Clara Franzini-Armstrong

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A method for the ultrastructural preservation of tiny percutaneous needle biopsy material from skeletal muscle
    Tiziana Pietrangelo
    Department of Neuroscience and Imaging, Section of Physiology and Physiopathology, G d Annunzio University of Chieti Pescara and Clinical Research Center of G d Annunzio Foundation, Chieti I 66100, Italy
    Int J Mol Med 32:965-70. 2013
  2. pmc Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles
    C Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 77:1528-39. 1999
  3. ncbi request reprint Functional implications of RyR-dHPR relationships in skeletal and cardiac muscles
    Clara Franzini-Armstrong
    Dept Cell Developmental Biology, University of Pennsylvania School of Medicine, Anatomy Chemistry, Building B42, Philadelphia, PA 19104 6058, USA
    Biol Res 37:507-12. 2004
  4. ncbi request reprint ER-mitochondria communication. How privileged?
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Physiology (Bethesda) 22:261-8. 2007
  5. ncbi request reprint The assembly of calcium release units in cardiac muscle
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1047:76-85. 2005
  6. doi request reprint Architecture and regulation of the Ca2+ delivery system in muscle cells
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Appl Physiol Nutr Metab 34:323-7. 2009
  7. pmc The evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biomed Biotechnol 2011:830573. 2011
  8. ncbi request reprint The sarcoplasmic reticulum and the control of muscle contraction
    C Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia 19104 6058, USA
    FASEB J 13:S266-70. 1999
  9. doi request reprint Ultrastructure of cardiac muscle in reptiles and birds: optimizing and/or reducing the probability of transmission between calcium release units
    Stefano Perni
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Muscle Res Cell Motil 33:145-52. 2012
  10. pmc Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery
    Valentina Di Biase
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104
    J Cell Biol 171:695-704. 2005

Research Grants

  1. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2002
  2. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2003
  3. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2004
  4. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2005
  5. Calcium release units in skeletal and cardiac muscle
    Clara Franzini Armstrong; Fiscal Year: 2007
  6. Core D
    Clara Franzini Armstrong; Fiscal Year: 2007
  7. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 2002
  8. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 2001
  9. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 1999
  10. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 1999

