Robert Freedman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia
    R Freedman
    Psychiatry and Pharmacology, University of Colorado, CO 80262, USA
    Am J Med Genet 97:58-64. 2000
  2. pmc Early biomarkers of psychosis
    Robert Freedman
    Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dialogues Clin Neurosci 7:17-29. 2005
  3. ncbi request reprint The genetics of sensory gating deficits in schizophrenia
    Robert Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C 268 71, Denver, CO 80262, USA
    Curr Psychiatry Rep 5:155-61. 2003
  4. pmc Initial phase 2 trial of a nicotinic agonist in schizophrenia
    Robert Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:1040-7. 2008
  5. ncbi request reprint Schizophrenia
    Robert Freedman
    Institute for Children s Mental Disorders, University of Colorado and the Veterans Affairs Medical Center, Denver, USA
    N Engl J Med 349:1738-49. 2003
  6. ncbi request reprint Characterization of allelic variants at chromosome 15q14 in schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA MIRECC, Denver, CO, USA
    Genes Brain Behav 5:14-22. 2006
  7. ncbi request reprint The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
    R Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Chem Neuroanat 20:299-306. 2000
  8. ncbi request reprint Evidence for the multigenic inheritance of schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet 105:794-800. 2001
  9. ncbi request reprint Input dysfunction, schizotypy, and genetic models of schizophrenia
    Robert Freedman
    Department of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, Campus Box C 268 71, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Schizophr Res 54:25-32. 2002
  10. ncbi request reprint Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    Ann Olincy
    Department of Veterans Affairs Schizophrenia Research Center, Denver, Colorado, USA
    Arch Gen Psychiatry 63:630-8. 2006

Detail Information

Publications72

  1. ncbi request reprint Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia
    R Freedman
    Psychiatry and Pharmacology, University of Colorado, CO 80262, USA
    Am J Med Genet 97:58-64. 2000
    ..It is certain that there are many genetic factors in schizophrenia and bipolar disorder; what is needed is a complete and precise description of the contribution of each individual factor to the pathophysiology of these illnesses...
  2. pmc Early biomarkers of psychosis
    Robert Freedman
    Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dialogues Clin Neurosci 7:17-29. 2005
    ..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
  3. ncbi request reprint The genetics of sensory gating deficits in schizophrenia
    Robert Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C 268 71, Denver, CO 80262, USA
    Curr Psychiatry Rep 5:155-61. 2003
    ..Polymorphisms in the core promoter of the gene are associated with schizophrenia and also with diminished inhibition of the P50 response. These genetic data may identify a new pathophysiologic target for drug discovery...
  4. pmc Initial phase 2 trial of a nicotinic agonist in schizophrenia
    Robert Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:1040-7. 2008
    ..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia...
  5. ncbi request reprint Schizophrenia
    Robert Freedman
    Institute for Children s Mental Disorders, University of Colorado and the Veterans Affairs Medical Center, Denver, USA
    N Engl J Med 349:1738-49. 2003
  6. ncbi request reprint Characterization of allelic variants at chromosome 15q14 in schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA MIRECC, Denver, CO, USA
    Genes Brain Behav 5:14-22. 2006
    ..Further sequencing in these two groups may yield more definitive identification of the molecular pathology...
  7. ncbi request reprint The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
    R Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Chem Neuroanat 20:299-306. 2000
    ..The alpha7-receptor is a ligand-gated ion channel that admits calcium ions into cells, and it has been proposed to have various developmental roles. Its malfunction may be part of the developmental pathogenesis of schizophrenia...
  8. ncbi request reprint Evidence for the multigenic inheritance of schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet 105:794-800. 2001
    ....
  9. ncbi request reprint Input dysfunction, schizotypy, and genetic models of schizophrenia
    Robert Freedman
    Department of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, Campus Box C 268 71, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Schizophr Res 54:25-32. 2002
    ..Thus, as predicted by Venables, the substrates of schizotypy and schizophrenia may arise from variants in normal brain function...
  10. ncbi request reprint Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    Ann Olincy
    Department of Veterans Affairs Schizophrenia Research Center, Denver, Colorado, USA
    Arch Gen Psychiatry 63:630-8. 2006
    ....
  11. pmc Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, Denver VA Medical Center, VISN19 MIRECC, Colorado, USA
    Biol Psychiatry 69:7-11. 2011
    ..This study examined the effects of DMXB-A on default network activity as a biomarker for drug effects on pathologic brain function associated with schizophrenia...
