MARION ELIZABETH FRANK

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Effects of selective adaptation on coding sugar and salt tastes in mixtures
    Marion E Frank
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1715, USA
    Chem Senses 37:701-9. 2012
  2. ncbi request reprint Taste responses to mixtures: analytic processing of quality
    Marion E Frank
    School of Dental Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington 06030 1605, USA
    Behav Neurosci 117:228-35. 2003
  3. ncbi request reprint Variation in intake of sweet and bitter solutions by inbred strains of golden hamsters
    Marion E Frank
    Neurosciences, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Behav Genet 34:465-76. 2004
  4. ncbi request reprint Effects of chlorhexidine on human taste perception
    M E Frank
    Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Taste and Smell Center MC 1718, 263 Farmington Avenue, Farmington, CT 06030 1718, USA
    Physiol Behav 74:85-99. 2001
  5. ncbi request reprint Neuron types, receptors, behavior, and taste quality
    M E Frank
    Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 1605, USA
    Physiol Behav 69:53-62. 2000
  6. ncbi request reprint What the tongue tells the brain about taste
    Marion E Frank
    University of Connecticut Health Center, Farmington, CT, USA
    Chem Senses 30:i68-9. 2005
  7. ncbi request reprint Peripheral gustatory processing of sweet stimuli by golden hamsters
    Marion E Frank
    Neurosciences, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Brain Res Bull 66:70-84. 2005
  8. ncbi request reprint Chorda tympani responses in two inbred strains of mice with different taste preferences
    M E Frank
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Physiol Behav 67:287-97. 1999
  9. pmc Cracking taste codes by tapping into sensory neuron impulse traffic
    Marion E Frank
    Center for Chemosensory Sciences, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030 1715, United States
    Prog Neurobiol 86:245-63. 2008
  10. pmc Time and intensity factors in identification of components of odor mixtures
    Marion E Frank
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1715, USA
    Chem Senses 35:777-87. 2010

Research Grants

  1. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2009
  2. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2000
  3. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
  4. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
  5. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
  6. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2006
  7. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2006
  8. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2003
  9. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2003
  10. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2002

