STUART FRANK

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity
    Yujun Gan
    MD, University of Alabama at Birmingham, 1530 Third Avenue South, BDB 720, Birmingham, Alabama 35294 0012
    Mol Endocrinol 27:1969-79. 2013
  2. pmc Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes
    YuChao Zhang
    The Institute of Cell Biology, Shandong University School of Medicine, Jinan 250012, China
    Lipids Health Dis 12:56. 2013
  3. pmc The role of prolactin receptor in GH signaling in breast cancer cells
    Jie Xu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Endocrinol 27:266-79. 2013
  4. pmc Growth hormone-induced JAK2 signaling and GH receptor down-regulation: role of GH receptor intracellular domain tyrosine residues
    Luqin Deng
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, 1530 3 Avenue South, Birmingham, Alabama 35294 0012, USA
    Endocrinology 153:2311-22. 2012
  5. ncbi request reprint Growth hormone, insulin-like growth factor I, and growth: local knowledge
    Stuart J Frank
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Endocrinology 148:1486-8. 2007
  6. doi request reprint Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling
    Stuart J Frank
    Department of Cell Biology and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    J Mammary Gland Biol Neoplasia 13:119-29. 2008
  7. ncbi request reprint In vivo imaging of hepatic growth hormone signaling
    Stuart J Frank
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 20:2819-30. 2006
  8. pmc Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system
    Stuart J Frank
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Biochim Biophys Acta 1782:785-94. 2008
  9. pmc Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping
    Jing Jiang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Endocrinology 152:4777-88. 2011
  10. pmc Noninvasive bioluminescence imaging in small animals
    Kurt R Zinn
    Laboratory of Multimodal Imaging, University of Alabama, Birmingham, AL 35294 0012, USA
    ILAR J 49:103-15. 2008