Collaborators

Detail Information

Publications42

  1. pmc A method for the ultrastructural preservation of tiny percutaneous needle biopsy material from skeletal muscle
    Tiziana Pietrangelo
    Department of Neuroscience and Imaging, Section of Physiology and Physiopathology, G d Annunzio University of Chieti Pescara and Clinical Research Center of G d Annunzio Foundation, Chieti I 66100, Italy
    Int J Mol Med 32:965-70. 2013
    ..However, it offers the major advantage of allowing multiple samples within a single session and this may be useful under specific circumstances. ..
  2. pmc Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles
    C Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 77:1528-39. 1999
    ..This paper presents a compilation of quantitative data on couplons in a variety of skeletal and cardiac muscles, which is useful in modeling calcium release events, both macroscopic and microscopic ("sparks")...
  3. ncbi request reprint Functional implications of RyR-dHPR relationships in skeletal and cardiac muscles
    Clara Franzini-Armstrong
    Dept Cell Developmental Biology, University of Pennsylvania School of Medicine, Anatomy Chemistry, Building B42, Philadelphia, PA 19104 6058, USA
    Biol Res 37:507-12. 2004
    ..A second location of RyR2 is on SR cisternae that are not attached to surface membrane/T tubules. The RyR2 in these cisternae, which are often several microns away from any DHPRs, must necessarily be activated indirectly...
  4. ncbi request reprint ER-mitochondria communication. How privileged?
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Physiology (Bethesda) 22:261-8. 2007
    ..This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum...
  5. ncbi request reprint The assembly of calcium release units in cardiac muscle
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1047:76-85. 2005
    ..In addition, the structural cues provided by the overexpression models allow us to define sequential steps in the synthetic pathway for JnC and CSQ and their targeting to the CRUs of differentiating myocardium...
  6. doi request reprint Architecture and regulation of the Ca2+ delivery system in muscle cells
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Appl Physiol Nutr Metab 34:323-7. 2009
    ..Cardiac muscles either overexpressing or bearing null mutations for 3 proteins of the junctional complex (CSQ, Jct, and Tr) reveal the contribution of these 3 components to the general architecture of the jSR...
  7. pmc The evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biomed Biotechnol 2011:830573. 2011
    ..This is most evident in fish muscles. Clustering of free subsarcolemmal mitochondria in proximity of capillaries is also more frequently achieved in mammalian than in other vertebrates...
  8. ncbi request reprint The sarcoplasmic reticulum and the control of muscle contraction
    C Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia 19104 6058, USA
    FASEB J 13:S266-70. 1999
    ..Molecular biology experiments combined with EM indicate that DHPRs are linked to RyRs in skeletal but probably not in cardiac muscle...
  9. doi request reprint Ultrastructure of cardiac muscle in reptiles and birds: optimizing and/or reducing the probability of transmission between calcium release units
    Stefano Perni
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Muscle Res Cell Motil 33:145-52. 2012
    ....
  10. pmc Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery
    Valentina Di Biase
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104
    J Cell Biol 171:695-704. 2005
    ..Our results show that a significant structural transition marks the protochordate to the Craniate evolutionary step, with the appearance of skeletal muscle-specific RyR and DHPR isoforms...
  11. ncbi request reprint Protein interactions within calcium release units of muscle
    Clara Franzini-Armstrong
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Muscle Res Cell Motil 25:586-7. 2004
  12. pmc Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle
    Edward Felder
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058, USA
    Biophys J 82:3144-9. 2002
    ..Interestingly, simultaneous lack of the two major excitation-contraction coupling proteins results in decrease of calcium release units frequency in the diaphragm, compared with either single knockout mutation...
  13. ncbi request reprint T-tubule profiles in Purkinje fibres of mammalian myocardium
    Alessandro Di Maio
    Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Anat Chem building, Philadelphia, PA 19104 6058, USA
    J Muscle Res Cell Motil 28:115-21. 2007
    ..It is thought that lack of T tubules in P-cells is necessary to reduce capacitance and thus accelerate action potential spread. This may not be as important in a small heart...
  14. ncbi request reprint The relative position of RyR feet and DHPR tetrads in skeletal muscle
    Cecilia Paolini
    University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia 19104 6058, USA
    J Mol Biol 342:145-53. 2004
    ..If the orientation for the two sets of images is carefully maintained, the superimposition provides specific constraints on the DHPR-RyR relative position...
  15. doi request reprint Structural evidence for perinuclear calcium microdomains in cardiac myocytes
    Matias Escobar
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    J Mol Cell Cardiol 50:451-9. 2011
    ..The frequency, distribution and distance from the nucleus of T tubules and dyads appropriately establish local perinuclear Ca(2+) microdomains in cardiac myocytes...
  16. pmc Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position
    Edward Felder
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Proc Natl Acad Sci U S A 99:1695-700. 2002
    ..On the basis of these two observations, we postulate that RyR3s are restricted to the parajunctional region, and thus their activation must be indirect and derivative during excitation-contraction coupling...
  17. pmc Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of dihydropyridine-receptor arrays in skeletal muscle
    Hiroaki Takekura
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 15:5408-19. 2004
    ..These findings suggest an inhibitory role in tetrad formation of the cardiac II-III loop and that the organization of DHPRs in tetrads vis-a-vis the RyR is necessary but not sufficient for skeletal-type e-c coupling...
  18. pmc Novel details of calsequestrin gel conformation in situ
    Stefano Perni
    From the Department of Cell Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058 and
    J Biol Chem 288:31358-62. 2013
    ..The latter directly illustrate the fundamental network nature of polymerized CASQ, revealing repeated nodal points connecting short segments of the linear polymer. ..
  19. ncbi request reprint T-tubule formation in cardiacmyocytes: two possible mechanisms?
    Alessandro Di Maio
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Anat Chem building, Room B42, Philadelphia, PA 19104 6058, USA
    J Muscle Res Cell Motil 28:231-41. 2007
    ..In the remaining CRUs, activation of Ca(2+) release must be dependent on some other mechanisms...
  20. ncbi request reprint Increased neuromuscular activity causes axonal defects and muscular degeneration
    Julie L Lefebvre
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 131:2605-18. 2004
    ..Together, our results provide compelling evidence that during pathfinding, myotomal muscle cells communicate extensively with extending motor axons through en passant synaptic contacts...
  21. ncbi request reprint Junctin and calsequestrin overexpression in cardiac muscle: the role of junctin and the synthetic and delivery pathways for the two proteins
