A Frazer

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Comparison of ΔFosB immunoreactivity induced by vagal nerve stimulation with that caused by pharmacologically diverse antidepressants
    Havan Furmaga
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, USA
    J Pharmacol Exp Ther 341:317-25. 2012
  2. ncbi request reprint Serotonin transporter function in vivo: assessment by chronoamperometry
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio 78250, USA
    Ann N Y Acad Sci 861:217-29. 1998
  3. ncbi request reprint What should animal models of depression model?
    Alan Frazer
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neurosci Biobehav Rev 29:515-23. 2005
  4. ncbi request reprint Norepinephrine involvement in antidepressant action
    A Frazer
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, USA
    J Clin Psychiatry 61:25-30. 2000
  5. ncbi request reprint Serotonergic and noradrenergic reuptake inhibitors: prediction of clinical effects from in vitro potencies
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Clin Psychiatry 62:16-23. 2001
  6. ncbi request reprint In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    J Pharmacol Exp Ther 286:967-76. 1998
  7. ncbi request reprint In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7564, USA
    J Neurosci Methods 78:139-50. 1997
  8. ncbi request reprint Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
    S Benmansour
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Neurosci 19:10494-501. 1999
  9. ncbi request reprint Regulation of the norepinephrine transporter by chronic administration of antidepressants
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 55:313-6. 2004
  10. ncbi request reprint 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 75:2113-22. 2000

