Marcos Frank

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor
    Marcos G Frank
    W M Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA
    Neuropsychopharmacology 27:869-73. 2002
  2. ncbi The mystery of sleep function: current perspectives and future directions
    Marcos G Frank
    Department of Neuroscience, University ofPennsylvania, Philadelphia, PA 19014, USA
    Rev Neurosci 17:375-92. 2006
  3. pmc A preliminary study of sleep ontogenesis in the ferret (Mustela putorius furo)
    Allison Thurber
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Behav Brain Res 189:41-51. 2008
  4. ncbi Sleep and developmental plasticity not just for kids
    Marcos Gabriel Frank
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Prog Brain Res 193:221-32. 2011
  5. ncbi Beyond the neuron: astroglial regulation of mammalian sleep
    Marcos G Frank
    University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, PA 19104 6074, USA
    Curr Top Med Chem 11:2452-6. 2011
  6. pmc The sedating antidepressant trazodone impairs sleep-dependent cortical plasticity
    Sara J Aton
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e6078. 2009
  7. pmc Translation regulation in sleep: Making experience last
    Julie Seibt
    Department of Neuroscience Perelman School of Medicine University of Pennsylvania Philadelphia, PA USA Institute of Physiology University of Bern Bern, Switzerland
    Commun Integr Biol 5:491-5. 2012
  8. pmc Why I Am Not SHY: A Reply to Tononi and Cirelli
    Marcos Gabriel Frank
    Department of Neuroscience, Perelman School of Medicine University of Pennsylvania, 215 Stemmler Hall, Philadelphia, PA 19104, USA
    Neural Plast 2013:394946. 2013
  9. ncbi Astroglial regulation of sleep homeostasis
    Marcos G Frank
    University of Pennsylvania, Perelman School of Medicine, Department of Neuroscience, 215 Stemmler Hall, 35th and Hamilton Walk, Philadelphia, PA 19104 6074, United States Electronic address
    Curr Opin Neurobiol 23:812-8. 2013
  10. pmc A preliminary analysis of sleep-like states in the cuttlefish Sepia officinalis
    Marcos G Frank
    Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e38125. 2012