    Pierre Tijskens
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, B1 Anatomy Chemistry Building, Philadelphia, PA 19104 6058, USA
    J Mol Cell Cardiol 35:961-74. 2003
    ..CSQ is delivered from the Golgi to the SR, where it buds out into precursors of the jSR vesicles. JNC reaches the jSR vesicles directly, but its arrival is delayed relative to CSQ...
  22. pmc In vivo nerve-macrophage interactions following peripheral nerve injury
    ALLISON F ROSENBERG
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Neurosci 32:3898-909. 2012
    ..Thus, live cell imaging defines novel cellular and functional interactions between injured nerves and immune cells...
  23. pmc Location of ryanodine and dihydropyridine receptors in frog myocardium
    Pierre Tijskens
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058, USA
    Biophys J 84:1079-92. 2003
    ..Interestingly, the free SR membrane in both heart chambers shows a low but equal density of intramembrane particles representing the Ca(2+) ATPase...
  24. pmc Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
    Cesar Cardenas
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    J Struct Biol 171:372-81. 2010
    ..The combination of nuclear isolation with freeze-drying and rotary shadow techniques allows direct visualization of InsP(3)Rs in native nuclear envelopes and can be used to determine their spatial distribution and density...
  25. ncbi request reprint Contribution of myosin rod protein to the structural organization of adult and embryonic muscles in Drosophila
    Erzsebet Polyak
    Department of Cell and Developmental Biology, University of Pennsylvania, 245 Anatomy Chemistry Building, 36th Street and Hamilton Walk, 19104 6058, Philadelphia, PA, USA
    J Mol Biol 331:1077-91. 2003
    ..Our findings support the conclusion that MRP has an active function to modulate the contractile activity of muscles in which it is expressed...
  26. pmc Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation
    Julie L Lefebvre
    Department of Cell, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Proc Natl Acad Sci U S A 104:2483-8. 2007
    ....
  27. ncbi request reprint Hugh E. Huxley: birth of the filament sliding model of muscle contraction
    Annemarie Weber
    Dept of Biochemistry, University of Pennsylvania, Philadelphia 19104, USA
    Trends Cell Biol 12:243-5. 2002
    ..He developed the entirely new concept of movement based on the relative motion of two elongated protein polymers powered by the action of independent molecular motors. The concept applies to a large number of cell motility mechanisms...
  28. pmc The structure of Ca(2+) release units in arthropod body muscle indicates an indirect mechanism for excitation-contraction coupling
    Hiroaki Takekura
    Department of Physiological Sciences, National Institute of Fitness and Sports, Kanoya, Kagoshima 891 23, Japan
    Biophys J 83:2742-53. 2002
    ..This matches the architecture of vertebrate cardiac muscle and is in keeping with the similarity in e-c coupling mechanisms in cardiac and invertebrate striated muscles...
  29. pmc Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle
    Feliciano Protasi
    Department of Anesthesia Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biophys J 83:3230-44. 2002
    ....
  30. pmc Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes
    Marcin P Gach
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biophys J 94:3023-34. 2008
    ..Thus, we conclude that the alpha(2)delta(1) dihydropyridine receptor subunit is physiologically necessary for sustaining Ca(2+) transients in response to prolonged depolarization or repeated trains of action potentials...
  31. pmc An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line
    Elena Zvaritch
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, 112 College Street, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 104:18537-42. 2007
    ....
  32. ncbi request reprint Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
    ..Overall, our data support an indirect role for triadin in regulating myoplasmic Ca(2+) homeostasis and organizing the molecular complex of the triad but not in regulating skeletal-type excitation-contraction coupling...
  33. pmc Ca2+ blinks: rapid nanoscopic store calcium signaling
    Didier X P Brochet
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:3099-104. 2005
    ..Visualization of local store Ca(2+) signaling thus broadens our understanding of cardiac store Ca(2+) regulation and function and opens the possibility for local regulation of diverse store-dependent functions...
  34. pmc Organization of Ca2+ release units in excitable smooth muscle of the guinea-pig urinary bladder
    Edwin D Moore
    Department of Physiology, University of British Columbia, Vancouver, British Columbia, Canada
    Biophys J 87:1836-47. 2004
    ..Structural analogies between smooth and cardiac muscle excitation-contraction coupling complexes suggest a common basic mechanism of action...
  35. pmc Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion
    Susan Treves
    Department of Anesthesiology, University of Basel Kantosspital, Basel, Switzerland
    J Cell Biol 166:537-48. 2004
    ..These results demonstrate that junctate is a new protein involved in calcium homeostasis in eukaryotic cells...
  36. pmc The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle
    Johann Schredelseker
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 102:17219-24. 2005
    ..This defect properly explains the complete deficiency of skeletal muscle excitation-contraction coupling in beta(1)-null model organisms...
  37. pmc Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia
    Bjorn C Knollmann
    Oates Institute for Experimental Therapeutics and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    J Clin Invest 116:2510-20. 2006
    ....
  38. pmc Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions
    David C Sheridan
    University of Colorado Health and Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:19760-5. 2006
    ....
  39. pmc A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice
    Wessel P Dirksen
    Department of Physiology and Cell Biology, 304 Hamilton Hall, 1645 Neil Ave, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Cardiovasc Res 75:69-78. 2007
    ..The goal of this study was to establish a causal link between CASQ2(D307H) and the CPVT phenotype using an in vivo model...
  40. ncbi request reprint Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice
    Nagesh Chopra
    Oates Institute for Experimental Therapeutics, and Division of Clinical Pharmacology, Vanderbilt University Medical Center, 1265 Medical Research Building IV, Nashville, TN 37232 0575, USA
    Circ Res 101:617-26. 2007
    ..The underlying mechanism is likely the direct regulation of SR Ca2+ release channels by Casq2 rather than altered luminal Ca2+...
  41. pmc Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle
    Richard T Tregear
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Biophys J 86:3009-19. 2004
    ..Moreover, in the absence of filament sliding, cross-bridges cannot change tilt angle while attached nor reach other target zones while detached, so may cycle repeatedly on and off the same actin target monomer...
  42. ncbi request reprint A flexible domain is essential for the large step size and processivity of myosin VI
    Ronald S Rock
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 17:603-9. 2005
    ..Based on these results, we present a mechanical model that describes stepping under an applied load...

