Brian C Freeman
Affiliation: University of Illinois
Echtenkamp F, Freeman B. Molecular chaperone-mediated nuclear protein dynamics. Curr Protein Pept Sci. 2014;15:216-24 pubmed
..We suggest that molecular chaperones have evolved, in part, to manage these challenges by fostering a general and continuous dynamic protein environment within the nucleus. ..
Zelin E, Freeman B. Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1. J Mol Biol. 2015;427:1644-54 pubmed publisher
..Besides HSF1, the deacetylases differentially modulate the activities of unrelated DNA binding proteins. Taken together, our data further support the model that lysine deacetylases are selective regulators of DNA binding proteins. ..
Echtenkamp F, Gvozdenov Z, Adkins N, Zhang Y, Lynch Day M, Watanabe S, et al
. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Mol Cell. 2016;64:888-899 pubmed publisher
..In the case of RSC, p23 and Hsp90 promote a dynamic action, allowing a limited number of remodelers to effectively maintain chromatin in a pliable state. ..