SALLY ANN FRAUTSCHY

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
    Miriam A Hickey
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Neurodegener 7:12. 2012
  2. pmc What was lost in translation in the DHA trial is whom you should intend to treat
    Sally A Frautschy
    Veterans Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, 16111 Plummer St, North Hills, CA 91343, USA
    Alzheimers Res Ther 3:2. 2011
  3. pmc Why pleiotropic interventions are needed for Alzheimer's disease
    Sally A Frautschy
    Geriatric Research and Clinical Center, Greater Los Angeles Healthcare System, Veteran s Administration, Los Angeles, USA
    Mol Neurobiol 41:392-409. 2010
  4. doi request reprint Thinking outside the box about COX-1 in Alzheimer's disease
    Sally A Frautschy
    Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, North Hills, CA 91343, USA
    Neurobiol Dis 38:492-4. 2010
  5. ncbi request reprint Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    S A Frautschy
    VAGLAHS Sepulveda GRECC, Departments of Medicine and Neurology, UCLA, 16111 Plummer Street, North Hills, CA, USA
    Neurobiol Aging 22:993-1005. 2001
  6. doi request reprint Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:9078-89. 2009
  7. ncbi request reprint A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
  8. doi request reprint GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
    Shuxin Hu
    Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, USA
    Neurobiol Dis 33:193-206. 2009
  9. ncbi request reprint Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, California, USA
    Eur J Neurosci 22:617-26. 2005
  10. ncbi request reprint Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    Fusheng Yang
    Department of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 280:5892-901. 2005

Research Grants

  1. Curcumin and Curcumin Derivatives for Alzheimer's
    SALLY FRAUTSCHY; Fiscal Year: 2007
  2. CYTOKINE REGULATION OF BETA PROTEIN DEPOSITION
    SALLY FRAUTSCHY; Fiscal Year: 2004
  3. ABETA ACCUMULATION AND TOXICITY IN AN ALZHEIMER
    SALLY FRAUTSCHY; Fiscal Year: 2004