Research Grants22

  1. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2002
    ..To understand how the eye performs its repertoire of motions under both normal and pathological circumstances, one must understand the synthetic capacity of each fiber and how it defines the functional properties of each fiber. ..
  2. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2003
    ..abstract_text> ..
  3. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2004
    ..abstract_text> ..
  4. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2005
    ..abstract_text> ..
  5. Calcium release units in skeletal and cardiac muscle
    Clara Franzini Armstrong; Fiscal Year: 2007
    ..The structural approaches to be used center on techniques of transmission and freeze-fracture electron microscopy, correlated with immunofluorescence and confocal light microscopy. ..
  6. Core D
    Clara Franzini Armstrong; Fiscal Year: 2007
    ..We will define the ultrastructure of sites where RyR1 and CaV1.3 are co-localized in dendritic cells (DC) and detect any variations introduced by the MH/CCD mutations (Supporting project 2) ..
  7. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 2002
    ..3) The composition of CRUs in skeletal muscle of Amphioxus will be examined using molecular biology and ultrastructural approaches. ..
  8. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 2001
    ..3) The composition of CRUs in skeletal muscle of Amphioxus will be examined using molecular biology and ultrastructural approaches. ..
  9. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 1999
    ..To understand how the eye performs its repertoire of motions under both normal and pathological circumstances, one must understand the synthetic capacity of each fiber and how it defines the functional properties of each fiber. ..
  10. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 1999
    ..3) The composition of CRUs in skeletal muscle of Amphioxus will be examined using molecular biology and ultrastructural approaches. ..
  11. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 1993
    ..Information from avian muscle will be correlated to rat muscle, whose physiology is best established...
  12. FUNCTIONAL RESPONSES OF EXTRAOCULAR EYE MUSCLES TO T3
    Neal Rubinstein; Fiscal Year: 2000
    ..To understand how the eye performs its repertoire of motions under both normal and pathological circumstances, one must understand the synthetic capacity of each fiber and how it defines the functional properties of each fiber. ..
  13. CALCIUM RELEASE UNITS IN CARDIAC MUSCLE
    Clara Franzini Armstrong; Fiscal Year: 2000
    ..3) The composition of CRUs in skeletal muscle of Amphioxus will be examined using molecular biology and ultrastructural approaches. ..