Research Topics
Genomes and Genes
| Sarah FranklinSummaryAffiliation: University of California Country: USA Publications
| Collaborators
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Detail Information
Publications
Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growthSarah Franklin
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Mol Cell Proteomics 11:M111.014258. 2012....
Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomySarah Franklin
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Mol Cell Proteomics 10:M110.000703. 2011..These studies are the first unbiased analysis of cardiac nuclear subcompartments and provide a foundation for exploration of this organelle's proteomes during disease...
Genomes, proteomes, and the central dogmaSarah Franklin
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Circ Cardiovasc Genet 4:576. 2011....
Features of endogenous cardiomyocyte chromatin revealed by super-resolution STED microscopyScherise Mitchell-Jordan
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, USA
J Mol Cell Cardiol 53:552-8. 2012..This approach is readily adaptable to investigation of other nuclear features using a similar antibody-based labeling technique and enables direct measurements of chromatin domain changes in response to physiological stimuli...
Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophyAnna K Paulsson
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Mol Cell Cardiol 48:1206-14. 2010..Overall, the findings expand the roles of calsarcins to include nuclear tasks during cardiac growth...
Stress signaling by Tec tyrosine kinase in the ischemic myocardiumMichael J Zhang
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Am J Physiol Heart Circ Physiol 299:H713-22. 2010..These experiments expand the role of the Tec family in the heart, identifying the Tec isoform as an ischemic injury-induced isoform, and map the subproteome of its interactors in isolated cells...
Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinaseYifeng Li
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Protein Sci 20:140-9. 2011....
Systems proteomics of healthy and diseased chromatinHaodong Chen
Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Methods Mol Biol 1005:77-93. 2013..The state-of-the-art methodology for data interpretation and integration through bioinformatics is reviewed...
