Guido K Frank

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Neuroimaging studies in eating disorders
    Guido K Frank
    Department of Eating Disorders Research, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    CNS Spectr 9:539-48. 2004
  2. ncbi request reprint Altered reward processing in women recovered from anorexia nervosa
    Angela Wagner
    University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1842-9. 2007
  3. ncbi request reprint Serotonin transporter binding after recovery from eating disorders
    Ursula F Bailer
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 195:315-24. 2007
  4. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
  5. doi request reprint Altered striatal response to reward in bulimia nervosa after recovery
    Angela Wagner
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Int J Eat Disord 43:289-94. 2010
  6. ncbi request reprint Regional cerebral blood flow after recovery from anorexia or bulimia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 40:488-92. 2007
  7. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
  8. ncbi request reprint Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies
    Walter H Kaye
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
    Physiol Behav 85:73-81. 2005
  9. ncbi request reprint Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness
    Ursula F Bailer
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 29:1143-55. 2004
  10. ncbi request reprint Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa
    Angela Wagner
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:513-23. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Neuroimaging studies in eating disorders
    Guido K Frank
    Department of Eating Disorders Research, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    CNS Spectr 9:539-48. 2004
    ..Taken together, these findings give promise for future investigations with the hope of delineating brain pathways that contribute to the etiology of EDs..
  2. ncbi request reprint Altered reward processing in women recovered from anorexia nervosa
    Angela Wagner
    University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1842-9. 2007
    ..Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder...
  3. ncbi request reprint Serotonin transporter binding after recovery from eating disorders
    Ursula F Bailer
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 195:315-24. 2007
    ..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)...
  4. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
    ..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors...
  5. doi request reprint Altered striatal response to reward in bulimia nervosa after recovery
    Angela Wagner
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Int J Eat Disord 43:289-94. 2010
    ..It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder...
  6. ncbi request reprint Regional cerebral blood flow after recovery from anorexia or bulimia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 40:488-92. 2007
    ..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN...
  7. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
    ..Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety...
  8. ncbi request reprint Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies
    Walter H Kaye
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
    Physiol Behav 85:73-81. 2005
    ..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches...
  9. ncbi request reprint Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness
    Ursula F Bailer
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 29:1143-55. 2004
    ..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects...
  10. ncbi request reprint Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa
    Angela Wagner
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:513-23. 2008
    ..These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns...
  11. ncbi request reprint Neural correlates of habituation to taste stimuli in healthy women
    Angela Wagner
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213, USA
    Psychiatry Res 147:57-67. 2006
    ..By contrast, for sequential blocks, both stimuli produced habituation in taste-related brain regions. These data suggest that habituation patterns in healthy subjects may depend on frequency and regularity of stimulus administration...
  12. ncbi request reprint An open trial of olanzapine in anorexia nervosa
    Nicole C Barbarich
    Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1480-2. 2004
    ..Recent reports raise the possibility that olanzapine can assist weight gain and improve behavioral symptoms during refeeding in anorexia nervosa...
  13. ncbi request reprint Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: a pilot study
    Guido K Frank
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 39:76-9. 2006
    ..Taste plays a role in the regulation of appetite and the purpose of the current study was to determine whether bulimic women have alterations in the physiologic response to the blind administration of glucose...
  14. ncbi request reprint Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systems
    Walter H Kaye
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 37:S15-9; discussion S20-1. 2005
    ....
  15. ncbi request reprint Brain imaging of serotonin after recovery from anorexia and bulimia nervosa
    Walter H Kaye
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Iroquois Building, PA 15213, USA
    Physiol Behav 86:15-7. 2005
    ..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches...
  16. ncbi request reprint Personality traits after recovery from eating disorders: do subtypes differ?
    Angela Wagner
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 39:276-84. 2006
    ..We compared individuals recovered from anorexia (AN) and bulimia nervosa (BN) to determine characteristics that are shared by or distinguish eating disorder (ED) subtypes...
  17. ncbi request reprint 5HT2A receptor binding is increased in borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Biol Psychiatry 62:580-7. 2007
    ..We examined 5HT(2A) receptor binding potential (BP) in impulsive subjects with BPD, with positron emission tomography neuroimaging with [(18)F] altanserin...
  18. ncbi request reprint Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa
    Nicole C Barbarich
    Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 35:10-5. 2004
    ..However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects...
  19. ncbi request reprint Olanzapine treatment of anorexia nervosa: a retrospective study
    Amanda Malina
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 33:234-7. 2003
    ..Recent reports raise the possibility that olanzapine, which commonly causes weight gain in non-eating-disordered subjects, assisted weight gain and mood during refeeding in anorexia nervosa (AN) patients...
  20. ncbi request reprint Reduced 5-HT2A receptor binding after recovery from anorexia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 52:896-906. 2002
    ..This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5HT2A) receptor, which could contribute to disturbances of appetite and behavior in AN...
  21. ncbi request reprint The evaluation of brain activity in response to taste stimuli--a pilot study and method for central taste activation as assessed by event-related fMRI
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Room 132, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Neurosci Methods 131:99-105. 2003
    ..We developed a standardized method for the assessment of brain activation in response to taste stimuli...
  22. ncbi request reprint Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosa
    Angela Wagner
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 59:291-3. 2006
    ..It is unclear whether such disturbances persist after recovery from an eating disorder...
  23. ncbi request reprint Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005
    ..Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN)...
  24. ncbi request reprint Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapy
    Guido K Frank
    Department of Child and Adolescent Psychiatry, Center for Eating Disorders Research, School of Medicine, University of California San Diego, 92123, USA
    Nucl Med Biol 32:755-61. 2005
    ..These recognized receptors may now help us to move away from rather nonspecific treatment approaches in psychiatric research and clinic to the possibility of more syndrome- and symptom-specific treatment approaches...