Collaborators

Detail Information

Publications47

  1. pmc IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity
    Yujun Gan
    MD, University of Alabama at Birmingham, 1530 Third Avenue South, BDB 720, Birmingham, Alabama 35294 0012
    Mol Endocrinol 27:1969-79. 2013
    ..Collectively, our data suggest that IGF-1R positively regulates acute GH signaling by preventing access of PTP-1B activity to Janus kinase 2 and thereby preventing PTP-1B-mediated suppression of GH-induced STAT5 activation. ..
  2. pmc Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes
    YuChao Zhang
    The Institute of Cell Biology, Shandong University School of Medicine, Jinan 250012, China
    Lipids Health Dis 12:56. 2013
    ..Growth hormone (GH) and insulin signaling pathways are known important regulators of adipose homeostasis. The cross-talk between GH and insulin signaling pathways in mature adipocytes is poorly understood...
  3. pmc The role of prolactin receptor in GH signaling in breast cancer cells
    Jie Xu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Endocrinol 27:266-79. 2013
    ..Our data suggest that PRLR's presence meaningfully affects GHR use in breast cancer cells...
  4. pmc Growth hormone-induced JAK2 signaling and GH receptor down-regulation: role of GH receptor intracellular domain tyrosine residues
    Luqin Deng
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, 1530 3 Avenue South, Birmingham, Alabama 35294 0012, USA
    Endocrinology 153:2311-22. 2012
    ..These findings are discussed in the context of determinants and mechanisms of regulation of GHR down-regulation...
  5. ncbi request reprint Growth hormone, insulin-like growth factor I, and growth: local knowledge
    Stuart J Frank
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Endocrinology 148:1486-8. 2007
  6. doi request reprint Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling
    Stuart J Frank
    Department of Cell Biology and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    J Mammary Gland Biol Neoplasia 13:119-29. 2008
    ..In particular, the role of GH- and PRL-induced phosphorylation of ErbB receptors in regulating EGF responsiveness is highlighted with attention to potential pathophysiological relevance...
  7. ncbi request reprint In vivo imaging of hepatic growth hormone signaling
    Stuart J Frank
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 20:2819-30. 2006
    ..Our imaging system allows detailed in vivo analysis of GH signaling and action and may be a paradigm for studies of additional signaling pathways in liver and other tissues...
  8. pmc Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system
    Stuart J Frank
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Biochim Biophys Acta 1782:785-94. 2008
    ....
  9. pmc Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping
    Jing Jiang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Endocrinology 152:4777-88. 2011
    ..These results have fundamental implications for understanding the role of the dimerization interface and subdomain 2 in GHR activation and regulated GHR metalloproteolysis and may inform development of therapeutics that target GHR...
  10. pmc Noninvasive bioluminescence imaging in small animals
    Kurt R Zinn
    Laboratory of Multimodal Imaging, University of Alabama, Birmingham, AL 35294 0012, USA
    ILAR J 49:103-15. 2008
    ..In summary, bioluminescence imaging has become an important component of biomedical research that will continue in the future...
  11. ncbi request reprint Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage
    Jon W Cowan
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    J Biol Chem 280:19331-42. 2005
    ..These data indicate that the GHR is subject to sequential proteolysis by metalloprotease and gamma-secretase activities and may suggest GH-independent roles for the GHR...
  12. pmc Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 22:1427-37. 2008
    ..These data are the first to demonstrate inducible in vivo GHR proteolysis and suggest this is a mechanism to regulate GH sensitivity and its anabolic effects during sepsis or inflammation...
  13. ncbi request reprint Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells
    Kimberly Loesch
    University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 0012, USA
    Endocrinology 148:5955-65. 2007
    ..In so doing, JAK2 enables efficient processing of precursor receptor to mature GHR...
  14. ncbi request reprint Mode of growth hormone action in osteoblasts
    Douglas J DiGirolamo
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 282:31666-74. 2007
    ..These results indicate that although direct IGF-1R-independent actions of GH on osteoblast apoptosis can be demonstrated in vitro, IGF-1R is required for anabolic effects of GH in osteoblasts in vivo...
  15. ncbi request reprint Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elements
    Yao Huang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 18:1471-85. 2004
    ..These findings suggest the existence of previously unappreciated relationships between these two hormones...
  16. ncbi request reprint Determinants of growth hormone receptor down-regulation
    Luqin Deng
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 21:1537-51. 2007
    ..The latter requires GH-induced JAK2 activation and GHR tyrosine phosphorylation and is correlated to GHR ubiquitination in our reconstitution system...
  17. ncbi request reprint Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation
    Ning Yang
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 21:1642-55. 2007
    ..Further, they suggest that the GHR ECD-TMD is more flexible than previously thought in terms of the ability to achieve the active conformation in response to GH...
  18. pmc Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering
    Ning Yang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 22:978-88. 2008
    ..Furthermore, we infer that there is substantial flexibility in the GHR extracellular domain, such that it productively accommodates GH dimers that are much larger than GH...
  19. ncbi request reprint Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling
    Ning Yang
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    J Biol Chem 279:20898-905. 2004
    ..Our results suggest that localization of GHRs in the CM fraction of the plasma membrane plays important roles in signaling...
  20. pmc ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling
    Xin Li
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 0012, United States
    Cell Signal 20:2145-55. 2008
    ..Collectively, these data indicate that ERK activity, by phosphorylation of a threonine residue in the EGFR juxtamembrane cytoplasmic domain, modulates EGFR trafficking and signaling...
  21. pmc Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1
    Xiangdong Wang
    University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 23:486-96. 2009
    ..Furthermore, our results are consistent with IRS-1 residing upstream of SHC in the GH-induced ERK-signaling pathway...
  22. ncbi request reprint Janus kinase 2 influences growth hormone receptor metalloproteolysis
    Kimberly Loesch
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294 0012, USA
    Endocrinology 147:2839-49. 2006
    ..Our data indicate that the susceptibility of GHR to proteolysis is substantially affected by JAK2, suggesting yet another role for this kinase in determining GH sensitivity...
  23. ncbi request reprint Insulin enhances growth hormone induction of the MEK/ERK signaling pathway
    Jie Xu
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 281:982-92. 2006
    ..These findings suggest that insulin may be necessary for sensitization of cells to GH-induced ERK1/2 activation and provides a potential cellular mechanism by which insulin promotes growth...
  24. ncbi request reprint Receptor dimerization in GH and erythropoietin action--it takes two to tango, but how?
    Stuart J Frank
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama at Birmingham, and Veterans Affairs Medical Center, Birmingham, AL 35294, USA
    Endocrinology 143:2-10. 2002
    ..This review critically examines the state of our knowledge pertaining to GHR and EpoR dimerization, noting differences and similarities between the two...
  25. ncbi request reprint Janus kinase 2 enhances the stability of the mature growth hormone receptor
    Kai He
