Research Topics
| MARION ELIZABETH FRANKSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
Research Grants
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Detail Information
Publications
Effects of selective adaptation on coding sugar and salt tastes in mixturesMarion E Frank
Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1715, USA
Chem Senses 37:701-9. 2012..Furthermore, like odors, stronger and recent tastes are emphasized in dynamic experimental conditions replicating natural situations...
Taste responses to mixtures: analytic processing of qualityMarion E Frank
School of Dental Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington 06030 1605, USA
Behav Neurosci 117:228-35. 2003..e., asymmetric). The behaviors reflect peripheral inhibition and/or central mixture suppression. Nonetheless, components retain their distinct qualities in mixtures, suggesting that taste processing is analytic...- Variation in intake of sweet and bitter solutions by inbred strains of golden hamstersMarion E Frank
Neurosciences, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Behav Genet 34:465-76. 2004..13 to 0.23 for the two optical isomers. Thus, although, compared to mice, genetic variation in laboratory hamsters may be small, genetic differences that influence taste behaviors in existing strains may help identify relevant genes... - Effects of chlorhexidine on human taste perceptionM E Frank
Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Taste and Smell Center MC 1718, 263 Farmington Avenue, Farmington, CT 06030 1718, USA
Physiol Behav 74:85-99. 2001..The ability of chlorhexidine to specifically disrupt saltiness of a wide range of salts is consistent with proposed peripheral transduction mechanisms for the salty quality that involve transepithelial ion transport... - Neuron types, receptors, behavior, and taste qualityM E Frank
Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 1605, USA
Physiol Behav 69:53-62. 2000..Definitive conclusions regarding "patterns" or "labeled lines" requires an understanding of mechanisms of central neural processing of the several specialist and generalist taste-afferent inputs... - What the tongue tells the brain about tasteMarion E Frank
University of Connecticut Health Center, Farmington, CT, USA
Chem Senses 30:i68-9. 2005 - Peripheral gustatory processing of sweet stimuli by golden hamstersMarion E Frank
Neurosciences, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
Brain Res Bull 66:70-84. 2005..Taste-bud processing, possibly between-cell inhibition and within-cell negative feedback, must modify signals initiated by T1 receptors before they are transmitted to the brain... - Chorda tympani responses in two inbred strains of mice with different taste preferencesM E Frank
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
Physiol Behav 67:287-97. 1999..Nonetheless, genes involved in the structuring of taste receptors and/or the chordae tympani, which transduce taste stimuli having diverse perceptual qualities, differ for the two mouse strains... - Cracking taste codes by tapping into sensory neuron impulse trafficMarion E Frank
Center for Chemosensory Sciences, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030 1715, United States
Prog Neurobiol 86:245-63. 2008..Establishing the information afferent neurons traffic to the brain about natural taste stimuli imbedded in dynamic complex mixtures will ultimately "crack taste codes.".. - Time and intensity factors in identification of components of odor mixturesMarion E Frank
Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1715, USA
Chem Senses 35:777-87. 2010..Rapid selective adaptation and mixture component suppression manipulate effective intensity to promote emergence of characteristic odor qualities in dynamic natural settings... - The distinctiveness of ionic and nonionic bitter stimuliMarion E Frank
Neuroscience Program and Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
Physiol Behav 80:421-31. 2004..Thus, the three ionic and two nonionic compounds form separate aversive stimulus classes in hamsters, neither of which appears to be a close homologue of the human bitter taste... - Taste qualities of solutions preferred by hamstersB I MacKinnon
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 3705, USA
Chem Senses 24:23-35. 1999..g. salience, cation taste), rather than the absence of a 'sucrose-like' quality. The results are consistent with a single hamster perceptual quality for a diverse set of chemical structures that are sweet to humans... - Responses of the rat chorda tympani nerve to glutamate-sucrose mixturesB K Formaker
Department of Oral Diagnosis, Division of Neurosciences, MC 1718, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Chem Senses 29:473-82. 2004.... - Opponent effects of quinine and sucrose on single fiber taste responses of the chorda tympani nerveB K Formaker