Collaborators

Detail Information

Publications34

  1. pmc Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
    Miriam A Hickey
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Neurodegener 7:12. 2012
    ..We have examined the ability of life-long dietary curcumin to improve the early pathological phenotype of CAG140 mice...
  2. pmc What was lost in translation in the DHA trial is whom you should intend to treat
    Sally A Frautschy
    Veterans Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, 16111 Plummer St, North Hills, CA 91343, USA
    Alzheimers Res Ther 3:2. 2011
    ..should preclinical and clinical studies be performed to optimize dose and mitigate oxidation before pursuing intervention or prevention trials with DHA? And finally, should DHA be tested now for mild cognitive impairment or prevention?..
  3. pmc Why pleiotropic interventions are needed for Alzheimer's disease
    Sally A Frautschy
    Geriatric Research and Clinical Center, Greater Los Angeles Healthcare System, Veteran s Administration, Los Angeles, USA
    Mol Neurobiol 41:392-409. 2010
    ....
  4. doi request reprint Thinking outside the box about COX-1 in Alzheimer's disease
    Sally A Frautschy
    Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, North Hills, CA 91343, USA
    Neurobiol Dis 38:492-4. 2010
    ..The animal model data in this article as well as the recently published trial data suggest that COX-1 may play an important role in early pathogenesis and should not be ignored as a potential target for early intervention...
  5. ncbi request reprint Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    S A Frautschy
    VAGLAHS Sepulveda GRECC, Departments of Medicine and Neurology, UCLA, 16111 Plummer Street, North Hills, CA, USA
    Neurobiol Aging 22:993-1005. 2001
    ..Because of its low side-effect profile and long history of safe use, curcumin may find clinical application for AD prevention...
  6. doi request reprint Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:9078-89. 2009
    ....
  7. ncbi request reprint A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
    ..Together, these results suggest that dietary DHA could be protective against beta-amyloid production, accumulation, and potential downstream toxicity...
  8. doi request reprint GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
    Shuxin Hu
    Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, USA
    Neurobiol Dis 33:193-206. 2009
    ..These data support a role for GSK3 hyperactivation in AD pathogenesis, but emphasize the importance of developing inhibitors that do not suppress constitutive activity...
  9. ncbi request reprint Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, California, USA
    Eur J Neurosci 22:617-26. 2005
    ..The marked effect of dietary n-3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk...
  10. ncbi request reprint Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    Fusheng Yang
    Department of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 280:5892-901. 2005
    ..These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD...
  11. ncbi request reprint Cat and mouse
    Greg M Cole
    Greater Los Angeles Healthcare System, Veterans Administration Medical Center, Geriatric Research Education Clinical Center, North Hills, California 91343, USA
    Neuron 51:671-2. 2006
    ..manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid, while inactivation accelerates beta-amyloidosis...
  12. pmc Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci 27:14299-307. 2007
    ..Because reduced LR11 is known to increase Abeta production and may be a significant genetic cause of LOAD, our results indicate that DHA increases in SorLA/LR11 levels may play an important role in preventing LOAD...
  13. pmc Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Neuron 43:633-45. 2004
    ..Since n-3 PFAs are essential for p85-mediated CNS insulin signaling and selective protection of postsynaptic proteins, these findings have implications for neurodegenerative diseases where synaptic loss is critical, especially AD...
  14. pmc DHA may prevent age-related dementia
    Greg M Cole
    Departments of Medicine and Neurology, University of California, Los Angeles, CA 90095, USA
    J Nutr 140:869-74. 2010
    ..We advocate early intervention in a prodromal period with nutrigenomically defined subjects with an appropriately designed nutritional supplement, including DHA and antioxidants...
  15. pmc Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California, USA
    Arch Neurol 66:448-57. 2009
    ..LR11 protein is reduced in patients with late-onset AD, and LR11 polymorphisms have been associated with late-onset AD...
  16. ncbi request reprint Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model
    Aynun N Begum
    Department of Medicine, University of California, Los Angeles, CA, USA
    J Alzheimers Dis 15:625-40. 2008
    ..In summary, the newly described in vivo infusion model may be useful cost-effective method for screening for new therapeutic drugs for AD...
  17. ncbi request reprint Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease
    Greg M Cole
    Geriatric Research and Education Center, North Hills, CA 91343, USA
    CNS Neurol Disord Drug Targets 9:140-8. 2010
    ..This encourages researchers to re-address possible mechanisms for a stage-dependent NSAID efficacy, the subject of this review...
  18. pmc Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
    Aynun N Begum
    Department of Medicine, University of California, Los Angeles, California, USA
    J Pharmacol Exp Ther 326:196-208. 2008
    ....
  19. doi request reprint Omega-3 fatty acids and dementia
    Greg M Cole
    Department of Medicine at University of California, Los Angeles, CA, USA
    Prostaglandins Leukot Essent Fatty Acids 81:213-21. 2009
    ..Clinical trials are underway to prevent and treat AD. Results to-date suggest that DHA may be more effective if it is begun early or used in conjunction with antioxidants...