Collaborators

Detail Information

Publications24

  1. pmc Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor
    Marcos G Frank
    W M Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA
    Neuropsychopharmacology 27:869-73. 2002
    ..These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin...
  2. ncbi The mystery of sleep function: current perspectives and future directions
    Marcos G Frank
    Department of Neuroscience, University ofPennsylvania, Philadelphia, PA 19014, USA
    Rev Neurosci 17:375-92. 2006
    ..The evidence for these possibilities, however, is weak or equivocal. On the other hand, converging lines of evidence support the hypothesis that sleep promotes brain plasticity...
  3. pmc A preliminary study of sleep ontogenesis in the ferret (Mustela putorius furo)
    Allison Thurber
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Behav Brain Res 189:41-51. 2008
    ....
  4. ncbi Sleep and developmental plasticity not just for kids
    Marcos Gabriel Frank
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Prog Brain Res 193:221-32. 2011
    ..This is followed by more recent findings in the developing visual cortex that more specifically address a possible role for sleep in cortical plasticity...
  5. ncbi Beyond the neuron: astroglial regulation of mammalian sleep
    Marcos G Frank
    University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, PA 19104 6074, USA
    Curr Top Med Chem 11:2452-6. 2011
    ..Recent findings, however, suggest that the glial cells known as astrocytes may play critical roles in mammalian sleep...
  6. pmc The sedating antidepressant trazodone impairs sleep-dependent cortical plasticity
    Sara J Aton
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e6078. 2009
    ....
  7. pmc Translation regulation in sleep: Making experience last
    Julie Seibt
    Department of Neuroscience Perelman School of Medicine University of Pennsylvania Philadelphia, PA USA Institute of Physiology University of Bern Bern, Switzerland
    Commun Integr Biol 5:491-5. 2012
    ..e., ARC and BDNF). Our study thus reveals a previously unknown mechanism operating during sleep that consolidates cortical plasticity in vivo...
  8. pmc Why I Am Not SHY: A Reply to Tononi and Cirelli
    Marcos Gabriel Frank
    Department of Neuroscience, Perelman School of Medicine University of Pennsylvania, 215 Stemmler Hall, Philadelphia, PA 19104, USA
    Neural Plast 2013:394946. 2013
    ..In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms...
  9. ncbi Astroglial regulation of sleep homeostasis
    Marcos G Frank
    University of Pennsylvania, Perelman School of Medicine, Department of Neuroscience, 215 Stemmler Hall, 35th and Hamilton Walk, Philadelphia, PA 19104 6074, United States Electronic address
    Curr Opin Neurobiol 23:812-8. 2013
    ..Implicit in both views is the idea that sleep homeostasis is solely the product of neurons. In this article, I discuss an emerging view that glial astrocytes may play an essential role in sleep homeostasis...
  10. pmc A preliminary analysis of sleep-like states in the cuttlefish Sepia officinalis
    Marcos G Frank
    Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e38125. 2012
    ..Our findings thus suggest that at least two different sleep-like states may exist in Sepia officinalis...
  11. pmc Erasing synapses in sleep: is it time to be SHY?
    Marcos Gabriel Frank
    Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6074, USA
    Neural Plast 2012:264378. 2012
    ..I conclude that while SHY remains an elegant idea, the underlying mechanisms are mysterious and its functional significance unknown...
  12. ncbi Unresolved issues in sleep ontogeny: a response to Blumberg et al
    Marcos G Frank
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6074, USA
    J Sleep Res 14:98-101. 2005
  13. ncbi Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex
    Marcos G Frank
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neuroreport 17:1459-63. 2006
    ..These findings demonstrate that postsynaptic activity during sleep is required for the consolidation of experience-dependent cortical plasticity...
  14. ncbi The role of sleep in memory consolidation and brain plasticity: dream or reality?
    Marcos G Frank
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia 19104 6074, USA
    Neuroscientist 12:477-88. 2006
    ..This impasse may be resolved by more integrated approaches that combine behavioral and neurophysiological measurements in well-described in vivo models of synaptic plasticity...
  15. ncbi Sleep-dependent plasticity requires cortical activity
    Sushil K Jha
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    J Neurosci 25:9266-74. 2005
    ..They provide an important insight into how sleep modifies synaptic circuitry by narrowing the range of possible candidate mechanisms to those that are activity dependent...
  16. pmc The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity
    Julie Seibt
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 31:1381-91. 2008
    ..We have shown that sleep enhances a canonical model of in vivo cortical plasticity, known as ocular dominance plasticity (ODP). We investigated the effects of 3 different classes of hypnotics on ODP...
  17. pmc Mechanisms of sleep-dependent consolidation of cortical plasticity
    Sara J Aton
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:454-66. 2009
    ..These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP...
  18. pmc T-type calcium channels regulate cortical plasticity in-vivo. [corrected]
    Victor N Uebele
    Department of Sleep Research, Merck Research Laboratories, Philadelphia, Pennsylvania, USA
    Neuroreport 20:257-62. 2009
    ..These results show that the T-type calcium channel plays a central role in cortical plasticity...
  19. pmc Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo
    Tommaso Fellin
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:15037-42. 2009
    ..These results demonstrate that rhythmic brain activity is generated by the coordinated action of the neuronal and glial networks...
  20. doi Paradoxical effects of the hypnotic Zolpidem in the neonatal ferret
    Nina Hsu
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Behav Brain Res 201:233-6. 2009
    ..Our findings demonstrate that hypnotics that improve sleep quality in adults may produce profoundly different behavioral changes in neonates...
  21. pmc Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    Michael M Halassa
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:213-9. 2009
    ....
  22. ncbi Sleep and sleep regulation in the ferret (Mustela putorius furo)
    Sushil K Jha
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6074, USA
    Behav Brain Res 172:106-13. 2006
    ..However, the large amount of REM sleep in this phylogenetically more ancient species suggests that REM sleep may have been present in greater amounts in early stages of mammalian evolution...
  23. ncbi The ontogeny of mammalian sleep: a reappraisal of alternative hypotheses
    Marcos G Frank
    Department of Neuroscience, University of Pennsylvania School of Medicine, 215 Stemmler Hall, 35th and Hamilton Walk, Philadelphia, PA 19104 6074, USA
    J Sleep Res 12:25-34. 2003
    ....
  24. ncbi Cellular and molecular connections between sleep and synaptic plasticity
    Joel H Benington
    Department of Biology, St Bonaventure University, St Bonaventure, NY 14778, USA
    Prog Neurobiol 69:71-101. 2003
    ..We have also provided a general review of evidence for and against the hypothesis that sleep does indeed facilitate learning, memory, and synaptic plasticity...

Research Grants8

  1. Sleep and neural plasticity in developing neocortex
    Marcos Frank; Fiscal Year: 2005
    ..We will then investigate the role of sleep in the cortical plasticity elicited by reverse-MD. ..
  2. Consolidation mechanisms in the developing visual cortex
    Marcos G Frank; Fiscal Year: 2010
    ..This will improve our understanding of normal and pathological brain development and memory formation. ..
  3. Sleep and neural plasticity in developing neocortex
    Marcos Frank; Fiscal Year: 2002
    ..We will then investigate the role of sleep in the cortical plasticity elicited by reverse-MD. ..
  4. Sleep and neural plasticity in developing neocortex
    Marcos Frank; Fiscal Year: 2003
    ..We will then investigate the role of sleep in the cortical plasticity elicited by reverse-MD. ..
  5. Sleep and neural plasticity in developing neocortex
    Marcos Frank; Fiscal Year: 2002
    ..We will then investigate the role of sleep in the cortical plasticity elicited by reverse-MD. ..
  6. Sleep and neural plasticity in developing neocortex
    Marcos Frank; Fiscal Year: 2004
    ..We will then investigate the role of sleep in the cortical plasticity elicited by reverse-MD. ..
  7. Consolidation mechanisms in the developing visual cortex
    Marcos Frank; Fiscal Year: 2009
    ..This will improve our understanding of normal and pathological brain development and memory formation. ..