Collaborators

Detail Information

Publications24

  1. pmc Effects of selective adaptation on coding sugar and salt tastes in mixtures
    Marion E Frank
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030 1715, USA
    Chem Senses 37:701-9. 2012
    ..Furthermore, like odors, stronger and recent tastes are emphasized in dynamic experimental conditions replicating natural situations...
  2. ncbi request reprint Taste responses to mixtures: analytic processing of quality
    Marion E Frank
    School of Dental Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington 06030 1605, USA
    Behav Neurosci 117:228-35. 2003
    ..e., asymmetric). The behaviors reflect peripheral inhibition and/or central mixture suppression. Nonetheless, components retain their distinct qualities in mixtures, suggesting that taste processing is analytic...
  3. ncbi request reprint Variation in intake of sweet and bitter solutions by inbred strains of golden hamsters
    Marion E Frank
    Neurosciences, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Behav Genet 34:465-76. 2004
    ..13 to 0.23 for the two optical isomers. Thus, although, compared to mice, genetic variation in laboratory hamsters may be small, genetic differences that influence taste behaviors in existing strains may help identify relevant genes...
  4. ncbi request reprint Effects of chlorhexidine on human taste perception
    M E Frank
    Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Taste and Smell Center MC 1718, 263 Farmington Avenue, Farmington, CT 06030 1718, USA
    Physiol Behav 74:85-99. 2001
    ..The ability of chlorhexidine to specifically disrupt saltiness of a wide range of salts is consistent with proposed peripheral transduction mechanisms for the salty quality that involve transepithelial ion transport...
  5. ncbi request reprint Neuron types, receptors, behavior, and taste quality
    M E Frank
    Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 1605, USA
    Physiol Behav 69:53-62. 2000
    ..Definitive conclusions regarding "patterns" or "labeled lines" requires an understanding of mechanisms of central neural processing of the several specialist and generalist taste-afferent inputs...
  6. ncbi request reprint What the tongue tells the brain about taste
    Marion E Frank
    University of Connecticut Health Center, Farmington, CT, USA
    Chem Senses 30:i68-9. 2005
  7. ncbi request reprint Peripheral gustatory processing of sweet stimuli by golden hamsters
    Marion E Frank
    Neurosciences, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Brain Res Bull 66:70-84. 2005
    ..Taste-bud processing, possibly between-cell inhibition and within-cell negative feedback, must modify signals initiated by T1 receptors before they are transmitted to the brain...
  8. ncbi request reprint Chorda tympani responses in two inbred strains of mice with different taste preferences
    M E Frank
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Physiol Behav 67:287-97. 1999
    ..Nonetheless, genes involved in the structuring of taste receptors and/or the chordae tympani, which transduce taste stimuli having diverse perceptual qualities, differ for the two mouse strains...
  9. pmc Cracking taste codes by tapping into sensory neuron impulse traffic
    Marion E Frank
    Center for Chemosensory Sciences, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030 1715, United States
    Prog Neurobiol 86:245-63. 2008
    ..Establishing the information afferent neurons traffic to the brain about natural taste stimuli imbedded in dynamic complex mixtures will ultimately "crack taste codes."..
  10. pmc Time and intensity factors in identification of components of odor mixtures
    Marion E Frank
    Department of Oral Health and Diagnostic Sciences, Division of Periodontology, Center for Chemosensory Sciences, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1715, USA
    Chem Senses 35:777-87. 2010
    ..Rapid selective adaptation and mixture component suppression manipulate effective intensity to promote emergence of characteristic odor qualities in dynamic natural settings...
  11. ncbi request reprint The distinctiveness of ionic and nonionic bitter stimuli
    Marion E Frank
    Neuroscience Program and Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1605, USA
    Physiol Behav 80:421-31. 2004
    ..Thus, the three ionic and two nonionic compounds form separate aversive stimulus classes in hamsters, neither of which appears to be a close homologue of the human bitter taste...
  12. ncbi request reprint Taste qualities of solutions preferred by hamsters
    B I MacKinnon
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 3705, USA
    Chem Senses 24:23-35. 1999
    ..g. salience, cation taste), rather than the absence of a 'sucrose-like' quality. The results are consistent with a single hamster perceptual quality for a diverse set of chemical structures that are sweet to humans...
  13. ncbi request reprint Responses of the rat chorda tympani nerve to glutamate-sucrose mixtures
    B K Formaker
    Department of Oral Diagnosis, Division of Neurosciences, MC 1718, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Chem Senses 29:473-82. 2004
    ....
  14. ncbi request reprint Opponent effects of quinine and sucrose on single fiber taste responses of the chorda tympani nerve
    B K Formaker
    Department of BioStructure and Function, School of Dental Medicine, The University of Connecticut Health Center, Farmington 06030, USA
    Brain Res 772:239-42. 1997
    ..Quinine may exert its effect as an opponent stimulus in the receptor cells at the second messenger level. This suppression may make bitter quinine more readily detected when embedded in mixtures with sweeteners...
  15. ncbi request reprint The taste of polycose in hamsters
    B K Formaker
    School of Dental Medicine, The University of Connecticut Health Center, Farmington, 06030, USA
    Chem Senses 23:675-82. 1998
    ..Finally, although the taste of 100 mM Polycose was more salient than the taste of 50 mM sucrose, the taste of sucrose could still be detected in a mixture with Polycose...
  16. ncbi request reprint Taste function in patients with oral burning
    B K Formaker
    Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Chem Senses 25:575-81. 2000
    ..Identification of NaCl as 'salty' and citric acid as 'sour' was particularly difficult for BMS women. The present findings are consistent with the hypothesis that pain pathway activation may affect neural and behavioral taste function...
  17. ncbi request reprint A confusion matrix for the study of taste perception
    T P Hettinger
    Department of BioStructure and Function, University of Connecticut Health Center, Farmington 06030 3705, USA
    Percept Psychophys 61:1510-21. 1999
    ..The patterns of taste confusion indicate that the 10 stimuli resemble one another to varying extents, yet each can be considered perceptually unique...
  18. ncbi request reprint Taste confusions following gymnemic acid rinse
    J F Gent
    Department of BioStructure and Function, University of Connecticut Health Center, Farmington 06030 3705, USA
    Chem Senses 24:393-403. 1999
    ..GA had no effect on discriminability of nonsweet stimulus pairs. The results suggest that specific error patterns in the TCM could be used to identify quality-specific taste disorders...
  19. ncbi request reprint The effects of topical anesthesia on oral burning in burning mouth syndrome
    B K Formaker
    Connecticut Chemosensory Clinical Research Center, School of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Ann N Y Acad Sci 855:776-80. 1998
    ..001) after anesthesia, suggesting BMS dysgeusia is related to the activation of peripheral taste mechanisms. The results also suggest that BMS oral burning may be a disorder of peripheral pain pathways in some patients...
  20. doi request reprint Regional specificity of chlorhexidine effects on taste perception
    Ruchi Grover
    Department of Biology, University of Hartford, CT 06117, USA
    Chem Senses 33:311-8. 2008
    ..The current results are the first to suggest that there may also be distinct, regionally specific populations of NaCl-taste receptors in humans...
  21. pmc Cycloheximide: no ordinary bitter stimulus
    Thomas P Hettinger
    Center for Neurosciences, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, United States
    Behav Brain Res 180:4-17. 2007
    ..The combination of T2R multiplicity, species divergence and gene duplication results in diverse ligands for multiple species-specific T2R receptors, which confounds definition of 'bitter' stimuli across species...
  22. ncbi request reprint The effect of orthognathic surgery on taste function on the palate and tongue
    Janneane F Gent
    Taste and Smell Center, Connecticut Chemosensory Clinical Research Center, Farmington, CT, USA
    J Oral Maxillofac Surg 61:766-73. 2003
    ..HCl) brushed with a cotton-tipped applicator on each of 6 oral locations (left and right soft palate, left and right anterior and posterolateral tongue)...
  23. ncbi request reprint Taste confusions following chlorhexidine treatment
    Janneane F Gent
    Division of Neurosciences, Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Chem Senses 27:73-80. 2002
    ..As a selective, effective, persistent and reversible blocker of taste perceptions, chlorhexidine should prove useful in defining taste mechanisms in humans...
  24. pmc Characteristic component odors emerge from mixtures after selective adaptation
    Holly F Goyert
    Department of Psychology, Cornell University, Ithaca, NY, USA
    Brain Res Bull 72:1-9. 2007
    ....

Research Grants16

  1. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2009
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  2. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2000
    ..Taste information processing within taste buds and its effect on taste perception may provide mechanisms to control excess intake of appetitive stimuli. ..
  3. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  4. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2007
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  5. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  6. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2006
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  7. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2006
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  8. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2003
    ..Taste information processing within taste buds and its effect on taste perception may provide mechanisms to control excess intake of appetitive stimuli. ..
  9. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2003
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  10. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2002
    ..Taste information processing within taste buds and its effect on taste perception may provide mechanisms to control excess intake of appetitive stimuli. ..
  11. PERIPHERAL GUSTATORY PROCESSING
    MARION FRANK; Fiscal Year: 2001
    ..Taste information processing within taste buds and its effect on taste perception may provide mechanisms to control excess intake of appetitive stimuli. ..
  12. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..