    Endocrinology Section Medical Service, Veterans Affairs Medical Center, and Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Endocrinology 146:4755-65. 2005
    ..These results are discussed in the context of emerging information on how JAK-family members modulate surface expression of other cytokine receptors...
  26. ncbi request reprint A role for Grb2-associated binder-1 in growth hormone signaling
    Sung Oh Kim
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama, Birmingham, Alabama 35294, USA
    Endocrinology 143:4856-67. 2002
    ..Our results suggest selective involvement of Gab1 in GH-induced ERK activation and implicate the Gab1 PH domain as critical in this involvement...
  27. ncbi request reprint A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysis
    Jing Jiang
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 18:2981-96. 2004
    ..Thus, our findings suggest that anti-GHR(ext-mAb) has promise as a GH antagonist and as a tool in studies of conformational changes required for GHR activation...
  28. pmc Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex
    Jie Xu
    Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 25:597-610. 2011
    ....
  29. ncbi request reprint Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling
    Kai He
    Department of Medicine, University of Alabama, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 17:2211-27. 2003
    ..Further, we report evidence for the existence of a novel GH-inducible functional interaction between JAK2 molecules that may be important in the mechanism of GH-triggered JAK2 signaling...
  30. pmc Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling
    Yujun Gan
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Endocrinol 24:644-56. 2010
    ..In addition to its role as a key IGF-I signal transducer, this receptor may directly facilitate acute GH signaling. The implications of these findings are discussed...
  31. ncbi request reprint Reduced proteolysis of rabbit growth hormone (GH) receptor substituted with mouse GH receptor cleavage site
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 17:1931-43. 2003
    ..These findings suggested that the GHR cleavage sites in the two species differ in their susceptibility to cleavage. This difference may underlie interspecies variation in utilization of proteolysis to generate GHBP...
  32. ncbi request reprint Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling
    Yao Huang
    Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:18902-13. 2003
    ..These data indicate that GH, by activating ERKs, can modulate EGF-induced EGFR trafficking and signaling and expand our understanding of mechanisms of cross-talk between the GH and EGF signaling systems...
  33. ncbi request reprint Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells
    Yao Huang
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Endocrinology 145:3297-306. 2004
    ..Overall, our findings suggest that GH can modulate both EGF binding kinetics and the EGFR's postbinding signaling itinerary in a MEK1/ERK pathway-dependent fashion...
  34. ncbi request reprint Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 277:50510-9. 2002
    ..These results suggest that inducible GHR proteolysis can regulate GH signaling...
  35. ncbi request reprint Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation
    Shaonin Ji
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, and the Birmingham Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 277:28384-93. 2002
    ..Our study suggests that both receptor and post-receptor mechanisms are important in GH-induced homologous desensitization...
  36. doi request reprint Growth hormone receptor targeting to lipid rafts requires extracellular subdomain 2
    Ning Yang
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, AL 35294 0012, USA
    Biochem Biophys Res Commun 391:414-8. 2010
    ..These data suggest LR targeting resides in ECD subdomain 2, a region relatively uninvolved in GH binding...
  37. ncbi request reprint Insulin increases the abundance of the growth hormone receptor in liver and adipose tissue of periparturient dairy cows
    Robert P Rhoads
    Department of Animal Science, Cornell University, Ithaca, NY 14853 4801, USA
    J Nutr 134:1020-7. 2004
    ..01), indicating that this effect is not liver specific. These results raise the possibility that insulin regulates the efficiency of GH signaling in liver and adipose tissue of dairy cows by acting as a rheostat of GHR synthesis...
  38. ncbi request reprint Dairy cows experience selective reduction of the hepatic growth hormone receptor during the periparturient period
    Jin Wook Kim
    Department of Animal Science, Cornell University, Ithaca, New York 14853 4801, USA
    J Endocrinol 181:281-90. 2004
    ..These data suggest a role for the GHR in regulating tissue-specific changes in growth hormone responsiveness in periparturient dairy cows...
  39. ncbi request reprint Growth hormone stimulates hepatic expression of bovine growth hormone receptor messenger ribonucleic acid through signal transducer and activator of transcription 5 activation of a major growth hormone receptor gene promoter
    Honglin Jiang
    Department of Animal and Poultry Sciences, Large Animal Clinical Sciences, 3130 Litton Reaves Hall, Virginia Tech, Blacksburg, Virginia 24061 0306, USA
    Endocrinology 148:3307-15. 2007
    ..These observations together suggest that GH directly stimulates the expression of one GHR mRNA variant, GHR1A, through binding STAT5 to its promoter, thereby increasing GHR mRNA and protein expression in the bovine liver...
  40. ncbi request reprint Impairment of liver GH receptor signaling by fasting
    Váronique Beauloye
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 143:792-800. 2002
    ..In conclusion, the GH resistance induced by fasting is associated with impairment of the JAK-STAT signaling pathway. This might contribute to the decrease in liver IGF-I production observed in fasting...
  41. ncbi request reprint Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and activa
    Eva Biener
    The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Endocrinology 144:3532-40. 2003
    ....
  42. ncbi request reprint Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3
    Lee A Denson
    The Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Gastrointest Liver Physiol 284:G646-54. 2003
    ..IL-6 inhibits hepatic GH signaling by upregulating Cis and Socs-3, which may involve activation of STAT3. Therapies that block IL-6 may enhance GH signaling in inflammatory diseases...
  43. ncbi request reprint Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain
    Bhooma Srinivasan
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Mol Cell Neurosci 36:449-61. 2007
    ..Increased levels of p75NTR and TACE were observed in photoreceptor cells of animals with photic injury. Our findings support a role for TACE in the proteolytic cleavage of p75NTR and light-induced apoptosis...
  44. ncbi request reprint Growth hormone/JAK-STAT axis signal-transduction defect. A novel treatable cause of growth failure
    Andrea P Rojas-Gil
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Patras School of Medicine, Greece
    FEBS J 273:3454-66. 2006
    ....
  45. ncbi request reprint Partial redirection of transgenic human growth hormone secretion from rat salivary glands
    Jianghua Wang
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Gene Ther 16:571-83. 2005
    ..03). Although this mutant is unlikely to be therapeutically beneficial, these results suggest that the final destination of a transgenic secretory protein may be controlled by reengineering its sorting determinants...
  46. ncbi request reprint Identification of the glomerular podocyte as a target for growth hormone action
    Gaddameedi R Reddy
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0718, USA
    Endocrinology 148:2045-55. 2007
    ..These results provide a novel mechanistic link between GH's actions and glomerular dysfunction in disorders such as acromegaly and diabetic glomerulosclerosis...
  47. ncbi request reprint A mutant signal transducer and activator of transcription 5b, associated with growth hormone insensitivity and insulin-like growth factor-I deficiency, cannot function as a signal transducer or transcription factor
    Peng Fang
    Department of Pediatrics, NRC5, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
    J Clin Endocrinol Metab 91:1526-34. 2006
    ....

