James Frank

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Claudins and alveolar epithelial barrier function in the lung
    James A Frank
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, USA
    Ann N Y Acad Sci 1257:175-83. 2012
  2. ncbi request reprint Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
    J A Frank
    Cardiovascular Research Institute, University of California, San Francisco VA Medical Center, 4150 Clement St, Box 111D, San Francisco, CA 94121, USA
    Thorax 63:147-53. 2008
  3. pmc Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs
    James A Frank
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L52-9. 2007
  4. pmc Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies
    James A Frank
    Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 4150 Clement Street, Mail Stop 111D, San Francisco, CA 94121, USA
    Chest 130:1906-14. 2006
  5. ncbi request reprint Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury
    James A Frank
    University of California San Francisco, Departmnet of Medicine, San Francisco CA 94121, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1191-8. 2006
  6. ncbi request reprint Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
  7. pmc Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
    Michael J Lafemina
    Univ of California, San Francisco, NCIRE VAMC, 94121, USA
    Am J Physiol Lung Cell Mol Physiol 299:L724-34. 2010
  8. ncbi request reprint Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:181-8; discussion 254-5. 2005
  9. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
  10. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008

Collaborators

Detail Information

Publications18

  1. doi request reprint Claudins and alveolar epithelial barrier function in the lung
    James A Frank
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, USA
    Ann N Y Acad Sci 1257:175-83. 2012
    ..This review considers recent advances in the understanding of the role of claudins in the breakdown of the alveolar epithelial barrier in disease and in epithelial repair...
  2. ncbi request reprint Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
    J A Frank
    Cardiovascular Research Institute, University of California, San Francisco VA Medical Center, 4150 Clement St, Box 111D, San Francisco, CA 94121, USA
    Thorax 63:147-53. 2008
    ..A study was undertaken to determine if IL-1 signalling is a necessary early event in the pathogenesis of experimental ventilator-induced lung injury...
  3. pmc Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs
    James A Frank
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L52-9. 2007
    ..Also, although additional studies are needed, a biological marker of alveolar epithelial injury may be useful clinically in predicting preserved AFC...
  4. pmc Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies
    James A Frank
    Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 4150 Clement Street, Mail Stop 111D, San Francisco, CA 94121, USA
    Chest 130:1906-14. 2006
    ..This analysis suggests that measurement of some of these biological markers may be of value in diagnosing VALI and in understanding its pathogenesis...
  5. ncbi request reprint Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury
    James A Frank
    University of California San Francisco, Departmnet of Medicine, San Francisco CA 94121, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1191-8. 2006
    ..These data demonstrate that injurious mechanical ventilation rapidly activates alveolar macrophages and that alveolar macrophages play an important role in the initial pathogenesis of VILI...
  6. ncbi request reprint Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
    ..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
  7. pmc Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
    Michael J Lafemina
    Univ of California, San Francisco, NCIRE VAMC, 94121, USA
    Am J Physiol Lung Cell Mol Physiol 299:L724-34. 2010
    ..In addition, these data demonstrate the complete claudin expression profile for AT1 and AT2 cells and indicate that claudins-3, -4, and -18 are the primary claudins expressed in these cell types...
  8. ncbi request reprint Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:181-8; discussion 254-5. 2005
    ..The primary objective of this study was to determine the effect of one type of recruitment maneuver--sustained inflation--on alveolar epithelial and lung endothelial injury in experimental acute lung injury...
  9. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
    ..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
  10. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  11. ncbi request reprint High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 284:L791-8. 2003
    ..Because air space edema fluid inactivates surfactant and reduces ventilated lung volume, the reduction of cAMP-dependent AFC by reactive nitrogen species may be an important mechanism of clinical ventilator-associated lung injury...
  12. pmc Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome
    Jan Hirsch
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Respir Crit Care Med 175:1006-13. 2007
    ..Mechanical ventilation with high tidal volumes leads to increased permeability, generation of inflammatory mediators, and damage to alveolar epithelial cells (ATII)...
  13. pmc Science review: mechanisms of ventilator-induced injury
    James A Frank
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, Cardiovascular Research Institute, San Francisco, California, USA
    Crit Care 7:233-41. 2003
    ..The objective of the present article is to review the potential cellular mechanisms of lung injury attributable to mechanical ventilation in patients with ARDS and acute lung injury...
  14. pmc Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function
    George Su
    Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Am J Respir Cell Mol Biol 36:377-86. 2007
    ..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI...
  15. ncbi request reprint Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ....
  16. ncbi request reprint Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs
    James A Frank
    Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Crit Care Med 165:242-9. 2002
    ..The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium...
  17. ncbi request reprint Progress toward a systems biology approach to acute lung injury
    James A Frank
    Am J Physiol Lung Cell Mol Physiol 293:L290-1. 2007
  18. pmc Leukotrienes in acute lung injury: a potential therapeutic target?
    James A Frank
    Am J Respir Crit Care Med 172:261-2. 2005

Research Grants7

  1. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  2. Regulation of alveolar epithelial barrier function by claudins
    James Frank; Fiscal Year: 2009
    ..These studies will provide a more complete understanding of the mechanisms of alveolar epithelial barrier regulation during lung injury and facilitate the development of new therapeutic strategies for ARDS patients. ..
  3. Regulation of alveolar epithelial barrier function by claudins
    James Frank; Fiscal Year: 2009
    ..These studies will provide a more complete understanding of the mechanisms of alveolar epithelial barrier regulation during lung injury and facilitate the development of new therapeutic strategies for ARDS patients. ..
  4. Regulation of alveolar epithelial barrier function by claudins
    James A Frank; Fiscal Year: 2010
    ..These studies will provide a more complete understanding of the mechanisms of alveolar epithelial barrier regulation during lung injury and facilitate the development of new therapeutic strategies for ARDS patients. ..