Department of BioStructure and Function, School of Dental Medicine, The University of Connecticut Health Center, Farmington 06030, USA
Brain Res 772:239-42. 1997..Quinine may exert its effect as an opponent stimulus in the receptor cells at the second messenger level. This suppression may make bitter quinine more readily detected when embedded in mixtures with sweeteners... - The taste of polycose in hamstersB K Formaker
School of Dental Medicine, The University of Connecticut Health Center, Farmington, 06030, USA
Chem Senses 23:675-82. 1998..Finally, although the taste of 100 mM Polycose was more salient than the taste of 50 mM sucrose, the taste of sucrose could still be detected in a mixture with Polycose... - Taste function in patients with oral burningB K Formaker
Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Chem Senses 25:575-81. 2000..Identification of NaCl as 'salty' and citric acid as 'sour' was particularly difficult for BMS women. The present findings are consistent with the hypothesis that pain pathway activation may affect neural and behavioral taste function... - A confusion matrix for the study of taste perceptionT P Hettinger
Department of BioStructure and Function, University of Connecticut Health Center, Farmington 06030 3705, USA
Percept Psychophys 61:1510-21. 1999..The patterns of taste confusion indicate that the 10 stimuli resemble one another to varying extents, yet each can be considered perceptually unique... - Taste confusions following gymnemic acid rinseJ F Gent
Department of BioStructure and Function, University of Connecticut Health Center, Farmington 06030 3705, USA
Chem Senses 24:393-403. 1999..GA had no effect on discriminability of nonsweet stimulus pairs. The results suggest that specific error patterns in the TCM could be used to identify quality-specific taste disorders... - The effects of topical anesthesia on oral burning in burning mouth syndromeB K Formaker
Connecticut Chemosensory Clinical Research Center, School of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Ann N Y Acad Sci 855:776-80. 1998..001) after anesthesia, suggesting BMS dysgeusia is related to the activation of peripheral taste mechanisms. The results also suggest that BMS oral burning may be a disorder of peripheral pain pathways in some patients... 
Regional specificity of chlorhexidine effects on taste perceptionRuchi Grover
Department of Biology, University of Hartford, CT 06117, USA
Chem Senses 33:311-8. 2008..The current results are the first to suggest that there may also be distinct, regionally specific populations of NaCl-taste receptors in humans...- Cycloheximide: no ordinary bitter stimulusThomas P Hettinger
Center for Neurosciences, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, United States
Behav Brain Res 180:4-17. 2007..The combination of T2R multiplicity, species divergence and gene duplication results in diverse ligands for multiple species-specific T2R receptors, which confounds definition of 'bitter' stimuli across species... - The effect of orthognathic surgery on taste function on the palate and tongueJanneane F Gent
Taste and Smell Center, Connecticut Chemosensory Clinical Research Center, Farmington, CT, USA
J Oral Maxillofac Surg 61:766-73. 2003..Palatal and lingual neurosensory testing can be used to identify reversible sequelae of oral maxillofacial surgery... - Taste confusions following chlorhexidine treatmentJanneane F Gent
Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Chem Senses 27:73-80. 2002..As a selective, effective, persistent and reversible blocker of taste perceptions, chlorhexidine should prove useful in defining taste mechanisms in humans... - Characteristic component odors emerge from mixtures after selective adaptationHolly F Goyert
Department of Psychology, Cornell University, Ithaca, NY, USA
Brain Res Bull 72:1-9. 2007....
Research Grants
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2009..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2007..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2007..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
- Human Salty and Bitter Taste MechanismsMARION FRANK; Fiscal Year: 2007..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
- Human Salty and Bitter Taste MechanismsMARION FRANK; Fiscal Year: 2006..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
- PERIPHERAL GUSTATORY PROCESSINGMARION FRANK; Fiscal Year: 2003..Taste information processing within taste buds and its effect on taste perception may provide mechanisms to control excess intake of appetitive stimuli. ..
- Human Salty and Bitter Taste MechanismsMARION FRANK; Fiscal Year: 2003..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
- PERIPHERAL GUSTATORY PROCESSINGMARION ELIZABETH FRANK; Fiscal Year: 2010..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..