Research Topics
Species | Carol E FranzSummaryAffiliation: University of California Country: USA Publications
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Publications
Genetic and environmental multidimensionality of well- and ill-being in middle aged twin menCarol E Franz
Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
Behav Genet 42:579-91. 2012..All measures had specific unique environmental influences. Results indicate that well-being is genetically and environmentally multidimensional and that ill-being has partial overlap with both latent factors...
When help becomes a hindrance: mental health referral systems as barriers to care for primary care physicians treating patients with Alzheimer's diseaseCarol E Franz
Department of Psychiatry, University of California, San Diego, CA, USA
Am J Geriatr Psychiatry 18:576-85. 2010..To describe structural barriers to mental health specialists and consequences of these barriers to care for patients with dementia and neuropsychological symptoms and their primary care physicians (PCPs)...- Adult romantic attachment, negative emotionality, and depressive symptoms in middle aged men: a multivariate genetic analysisCarol E Franz
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0738, USA
Behav Genet 41:488-98. 2011..41, indicating some, but not complete overlap of genetic factors. Genetically informative longitudinal studies on attachment relationship dimensions can help to illuminate the role of relationship-based risk factors in healthy aging... 
Nonmedical influences on the use of cholinesterase inhibitors in dementia careCarol E Franz
University of California, San Diego, La Jolla, CA 92093, USA
Alzheimer Dis Assoc Disord 21:241-8. 2007..Physicians reported feeling pressured by families to prescribe ChEI. Under these ambiguous conditions, some physicians prescribed medications simply to be able to offer "something" to patients...- Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal studyCarol E Franz
Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
Twin Res Hum Genet 10:537-45. 2007..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status... - Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged menCarol E Franz
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0738, USA
Behav Genet 40:467-79. 2010..The results suggest that genetic factors influence cortisol responses to specific environmental stressors. Thus, cortisol levels are correlated in identical twins only when they undergo similar experiences... - Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of agingCarol E Franz
University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738, La Jolla, CA 92093, USA
Psychoneuroendocrinology 36:1040-52. 2011..The results also suggest that the direction of effect is complex... - A 35-year longitudinal assessment of cognition and midlife depression symptoms: the Vietnam Era Twin Study of AgingCarol E Franz
Department of Psychiatry, University of California, San Diego, 92093, USA
Am J Geriatr Psychiatry 19:559-70. 2011.... - Genes, environment, and time: the Vietnam Era Twin Study of Aging (VETSA)William S Kremen
Department of Psychiatry, University of California-San Diego, San Diego, CA, USA
Twin Res Hum Genet 9:1009-22. 2006.... - Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?Matthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 60:1686-95. 2012..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics... - A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Twin Res Hum Genet 15:304-14. 2012..Implications regarding brain phenotypes for future genetic association studies are discussed... - Genetic architecture of learning and delayed recall: a twin study of episodic memoryMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuropsychology 25:488-98. 2011.... - Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 53:1093-102. 2010..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology... - Genetic architecture of context processing in late middle age: more than one underlying mechanismWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, USA
Psychol Aging 26:852-63. 2011..In contrast, the reactive control component was unrelated to general cognitive ability... - Hierarchical genetic organization of human cortical surface areaChi Hua Chen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Science 335:1634-6. 2012..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns... - Heritability of brain ventricle volume: converging evidence from inconsistent resultsWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neurobiol Aging 33:1-8. 2012..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging... - Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
Neuroimage 49:1213-23. 2010..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life... - Genetic influences on cortical regionalization in the human brainChi Hua Chen
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Neuron 72:537-44. 2011..Broad similarities in genetic patterning between rodents and humans might suggest a conservation of cortical patterning mechanisms, whereas dissimilarities might reflect the functionalities most essential to each species... - Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 21:2313-21. 2011.... - Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged menMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 59:1123-31. 2012..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor... - Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Hum Brain Mapp 32:641-53. 2011.... - Distinct genetic influences on cortical surface area and cortical thicknessMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 19:2728-35. 2009..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure... - Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of agingWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age... - Presence of ApoE ε4 allele associated with thinner frontal cortex in middle ageChristine Fennema-Notestine
