Research Topics
| Stanley S FranklinSummaryAffiliation: University of California Country: USA Publications
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Publications
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart studyS S Franklin
Heart Disease Prevention Program, University of California, Irvine, USA
Circulation 100:354-60. 1999..We examined whether PP adds useful information for predicting coronary heart disease (CHD) in the population-based Framingham Heart Study...
Ageing and hypertension: the assessment of blood pressure indices in predicting coronary heart diseaseS S Franklin
Heart Disease Prevention Program, University of California, Irvine 92697, USA
J Hypertens Suppl 17:S29-36. 1999..To determine whether pulse pressure (PP), diastolic blood pressure (DBP), systolic blood pressure (SBP), or mean arterial pressure (MAP) is the superior haemodynamic predictor for the risk of coronary heart disease (CHD)...
Is there a preferred antihypertensive therapy for isolated systolic hypertension and reduced arterial compliance?S S Franklin
UCI Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
Curr Hypertens Rep 2:253-9. 2000....
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart StudyS S Franklin
Preventive Cardiology Program, University of California, Irvine 92697, USA
Circulation 103:1245-9. 2001..We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age groups of Framingham Heart Study participants...
Definition and epidemiology of hypertensive cardiovascular disease in women: the size of the problemStanley S Franklin
Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
J Hypertens Suppl 20:S3-5. 2002..This short review will highlight gender differences and similarities as noted in recent observational studies and intervention trials...
Cardiovascular comorbidities and blood pressure control in stroke survivorsManoj Kesarwani
Heart Disease Prevention Program, Division of Cardiology, Department ofMedicine, University of California, Irvine, California 92697 4101, USA
J Hypertens 27:1056-63. 2009..To examine the association of cardiovascular(CV) comorbidities with the likelihood of being a stroke survivor and to determine the prevalence, treatment, and control of hypertension in this population...
Comparison of demographic factors and cardiovascular risk factor control among U.S. adults with type 2 diabetes by insulin treatment classificationKalina Wong
Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, CA 92697, USA
J Diabetes Complications 26:169-74. 2012..We examined DM control, risk factors, and comorbidities among U.S. persons according to insulin treatment status...
Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart StudyStanley S Franklin
Heart Disease Prevention Program, Department of Medicine, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
Circulation 119:243-50. 2009..We compared systolic BP (SBP) and diastolic BP (DBP) versus pulse pressure (PP) and mean arterial pressure (MAP) combined and each of these 4 BP components alone in predicting CVD events...
Global cardiovascular risk associated with hypertension and extent of treatment and control according to risk groupNathan D Wong
Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California, USA
Am J Hypertens 25:561-7. 2012..We examined CVD risk distribution and treatment and control patterns according to risk group...
Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart StudyStanley S Franklin
Heart Disease Prevention Program, University of California, C240 Medical Sciences, Irvine, CA 92697, USA
Circulation 111:1121-7. 2005..We examined the relations of blood pressure (BP) and clinical risk factors to the new onset of the 3 forms of hypertension...
Hypertension in older people: part 1Stanley S Franklin
Heart Disease Prevention Program, University of California, Irvine, Irvine, CA 92697, USA
J Clin Hypertens (Greenwich) 8:444-9. 2006....
Efficacy and safety of irbesartan/HCTZ in severe hypertension according to cardiometabolic factorsStanley S Franklin
Department of Medicine, University of California, Irvine, CA, USA
J Clin Hypertens (Greenwich) 12:487-94. 2010..No excess of prespecified events was noted. Thus, initial treatment with irbesartan/hydrochlorothiazide was rapidly effective in high-risk, difficult-to-treat, severely hypertensive patients...
Inadequate control of hypertension in US adults with cardiovascular disease comorbidities in 2003-2004Nathan D Wong
Heart Disease Prevention Program, Department of Medicine, University of California, C240 Medical Sciences, Irvine, CA 92697, USA
Arch Intern Med 167:2431-6. 2007....
Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adultsShaista Malik
Heart Disease Prevention Program, University of California, Irvine 92697, USA
Circulation 110:1245-50. 2004..Moreover, MetS more strongly predicts CHD, CVD, and total mortality than its individual components. CONCLUSIONS: CHD, CVD, and total mortality are significantly higher in US adults with than in those without MetS...
Global cardiovascular disease risk assessment in United States adults with diabetesNathan D Wong
Heart Disease Prevention Program, Division of Cardiology, University of California, 112 Sprague Hall, Irvine, CA 92697, USA
Diab Vasc Dis Res 9:146-52. 2012..Diabetes mellitus (DM) is often considered a risk equivalent for cardiovascular disease (CVD); however, the variation in CVD risk in adults with DM has not been described...
