Curt Freed

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?
    Curt R Freed
    Division of Clinical Pharmacology and Toxicology, University of Colorado School of Medicine, C237, 4200 East Ninth Avenue, Denver, CO 80220, USA
    Proc Natl Acad Sci U S A 99:1755-7. 2002
  2. ncbi request reprint Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?
    Curt R Freed
    Departments of Medicine, Neurology, Psychiatry, and Neurosurgery Box, University of Colorado School of Medicine, 4200 East Ninth Avenue, C237, Denver, CO 80220, USA
    J Neurol 250:III44-6. 2003
  3. ncbi request reprint Does personality change as a result of fetal tissue transplantation in the brain?
    Cynthia McRae
    College of Education, University of Denver, Denver, CO 80208, USA
    J Neurol 250:282-6. 2003
  4. ncbi request reprint Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture
    Wenbo Zhou
    Division of Clinical Pharmacology, Department of Medicine, and the Neuroscience Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Brain Res 926:42-50. 2002
  5. ncbi request reprint DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
  6. ncbi request reprint Characterization of the Bex gene family in humans, mice, and rats
    Enrique Alvarez
    Medical Scientist Training Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Gene 357:18-28. 2005
  7. ncbi request reprint Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF
    Kimberley A Buytaert-Hoefen
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Stem Cells 22:669-74. 2004
  8. ncbi request reprint Reaction time and movement time after embryonic cell implantation in Parkinson disease
    Paul H Gordon
    Department of Neurology and Clinical Motor Physiology Laboratory, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Arch Neurol 61:858-61. 2004
  9. ncbi request reprint Preoperative response to levodopa is the best predictor of transplant outcome
    Curt R Freed
    Ann Neurol 55:896; author reply 896-7. 2004
  10. ncbi request reprint Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial
    Cynthia McRae
    College of Education, University of Denver, Denver, CO 80208, USA
    Arch Gen Psychiatry 61:412-20. 2004

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?
    Curt R Freed
    Division of Clinical Pharmacology and Toxicology, University of Colorado School of Medicine, C237, 4200 East Ninth Avenue, Denver, CO 80220, USA
    Proc Natl Acad Sci U S A 99:1755-7. 2002
  2. ncbi request reprint Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?
    Curt R Freed
    Departments of Medicine, Neurology, Psychiatry, and Neurosurgery Box, University of Colorado School of Medicine, 4200 East Ninth Avenue, C237, Denver, CO 80220, USA
    J Neurol 250:III44-6. 2003
    ..Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment...
  3. ncbi request reprint Does personality change as a result of fetal tissue transplantation in the brain?
    Cynthia McRae
    College of Education, University of Denver, Denver, CO 80208, USA
    J Neurol 250:282-6. 2003
    ..Results indicate that personality, as measured by the NEO-FFI, basically remained stable during the two-year follow-up period of this study. In this case, no change is regarded as a positive outcome...
  4. ncbi request reprint Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture
    Wenbo Zhou
    Division of Clinical Pharmacology, Department of Medicine, and the Neuroscience Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Brain Res 926:42-50. 2002
    ..These results show that overexpression of human alpha-synuclein, particularly the mutant form, can cause human DA neuron death, suggesting that alpha-synuclein may have a primary role in the pathogenesis of PD...
  5. ncbi request reprint DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
    ..We conclude that DJ-1 has multiple specific mechanisms for protecting dopamine neurons from cell death...
  6. ncbi request reprint Characterization of the Bex gene family in humans, mice, and rats
    Enrique Alvarez
    Medical Scientist Training Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Gene 357:18-28. 2005
    ..We conclude that the Bex gene family members are highly homologous but differ in their expression patterns, subcellular localization, and degradation by the proteasome...
  7. ncbi request reprint Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF
    Kimberley A Buytaert-Hoefen
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Stem Cells 22:669-74. 2004
    ..05). We conclude that substrates of striatal astrocytes and PA6 cells can promote differentiation of human embryonic stem cells to a TH-positive phenotype and that GDNF can increase the number of cells expressing that phenotype...
  8. ncbi request reprint Reaction time and movement time after embryonic cell implantation in Parkinson disease
    Paul H Gordon
    Department of Neurology and Clinical Motor Physiology Laboratory, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Arch Neurol 61:858-61. 2004
    ..Reaction time (RT) and movement time (MT) analysis, validated quantitative measures of premovement neural processing and motor execution, can be used as objective physiological markers of motor performance in PD...
  9. ncbi request reprint Preoperative response to levodopa is the best predictor of transplant outcome
    Curt R Freed
    Ann Neurol 55:896; author reply 896-7. 2004
  10. ncbi request reprint Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial
    Cynthia McRae
    College of Education, University of Denver, Denver, CO 80208, USA
    Arch Gen Psychiatry 61:412-20. 2004
    ..This portion of the study investigated the quality of life (QOL) of participants during the 1 year of double-blind follow-up...
  11. ncbi request reprint Neural transplantation for the treatment of Parkinson's disease
    Anders Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
    Lancet Neurol 2:437-45. 2003
  12. ncbi request reprint Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells
    Piruz Nahreini
    Department of Radiology, Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cell Mol Neurobiol 23:27-42. 2003
    ..7. This suggests that the mechanisms for inducing neuronal differentiation are still intact in HEB-E6E7 and HEB-LTA cells. More importantly, differentiation signals can override the effects of viral oncogenes in HEB cells...
  13. ncbi request reprint Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats
    Lone M Veng
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Cell Transplant 11:5-16. 2002
    ..Our results show that MHC class II-deficient xenografts survive transplantation for at least 6 weeks in the absence of immunosuppression, reduce rotational asymmetry, and provoke lesser immune reaction than wt grafts...
  14. doi request reprint Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, School of Medicine, University of Colorado Denver, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Biol Chem 283:9863-70. 2008
    ....
  15. ncbi request reprint Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology, Department of Medicine, and the Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:10128-35. 2004
    ..We conclude that cysteine substitution at critical positions in the alpha-synuclein molecule can increase dimer formation and accelerate protein aggregation and cellular toxicity of alpha-synuclein...
  16. ncbi request reprint The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons
    Ferogh A Ahmadi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 87:914-21. 2003
    ..Understanding the mechanism of rotenone-induced apoptosis in dopamine neurons may contribute to the development of new neuroprotective strategies against Parkinson's disease...
  17. ncbi request reprint Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line
    Birgit Schilling
    Buck Institute for Age Research, Novato, CA 94945, USA
    Mol Cell Proteomics 4:84-96. 2005
    ....
  18. doi request reprint Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions
    Christopher G Goetz
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 23:690-9. 2008
    ..Recognition of factors that impact placebo response rates should be incorporated into individual study designs for PD clinical trials...

Research Grants10

  1. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..Brains will be stained with H+E and immunostained for tyrosine hydroxylase and B and T cell markers. Stereologically corrected counts of TH-positive neurons will be determined. ..
  2. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 1999
    ..In the long term, we predict that implant patients will show progressive improvement for several years after transplant. Our patient cohort is uniquely able to define the early and long term outcome of neurotransplantation. ..