Carol E Franz

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults
    Carol E Franz
    University of California San Diego, Department of Psychiatry, MC0738, La Jolla, CA 92093, USA Electronic address
    Psychoneuroendocrinology 38:2127-39. 2013
  2. ncbi request reprint Genetic and environmental multidimensionality of well- and ill-being in middle aged twin men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
    Behav Genet 42:579-91. 2012
  3. ncbi request reprint Nonmedical influences on the use of cholinesterase inhibitors in dementia care
    Carol E Franz
    University of California, San Diego, La Jolla, CA 92093, USA
    Alzheimer Dis Assoc Disord 21:241-8. 2007
  4. pmc Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0738, USA
    Behav Genet 40:467-79. 2010
  5. ncbi request reprint Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
  6. pmc When help becomes a hindrance: mental health referral systems as barriers to care for primary care physicians treating patients with Alzheimer's disease
    Carol E Franz
    Department of Psychiatry, University of California, San Diego, CA, USA
    Am J Geriatr Psychiatry 18:576-85. 2010
  7. pmc A 35-year longitudinal assessment of cognition and midlife depression symptoms: the Vietnam Era Twin Study of Aging
    Carol E Franz
    Department of Psychiatry, University of California, San Diego, 92093, USA
    Am J Geriatr Psychiatry 19:559-70. 2011
  8. pmc Adult romantic attachment, negative emotionality, and depressive symptoms in middle aged men: a multivariate genetic analysis
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0738, USA
    Behav Genet 41:488-98. 2011
  9. pmc Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of aging
    Carol E Franz
    University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738, La Jolla, CA 92093, USA
    Psychoneuroendocrinology 36:1040-52. 2011
  10. pmc Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States Electronic address
    Psychoneuroendocrinology 38:2163-72. 2013

Detail Information

Publications47

  1. doi request reprint Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults
    Carol E Franz
    University of California San Diego, Department of Psychiatry, MC0738, La Jolla, CA 92093, USA Electronic address
    Psychoneuroendocrinology 38:2127-39. 2013
    ..8% of the total effect of childhood disadvantage [β=0.12 (0.05; 0.18)] on total daytime cortisol. Associations remained significant after accounting for ethnicity, smoking status, and self-reported depressive symptoms. ..
  2. ncbi request reprint Genetic and environmental multidimensionality of well- and ill-being in middle aged twin men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
    Behav Genet 42:579-91. 2012
    ..All measures had specific unique environmental influences. Results indicate that well-being is genetically and environmentally multidimensional and that ill-being has partial overlap with both latent factors...
  3. ncbi request reprint Nonmedical influences on the use of cholinesterase inhibitors in dementia care
    Carol E Franz
    University of California, San Diego, La Jolla, CA 92093, USA
    Alzheimer Dis Assoc Disord 21:241-8. 2007
    ..Physicians reported feeling pressured by families to prescribe ChEI. Under these ambiguous conditions, some physicians prescribed medications simply to be able to offer "something" to patients...
  4. pmc Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0738, USA
    Behav Genet 40:467-79. 2010
    ..The results suggest that genetic factors influence cortisol responses to specific environmental stressors. Thus, cortisol levels are correlated in identical twins only when they undergo similar experiences...
  5. ncbi request reprint Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
    ..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status...
  6. pmc When help becomes a hindrance: mental health referral systems as barriers to care for primary care physicians treating patients with Alzheimer's disease
    Carol E Franz
    Department of Psychiatry, University of California, San Diego, CA, USA
    Am J Geriatr Psychiatry 18:576-85. 2010
    ..To describe structural barriers to mental health specialists and consequences of these barriers to care for patients with dementia and neuropsychological symptoms and their primary care physicians (PCPs)...
  7. pmc A 35-year longitudinal assessment of cognition and midlife depression symptoms: the Vietnam Era Twin Study of Aging
    Carol E Franz
    Department of Psychiatry, University of California, San Diego, 92093, USA
    Am J Geriatr Psychiatry 19:559-70. 2011
    ....
  8. pmc Adult romantic attachment, negative emotionality, and depressive symptoms in middle aged men: a multivariate genetic analysis
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0738, USA
    Behav Genet 41:488-98. 2011
    ..41, indicating some, but not complete overlap of genetic factors. Genetically informative longitudinal studies on attachment relationship dimensions can help to illuminate the role of relationship-based risk factors in healthy aging...