Coronary heart disease events preventable by control of blood pressure and lipids in US adults with hypertensionVictor A Lopez
Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, CA 92697, USA
J Clin Hypertens (Greenwich) 9:436-43. 2007..The authors' results demonstrate that combined control of BP and lipid levels may prevent the majority of CHD events in Americans with HTN...
Impact of C-reactive protein on the likelihood of peripheral arterial disease in United States adults with the metabolic syndrome, diabetes mellitus, and preexisting cardiovascular diseaseJohn D Vu
Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, School of Medicine, Irvine, California, USA
Am J Cardiol 96:655-8. 2005..6, 95% confidence interval 2.2 to 34.0, p = 0.001). In conclusion, the likelihood of PAD in US adults with MS and DM is enhanced by elevated CRP levels...
Systolic blood pressure: it's time to take controlStanley S Franklin
Department of Medicine, Heart Disease Prevention Program, University of California, Irvine, California, USA
Am J Hypertens 17:49S-54S. 2004..Improving patient outcomes relies on antihypertensive therapy that appropriately addresses control of SBP and pulse pressure, underscoring the importance of therapeutic options that effectively reduce arterial stiffness...
Arterial stiffness: is it ready for prime time?Stanley S Franklin
Heart Disease Prevention Program, C 240 Medical Sciences, University of California, Irvine, CA 92697, USA
Curr Cardiol Rep 9:462-9. 2007..This article asks the question: How useful are PWV and PWA, when compared with traditional measurement of blood pressure components, as biomarkers of CV disease?..
Preventing coronary events by optimal control of blood pressure and lipids in patients with the metabolic syndromeNathan D Wong
Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
Am J Cardiol 91:1421-6. 2003..6% for women; control to optimal levels resulted in preventing 80.5% and 82.1% of events, respectively. Thus, many CHD events in patients with MetS may be preventable by nominal or optimal control of lipids and/or blood pressure...
Significance of white-coat hypertension in older persons with isolated systolic hypertension: a meta-analysis using the International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes populationStanley S Franklin
Heart Disease Prevention Program, Division of Cardiology, School of Medicine, University of California, Irvine, CA, USA
Hypertension 59:564-71. 2012..Therefore, one should be cautious in applying the term "white-coat hypertension" to persons receiving antihypertensive treatment...
Blood pressure categories, hypertensive subtypes, and the metabolic syndromeStanley S Franklin
Heart Disease Prevention Program, University of California, Irvine, California 92697, USA
J Hypertens 24:2009-16. 2006..Elevated blood pressure (BP) is one element of metabolic syndrome (MetS); however, the relation of various BP categories and hypertension subtypes to the likelihood of having MetS is not well defined...
Hypertension in older people: part 2Stanley S Franklin
Heart Disease Prevention Program, University of California, Irvine, 92697, USA
J Clin Hypertens (Greenwich) 8:521-5. 2006..Reaching target systolic blood pressure levels most often requires the use of polypharmacy that includes a diuretic and perhaps specific agents that target arterial stiffness and early wave reflection...
The significance of low DBP in US adults with isolated systolic hypertensionStanley S Franklin
The Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California, USA
J Hypertens 29:1101-8. 2011....
Cardiovascular morbidity and mortality in hypertensive patients with lower versus higher risk: a LIFE substudyStanley S Franklin
Heart Disease Prevention Program, University of California, Irvine, CA 92697, USA
Hypertension 46:492-9. 2005..In conclusion, losartan compared with atenolol reduces the risk of stroke, new-onset diabetes, and new-onset atrial fibrillation in the LRG and the HRG...
Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) IIIS S Franklin
Heart Disease Prevention Program, University of California, Irvine, CA 92697, USA
Hypertension 37:869-74. 2001..Better awareness of this middle-aged and older high-risk group and more aggressive antihypertensive therapy are necessary to address this treatment gap...
Preventing heart disease by controlling hypertension: impact of hypertensive subtype, stage, age, and sexNathan D Wong
Heart Disease Prevention Program, University of California, Irvine, Calif 92697, USA
Am Heart J 145:888-95. 2003..Hypertension is related to significant morbidity and mortality rates from coronary heart disease (CHD). This report examines the relative and absolute impact on risk for CHD by controlling hypertension to high normal and optimal levels...
Initial combination therapy for rapid and effective control of moderate and severe hypertensionS S Franklin
Department of Medicine, Medical Sciences I, College of Medicine, University of California, Irvine, CA 92697, USA
J Hum Hypertens 23:4-11. 2009....