Research Grants23

  1. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2006
    ..We will test this antibody's ability to act in vivo as a GH antagonist. Results of these studies will significantly expand our knowledge of GH action and tools available to manipulate it. . ..
  2. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    STUART FRANK; Fiscal Year: 2006
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologically- relevant crosstalk between cytokine and growth factor signaling systems. ..
  3. "Growth Hormone Receptor Dimerization/Disulfide Linkage"
    STUART FRANK; Fiscal Year: 2007
    ..We will test this antibody's ability to act in vivo as a GH antagonist. Results of these studies will significantly expand our knowledge of GH action and tools available to manipulate it. . ..
  4. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    STUART FRANK; Fiscal Year: 2007
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologically- relevant crosstalk between cytokine and growth factor signaling systems. ..
  5. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    STUART FRANK; Fiscal Year: 2009
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologically- relevant crosstalk between cytokine and growth factor signaling systems. ..
  6. "Growth Hormone Receptor Dimerization/Disulfide Linkage"
    STUART FRANK; Fiscal Year: 2009
    ..We will test this antibody's ability to act in vivo as a GH antagonist. Results of these studies will significantly expand our knowledge of GH action and tools available to manipulate it. . ..
  7. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    Stuart J Frank; Fiscal Year: 2010
    ..The knowledge gained will have broad relevance in our understanding of normal physiology and potentially in hormonal contributions to cancer pathophysiology. ..
  8. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2005
    ....
  9. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2004
    ....
  10. Tyrosine Phosphorylation and Growth Hormone Signalling
    STUART FRANK; Fiscal Year: 2004
    ..Results of these studies will significantly expand our knowledge of GH and cytokine signaling and of biologically relevant crosstalk between cytokine and growth factor signaling systems. ..
  11. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    STUART FRANK; Fiscal Year: 1999
    ..These studies are relevant to understanding: a) the insulin resistance common to NIDDM; and b) the nature of the inflammatory state and body's response to tissue injury. ..
  12. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    STUART FRANK; Fiscal Year: 2000
    ..These studies are relevant to understanding: a) the insulin resistance common to NIDDM; and b) the nature of the inflammatory state and body's response to tissue injury. ..
  13. Tyrosine Phosphorylation and Growth Hormone Signalling
    STUART FRANK; Fiscal Year: 2001
    ..Results of these studies will significantly expand our knowledge of GH and cytokine signaling and of biologically relevant crosstalk between cytokine and growth factor signaling systems. ..
  14. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2001
    ....
  15. Tyrosine Phosphorylation and Growth Hormone Signalling
    STUART FRANK; Fiscal Year: 2002
    ..Results of these studies will significantly expand our knowledge of GH and cytokine signaling and of biologically relevant crosstalk between cytokine and growth factor signaling systems. ..
  16. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2002
    ....
  17. Tyrosine Phosphorylation and Growth Hormone Signalling
    STUART FRANK; Fiscal Year: 2003
    ..Results of these studies will significantly expand our knowledge of GH and cytokine signaling and of biologically relevant crosstalk between cytokine and growth factor signaling systems. ..
  18. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2003
    ....
  19. "Growth Hormone Receptor Dimerization/Disulfide Linkage"
    Stuart J Frank; Fiscal Year: 2010
    ..We will test this antibody's ability to act in vivo as a GH antagonist. Results of these studies will significantly expand our knowledge of GH action and tools available to manipulate it. . ..