Christopher J Frederickson

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitro
    Christopher J Frederickson
    NeuroBioTex, Inc, Galveston, Texas 77550, USA
    J Histochem Cytochem 50:1659-62. 2002
  2. ncbi request reprint The neurobiology of zinc in health and disease
    Christopher J Frederickson
    NeuroBio Tex, Inc, 101 Christopher Columbus Blvd, Galveston, Texas 77550, USA
    Nat Rev Neurosci 6:449-62. 2005
  3. ncbi request reprint Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration
    Christopher J Frederickson
    NeuroBioTex Inc, Galveston, TX 77550, USA
    J Neurosci Methods 154:19-29. 2006
  4. pmc Fluorophilia: fluorophore-containing compounds adhere non-specifically to injured neurons
    Bridget E Hawkins
    Charles R Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1102, USA
    Brain Res 1432:28-35. 2012
  5. ncbi request reprint Zinc and excitotoxic brain injury: a new model
    Christopher J Frederickson
    NeuroBioTex, Inc, Galveston, Texas 77550, USA
    Neuroscientist 10:18-25. 2004
  6. ncbi request reprint Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor
    Christopher J Frederickson
    NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
    J Neurosci Methods 139:79-89. 2004
  7. pmc Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles
    David H Linkous
    NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
    J Histochem Cytochem 56:3-6. 2008
  8. ncbi request reprint Zinc-secreting Paneth cells studied by ZP fluorescence
    Leonard J Giblin
    NeuroBioTex, Inc, Galveston, TX 77550, USA
    J Histochem Cytochem 54:311-6. 2006
  9. ncbi request reprint Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biology
    Cathleen Frederickson
    NeuroBioTex, Galveston, TX 77550, USA
    Sci STKE 2007:pe61. 2007
  10. ncbi request reprint Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain
    Helen L Hellmich
    Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0830, USA
    Neurosci Lett 355:221-5. 2004