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
J Alzheimers Dis 26:49-60. 2011..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status... - Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin studyWilliam S Kremen
Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Arch Gen Psychiatry 64:361-8. 2007..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved... - Do patient requests for antidepressants enhance or hinder physicians' evaluation of depression? A randomized controlled trialMitchell D Feldman
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, USA
Med Care 44:1107-13. 2006.... - A twin study of spatial and non-spatial delayed response performance in middle ageWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
Brain Cogn 76:43-51. 2011..Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples... - Caught in the act? Prevalence, predictors, and consequences of physician detection of unannounced standardized patientsCarol E Franz
University of California San Diego, Department of Psychiatry, La Jolla, CA 92093, USA
Health Serv Res 41:2290-302. 2006..Systematic assessment of detection is recommended when SPs are used in studies of clinical process and quality of care... - Beyond familism: a case study of the ethics of care of a Latina caregiver of an elderly parent with dementiaYvette G Flores
Chicana o Studies Program, University of California, Davis, Davis, California 95616, USA
Health Care Women Int 30:1055-72. 2009..Through a case study of a second-generation daughter, we explore the nuances of an ethics of care that constitute her caregiving experiences and the tensions generated by efforts to respect divergent cultural mandates... - Cortical thickness is influenced by regionally specific genetic factorsLars M Rimol
Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
Biol Psychiatry 67:493-9. 2010..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes... - Conceptions of dementia in a multiethnic sample of family caregiversLadson Hinton
Department of Psychiatry, University of California at Davis, Davis, California 95817, USA
J Am Geriatr Soc 53:1405-10. 2005..Further research on cross-ethnic differences in a larger, more-representative sample is needed... - VETSA: The Vietnam Era Twin Study of AgingWilliam S Kremen
Department of Psychiatry and Center for Behavioral Genomics Twin Research Laboratory, University of California, San Diego, CA, USA
Twin Res Hum Genet 16:399-402. 2013..These features make the VETSA ideal for studying the heterogeneity of within-individual trajectories from midlife to old age, and for early detection of risk factors for cognitive decline... - Influence of patients' requests for direct-to-consumer advertised antidepressants: a randomized controlled trialRichard L Kravitz
Center for Health Services Research in Primary Care, University of California, Davis, Sacramento, CA 95817, USA
JAMA 293:1995-2002. 2005..Critics charge that it leads to overprescribing, while proponents counter that it helps avert underuse of effective treatments, especially for conditions that are poorly recognized or stigmatized... - Networked for change? Identifying obstetric opinion leaders and assessing their opinions on caesarean deliveryRichard L Kravitz
Center for Health Services Research in Primary Care, University of California, Davis, 4150 V Street Suite 2500, Sacramento, CA 95817, USA
Soc Sci Med 57:2423-34. 2003..However, they did not consistently support policies designed to reduce the caesarean delivery rate. The results have implications for the generalizability of opinion leader strategies... - A twin-study of genetic contributions to hearing acuity in late middle ageArthur Wingfield
Department of Psychology, Brandeis University, Waltham, MA 02454 9110, USA
J Gerontol A Biol Sci Med Sci 62:1294-9. 2007..Declines in hearing acuity, especially in the high frequency range, often appear in middle age. The objective of this study was to characterize genetic and environmental influences that may underlie this pattern... - Genetic influence on contrast sensitivity in middle-aged male twinsAlice Cronin-Golomb
Department of Psychology, Boston University, 648 Beacon St, 2nd Floor, Boston, MA 02215, USA
Vision Res 47:2179-86. 2007..Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age... - Practice constraints, behavioral problems, and dementia care: primary care physicians' perspectivesLadson Hinton
Department of Psychiatry and Behavioral Sciences and Alzheimer s Disease Center, UC Davis, Sacramento, California 95817, USA
J Gen Intern Med 22:1487-92. 2007..To examine how practice constraints contribute to barriers in the health care of persons with dementia and their families, particularly with respect to behavioral aspects of care... - Characterizing patient requests and physician responses in office practiceRichard L Kravitz
UC Davis Center for Health Services Research in Primary Care, Sacramento, CA 95817, USA
Health Serv Res 37:217-38. 2002..In addition, the system appears applicable to both generalist and specialist practices. More experience with the system is necessary to appraise TORP's ability to predict important clinical outcomes...