Collaborators

Detail Information

Publications36

  1. pmc Comparison of ΔFosB immunoreactivity induced by vagal nerve stimulation with that caused by pharmacologically diverse antidepressants
    Havan Furmaga
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, USA
    J Pharmacol Exp Ther 341:317-25. 2012
    ..The effects of VNS were somewhat more widespread than those caused by the antidepressants. The increases in ΔFosB produced by VNS were either equivalent to and/or more robust than those seen with antidepressants...
  2. ncbi request reprint Serotonin transporter function in vivo: assessment by chronoamperometry
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio 78250, USA
    Ann N Y Acad Sci 861:217-29. 1998
    ..These and other data have generated a working hypothesis that activation of the terminal serotonin autoreceptor enhances the kinetics of 5-HT uptake through an effect on the serotonin transporter...
  3. ncbi request reprint What should animal models of depression model?
    Alan Frazer
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neurosci Biobehav Rev 29:515-23. 2005
    ..Such models may then provide access not only to the neural regulatory mechanisms underlying effective antidepressant treatment, but may also provide clues to the processes underlying the development and manifestation of depression...
  4. ncbi request reprint Norepinephrine involvement in antidepressant action
    A Frazer
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, USA
    J Clin Psychiatry 61:25-30. 2000
    ..Finally, it is speculated how drugs that enhance central noradrenergic transmission might ameliorate the symptoms of depression...
  5. ncbi request reprint Serotonergic and noradrenergic reuptake inhibitors: prediction of clinical effects from in vitro potencies
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Clin Psychiatry 62:16-23. 2001
    ..This analysis reveals that venlafaxine may be unique among antidepressants in having a dose-dependent nonselectivity; at low doses it acts primarily as an SSRI, but at higher doses it inhibits the reuptake of NE as well...
  6. ncbi request reprint In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    J Pharmacol Exp Ther 286:967-76. 1998
    ..Only 5,7-DHT treatment caused this effect in the CA3 region. From these data, it is inferred that in certain regions of brain (dentate gyrus), both the SERT and NET contribute to the active clearance of exogenously applied 5-HT...
  7. ncbi request reprint In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7564, USA
    J Neurosci Methods 78:139-50. 1997
    ....
  8. ncbi request reprint Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
    S Benmansour
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Neurosci 19:10494-501. 1999
    ..Based on these results, it appears that the SERT is downregulated by chronic administration of SSRIs but not other types of antidepressants; furthermore, the downregulation is not caused by decreases in SERT gene expression...
  9. ncbi request reprint Regulation of the norepinephrine transporter by chronic administration of antidepressants
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 55:313-6. 2004
    ..This study investigated if chronic treatment of rats with selective NRIs or SSRIs also affected the norepinephrine transporter (NET)...
  10. ncbi request reprint 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 75:2113-22. 2000
    ..These data are consistent with the hypothesis that activation of terminal 5-HT(1B) autoreceptors increases 5-HTT activity...
  11. ncbi request reprint 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7764, USA
    Neurosci Lett 266:165-8. 1999
    ..By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT1B receptors can modulate the activity of the 5-HT transporter...
  12. ncbi request reprint Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region
    Sylvia Montañez
    Department of Psychiatry, MS 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Brain Res 955:236-44. 2002
    ....
  13. doi request reprint Impact of ovarian hormones on the modulation of the serotonin transporter by fluvoxamine
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 34:555-64. 2009
    ..The finding that acutely both estradiol and progesterone can inhibit the ability of an SSRI to slow the clearance of 5-HT, may have important implications for the use of SSRIs in women...
  14. ncbi request reprint Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation
    J Thomas Cunningham
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 33:1884-95. 2008
    ..This study, then, identified potential sites in brain where VNS may produce its clinical effects...
  15. ncbi request reprint [(3)H] citalopram binding to serotonin transporter sites in minnow brains
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Basic Clin Pharmacol Toxicol 101:203-10. 2007
    ..However, magnitudes of affinity are similar, and minnow SERT binding is decreased by chronic sertraline or chlorpyrifos administration...
  16. ncbi request reprint Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 61:210-5. 2007
    ....
  17. pmc Leptin: a potential novel antidepressant
    Xin Yun Lu
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 103:1593-8. 2006
    ....
  18. ncbi request reprint A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 59:408-14. 2006
    ..We hypothesized that venlafaxine would affect monoamine transporters dose-dependently, with low doses causing selective reduction of SERT binding sites and higher doses reducing both SERT and NET binding sites...
  19. ncbi request reprint Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry
    Lynette C Daws
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neurosci Methods 143:49-62. 2005
    ..e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). These data show for the first time in the whole animal that 5-HT clearance in brain is regionally distinct with regard to rate and affinity...
  20. ncbi request reprint A multivantaged behavioural method for measuring onset and sequence of the clinical actions of antidepressants
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 7:471-9. 2004
    ..Thus, the Brief MV, in uncovering underlying behavioural actions, represents an important addition to the current unidimensional HAMD approach in drug research...
  21. ncbi request reprint Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 22:6766-72. 2002
    ..SERT binding sites decreases are not a consequence of reduced SERT gene expression, as revealed by in situ hybridization measurements. SSRI-induced downregulation of the SERT may be a key component for the clinical response to SSRIs...
  22. ncbi request reprint Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 28:1633-41. 2003
    ..Thus, pretreatment of rats with PRX actually enhanced at least one regulatory effect of RBX treatment on the noradrenergic system, and did not interfere with any other pharmacological effect caused by RBX treatment...
  23. ncbi request reprint Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229 3900, San Antonio, TX, USA
    Brain Res 979:51-6. 2003
    ..The distribution of GHB binding sites as defined by [(3)H]NCS-382 suggests that GHB may play a role in neuromodulation or neurotransmission in frontal brain areas...
  24. ncbi request reprint Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Int J Neuropsychopharmacol 7:193-218. 2004
    ....
  25. ncbi request reprint Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons
    Sylvia Montañez
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 87:861-7. 2003
    ..Functional loss of SERT activity occurs when destruction of serotonergic innervation is greater than 90% but serotonin clearance and efficacy of fluvoxamine is maintained with as few as one fifth of a full complement of SERTs...
  26. ncbi request reprint Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression
    Martin M Katz
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 29:566-79. 2004
    ..Early drug-specific behavioral changes were highly predictive of ultimate clinical response to the different ADs, results that could eventually be applied directly to clinical practice...
  27. ncbi request reprint Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats
    Ruggero Galici
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Tex 78229, USA
    Neuroendocrinology 77:132-40. 2003
    ..Collectively, these studies suggest that insulin pathways in the brain may play an important role in regulating DAT activity and amphetamine action...
  28. doi request reprint Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Eur J Pharmacol 587:90-8. 2008
    ..Such acute effects of BDNF would be expected to counter early effects of SSRIs, which might, in part, account for some delay in therapeutic effect...
  29. ncbi request reprint Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment
    Corina O Bondi
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 33:320-31. 2008
    ..These effects were prevented by chronic treatment with antidepressant drugs, consistent also with clinical evidence that relapse of depressive episodes can be prevented by antidepressant drug treatment...
  30. ncbi request reprint CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum
    David A Price
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Neurochem 101:389-96. 2007
    ..These results indicate that both cannabinoid agonists and antagonists inhibit dopamine transporter activity via molecular targets other than CB(1) receptors...
  31. ncbi request reprint Delayed pharmacological effects of antidepressants
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Psychiatry 7:S23-8. 2002
    ..Substantial loss of serotonin transporter binding sites takes 15 days to occur and is accompanied by a marked reduction of serotonin transporter function in vivo...
  32. doi request reprint Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress
    M K Green
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuroscience 192:438-51. 2011
    ..These results suggest that PNS induces vulnerability to subsequent adult stress, resulting in an enhanced fear-like behavioral profile, and dysregulation of brain noradrenergic and hypothalamic-pituitary-adrenal axis (HPA) activity...
  33. ncbi request reprint A video method for the evaluation of antidepressant clinical and behavioural actions
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 9:327-36. 2006
    ..e. effect motor activity and depressed mood, and paroxetine to reduce global severity and anxiety. The study shows the VIBES to be capable of uncovering behavioural mechanisms underlying AD's capacity to resolve depressive disorder...
  34. ncbi request reprint Enhancing the technology of clinical trials and the trials model to evaluate newly developed, targeted antidepressants
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuropsychopharmacology 27:319-28. 2002
    ..This article discusses these four areas and presents the consensus of the panel participants...
  35. doi request reprint Rethinking depression and the actions of antidepressants: uncovering the links between the neural and behavioral elements
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    J Affect Disord 120:16-23. 2010
    ....
  36. ncbi request reprint Resolving the onset of antidepressants' clinical actions: critical for clinical practice and new drug development
    Martin M Katz
    J Clin Psychopharmacol 26:549-53. 2006