  12. pmc Olanzapine improves deficient sensory inhibition in DBA/2 mice
    Johanna K Simosky
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Brain Res 1233:129-36. 2008
    ..This improvement was blocked by pre-administration of alpha-bungarotoxin but not di-hydro-beta-erythroidine. Like clozapine, olanzapine acts via alpha7 nicotinic receptors to elicit improved inhibitory processing of auditory stimuli...
  13. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  14. ncbi request reprint Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder
    Laura F Martin
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Psychiatry 164:1900-6. 2007
    ..A second aim was to determine whether subjects with schizoaffective disorder, bipolar type, were neurophysiologically more similar to subjects with schizophrenia or subjects with bipolar disorder...
  15. pmc Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  16. pmc Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, Denver VA Medical Center VISN19 MIRECC and University of Colorado Denver, Aurora, CO 80045, USA
    Neuropsychopharmacology 35:938-42. 2010
    ..Imaging of drug response is useful in planning future clinical tests of this compound and other nicotinic agonists for schizophrenia...
  17. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  18. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  19. pmc Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type
    Laura F Martin
    Department of Psychiatry, Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 144:611-4. 2007
    ..The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type...
  20. pmc Sex differences in familiality effects on neurocognitive performance in schizophrenia
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Psychiatry 73:976-84. 2013
    ..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
  21. pmc Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk
    Randal G Ross
    Department of Psychiatry, Obstetrics and Gynecology, University of Colorado Denver, Aurora, USA
    Am J Psychiatry 170:290-8. 2013
    ..The authors investigated the effects of perinatal choline supplementation on the development of cerebral inhibition in human infants...
  22. pmc Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia
    Sarah H Stephens
    Department of Psychiatry, University of Colorado Denver, Colorado 80045, USA
    Psychiatr Genet 22:1-14. 2012
    ..This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7...
  23. pmc A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia
    Melissa L Sinkus
    Department of Psychiatry, University of Colorado at Denver, Denver, CO 80045, USA
    Brain Res 1291:1-11. 2009
    ..005, allele p=0.015), and in Caucasians (genotype p=0.015, allele p=0.009). We conclude that the presence of the 2 bp polymorphism at the CHRFAM7A locus may have a functional significance in schizophrenia...
  24. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  25. ncbi request reprint Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects
    Judith Gault
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 123:39-49. 2003
    ..Twenty-one variants were found in the exons, but non-synonymous changes were rare. Although the expression of CHRNA7 is decreased in schizophrenia, the general structure of the remaining receptors is likely to be normal...
  26. ncbi request reprint Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
    Randal G Ross
    Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
    Psychophysiology 39:809-19. 2002
    ..Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia...
  27. ncbi request reprint P50 sensory gating in adolescents from a pacific island isolate with elevated risk for schizophrenia
    Marina Myles-Worsley
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Biol Psychiatry 55:663-7. 2004
    ..P50 sensory gating deficits have been found repeatedly in schizophrenic patients and in their unaffected first-degree relatives. P50 sensory gating has not yet been studied in high-risk (HR) offspring nor in prodromal adolescents...
  28. pmc Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine
    Jody Tanabe
    Department of Radiology, University of Colorado at Denver Health Sciences, Denver, CO 80262, USA
    Neuropsychopharmacology 33:627-33. 2008
    ..The lack of a main effect on withdrawal, but correlation of thalamic blood flow with withdrawal symptoms suggests that more complex mechanisms mediate the subjective features of the withdrawal state...
  29. pmc Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
    J Child Psychol Psychiatry 51:535-49. 2010
    ..Therapeutic implications, including perinatal dietary choline supplementation, are discussed...
  30. ncbi request reprint FMRI of response to nicotine during a smooth pursuit eye movement task in schizophrenia
    Jason R Tregellas
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Psychiatry 162:391-3. 2005
    ..This study used functional magnetic resonance imaging (fMRI) to examine changes in brain hemodynamic response associated with nicotine administration during a smooth pursuit eye movement task in subjects with schizophrenia...
  31. ncbi request reprint Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia
    Laura F Martin
    Department of Psychiatry, Department of Veterans Affairs and University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C268 71, Denver, CO 80262, USA
    Psychopharmacology (Berl) 174:54-64. 2004
    ..This inhibitory process, which involves the alpha(7) nicotinic receptor mediated release of gamma-aminobutyric acid (GABA) by hippocampal interneurons, represents a potential new target for therapeutic intervention in schizophrenia...
  32. ncbi request reprint Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients
    Lawrence E Adler
    Box C268 26, Psychiatry, University of Colorado Health Science Ctr, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Psychiatry 161:1822-8. 2004
    ..This study sought to determine whether other atypical neuroleptics improve P50 ratios...