  9. pmc Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of aging
    Carol E Franz
    University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738, La Jolla, CA 92093, USA
    Psychoneuroendocrinology 36:1040-52. 2011
    ..The results also suggest that the direction of effect is complex...
  10. pmc Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States Electronic address
    Psychoneuroendocrinology 38:2163-72. 2013
    ..The aim of the present study was to determine the degree to which genetic and environmental factors contribute to individual differences in testosterone throughout the day in middle-aged men...
  11. ncbi request reprint Genes, environment, and time: the Vietnam Era Twin Study of Aging (VETSA)
    William S Kremen
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    Twin Res Hum Genet 9:1009-22. 2006
    ....
  12. pmc Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 60:1686-95. 2012
    ..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics...
  13. ncbi request reprint Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, California Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, California
    Am J Med Genet B Neuropsychiatr Genet 162:751-61. 2013
    ..Examples supporting the validity of these conclusions are provided...
  14. pmc A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Twin Res Hum Genet 15:304-14. 2012
    ..Implications regarding brain phenotypes for future genetic association studies are discussed...
  15. pmc Genetic architecture of learning and delayed recall: a twin study of episodic memory
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropsychology 25:488-98. 2011
    ....
  16. ncbi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  17. pmc Genetic architecture of context processing in late middle age: more than one underlying mechanism
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, USA
    Psychol Aging 26:852-63. 2011
    ..In contrast, the reactive control component was unrelated to general cognitive ability...
  18. pmc Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age
    Eero Vuoksimaa
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychologia 51:1124-31. 2013
    ..e., lower levels of cognitive reserve. Our results provide support for the hypothesis that cognitive reserve moderates the relationship between brain structure and cognition in middle age, well before the onset of dementia...
  19. pmc Hierarchical genetic organization of human cortical surface area
    Chi Hua Chen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 335:1634-6. 2012
    ..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
  20. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  21. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
    ..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
  22. pmc Genetic influences on cortical regionalization in the human brain
    Chi Hua Chen
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuron 72:537-44. 2011
    ..Broad similarities in genetic patterning between rodents and humans might suggest a conservation of cortical patterning mechanisms, whereas dissimilarities might reflect the functionalities most essential to each species...
  23. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
    ....
  24. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
    ..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
  25. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
    ....
  26. pmc Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of aging
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008
    ..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...
  27. pmc Distinct genetic influences on cortical surface area and cortical thickness
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 19:2728-35. 2009
    ..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
  28. ncbi request reprint Conceptual and data-based investigation of genetic influences and brain asymmetry: a twin study of multiple structural phenotypes
    Lisa T Eyler
    University of California, San Diego
    J Cogn Neurosci 26:1100-17. 2014
    ..Despite varying interpretations of existing data, we view the present results as consistent with previous findings. ..
  29. ncbi request reprint Early identification and heritability of mild cognitive impairment
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA, Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA, Psychology Service, VA San Diego Healthcare System, La Jolla, CA, USA, Computational Science Research Center, San Diego State University Claremont Graduate University, San Diego, CA, USA, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA, Department of Public Health, University of Helsinki, Helsinki, Finland, Department of Statistics, St Louis University, St Louis, MO, USA, Research Service, VA St Louis Healthcare System, St Louis, MO, USA and Department of Psychology, Boston University, Boston, MA, USA
    Int J Epidemiol 43:600-10. 2014
    ..We estimated prevalence rates, association with premorbid general cognitive ability (GCA) and heritability for different definitions of neuropsychologically defined MCI in adults in their 50s...
  30. pmc Genetic topography of brain morphology
    Chi Hua Chen
    Departments of Psychiatry, Cognitive Science, Radiology, and Neurosciences, Center for Behavioral Genomics, and Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 110:17089-94. 2013
    ..Our findings highlight the complexity of genetic influences on cortical morphology and provide a glimpse into emerging principles of genetic organization of the cortex. ..
  31. pmc VETSA: the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, CA, USA
    Twin Res Hum Genet 16:399-402. 2013
    ..These features make the VETSA ideal for studying the heterogeneity of within-individual trajectories from midlife to old age, and for early detection of risk factors for cognitive decline...
  32. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
    ..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
  33. pmc A twin study of spatial and non-spatial delayed response performance in middle age
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Brain Cogn 76:43-51. 2011
    ..Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples...
  34. ncbi request reprint Do patient requests for antidepressants enhance or hinder physicians' evaluation of depression? A randomized controlled trial
    Mitchell D Feldman
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, USA
    Med Care 44:1107-13. 2006
    ....