Research Grants18

  1. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2010
    ..The results obtained could have important implications for understanding treatment non-response in some women. ..
  2. Epigenetic mechanisms: CIE-induced NR2B gene up-regulation in alcohol dependence
    Alan Frazer; Fiscal Year: 2010
    ....
  3. Vagal Nerve Stimulation and Antidepressants: c-Fos deltaFosB and Activation of T
    Alan Frazer; Fiscal Year: 2010
    ..The results could provide important, new information regarding the central nervous system effects of VNS that are important for the treatment of depression. ..
  4. Epigenetic mechanisms: CIE-induced NR2B gene up-regulation in alcohol dependence
    Alan Frazer; Fiscal Year: 2009
    ....
  5. Epigenetic mechanisms: CIE-induced NR2B gene up-regulation in alcohol dependence
    Alan Frazer; Fiscal Year: 2007
    ....
  6. South Texas Graduate Diversification Program
    Alan Frazer; Fiscal Year: 2006
    ..Talented URMs are available who are capable of having successful careers in mental health research. Our program is designed to recruit these students and demonstrate to them that the can be successful. ..
  7. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..These experiments involve multiple approaches to study an effect of specific antidepressant drugs that may be very important in sustaining the enhancement of monoaminergic transmission that underlies clinical improvement ..
  8. CHRONOAMPEROMETRY TO MEASURE EXTRACELLULAR 5HT
    Alan Frazer; Fiscal Year: 2000
    ..These experiments provide a new approach to study whether the SERT, a primary target for several types of antidepressants, is capable of being regulated either acutely or chronically in vivo. ..