  33. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  34. ncbi request reprint Brain activation during smooth-pursuit eye movements
    Jody Tanabe
    Department of Radiology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Neuroimage 17:1315-24. 2002
    ..In addition, session-dependent changes in activation were greater in some regions than others and may indicate areas of brain, such as the supplementary eye fields, that are sensitive to attentional modulation of eye movements...
  35. ncbi request reprint Effects of nicotine on cognitive deficits in schizophrenia
    Josette G Harris
    Department of Psychiatry, University of Colorado School of Medicine, Denver, CO 80262, USA
    Neuropsychopharmacology 29:1378-85. 2004
    ..Effects on attention may be severely limited by tachyphylaxis, such that decremented performance occurs in smokers, while modest effects may be achieved in nonsmokers...
  36. ncbi request reprint Effects of nicotine on hippocampal and cingulate activity during smooth pursuit eye movement in schizophrenia
    Jody Tanabe
    Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biol Psychiatry 59:754-61. 2006
    ..The purpose of this work was to determine if nicotine differentially affects brain activity in schizophrenic and control subjects during pursuit eye tracking...
  37. pmc Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia
    Jason R Tregellas
    VISN19 MIRECC, Denver VA Medical Center, Denver, Colorado, USA
    Schizophr Res 92:262-72. 2007
    ..This study used functional magnetic resonance imaging (fMRI) to investigate the functional neuroanatomy of sensory gating deficits in schizophrenia...
  38. ncbi request reprint Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
    Sherry Leonard
    Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Arch Gen Psychiatry 59:1085-96. 2002
    ..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
  39. ncbi request reprint Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study
    Jason R Tregellas
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Psychiatry 161:315-21. 2004
    ..The investigators used functional magnetic resonance imaging (fMRI) to compare brain hemodynamic response during a smooth pursuit eye movement task in patients with schizophrenia and healthy comparison subjects...
  40. ncbi request reprint Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings
    James Schmeidler
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L Levy Place, Box 1230, New York, NY, USA
    Psychiatry Res 219:67-71. 2014
    ..A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes. ..
  41. pmc Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia
    Melissa L Sinkus
    Department of Psychiatry, University of Colorado Denver, Anschutz Medical Campus, Colorado 80045, USA
    Brain Behav Immun 32:51-62. 2013
    ..There were also significant interactions between schizophrenia diagnosis and both inflammatory illness and smoking...
  42. pmc Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
    David L Braff
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093, USA
    Schizophr Bull 33:21-32. 2007
    ..The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia...
  43. ncbi request reprint Schizophrenia and the alpha7 nicotinic acetylcholine receptor
    Laura F Martin
    Research Service, VA Eastern Colorado Health Care System, Denver, Colorado 80220, USA
    Int Rev Neurobiol 78:225-46. 2007
    ..alpha7 Nicotinic acetylcholine receptor agonists appear to be viable candidates for the treatment of cognitive disturbances in schizophrenia...
  44. ncbi request reprint Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism
    Johanna K Simosky
    Department of Pharmacology, University of Colorado Health Sciences Center, Campus Box C268 71, 4200 East 9th Avenue, Denver, CO 80262, USA
    Psychopharmacology (Berl) 165:386-96. 2003
    ..The atypical antipsychotic clozapine also normalizes this deficit in schizophrenia patients, but by an unknown mechanism...
  45. ncbi request reprint Increased hippocampal volume in schizophrenics' parents with ancestral history of schizophrenia
    Josette G Harris
    Department of Psychiatry, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Schizophr Res 55:11-7. 2002
    ..The aim of this study was to measure the hippocampal volume of the parents of schizophrenic probands, in relationship to the apparent transmission of genetic risk...
  46. ncbi request reprint Sensory gating impairment associated with schizophrenia persists into REM sleep
    Michael A Kisley
    Department of Psychiatry, University of Colorado Health Sciences Center and Denver Veteran s Affairs Medical Center, Denver, Colorado, USA
    Psychophysiology 40:29-38. 2003
    ..These results suggest that REM sleep is an appropriate state during which to assess P50 gating in order to disentangle the effects of state and trait on sensory gating impairment in other clinical populations...
  47. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  48. pmc Antidepressants may mitigate the effects of prenatal maternal anxiety on infant auditory sensory gating
    Sharon K Hunter
    Department of Psychiatry, University of Colorado Denver, Aurora, USA
    Am J Psychiatry 169:616-24. 2012
    ..The authors used P50 auditory sensory gating, a putative marker of early attentional processes measurable in young infants, to assess the impact of maternal anxiety and antidepressant use...