Research Grants

  1. Does Nitric Oxide Control Synaptic Zinc Release?
    Christopher Frederickson; Fiscal Year: 2003
  2. ZINC-BASED DIAGNOSTIC FOR PROSTATE CANCER
    Christopher Frederickson; Fiscal Year: 2002
  3. HIGH-SPEED MICROFLUIDIC SORTING OF BIOHAZARDOUS CELLS.
    Christopher Frederickson; Fiscal Year: 2004
  4. Tools For Measuring Free Zinc (pZn) In The Brain
    Christopher Frederickson; Fiscal Year: 2006
  5. FLOURESCENT TOOLS FOR THE STUDY OF METALLOTHIONEIN
    Christopher Frederickson; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitro
    Christopher J Frederickson
    NeuroBioTex, Inc, Galveston, Texas 77550, USA
    J Histochem Cytochem 50:1659-62. 2002
    ..Caution is therefore warranted in attempting to manipulate extracellular or intracellular Zn(2+) selectively...
  2. ncbi request reprint The neurobiology of zinc in health and disease
    Christopher J Frederickson
    NeuroBio Tex, Inc, 101 Christopher Columbus Blvd, Galveston, Texas 77550, USA
    Nat Rev Neurosci 6:449-62. 2005
    ..However, the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'...
  3. ncbi request reprint Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration
    Christopher J Frederickson
    NeuroBioTex Inc, Galveston, TX 77550, USA
    J Neurosci Methods 154:19-29. 2006
    ..We show that common errors can cause up to a 3000-fold underestimation of the concentration of released zinc. The results should help bring consistency to the study of synaptic release of zinc...
  4. pmc Fluorophilia: fluorophore-containing compounds adhere non-specifically to injured neurons
    Bridget E Hawkins
    Charles R Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1102, USA
    Brain Res 1432:28-35. 2012
    ..Further experiments may be advised to clarify whether Zn(2+)-binding dyes bind more specifically in intact neurons in culture or organotypic slices...
  5. ncbi request reprint Zinc and excitotoxic brain injury: a new model
    Christopher J Frederickson
    NeuroBioTex, Inc, Galveston, Texas 77550, USA
    Neuroscientist 10:18-25. 2004
    ..The authors present a new model of zinc currents and zinc toxicity that offers expanded opportunities for zinc-selective therapeutic chelation interventions...
  6. ncbi request reprint Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor
    Christopher J Frederickson
    NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
    J Neurosci Methods 139:79-89. 2004
    ..Thus, the presence of rapidly-exchangeable, "stainable" perikaryal zinc may be taken as an indicator of cell injury...
  7. pmc Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles
    David H Linkous
    NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
    J Histochem Cytochem 56:3-6. 2008
    ..Thus, the ZNT3 protein evidently controls not only the "stainability" but also the actual mass of zinc in mossy-fiber synaptic vesicles. This work thus confirms the metal-transporting role of the ZNT3 protein in the brain...
  8. ncbi request reprint Zinc-secreting Paneth cells studied by ZP fluorescence
    Leonard J Giblin
    NeuroBioTex, Inc, Galveston, TX 77550, USA
    J Histochem Cytochem 54:311-6. 2006
    ..These findings suggest that zinc is coreleased with other Paneth cell anti-microbials, and that the intact intestine is necessary for secretion into the crypt lumen...
  9. ncbi request reprint Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biology
    Cathleen Frederickson
    NeuroBioTex, Galveston, TX 77550, USA
    Sci STKE 2007:pe61. 2007
    ....
  10. ncbi request reprint Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain
    Helen L Hellmich
    Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0830, USA
    Neurosci Lett 355:221-5. 2004
    ..Zinc chelation induced the expression of several neuroprotective genes; neuroprotective gene expression correlated with substantially decreased numbers of TUNEL-positive cells...
  11. ncbi request reprint Neurotoxic zinc translocation into hippocampal neurons is inhibited by hypothermia and is aggravated by hyperthermia after traumatic brain injury in rats
    Sang Won Suh
    Department of Neurology, University of California, San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 26:161-9. 2006
    ..We conclude that pathological Zn2+ translocation in brain after TBI is temperature-dependent and that hypothermic neuronal protection might be mediated in part by reduced Zn2+ translocation...
  12. ncbi request reprint Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?
    Christopher J Frederickson
    NeuroBioTex, Inc and The University of Texas Medical School, Galveston TX 77550, USA
    J Alzheimers Dis 8:155-60; discussion 209-15. 2005
    ..Rapid and aggressive administration of zinc buffering compounds to patients suffering brain injury may therefore not only ameliorate the acute injury but might also reduce the risk of subsequent development of Alzheimer's disease...
  13. ncbi request reprint ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family
    Shawn C Burdette
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 125:1778-87. 2003
    ....
  14. ncbi request reprint Clioquinol effects on tissue chelatable zinc in mice
    Yuval B Nitzan
    Department of Morphology, Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Mol Med (Berl) 81:637-44. 2003
    ..Thus, our findings indicate that CQ has considerable potential as a versatile scientific and clinical tool used for selective modulation of zinc pools...
  15. ncbi request reprint Amyloid-beta metal interaction and metal chelation
    Math P Cuajungco
    Harvard Medical School, Boston, MA 02114, USA
    Subcell Biochem 38:235-54. 2005
    ..Here we discuss the interaction of Abeta with metals, metal dyshomeostasis in the CNS of patients with AD, and the potential therapeutic effects of metal chelators...
  16. ncbi request reprint High concentration of zinc in sub-retinal pigment epithelial deposits
    Imre Lengyel
    Division of Pathology, Institute of Ophthalmology, 11 43 Bath Street, University College London, and Department of Research and Development, Moorfields Eye Hospital, London EC1V 9EL, UK
    Exp Eye Res 84:772-80. 2007
    ..Based on the evidence provided here we suggest that zinc plays a role in sub-RPE deposit formation in the aging human eye and possibly also in the development and/or progression of AMD...
  17. ncbi request reprint Membrane-permeable and -impermeable sensors of the Zinpyr family and their application to imaging of hippocampal zinc in vivo
    Carolyn C Woodroofe
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Biol 11:1659-66. 2004
    ..Intracranial microinfusion of ZP1(6-CO2Et) into rat hippocampus produces reduced staining of vesicular zinc in neuropil and very clear delineation of zinc-positive injured neuronal somata and dendrites as compared with ZP1...

Research Grants6

  1. Does Nitric Oxide Control Synaptic Zinc Release?
    Christopher Frederickson; Fiscal Year: 2003
    ..The objective of the present proposal is to establish with certainty whether, in fact, NO controls Zn2+ release during excitotoxicity. ..
  2. ZINC-BASED DIAGNOSTIC FOR PROSTATE CANCER
    Christopher Frederickson; Fiscal Year: 2002
    ..If a zinc-based test were used along with PSA testing, the sales of the tests could be vast, and the contribution to men's health and wellness, equally vast. ..
  3. HIGH-SPEED MICROFLUIDIC SORTING OF BIOHAZARDOUS CELLS.
    Christopher Frederickson; Fiscal Year: 2004
    ..abstract_text> ..
  4. Tools For Measuring Free Zinc (pZn) In The Brain
    Christopher Frederickson; Fiscal Year: 2006
    ....
  5. FLOURESCENT TOOLS FOR THE STUDY OF METALLOTHIONEIN
    Christopher Frederickson; Fiscal Year: 2006
    ..healthy cell growth. Our tools will facilitate research in all of those areas and contribute to the advancement and development of diagnostic and therapeutic medical science. ..