properties for assessing three dimensions of menopause-related symptoms and demonstrated sensitivity to menopausal status in a population-based cohort. ..
  4. Freeman E, Rickels K, Sondheimer S, Polansky M, Xiao S. Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder. Am J Psychiatry. 2004;161:343-51 pubmed
    ..Higher levels of postmenstrual symptoms limit treatment response and are important to define in treatment of premenstrual syndrome. ..
  5. Freeman E, Sammel M, Lin H, Boorman D, Gracia C. Contribution of the rate of change of antimüllerian hormone in estimating time to menopause for late reproductive-age women. Fertil Steril. 2012;98:1254-9.e1-2 pubmed publisher
    ..The rate of AMH change may be a more direct surrogate than age and increases the precision of estimates of TTM during this clinically important time period. ..
  6. Jiang B, Sammel M, Freeman E, Wang N. Bayesian estimation of associations between identified longitudinal hormone subgroups and age at final menstrual period. BMC Med Res Methodol. 2015;15:106 pubmed publisher
    ..Periodic evaluations of FSH in these age ranges are potentially useful for predicting age at FMP. ..
  7. Freeman E, Lukes A, VanDrie D, Mabey R, Gersten J, Adomako T. A dose-response study of a novel, oral tranexamic formulation for heavy menstrual bleeding. Am J Obstet Gynecol. 2011;205:319.e1-7 pubmed publisher
    ..There were no serious study-related AEs. The 3.9-g/d dose met all 3 primary efficacy endpoints, whereas the 1.95 g/d dose met 2 primary efficacy endpoints. Both doses were well tolerated. ..
  8. Freeman E, Gracia C, Sammel M, Lin H, Lim L, Strauss J. Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril. 2007;87:101-6 pubmed
    ..Obese women have lower AMH levels compared to non-obese women in the late reproductive years. The findings offer further evidence of the complex relationships between obesity and reproductive hormone levels in women. ..
  9. Freeman E, Sammel M, Lin H, Gracia C, Pien G, Nelson D, et al. Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol. 2007;110:230-40 pubmed
    ..Fluctuations of E2, decreased levels of inhibin b, and increased FSH levels were associated with these symptoms. II. ..

More Information


  1. Freeman E, Sammel M, Lin H, Liu Z, Gracia C. Duration of menopausal hot flushes and associated risk factors. Obstet Gynecol. 2011;117:1095-104 pubmed publisher
    ..The identified risk factors, particularly menopausal stage, race, and BMI, are important to consider in individualizing treatment and evaluating the risk-to-benefit ratio of hormones and other therapies. ..
  2. Freeman E, Guthrie K, Caan B, Sternfeld B, Cohen L, Joffe H, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2011;305:267-74 pubmed publisher
    ..Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes...
  3. Freeman E, Sammel M, Lin H, Rickels K, Sondheimer S. Clinical subtypes of premenstrual syndrome and responses to sertraline treatment. Obstet Gynecol. 2011;118:1293-300 pubmed publisher
    ..To estimate response of diagnosis and symptom-based subtypes to sertraline treatment...