  20. doi request reprint Dietary fatty acids and the aging brain
    Greg M Cole
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nutr Rev 68:S102-11. 2010
    ..Evidence presented here shows DHA acts to oppose this, exerting a plethora of pleiotropic activities to protect against the pathogenesis of Alzheimer's disease...
  21. ncbi request reprint NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models
    Greg M Cole
    Greater Los Angeles Healthcare System, Veterans Administration Medical Center, North Hills, CA 91343, USA
    Ann N Y Acad Sci 1035:68-84. 2004
    ..Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration...
  22. pmc A potential role of the curry spice curcumin in Alzheimer's disease
    John M Ringman
    University of California, Los Angeles, Department of Neurology, Alzheimer s Disease Research Center, Los Angeles, CA 90095, USA
    Curr Alzheimer Res 2:131-6. 2005
    ..We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology...
  23. ncbi request reprint Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory
    Marni E Harris-White
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 77:217-28. 2004
    ..Using both in vitro and in vivo methods, we identify LRP as playing a role in TGFbeta2-mediated Abeta uptake, neurodegeneration, and spatial memory impairment...
  24. ncbi request reprint Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Sepulveda, CA 91343, USA
    Neurobiol Aging 26:133-6. 2005
    ..Both DHA and curcumin have favorable safety profiles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.)...
  25. ncbi request reprint Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 83:374-84. 2006
    ..These data suggest that antibodies that are highly specific for toxic oligomer subspecies may reduce toxicity via reduction of GSK-3beta, which could be an important strategy for Alzheimer's disease (AD) therapeutics...
  26. ncbi request reprint Alzheimer's amyloid story finds its star
    Greg M Cole
    Department of Medicine and Neurology, UCLA SFVP and GLAVA GRECC 11E, 16111 Plummer, North Hills, CA 91343, USA
    Trends Mol Med 12:395-6. 2006
    ..These authors used a transgenic mouse model to identify a specific type of aggregate that emerges with cognitive deficits and is capable of transmitting a spatial memory defect to unimpaired animals...
  27. ncbi request reprint The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Exp Gerontol 42:10-21. 2007
    ..A better understanding of the precise mechanisms underlying alterations in the insulin/neurotrophic factor signal transduction pathways should aid the search for better AD therapeutic and prevention strategies...
  28. ncbi request reprint Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, California, USA
    Nutr Health 18:249-59. 2006
    ..Many Western diets are typically deficient in DHA and low in polyphenolic antioxidant intake. These and other data argue that increasing dietary intake of both DHA and polyphenolic antioxidants may be useful for AD prevention...
  29. pmc Neuroprotective effects of curcumin
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education, and Clinic Center, Sepulveda, CA 91343, USA
    Adv Exp Med Biol 595:197-212. 2007
    ..Promising results have already led to ongoing pilot clinical trials...
  30. pmc p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis
    Qiu Lan Ma
    Department of Medicine, UCLA, Los Angeles, California, USA
    J Biol Chem 283:14132-43. 2008
    ..Our results implicate aberrant PAK in Abeta oligomer-induced signaling and synaptic deficits in Alzheimer disease...
  31. pmc Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California, USA
    J Neurochem 103:1594-607. 2007
    ..These effects were reversed by anti-oligomer. Our data strongly support the existence of an APPsw transgene-dependent and Abeta oligomer-mediated defect in regulation of ERK activation...
  32. ncbi request reprint Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography
    Dennis D Heath
    Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, CA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 824:206-12. 2005
    ..6%. The average recovery of THC from plasma and urine was greater than 98.5%. These data demonstrate a rapid, sensitive and accurate method for HPLC quantification of THC in plasma and urine...
  33. ncbi request reprint Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models
    Takashi Morihara
    Greater Los Angeles VA Healthcare System, GRECC, Sepulveda, CA, USA
    Neuropsychopharmacology 30:1111-20. 2005
    ..We present evidence supporting the hypothesis that ibuprofen-dependent amyloid reduction is mediated by inhibition of an alternate pathway (IL-1beta and its downstream target ACT)...
  34. pmc Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior
    Lalini Ramanathan
    Neurobiology Research 151A3, Greater Los Angeles Health Care System, North Hills, CA, USA
    Behav Brain Res 207:305-9. 2010
    ..We conclude that acute (6h) sleep loss may trigger compensatory mechanisms (like increased antioxidant responses) that prevent initial deterioration in working memory...

Research Grants4

  1. Curcumin and Curcumin Derivatives for Alzheimer's
    SALLY FRAUTSCHY; Fiscal Year: 2007
    ..Year 3. Long term (2 yr) safety studies completed and single dose efficacy for curcumin in long-term models. Year 4. Dose-response and behavior battery for curcumin completed in long-term models. Prepare for AD pilot clinical trial. ..
  2. CYTOKINE REGULATION OF BETA PROTEIN DEPOSITION
    SALLY FRAUTSCHY; Fiscal Year: 2004
    ..It should be of direct relevance to the prevention and treatment of Alzheimer's disease. ..
  3. ABETA ACCUMULATION AND TOXICITY IN AN ALZHEIMER
    SALLY FRAUTSCHY; Fiscal Year: 2004
    ..Aim 4 will evaluate if age-related defects in intracellular degradation increase ABeta accumulation and toxicity. ..