  35. pmc Caught in the act? Prevalence, predictors, and consequences of physician detection of unannounced standardized patients
    Carol E Franz
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093, USA
    Health Serv Res 41:2290-302. 2006
    ..Systematic assessment of detection is recommended when SPs are used in studies of clinical process and quality of care...
  36. ncbi request reprint Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study
    William S Kremen
    Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 64:361-8. 2007
    ..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved...
  37. ncbi request reprint Imputing observed blood pressure for antihypertensive treatment: impact on population and genetic analyses
    Brinda K Rana
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Am J Hypertens 27:828-37. 2014
    ..Routine methods to adjust for antihypertensives may not sufficiently account for newer treatment protocols (i.e., combination or multiple drug therapy) found in contemporary cohorts...
  38. ncbi request reprint Interaction of APOE genotype and testosterone on episodic memory in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, CA, USA Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA Electronic address
    Neurobiol Aging 35:1778.e1-8. 2014
    ..Results support the hypothesis that APOE-ε4 status increases susceptibility to other risk factors, such as low testosterone, which may ultimately contribute to cognitive decline or dementia...
  39. pmc Beyond familism: a case study of the ethics of care of a Latina caregiver of an elderly parent with dementia
    Yvette G Flores
    Chicana o Studies Program, University of California, Davis, Davis, California 95616, USA
    Health Care Women Int 30:1055-72. 2009
    ..Through a case study of a second-generation daughter, we explore the nuances of an ethics of care that constitute her caregiving experiences and the tensions generated by efforts to respect divergent cultural mandates...
  40. pmc Cortical thickness is influenced by regionally specific genetic factors
    Lars M Rimol
    Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
    Biol Psychiatry 67:493-9. 2010
    ..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
  41. ncbi request reprint Conceptions of dementia in a multiethnic sample of family caregivers
    Ladson Hinton
    Department of Psychiatry, University of California at Davis, Davis, California 95817, USA
    J Am Geriatr Soc 53:1405-10. 2005
    ..Further research on cross-ethnic differences in a larger, more-representative sample is needed...
  42. ncbi request reprint Networked for change? Identifying obstetric opinion leaders and assessing their opinions on caesarean delivery
    Richard L Kravitz
    Center for Health Services Research in Primary Care, University of California, Davis, 4150 V Street Suite 2500, Sacramento, CA 95817, USA
    Soc Sci Med 57:2423-34. 2003
    ..However, they did not consistently support policies designed to reduce the caesarean delivery rate. The results have implications for the generalizability of opinion leader strategies...
  43. pmc Influence of patients' requests for direct-to-consumer advertised antidepressants: a randomized controlled trial
    Richard L Kravitz
    Center for Health Services Research in Primary Care, University of California, Davis, Sacramento, CA 95817, USA
    JAMA 293:1995-2002. 2005
    ..Critics charge that it leads to overprescribing, while proponents counter that it helps avert underuse of effective treatments, especially for conditions that are poorly recognized or stigmatized...
  44. pmc Genetic influence on contrast sensitivity in middle-aged male twins
    Alice Cronin-Golomb
    Department of Psychology, Boston University, 648 Beacon St, 2nd Floor, Boston, MA 02215, USA
    Vision Res 47:2179-86. 2007
    ..Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age...
  45. pmc A twin-study of genetic contributions to hearing acuity in late middle age
    Arthur Wingfield
    Department of Psychology, Brandeis University, Waltham, MA 02454 9110, USA
    J Gerontol A Biol Sci Med Sci 62:1294-9. 2007
    ..Declines in hearing acuity, especially in the high frequency range, often appear in middle age. The objective of this study was to characterize genetic and environmental influences that may underlie this pattern...
  46. pmc Practice constraints, behavioral problems, and dementia care: primary care physicians' perspectives
    Ladson Hinton
    Department of Psychiatry and Behavioral Sciences and Alzheimer s Disease Center, UC Davis, Sacramento, California 95817, USA
    J Gen Intern Med 22:1487-92. 2007
    ..To examine how practice constraints contribute to barriers in the health care of persons with dementia and their families, particularly with respect to behavioral aspects of care...
  47. ncbi request reprint Characterizing patient requests and physician responses in office practice
    Richard L Kravitz
    UC Davis Center for Health Services Research in Primary Care, Sacramento, CA 95817, USA
    Health Serv Res 37:217-38. 2002
    ..STUDY SETTINGS: Data were obtained from visits to six general internists practicing in North-Central California in 1994 and eight cardiologists practicing in the same region in 1998...