  49. doi request reprint Clinically responsible genetic testing in neuropsychiatric patients: a bridge too far and too soon
    David L Braff
    University of California, San Diego, School of Medicine, Department of Psychiatry, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 165:952-5. 2008
  50. ncbi request reprint Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation
    Catherine E Adams
    VAMC Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C268 71, Denver, CO 80262, USA
    Brain Res Dev Brain Res 139:175-87. 2002
    ..The early appearance and complex, prolonged pattern of development of the alpha7 receptor suggest that it may influence processes as diverse as cell migration, dendritic elaboration and apoptosis during hippocampal maturation...
  51. ncbi request reprint Early postnatal development of sensory gating
    Michael A Kisley
    Schizophrenia Research Center, Denver Veteran s Affairs Medical Center, Colorado, USA
    Neuroreport 14:693-7. 2003
    ..Nevertheless, these results demonstrate that the neural circuits underlying sensory gating are functional very early in postnatal development...
  52. ncbi request reprint Genetics of chromosome 15q13-q14 in schizophrenia
    Sherry Leonard
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Fitzsimmons Campus, Aurora, Colorado 80045, USA
    Biol Psychiatry 60:115-22. 2006
    ..Evidence from multiple studies supports a broad region of genetic linkage around the marker D15S1360...
  53. ncbi request reprint Electrophysiological phenotypes
    Robert Freedman
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Med 77:215-25. 2003
  54. ncbi request reprint Monitoring eye movements during fMRI tasks with echo planar images
    Jason R Tregellas
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Hum Brain Mapp 17:237-43. 2002
    ..We demonstrate that local eye movements will influence whole-head motion correction procedures, resulting in inaccurate movement parameters and potentially lowering the sensitivity to detect activations...
  55. ncbi request reprint Comparison of detrending methods for optimal fMRI preprocessing
    Jody Tanabe
    Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Neuroimage 15:902-7. 2002
    ..However, auto-detrending (selecting the best algorithm or none, if detrending is not useful) appears to be the most judicious choice, particularly for analyzing fMRI data with weak activations in the presence of baseline drift...
  56. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  57. ncbi request reprint Exacerbation of schizophrenia by varenicline
    Robert Freedman
    Am J Psychiatry 164:1269. 2007
  58. ncbi request reprint Neuronal dysfunction and schizophrenia symptoms
    Robert Freedman
    Am J Psychiatry 164:385-90. 2007
  59. ncbi request reprint The costs of drugs for schizophrenia
    Robert Freedman
    Am J Psychiatry 163:2029-31. 2006
  60. ncbi request reprint Heritability and reliability of P300, P50 and duration mismatch negativity
    Mei Hua Hall
    Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 36:845-57. 2006
    ..Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs...
  61. ncbi request reprint The choice of antipsychotic drugs for schizophrenia
    Robert Freedman
    N Engl J Med 353:1286-8. 2005
  62. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  63. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  64. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  65. pmc Genomewide association for schizophrenia in the CATIE study: results of stage 1
    P F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 13:570-84. 2008
    ....
  66. ncbi request reprint Behavioral and electrophysiological indices of temporal processing dysfunction in schizophrenia
    Deana B Davalos
    Department of Psychology, Colorado State University, Fort Collins, CO 80523, USA
    J Neuropsychiatry Clin Neurosci 17:517-25. 2005
    ..These results suggest that behavioral measures of time processing may reflect different processes than those captured by preattentive physiological measures in this population...
  67. pmc Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia
    Robert W Buchanan
    Schizophr Bull 33:1120-30. 2007
    ..This article reviews the rationale for these 3 approaches and provides an update on the development of therapeutic agents, which act through one of these 3 mechanisms...
  68. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  69. ncbi request reprint Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 183:13-9. 2005
    ..Similar to schizophrenic patients, DBA/2 mice spontaneously exhibit a deficit in inhibitory processing of the P20-N40 auditory evoked potential, which is thought to be a rodent analog of the human P50 auditory evoked potential...
  70. ncbi request reprint Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    Kaori Koike
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Schizophr Res 76:67-72. 2005
    ..These data are consistent with biological activity at a pathophysiological mechanism in schizophrenia and support further trials of this drug as a possible therapeutic for neurocognitive deficits in schizophrenia...
  71. doi request reprint Cannabis, inhibitory neurons, and the progressive course of schizophrenia
    Robert Freedman
    Am J Psychiatry 165:416-9. 2008
  72. ncbi request reprint Psychotherapy in the Journal: what's missing?
    Glen O Gabbard
    Am J Psychiatry 163:182-4. 2006