Research Topics
Genomes and GenesSpecies | Guido K FrankSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Neuroimaging studies in eating disordersGuido K Frank
Department of Eating Disorders Research, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
CNS Spectr 9:539-48. 2004..Taken together, these findings give promise for future investigations with the hope of delineating brain pathways that contribute to the etiology of EDs..- Altered reward processing in women recovered from anorexia nervosaAngela Wagner
University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1842-9. 2007..Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum to reward and loss in this disorder... - Serotonin transporter binding after recovery from eating disordersUrsula F Bailer
Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 195:315-24. 2007..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)... - Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosaUrsula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:1090-9. 2007..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors... 
Altered striatal response to reward in bulimia nervosa after recoveryAngela Wagner
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
Int J Eat Disord 43:289-94. 2010..It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder...- Regional cerebral blood flow after recovery from anorexia or bulimia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 40:488-92. 2007..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN... - Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studiesWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
Physiol Behav 85:73-81. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinnessUrsula F Bailer
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 29:1143-55. 2004..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects... - Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosaAngela Wagner
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 33:513-23. 2008..These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns... - Neural correlates of habituation to taste stimuli in healthy womenAngela Wagner
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213, USA
Psychiatry Res 147:57-67. 2006..By contrast, for sequential blocks, both stimuli produced habituation in taste-related brain regions. These data suggest that habituation patterns in healthy subjects may depend on frequency and regularity of stimulus administration... - An open trial of olanzapine in anorexia nervosaNicole C Barbarich
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Clin Psychiatry 65:1480-2. 2004..CONCLUSION: These data lend support to the possibility that olanzapine may be useful in treating anorexia nervosa. However, a controlled trial is necessary to demonstrate that olanzapine is efficacious... - Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: a pilot studyGuido K Frank
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 39:76-9. 2006..However, this is a small sample and the current study will need replication in a larger sample size with investigation of additional regions of interest... - Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systemsWalter H Kaye
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 37:S15-9; discussion S20-1. 2005.... - Brain imaging of serotonin after recovery from anorexia and bulimia nervosaWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Iroquois Building, PA 15213, USA
Physiol Behav 86:15-7. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - Personality traits after recovery from eating disorders: do subtypes differ?Angela Wagner
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 39:276-84. 2006..We compared individuals recovered from anorexia (AN) and bulimia nervosa (BN) to determine characteristics that are shared by or distinguish eating disorder (ED) subtypes... - 5HT2A receptor binding is increased in borderline personality disorderPaul H Soloff
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Biol Psychiatry 62:580-7. 2007..We examined 5HT(2A) receptor binding potential (BP) in impulsive subjects with BPD, with positron emission tomography neuroimaging with [(18)F] altanserin... - Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosaNicole C Barbarich
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 35:10-5. 2004..DISCUSSION: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects... - Olanzapine treatment of anorexia nervosa: a retrospective studyAmanda Malina
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 33:234-7. 2003..DISCUSSION: These data lend support to the possibility that olanzapine may be useful in AN patients. CONCLUSION: A controlled trial is necessary to prove that olanzapine is efficacious... - Reduced 5-HT2A receptor binding after recovery from anorexia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 52:896-906. 2002..Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of AN... - The evaluation of brain activity in response to taste stimuli--a pilot study and method for central taste activation as assessed by event-related fMRIGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Room 132, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Neurosci Methods 131:99-105. 2003..We developed a standardized method for the assessment of brain activation in response to taste stimuli... - Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosaAngela Wagner
Department of Psychiatry, Western Psychiatric Institute and Clinic, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania, USA
Biol Psychiatry 59:291-3. 2006..CONCLUSIONS: These findings suggest that structural brain abnormalities are reversible in individuals with eating disorders after long-term recovery... - Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]racloprideGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
Biol Psychiatry 58:908-12. 2005..Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament... - Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapyGuido K Frank
Department of Child and Adolescent Psychiatry, Center for Eating Disorders Research, School of Medicine, University of California San Diego, 92123, USA
Nucl Med Biol 32:755-61. 2005..These recognized receptors may now help us to move away from rather nonspecific treatment approaches in psychiatric research and clinic to the possibility of more syndrome- and symptom-specific treatment approaches...