WILLIAM G FRANKLE

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Neuroreceptor imaging studies in schizophrenia
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Harv Rev Psychiatry 15:212-32. 2007
  2. ncbi request reprint Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635
    W Gordon Frankle
    Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 189:155-64. 2006
  3. pmc [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32443. 2012
  4. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
  5. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
  6. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
  7. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
  8. doi request reprint Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride
    Lawrence S Kegeles
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 33:3111-25. 2008
  9. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
  10. doi request reprint Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009

Research Grants

Detail Information

Publications28

  1. ncbi request reprint Neuroreceptor imaging studies in schizophrenia
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Harv Rev Psychiatry 15:212-32. 2007
    ..This review will consider both studies of pathophysiology and pharmacology, with a discussion of the application of these techniques to drug development...
  2. ncbi request reprint Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635
    W Gordon Frankle
    Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 189:155-64. 2006
    ..This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder...
  3. pmc [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32443. 2012
    ..67, p = 0.05) measured via EEG during a cognitive control task. These data provide a replication of our previous study demonstrating the ability to measure in vivo, with PET, acute shifts in extracellular GABA...
  4. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  5. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
    ..In contrast to the measurement of DA release, the combination of low D(2) receptor density and low basal DA levels in the cortex greatly reduce the power to detect alterations in [(11)C]FLB 457 binding secondary to DA depletion...
  6. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
    ..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...
  7. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  8. doi request reprint Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride
    Lawrence S Kegeles
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 33:3111-25. 2008
    ....
  9. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  10. doi request reprint Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  11. pmc Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA...
  12. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  13. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  14. pmc Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:35-40. 2011
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  15. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
    ..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT...
  16. ncbi request reprint Neuroreceptor imaging in psychiatric disorders
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York 10032, USA
    Ann Nucl Med 16:437-46. 2002
    ..Emphasis will be placed on how these findings and techniques are currently being used to inform the development of novel treatments for schizophrenia...
  17. doi request reprint Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET
    Charles M Laymon
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:814-7. 2009
    ..We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses...
  18. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  19. doi request reprint COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
    M Slifstein
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 13:821-7. 2008
    ..These results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia...
  20. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  21. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...
  22. pmc Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46832. 2012
    ..However, the lack of change in [(11)C]DBTZ BP(ND) indicates that striatal VMAT2 regulation is not the mechanism of action by which n-3 PUFA improves cognitive performance...
  23. ncbi request reprint [11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 27:1733-41. 2007
    ..These results suggest caution in interpreting data from studies using this tracer to measure cortical D(1) receptors as well as the need for more selective radioligands to assess cortical D(1) receptors...
  24. ncbi request reprint Positron emission tomography and single photon emission CT molecular imaging in schizophrenia
    David Erritzoe
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA
    Neuroimaging Clin N Am 13:817-32. 2003
    ..Expanding the availability of PET and the current radiopharmaceutical portfolio will be critical for these predictions to become reality...
  25. pmc Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
    ..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism...
  26. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  27. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
    ..The purpose of this study was to compare these 2 agents in healthy humans...
  28. ncbi request reprint The synaptic hypothesis of schizophrenia
    W Gordon Frankle
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
    Neuron 39:205-16. 2003

Research Grants4

  1. The Neuroanatomy of Antipsychotic Drug Action
    WILLIAM FRANKLE; Fiscal Year: 2007
    ..abstract_text> ..
  2. In vivo measurement of dopamine transmission in schizophrenia
    WILLIAM G FRANKLE; Fiscal Year: 2010
    ..In this proposal we seek to better understand the neurobiology underlying the cognitive abnormalities in schizophrenia;with the hope that, in turn, this will advance the development of novel treatments for these cognitive impairments. ..