Matthew G Frank

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. doi request reprint Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, USA Electronic address
    Psychoneuroendocrinology 40:191-200. 2014
  2. ncbi request reprint Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, USA Electronic address
    Brain Behav Immun 33:1-6. 2013
  3. doi request reprint IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    J Neuroimmunol 252:33-9. 2012
  4. doi request reprint Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 26:337-45. 2012
  5. ncbi request reprint Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
    J Neurosci Methods 151:121-30. 2006
  6. doi request reprint Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 25:S21-8. 2011
  7. pmc IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:254-62. 2010
  8. doi request reprint Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO, 80309 0345, USA
    Brain Behav Immun 24:19-30. 2010
  9. ncbi request reprint Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 32:376-84. 2007
  10. ncbi request reprint mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:717-22. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, USA Electronic address
    Psychoneuroendocrinology 40:191-200. 2014
    ....
  2. ncbi request reprint Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, USA Electronic address
    Brain Behav Immun 33:1-6. 2013
    ..Thus, a new understanding of the stress response and its function (priming CNS innate immune responses to infection or injury during a fight/flight emergency) would be suggested. ..
  3. doi request reprint IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    J Neuroimmunol 252:33-9. 2012
    ..IL-1RA might be administered prophylactically to prevent the neuroinflammatory effects of trauma...
  4. doi request reprint Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 26:337-45. 2012
    ..The present results suggest that stress-induced GCs function to sensitize the microglial pro-inflammatory response (IL-1β, IL-6, NFκBIα) to immunologic challenges...
  5. ncbi request reprint Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
    J Neurosci Methods 151:121-30. 2006
    ....
  6. doi request reprint Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse
    Matthew G Frank
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 25:S21-8. 2011
    ....
  7. pmc IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:254-62. 2010
    ..The present results suggest that central pro-inflammatory cytokines play a salient role in the suppression of Arc and impairments of LTM by a peripheral immune challenge in older animals...
  8. doi request reprint Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO, 80309 0345, USA
    Brain Behav Immun 24:19-30. 2010
    ..The present data suggest that the temporal relationship between GC treatment and immune challenge may be an important factor determining whether GCs exhibit pro- or anti-inflammatory properties...
  9. ncbi request reprint Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 32:376-84. 2007
    ..Exogenous CORT mimicked the effects of ES and IS on FGF-2, but not FGF-2-AS mRNA. The present study demonstrates that glucocorticoids mediate the effects of stress on FGF-2 and FGF-2-AS...
  10. ncbi request reprint mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:717-22. 2006
    ..The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS...
  11. ncbi request reprint Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:47-59. 2007
    ..The present results suggest that stress can activate microglia, thereby sensitizing the pro-inflammatory reactivity of microglia to immunogenic stimuli...
  12. pmc Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
    Matthew G Frank
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    J Neuroimmunol 226:181-4. 2010
    ..The present results demonstrate that aging sensitizes hippocampal microglia to pro-inflammatory challenges...
  13. pmc Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation
    Lisa C Loram
    Department of Psychology and Neuroscience, and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Brain Behav Immun 25:1408-15. 2011
    ..Prior CORT before a direct spinal immune challenge is able to potentiate pain responses and pro-inflammatory cytokine production...
  14. pmc Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:46-54. 2009
    ..These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection...
  15. pmc Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge
    Michael D Weber
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 32:112-21. 2013
    ....
  16. pmc Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration
    Ryan Gene Soderquist
    Department of Chemical and Biological Engineering, University of Colorado at Boulder, 424 UCB, Boulder, Colorado, 80309, USA
    Pharm Res 27:841-54. 2010
    ..In this work, the potential of plasmid DNA-encoding IL-10 (pDNA-IL-10) slowly released from biodegradable microparticles to provide long-term pain relief in an animal model of neuropathic pain was investigated...
  17. pmc Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats
    Ruth M Barrientos
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:14641-8. 2012
    ..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes...
  18. pmc Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120
    Diana K Schoeniger-Skinner
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 30809 0345, USA
    Brain Behav Immun 21:660-7. 2007
    ..These results would suggest that IL-6 induces pain facilitation, and may do so in part by stimulating the production and release of other pro-inflammatory cytokines...
  19. pmc Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes
    Ruth M Barrientos
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 31:11578-86. 2011
    ..Moreover, voluntary exercise abrogated age-related microglial sensitization, suggesting a possible mechanism for exercise-induced neuroprotection in aging...
  20. pmc Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition
    Ruth M Barrientos
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Horm Behav 62:219-27. 2012
    ..We will show that each of these mechanisms is important for long-term memory formation, and is compromised by elevated pro-inflammatory cytokines...
  21. ncbi request reprint Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...
  22. pmc Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming
    Leah E Hains
    Department of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Pain 11:1004-14. 2010
    ..Therefore, spinal microglial priming may increase vulnerability to pain enhancement...
  23. pmc Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta
    Adelina Holguin
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Neurosci Methods 161:265-72. 2007
    ..This IL-1beta response was also temporo-spatially dependent. Thus, the pro-inflammatory sequelae of intracranial cannulation should be considered when designing studies of neuroinflammatory processes...
  24. ncbi request reprint A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine
    Ian N Johnston
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:7353-65. 2004
    ..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates...
  25. ncbi request reprint Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
    ..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states...
  26. pmc Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus
    Robert R Rozeske
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309 0354, USA
    J Neurosci 31:14107-15. 2011
    ..These data suggest that uncontrollable stressors produce a desensitization of DRN 5-HT(1A) autoreceptors and that this desensitization is responsible for the behavioral consequences of uncontrollable stress...
  27. ncbi request reprint Age at onset of major depressive disorder predicts reductions in NK cell number and activity
    Matthew G Frank
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Affect Disord 71:159-67. 2002
    ..The present study addressed the question of whether age at onset of index episode and/or duration of the present episode of MDD predicted alterations in NKCA and NK cell number...