Blood pressure and cardiovascular disease: what remains to be achieved?S S Franklin
Heart Disease Prevention Program, University of California, Irvine 92697, USA
J Hypertens Suppl 19:S3-8. 2001..Hypertensive cardiovascular disease represents a world-wide public health challenge that can be solved only by new innovative measures aimed at both prevention and treatment...
Pulse pressure as a risk factorStanley S Franklin
UCI Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, California 92697, USA
Clin Exp Hypertens 26:645-52. 2004....
Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adultsCarmel M McEniery
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Hypertension 46:221-6. 2005..Long-term follow-up of these individuals is now required to determine whether they are at increased risk compared with age-matched normotensive individuals...
beta-Blockers in hypertension-the emperor has no clothes: an open letter to present and prospective drafters of new guidelines for the treatment of hypertensionFranz H Messerli
Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
Am J Hypertens 16:870-3. 2003....
Systolic and diastolic blood pressure lowering as determinants of cardiovascular outcomeJi-Guang Wang
Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
Hypertension 45:907-13. 2005..These findings remained consistent if the achieved DBP averaged <70 mm Hg. In conclusion, our overview suggests that antihypertensive drug treatment improves outcome mainly through lowering of SBP...
Age-specific relevance of usual blood pressure to vascular mortalityStanley S Franklin
Lancet 361:1389; author reply 1391-2. 2003
Cardiovascular risk evaluation: an inexact scienceStanley S Franklin
J Hypertens 20:2127-30. 2002
Do diabetes and hypertension interact to accelerate vascular ageing?Stanley S Franklin
J Hypertens 20:1693-6. 2002
How important is pulse pressure as a predictor of cardiovascular risk?Stanley S Franklin
Hypertension 39:E12-3. 2002
Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adultsLawrence F Bielak
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, 48104 3028, USA
J Hypertens 22:719-25. 2004..The age-dependent roles of the components of blood pressure (BP) in the development of coronary artery calcification (CAC) are poorly understood...
Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacologyIan B Wilkinson
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Hypertension 44:112-6. 2004
Metabolic syndrome is associated with aortic stiffness in untreated essential hypertensionGiuseppe Schillaci
University of Perugia, Perugia, Italy
Hypertension 45:1078-82. 2005..Central, but not general, adiposity is an important determinant of aortic stiffness in hypertension...
Relation between renal function within the normal range and central and peripheral arterial stiffness in hypertensionGiuseppe Schillaci
Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia, Italy
Hypertension 48:616-21. 2006..These relations are in part independent from the effect of several confounders, including age, sex, and blood pressure values...
Systolic hypertension: an overviewTodd F Griffith
Duke Institute of Renal Outcomes Research and Health Policy, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Am Heart J 149:769-75. 2005
Clinical trials in hypertensionFranz H Messerli
JAMA 296:1463; author reply 1464-5. 2006
Efficacy and safety of irbesartan/HCTZ combination therapy as initial treatment for rapid control of severe hypertensionJoel M Neutel
Orange County Heart Institute and Research Center, 14351 Myford Road, Tustin, CA 92780, USA
J Clin Hypertens (Greenwich) 8:850-7; quiz 858-9. 2006..7 mm Hg and 9.7 mm Hg (P<.0001). Greater and more rapid BP reduction with irbesartan/HCTZ was achieved without additional side effects...
The nonpharmacologic treatment of hypertension: how effective is it? An updateMarvin Moser
J Clin Hypertens (Greenwich) 9:209-16. 2007....
Hypertension management: results of a new national survey for the hypertension education foundation: Harris interactiveMarvin Moser
Hypertension Education Foundation, Inc, Scarsdale, NY 10583, USA
J Clin Hypertens (Greenwich) 9:316-23. 2007..The survey suggests a high degree of risk awareness and treatment, and what appears to be an increase in control rates among hypertensive patients...
Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overviewJi Guang Wang
Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Hypertension 50:181-8. 2007..01) for stroke in trials involving an amlodipine group. In conclusion, blood pressure differences largely accounted for cardiovascular outcome...
Arterial stiffness and hypertension: a two-way street?Stanley S Franklin
Hypertension 45:349-51. 2005
Hypertension control: still not there-how to select the right add-on therapy to reach goal blood pressuresJoel M Neutel
Orange County Research Center, Tustin, CA, USA
J Clin Hypertens (Greenwich) 9:889-96. 2007..The authors maintained full control of the discussion and the resulting content of this article...
